Clinical trials: Oncologic
Pediatric Cancer, Quality of Life
Parent/Child Dyad Approach to Symptom Screening for Children With Cancer
Symptoms are common and often severely bothersome in pediatric patients receiving cancer treatments. In order to measure the extent of bothersome symptoms, the Symptom Screening in Pediatrics Tool (SSPedi) was developed.
- Conditions
- Pediatric Cancer, Quality of Life, Symptom Screening
- Trial name
- NCT05012917
- Testing
- Patient/Proxy-SSPedi, Co-SSPedi
- Where
- Canada
- Volunteers
- 420 people
- Sponsor
- The Hospital for Sick Children
Small Cell Lung Carcinoma
Study Evaluating Safety, Tolerability and Pharmacokinetics (PK) of Tarlatamab in Adults With Small Cell Lung Cancer (SCLC)
A study to assess the safety, tolerability, and PK of tarlatamab in participants with SCLC
- Trial name
- NCT03319940
- Testing
- Tarlatamab, Pembrolizumab, CRS Mitigation Strategies
- Where
- 39 sites in United States, Australia and 11 more
- Volunteers
- 269 people
- Sponsor
- Amgen
Heart Failure
Evaluation and Management of Cardio Toxicity in Oncologic Patients
The survival rate of cancer patients has greatly increased over the past decades' mainly due to early detection and the use of new medications with higher doses and combined protocols.
- Trial name
- NCT02818517
- Testing
- ACE inhibitors, beta blockers
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Implementation Development for Distress Screening in Pediatric Oncology (ID-DISTRESSS)
This study is being done to understand how digital strategies (e.g., electronic health record [EHR]-technology, third-party platforms, and institution-developed solutions) can be used to deliver and respond to evidence-based…
- Trial name
- NCT07908485
- Testing
- Non-Interventional Study
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Non-Small Cell Lung Cancer
Erlotinib vs. Standard Chemotherapy in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) and Eastern Cooperative Oncology Group (ECOG)Performance Status (PS) 2
The purpose of this noncomparative study is to obtain preliminary estimates of the efficacy of erlotinib and standard chemotherapy in patients with advanced, previously untreated nonsmall cell lung cancer (NSCLC) and an Eastern…
- Trial name
- NCT00085839
- Testing
- Tarceva (Trademark) (erlotinib HCl, OSI-774), Combination carboplatin and paclitaxel
- Where
- 19 sites in United States
- Volunteers
- 103 people
- Sponsor
- OSI Pharmaceuticals
Oncology
Evaluation of a New Generation of PET-CT OMNI
The overarching purpose of the study is to provide supporting evidence to the value proposition of OMNI, that offers global access to an affordable hybrid PET/CT system similar in performance to that of systems utilized by…
- Trial name
- NCT05154877
- Testing
- OMNI PET/CT Scan
- Where
- France
- Volunteers
- 45 people
- Sponsor
- GE Healthcare
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Impact of Aminoglycosides in Hypotensive Septic Oncology Patients
This study evaluates the impact of aminoglycosides in hypotensive septic oncologic patients. In the oncologic patient population, sepsis is a major health concern due to high mortality rates and healthcare costs.
- Conditions
- Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm, Septicemia
- Trial name
- NCT05045963
- Testing
- Electronic Health Record Review
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- M.D. Anderson Cancer Center
mCRPC (Metastatic Castration-resistant Prostate Cancer)
Four-Timepoint Multi-tracer PET Imaging to Characterize Metastatic prOstate Cancer Heterogeneity
Imaging modalities currently used in the clinics do not image cancer, but the effect ofncancer on bone (bone scan) or on the anatomy (CT-scan). Bone scan and CT-scan are therefore named conventional imaging (CI) modalities.
- Trial name
- 4TMPO (NCT07302763)
- Testing
- PET Tracer
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Frederic Pouliot
Advanced Cancer, Advanced Solid Tumor
TT-816 As Monotherapy or in Combination with a PD-1 Inhibitor in Patients with Advanced Cancers (SEABEAM) (MK3475-E88)
A first-in-human study using TT-816 as a single agent and in combination with a PD-1 inhibitor in advanced cancers.
- Conditions
- Advanced Cancer, Advanced Solid Tumor, Cancer, Oncology
- Trial name
- NCT05525455
- Testing
- TT-816, A PD-1 inhibitor
- Where
- 5 sites in United States
- Volunteers
- 9 people
- Sponsor
- Teon Therapeutics, Inc.
Relapsed AML, Refractory AML
Phase 1 Study of Quizartinib
This is a dose escalation study to evaluate the safety, tolerability, and pharmacokinetics of quizartinib for Japanese acute myeloid leukemia (AML) subjects.
- Trial name
- NCT02675478
- Testing
- AC220
- Where
- Japan
- Volunteers
- 17 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Oncology
A Remote Evaluation of NAVIFY Oncology Hub Using Clinical Simulation
This work seeks to understand current clinical workflow practice and validate use cases for NAVIFY Oncology Hub. The main purpose of NAVIFY Oncology Hub is to enhance clinical and operational effectiveness, from diagnostic workup…
- Trial name
- NCT05478135
- Testing
- NAVIFY Oncology Hub
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Prova Health Limited
Health Care Provider
Developing an eLearning Program in Helping Spanish and Portuguese Speaking Cancer Care Providers During Tobacco Use Counselling
This trial aims to develop an electronic learning (eLearning) program and mobile tool for Spanish and Portuguese speaking cancer care providers to use in tobacco counseling of their patients.
- Trial name
- NCT03539991
- Testing
- Internet-Based Intervention, Meeting, Survey Administration
- Where
- 3 sites in Brazil, Colombia and 1 more
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Mantle Cell Lymphoma, Diffuse Large Cell Lymphoma
Study of Infusion of Blood Cells (Lymphocytes) to Stimulate the Immune System to Fight Leukemia/Lymphoma
The study of whether an infusion of blood cells called lymphocytes from a donor can stimulate the immune system to fight your leukemia/lymphoma.
- Conditions
- Mantle Cell Lymphoma, Diffuse Large Cell Lymphoma, Burkitts Lymphoma, T Cell Lymphomas
- Trial name
- 273 (NCT01685606)
- Testing
- cellular immunotherapy
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Brown University
Oncology
Pharmacokinetics of Entospletinib in Adults With Normal and Impaired Liver Function
The primary objective of this study is to evaluate the pharmacokinetics of entospletinib (ENTO) and/or its metabolites (if applicable) in participants with impaired hepatic function (stratified by smoking status, as appropriate)…
- Trial name
- NCT02521376
- Testing
- Entospletinib
- Where
- 6 sites in United States, Germany and 1 more
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Recurrent Non Small Cell Lung Cancer
APRiCOT-L: Study to Evaluate Efficacy and Safety of Apricoxib With Erlotinib in Patients With Non-small Cell Lung Cancer
This study will compare the anti-tumor efficacy of apricoxib and erlotinib with placebo and erlotinib as measured by time to disease progression to test the hypothesis that down regulation of COX-2 and EGFR pathways in patients…
- Trial name
- TP2001-201 (NCT00652340)
- Testing
- apricoxib/erlotinib
- Where
- 47 sites in United States
- Volunteers
- 120 people
- Sponsor
- Tragara Pharmaceuticals, Inc.
Cancer Pain Self-management
Praxis Evaluation of a Pain Self-management Support Intervention for Oncology Patients: A Stepped Wedge Design Study
Background: Significant barriers to cancer pain management are patient-related. So far, cancer pain self-management support interventions have only been tested in strictly controlled settings of randomized controlled trials (RCT)…
- Trial name
- EvANtiPain (NCT02891785)
- Testing
- ANtiPain
- Where
- 3 sites in Austria
- Volunteers
- 153 people
- Sponsor
- University of Vienna
Leukemia, Multiple Mieloma
The Implementation of the Go Wish Game to Promote Advance Care Planning in Onco- Hematologic Disease
This is a mixed-method, device-free and drug-free multicenter interventional study. The study aims at facilitating end-of-life conversations within the doctor-patient relationship through the use of the Go Wish Game (GWG) and…
- Conditions
- Leukemia, Multiple Mieloma, Advanced Solid Tumors, Lymphoma
- Trial name
- OHGW-ACP (NCT06795815)
- Testing
- Go Wish Game
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Bone Marrow Diseases, Lymphoma
Thromboelastography, Platelet Function and Platelet Recovery in Haemato-oncologic Patients With Thrombocytopenia
This is a prospective observational clinical study to characterise abnormalities of thromboelastography (TEG) parameters in patients with chemotherapy-induced thrombocytopenia.
- Trial name
- NCT01928017
- Where
- Norway
- Volunteers
- 13 people
- Sponsor
- University of Bergen
Tumors, Medical Oncology
A Study of the Safety and Pharmacokinetics of AGS-22M6E in Subjects With Malignant Solid Tumors That Express Nectin-4
A study examining the safety of AGS-22M6E or ASG-22CE administered as monotherapy therapy in subjects with malignant solid tumors that express Nectin-4.
- Conditions
- Tumors, Medical Oncology, Neoplasms
- Trial name
- NCT01409135
- Testing
- AGS-22M6E, ASG-22CE
- Where
- 9 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Astellas Pharma Inc
Hepatocellular Carcinoma
Phase Ⅲ Randomized Trial in Postoperative Hepatocellular Carcinoma
OBJECTIVES 1. To investigate whether adjuvant IFN-α therapy can delay or reduce the 2-5 years recurrence rate in curatively resected HCC . 2.
- Trial name
- NCT00149565
- Testing
- IFN-α2b
- Where
- Taiwan
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- National Health Research Institutes, Taiwan
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