Clinical trials: Oncologic
Chemotherapy Induced Nausea and Vomiting
Pharmacokinetics and Safety of Sancuso and IV Granisetron in Pediatrics Aged 6 to 12 Years
The purpose of this study is to determine the dosing strategy for adolescents aged 6 to 12 years.
- Trial name
- NCT01596413
- Testing
- Sancuso, IV granisetron
- Sponsor
- Kyowa Kirin Pharmaceutical Development Ltd
Unresectable Hepatocellular Carcinoma
An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery
This is an observational study in which only data will be collected from adults with unresectable hepatocellular carcinoma. These adults should be prescribed a different treatment after treatment with atezolizumab and…
- Trial name
- REFINE-IO (NCT06117891)
- Testing
- Atezolizumab, Bevacizumab, Durvalumab
- Where
- 17 sites in United States, Argentina and 10 more
- Volunteers
- 300 people
- Sponsor
- Bayer
Cancer, Neoplasms
Immuno Positron Emission Tomography Study of GSK2849330 in Subjects With Human Epidermal Growth Factor Receptor 3-Positive Solid Tumors
Human epidermal growth factor receptor 3 (HER3) expression is seen across a wide variety of solid malignancies and is associated with poor prognosis.
- Trial name
- NCT02345174
- Testing
- GSK2849330, 89Zr-GSK2849330
- Where
- 2 sites in Netherlands
- Volunteers
- 6 people
- Sponsor
- GlaxoSmithKline
Cancer
Follow-up of Oncology Patients After Hospitalization in ICU
"Purpose: The overall prognosis of oncology patients admitted to intensive care has improved greatly in recent years, leading to a wider admission policy.
- Trial name
- SALTO (NCT02398890)
- Testing
- routine care
- Where
- France
- Volunteers
- 309 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Retinoblastoma, Retinoblastoma Bilateral
Retinoblastoma Patient Clinical Database and Tissue Repository
Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed.
- Conditions
- Retinoblastoma, Retinoblastoma Bilateral, Retinoblastoma Unilateral
- Trial name
- NCT04959097
- Where
- 9 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- Children's Hospital Los Angeles
Adverse Effects of Medical Drugs
Adverse Drug Reactions to Cancer Therapies in Patients with Depression: Insights from VigiBase
Importance: Depression is prevalent among oncology patients and may influence the perception, reporting, and severity of adverse events (AEs) related to cancer therapies.
- Trial name
- NCT06801158
- Testing
- use of anticancer drugs in monotherapy or in combination therapy
- Where
- France
- Volunteers
- 8,804,863 people
- Sponsor
- University Hospital, Caen
Leukemia, Leukemia, Chronic
Total Body Irradiation Treatments for Patients Treated at European Institute of Oncology
Patients eligible undergoing total body irradiation as candidates for bone marrow or peripheral stem cell transplant.
- Conditions
- Leukemia, Leukemia, Chronic, Leukemia, Acute, Lymphoma
- Trial name
- NCT06335277
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- European Institute of Oncology
Radiotherapy Side Effect
SMC Radiation Oncology Breast Cancer Cohort Study
The goal of this observational study is to learn about toxicities and cosmetic outcomes in breast cancer patients treated with hypofractionated radiotherapy.
- Trial name
- RASCO (NCT05775757)
- Testing
- Hypofractionated radiation therapy
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Cancer, Depression
Pharmacogenomic Testing to Personalize Supportive Oncology
The purpose of this study is to evaluate pharmacogenomics (PGx) guided drug prescribing for pain and depression in patients with cancer.
- Conditions
- Cancer, Depression, Pain
- Trial name
- NCT04500301
- Testing
- Preemptive Pharmacogenomic Testing
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Wake Forest University Health Sciences
Respiration Disorders
Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy
OBJECTIVES: I. Assess the degree of amnesia afforded by study sedatives relative to the patient's intensive care unit experiences. II.
- Trial name
- NCT00004424
- Testing
- fentanyl, Midazolam, propofol
- Volunteers
- 120 people
- Sponsor
- FDA Office of Orphan Products Development
Pain Management
Measuring the Effects of Therapeutic Education Program "Caratif" Patient Under Strong Opioids Versus Standard Taking Charge of Patient Pain Receiving Opioid Therapy in Medical Oncology.
A first empirical evidence on the difficulties of observance of morphine in cancer patients invited a multidisciplinary team to initiate an innovative quality approach.
- Trial name
- NCT02862002
- Testing
- therapeutic education of type "caratif, Standard care
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Pediatric Cancer, Febrile Neutropenia
Feasibility and Comparison of Continuously Monitored Vital Signs in Pediatric Patients With Cancer.
In this pilot study the feasibility continous recording of vital signs in pediatric patients under chemotherapy for cancer, is studied.
- Conditions
- Pediatric Cancer, Febrile Neutropenia, Oncology, Chemotherapy-induced Neutropenia
- Trial name
- NCT04914702
- Testing
- Everion®, CORE®
- Where
- 2 sites in Switzerland
- Volunteers
- 20 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Thoracic Cancer, Lung Cancer
Reirradiation Dose Escalation in Thoracic Cancers
This is a study involving patients with recurrence, metastasis, or new primary malignancies in the thorax requiring radiation and who have previously received radiotherapy to the thorax, where re-irradiation is expected to exceed…
- Conditions
- Thoracic Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- REPAIR (NCT06558175)
- Testing
- stereotactic body radiation therapy (SBRT)
- Volunteers
- 48 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Solid Tumours
Open-label Study to Investigate the Safety, PK, and Pharmacodynamics of GSK1120212 in Subjects With Solid Tumors or Lymphoma
MEK111054 is a first-time-in-human, open-label study to determine recommended dose and regimen for the orally administered GSK1120212. The study consists of three parts. Part 1 will identify the maximum tolerated dose.
- Trial name
- NCT00687622
- Testing
- GSK1120212
- Where
- 12 sites in United States
- Volunteers
- 206 people
- Sponsor
- GlaxoSmithKline
Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer
Improving Informed Consent for Palliative Chemotherapy
Patients are routinely asked to sign an "informed consent" document prior to starting chemotherapy, indicating they understand the risks and benefits of treatment.
- Conditions
- Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer, Unresectable Pancreatic Cancer
- Trial name
- NCT02282722
- Testing
- Investigational informed consent for chemotherapy, Usual, standard-of-care informed consent for chemotherapy
- Where
- 8 sites in United States
- Volunteers
- 216 people
- Sponsor
- Dana-Farber Cancer Institute
Cancer
Open-label Study to Evaluate the Safety, PK, and PD of MEK Inhibitor GSK1120212 in Subjects With Relapsed or Refractory Leukemias
MEK111759 is a dose-escalation, Phase I/II, open-label study to determine the recommended dose and regimen for the orally administered MEK inhibitor GSK1120212 in subjects with relapsed or refractory leukemias.
- Trial name
- NCT00920140
- Testing
- GSK1120212
- Where
- 28 sites in United States, Belgium and 2 more
- Volunteers
- 97 people
- Sponsor
- GlaxoSmithKline
Head and Neck Cancer
Carboplatin + Paclitaxel + Cetuximab (PCC) After Failure of Pembrolizumab +/- First-line Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
This study targets an adult population of patients with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC), who have failed after a first line of treatment with pembrolizumab associated or not with…
- Trial name
- CARPACCIO (NCT06725368)
- Testing
- PCC
- Where
- 5 sites in France
- Volunteers
- 46 people
- Sponsor
- Centre Paul Strauss
Locally Advanced / Metastatic Solid Tumors
CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
The purpose of this study is to determine the safety and tolerability of monotherapy CR-001 and identify the maximum tolerated dose (MTD), and/or optimal biologic dose and Recommended Phase 2 Dose(s) (RP2D) in participants with…
- Trial name
- ASCEND (NCT07335497)
- Testing
- CR-001, Paclitaxel, trifluridine and tipiracil
- Where
- 34 sites in United States, Australia and 7 more
- Volunteers
- 540 people
- Sponsor
- Crescent Biopharma, Inc.
Oncological Disease, Fertility Preservation
Ovarian Tissue Cryopreservation Combined With Oocyte Cryopreservation Versus Oocyte Cryopreservation Alone
Fertility preservation is a crucial aspect of care for oncological patients undergoing gonadotoxic treatments such as chemotherapy, radiotherapy, or surgery, which can significantly reduce ovarian reserve and cause infertility or…
- Trial name
- NCT07546123
- Where
- Italy
- Volunteers
- 127 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Neoplasms, Carcinoma
Addressing Cancer-Related Financial Toxicity in North Carolina Oncology Care Settings
The financial burden, or financial toxicity (FT), of cancer is a consequential and growing problem, particularly for rural patients.
- Trial name
- NCT04931251
- Testing
- Financial Navigation
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
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