Clinical trials: Oncologic
Breast Neoplasms, Lung Neoplasms
Benchmarking Large Language Models Against Tumour Boards for Oncology Treatment Recommendations
BEACON (Benchmarking AI for Clinical Oncology decisioNmaking) is a prospective, multicentre, comparative, blinded, non-interventional benchmark comparing the treatment recommendations of six frontier large language models (LLMs)…
- Conditions
- Breast Neoplasms, Lung Neoplasms, Urologic Neoplasms, Prostatic Neoplasms
- Trial name
- BEACON (NCT07739121)
- Testing
- Multidisciplinary tumour boards, Frontier large language models
- Where
- 5 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Smoking Cessation
Implementation of Smoking Cessation Within NCI Community Oncology Research Program (NCORP) Sites
Evaluate a multi-faceted training program to improve short-term smoking cessation rates (<14 days post-visit) and short (3 months) and sustained abstinence (6 months) among 1,114 enrolled smokers who present for low-dose computed…
- Trial name
- OaSiS (NCT03291587)
- Testing
- Personnel Training and Coaching Calls
- Where
- 49 sites in United States
- Volunteers
- 1,094 people
- Sponsor
- Wake Forest University Health Sciences
Pediatric Oncology
The Effects of Nonpharmacological Methods Used in Subcutaneous Application on Pain, Anxiety, and Fear Levels in Children
Childhood cancers are increasing globally and require long-term invasive treatments, particularly subcutaneous applications that often cause pain, swelling, and anxiety.
- Trial name
- NCT07163104
- Testing
- Kaleidoscope, Buzzy, Cognitive behavioral intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Zubeyde Ezgi Ercelik
Breast Cancer, Cardiotoxicity
Understanding CARdiac Events in Breast Cancer
In Ireland, over 3,000 patients are diagnosed with breast cancer annually, and 1 in 9 Irish women will be diagnosed with breast cancer in their lifetime.
- Conditions
- Breast Cancer, Cardiotoxicity, Cardiomyopathies, Chemotherapeutic Toxicity
- Trial name
- UCARE (NCT05921279)
- Where
- 4 sites in Ireland
- Volunteers
- 100 people
- Sponsor
- National University of Ireland, Galway, Ireland
Cancer Survivor, Cancer
Leading Healthy Eating and Activity Promotion Program
The goal of the LEAP project is to improve the health and well-being of cancer survivors and their co-survivors living in persistent poverty areas by providing healthy behavior change support.
- Conditions
- Cancer Survivor, Cancer, Oncology
- Trial name
- LEAP (NCT06868524)
- Testing
- LEAP Program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Medical Oncology, Integrative Oncology
A Pilot and Feasibility Study of a Dietary Intervention With Low-protein Meals in Cancer Patients Receiving Immunotherapies
The main idea of this study is that a low protein diet may alter the environment surrounding the tumor, enhancing the body's immune response leading to greater anticancer effects of treatment.
- Conditions
- Medical Oncology, Integrative Oncology, Medical Nutrition Therapy
- Trial name
- NCT05356182
- Testing
- Diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Sarcoma
Evaluating the Use of Educational Videos in Newly Diagnosed Patients in a Medical Oncology Sarcoma Clinic
This study aims to evaluate how sarcoma-specific educational videos improve patients' knowledge of their disease and treatment options before their first clinic appointment.
- Trial name
- NCT06805773
- Testing
- Educational videos, Standard of Care
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mount Sinai Hospital, Canada
Undefined
Study on the Impact of a Modified Mediterranean Diet, in Patients With Colorectal Cancer Undergoing Active Medical Oncology Treatment
The study plans to evaluate the impact of the Modified Mediterranean Diet on the biodiversity of the intestinal microbiota (the set of physiological bacteria present at the intestinal level) in patients suffering from metastatic…
- Trial name
- MIC-1 (NCT06794931)
- Testing
- Nutrition, Biological samples collection
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Socio Sanitaria della Brianza
Cancer
Evaluation of the Therapeutic Approach of Aromatherapy by Olfaction of Essential Oils in Association With Hypnosis in the Management of Patients Followed for Cancer
Patients having the following gestures (blood test, change of dressing for cancerous lesion and complete toilet in bed) will be identified by the team of the medical oncology department.
- Trial name
- HYPNO-AROMA (NCT05714995)
- Testing
- hypnosis, Hypnosis with aromatherapy
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Prostatic Neoplasms, Psychological Distress
ComCancer: Use of Let's Discuss Health Website by Patients With Prostate Cancer Undergoing Radiation Oncology Treatment
In Canada, the prevalence of cancer is growing and contributes significantly to health costs. The prevention and treatment of cancer is a major concern of our health system.
- Conditions
- Prostatic Neoplasms, Psychological Distress, Physician-Patient Relations, Communication
- Trial name
- NCT05787145
- Testing
- Let's Discuss Health Group
- Where
- 3 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Prostate Cancer
Randomized Controlled Trial of CAN-2409 Immunotherapy During Active Surveillance for Prostate Cancer (ULYSSES)
The purpose of this study is to evaluate the effectiveness of CAN-2409 immunotherapy in patients undergoing active surveillance for localized prostate cancer.
- Trial name
- NCT02768363
- Testing
- aglatimagene besadenovec, valacyclovir
- Where
- 23 sites in United States, Mexico
- Volunteers
- 187 people
- Sponsor
- Candel Therapeutics, Inc.
Cancer Patients With Solid Tumors
Dose-Escalation and Safety Trial of YN968D1
This protocol will be divided into two parts: Part 1 will evaluate the safety and pharmacokinetics of three doses of YN968D1 after a single administration followed by a 28-Day continuous course of therapy; Part 2 will evaluate…
- Trial name
- NCT01497704
- Testing
- YN968D1
- Where
- 2 sites in United States, South Korea
- Volunteers
- 55 people
- Sponsor
- Elevar Therapeutics
Pancreatic Adenocarcinoma, PET / CT
68Ga-FAPI-46 in Staging of Pancreatic Adenocarcinoma
This clinical study investigates the use of a new imaging technique called 68Ga-FAPI-46 PET/CT in people with pancreatic ductal adenocarcinoma (PDAC), a type of cancer known for its rapid progression, late diagnosis, and poor…
- Conditions
- Pancreatic Adenocarcinoma, PET / CT, FAPI, Surgical Oncology
- Trial name
- NCT06911021
- Testing
- 68Ga-FAPI-46 PET/CT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cancer
Study to Investigate the Absorption, Distribution, Metabolism and Elimination of [14C]GSK1120212
GSK1120212 is a reversible and highly selective allosteric inhibitor of MEK1 and MEK2 activation and kinase activity currently being developed for the treatment of malignant melanoma.
- Trial name
- NCT01387204
- Testing
- GSK1120212
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- GlaxoSmithKline
Late Effects, Testicular Germ Cell Tumor Mixed
A Post-treatment Program to Identify and Manage Complications Related to Oncology or Hematology Treatments in Cancer Survivors.
INTRODUCTION: Approximately 44% of cancer survivors experience a deteriorated quality of life 5 years after diagnosis due to late onset of complications related to cancer treatments.
- Conditions
- Late Effects, Testicular Germ Cell Tumor Mixed, Non-Metastatic Breast Carcinoma, Soft Tissue Sarcoma, Adult, Stage IIC
- Trial name
- PASCA (NCT04671693)
- Testing
- PASCA intervention
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Leon Berard
Lymphoma, Large-Cell, Diffuse
Ofatumumab Versus Rituximab Salvage Chemoimmunotherapy Followed by Autologous Stem Cell Transplant in Relapsed or Refractory Diffuse Large B Cell Lymphoma
This study is being conducted to compare the efficacy and safety of ofatumumab in addition to salvage chemotherapy versus rituximab in addition to salvage chemotherapy in CD20 positive DLBCL subjects relapsing, or with persistent…
- Trial name
- ORCHARRD (NCT01014208)
- Testing
- OFATUMUMAB + DHAP, RITUXIMAB + DHAP
- Where
- 173 sites in United States, Argentina and 24 more
- Volunteers
- 447 people
- Sponsor
- GlaxoSmithKline
Anxiety, Oncology
Mindfulness-Music Intervention for Adolescents and Young Adults With Cancer
This study is evaluating how well a music therapy program works to improve anxiety and stress in adolescents and young adults receiving cancer treatment.
- Conditions
- Anxiety, Oncology, Stress
- Trial name
- MAYA (NCT03709225)
- Testing
- Music-based meditation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Dana-Farber Cancer Institute
Cancer
The MATCH Study: Mindfulness And Tai Chi for Cancer Health
Background: As more people survive cancer, the importance of research on effective interventions for improving quality of life (QOL) amongst survivors is growing.
- Trial name
- MATCH (NCT02801123)
- Testing
- Mindfulness Based Cancer Recovery (MBCR), Tai Chi/Qigong (TCQ) for Cancer Patients
- Where
- 2 sites in Canada
- Volunteers
- 600 people
- Sponsor
- Linda E. Carlson
Metastatic Solid Tumor, Colon Cancer
Intratumoral Injection of IP-001 Following Thermal Ablation in Patients With CRC, NSCLC, and STS
The goal of this clinical trial is to determine the safety and efficacy of IP-001 for intratumoral injection administration following thermal ablation of a solid tumor.
- Conditions
- Metastatic Solid Tumor, Colon Cancer, Nonsmall Cell Lung Cancer, Soft Tissue Sarcoma
- Trial name
- INJECTABL-1 (NCT05688280)
- Testing
- 1.0% IP-001 for Injection
- Where
- 16 sites in United States, France and 3 more
- Volunteers
- 42 people
- Sponsor
- Immunophotonics, Inc.
Oncologic Diseases
Muscle Deterioration in Hospitalized Cancer Patient
Cancer cachexia and skeletal muscle deterioration represent significant challenges in oncology, affecting up to 42% of cancer patients and correlating with poor clinical outcomes, increased treatment toxicity, and reduced overall…
- Trial name
- MUSONC (NCT07387770)
- Testing
- Screenig Phase
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Salamanca
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