Clinical trials: Oncologic
Pediatric Cancer, Growth, Posttraumatic
Expressive Storytelling to Share Adolescents/Young Adults Cancer Stories
The purpose of this study is to test the feasibility, acceptability, and preliminary efficacy of an online expressive storytelling intervention for adolescents and young adults (AYA) with cancer. Specific Aim 1.
- Conditions
- Pediatric Cancer, Growth, Posttraumatic, Nurse-Patient Relations, Narrative Medicine
- Trial name
- ESSAY (NCT04855487)
- Testing
- Nurse-patient dyadic storytelling intervention
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Vanderbilt University
Prostate Cancer
Randomized Controlled Trial of CAN-2409 Immunotherapy During Active Surveillance for Prostate Cancer (ULYSSES)
The purpose of this study is to evaluate the effectiveness of CAN-2409 immunotherapy in patients undergoing active surveillance for localized prostate cancer.
- Trial name
- NCT02768363
- Testing
- aglatimagene besadenovec, valacyclovir
- Where
- 23 sites in United States, Mexico
- Volunteers
- 187 people
- Sponsor
- Candel Therapeutics, Inc.
Mindfulness Meditation, Selfcompassion
The Effect of Mindful Hand Hygiene Practice on Self-Care Perception and Self-Compassion Levels of Oncology Nurses; Mixed Design Example
This study was planned to evaluate the effect of hand hygiene awareness activities to be carried out by nurses with positive affirmation words and breathing exercises during hand washing or hand hygiene with hand antiseptic on…
- Trial name
- NCT07059416
- Testing
- Oncology nurses carried out hand hygiene awareness activities with positive affirmation words and breathing exercises while washing hands or providing hand hygiene with hand antiseptic.
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- KTO Karatay University
Cancer, Rectal
Safety & Efficacy of Ischemic Preconditioning by Embolization of the Inferior Mesenteric Artery in Surgery for Tumors of Lower and Middle Rectum
The present study will investigate the safety of inferior mesenteric artery embolization prior to rectal surgery, according to IDEAL recommendations (Lancet 2009).
- Trial name
- AMIREMBOL_2 (NCT06236633)
- Testing
- Ischemic preconditioning, Arteriogram
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Gastrointestinal Stromal Tumors
Patients Completing Core Protocol (CAMN107A2103), Exhibiting Stable Disease (SD), Partial Response (PR) or Complete Response (CR) to Nilotinib in Combination With Imatinib
To provide study drug to patients that benefit from treatment judged by the investigator - to obtain additional long-term safety and efficacy data of this combination regimen in GIST
- Trial name
- NCT00441155
- Testing
- Nilotinib, Imatinib
- Where
- 4 sites in United States, France and 1 more
- Volunteers
- 14 people
- Sponsor
- Novartis Pharmaceuticals
Solid Tumor, Adult, Pancreatic Cancer
Atezolizumab Combined With BDB001 AnD Immunogenic Radiotherapy in Patients With Advanced Solid Tumors
Basket trial concept to independently and simultaneously assess the effects of the association of atezolizumab + BDB001 + radiotherapy in multiple solid tumors.
- Conditions
- Solid Tumor, Adult, Pancreatic Cancer, Virus-associated Tumors, Non Small Cell Lung Cancer
- Trial name
- AGADIR (NCT03915678)
- Testing
- Association atezolizumab + BDB001 + RT, Association atezolizumab + BDB001+ RT
- Where
- 11 sites in France
- Volunteers
- 247 people
- Sponsor
- Institut Bergonié
Neutropenia, Sarcoma
Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor
Phase II trial to study the effectiveness of combination chemotherapy in treating patients with newly diagnosed metastatic Ewing's sarcoma or primitive neuroectodermal tumor.
- Trial name
- NCT00002643
- Testing
- filgrastim, amifostine trihydrate, cyclophosphamide
- Where
- 49 sites in United States, Australia and 3 more
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Covid19, Vaccination Refusal
Strategies to Continue Gynae-oncology Services in the Era of COVID-19 Outbreak: Concerns and Challenges in a Referral Centre in Malaysia
A short survey involving 100 participants was conducted online to explore the understanding of Covid 19 pandemic impact and importance of vaccination among cancer survivors.
- Conditions
- Covid19, Vaccination Refusal, Survivorship
- Trial name
- NCT05043155
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Oncology
The Effect of Peer Comparison Emails on Oncologists' Documentation of Cancer Stage
Documenting cancer stage is the most important determinant of treatment approach and survival for cancer patients. However, oncologists do not routinely document a patient's cancer stage in the structured field in electronic…
- Trial name
- NCT04298762
- Testing
- No peer comparison email, Peer comparison email
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Cancer
Reducing Emotional Distress, Enhancing Function and Improving Network Engagement in Adolescent and Young Adult Oncology
We propose to examine the effects of mindfulness based stress reduction (MBSR) on outcomes of health related quality of life, disease symptoms, and biological correlates of stress in a sample of young adults with cancer.
- Trial name
- REDEFINEAYAO (NCT02495376)
- Testing
- MBSR
- Where
- 2 sites in United States
- Volunteers
- 151 people
- Sponsor
- Northwestern University
Solid Tumor, Lymphoma
Simultaneous Care: Linking Palliation to Clinical Trials
This is a multi-site randomized control trial taking place at six cancer centers. UC Davis is the lead site. Additional performance sites include the City of Hope Medical Center, Fred Hutchinson Cancer Center at the Univ.
- Trial name
- NCT00283257
- Testing
- Patients and caregivers are taught problem solving skills
- Where
- United States
- Volunteers
- 441 people
- Sponsor
- University of California, Davis
Prostate Cancer, Prostate Cancer (Diagnosis)
Study of the Epidemiological, Clinical, Diagnostic, and Therapeutic Characteristics of Prostate Cancers in Algeria
The goal of this observational study is to describe the demographic, epidemiological, clinical, and outcome characteristics of patients with prostate cancer.
- Conditions
- Prostate Cancer, Prostate Cancer (Diagnosis), Prostate Cancer (Post Prostatectomy), Prostate Cancer Patients Treated by Radiotherapy
- Trial name
- CLIQQC (NCT07484971)
- Where
- 24 sites in Algeria
- Volunteers
- 2,000 people
- Sponsor
- Société Algérienne de Formation et Recherche en Oncologie
Advanced Solid Tumors
A Dose Escalation and Cohort Expansion Study of Subcutaneously-Administered Cytokine ALKS 4230 (Nemvaleukin Alfa) as a Single Agent and in Combination With Anti-PD-1 Antibody (Pembrolizumab) in Subjects With Select Advanced or Metastatic Solid Tumors (ARTISTRY-2)
This study will characterize the safety and tolerability and identify the recommended Phase 2 dose (RP2D) of subcutaneous (SC) ALKS 4230 as monotherapy and in combination with pembrolizumab.
- Trial name
- NCT03861793
- Testing
- ALKS 4230, Pembrolizumab
- Where
- 48 sites in United States, Canada and 4 more
- Volunteers
- 116 people
- Sponsor
- Mural Oncology, Inc
Breast Cancer, Breast Reconstruction
Hypofractionated vs Conventional RT After Prosthetic Breast Reconstruction
This study investigates the safety and efficacy of hypofractionated radiotherapy (HFRT) versus conventional fractionated radiotherapy (CFRT) in breast cancer patients undergoing total mastectomy with prosthetic reconstruction.
- Conditions
- Breast Cancer, Breast Reconstruction, Radiation Oncology
- Trial name
- NCT07084519
- Testing
- hypofractionated radiotherapy, conventional fractionated radiotherapy
- Where
- China
- Volunteers
- 506 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Cancer Pain
Case-control Study- Cancer Pain: Uncontrolled Pain as Depression Development Predictor in Oncologic Patients (Fentanyl)
The purpose of this study is to evaluate the relationship between cancer pain and risk of depression among cancer patients.
- Trial name
- NCT01402830
- Testing
- Visual analogue scales (EVAs)
- Volunteers
- 271 people
- Sponsor
- Janssen-Cilag, S.A.
Anxiety
A Nurse Led Project to Introduce Hand Lettering as a Form of Creative Art Expression to Patients in an Ambulatory Oncology Setting
The investigators are conducting a project to provide a new type of resource called "hand lettering" to patients receiving chemotherapy. This is a type of art therapy.
- Trial name
- NCT03291730
- Testing
- Breathing and journaling exercise, Art-therapy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer, Psychological Distress
The Validation of ICBT Clinical Trial: Disease Stress Adjustment in Breast Cancer Patients
Breast cancer and its treatment can cause ongoing emotional distress, including anxiety, depressive symptoms, stress-related reactions, and difficulties adjusting to life after treatment.
- Trial name
- ICBT-TW-2 (NCT07835698)
- Testing
- Internet-Based Cognitive Behavioral Therapy Program for Breast Cancer Survivors, Treatment as Usual (TAU)
- Volunteers
- 100 people
- Sponsor
- National Health Research Institutes, Taiwan
Refractory Metastatic Colorectal Cancer, pMMR
RP2/RP3 in Combination With Atezolizumab and Bevacizumab for the Treatment of Patients With CRC
This is an open-label, Phase 2 clinical trial evaluating therapy with an oncolytic immunotherapy (RP2 or RP3) in combination with atezolizumab and bevacizumab in patients with advanced Microsatellite Stable and Mismatch Repair…
- Conditions
- Refractory Metastatic Colorectal Cancer, pMMR, MSS
- Trial name
- NCT05733611
- Testing
- RP2, RP3, atezolizumab
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- Replimune, Inc.
Serious Adverse Events, Patient Safety
Chemokeyp: A Feasibility Study for Realtime Safety Data-Capture for Potential Serious Adverse Drug Events
Chemokeyp is a feasibility study testing a secure ED-Oncology interface for patients receiving chemotherapy who may present to unscheduled care with possible treatment-related complications.
- Conditions
- Serious Adverse Events, Patient Safety, Pharmacovigilance, Oncology
- Trial name
- NCT07592234
- Where
- Ireland
- Volunteers
- 100 people
- Sponsor
- St Vincent's University Hospital, Ireland
Metastatic Nonsmall Cell Lung Cancer
CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS3]
The goal of this non-interventional study is to emulate the KEYNOTE-189 randomized controlled trial of pembrolizumab for the treatment of metastatic non-small cell lung cancer using real-world, electronic health record data.
- Trial name
- NCT06607393
- Testing
- Pembrolizumab, Pemetrexed, Cisplatin
- Volunteers
- 851 people
- Sponsor
- Aetion, Inc.
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