Clinical trials: Oncologic
Advanced Malignancy, Advanced Solid Tumors
A Phase 1b/2a Study Evaluating AMG 232 in Metastatic Melanoma
Phase 1b/2a, open-label, sequential dose escalation and expansion study of AMG 232 in combination with trametinib and dabrafenib in subjects with metastatic melanoma followed by a direct comparison of AMG 232 combined with…
- Conditions
- Advanced Malignancy, Advanced Solid Tumors, Cancer, Oncology
- Trial name
- NCT02110355
- Testing
- AMG 232, Trametinib, Dabrafenib
- Where
- 7 sites in United States, Australia
- Volunteers
- 31 people
- Sponsor
- Kartos Therapeutics, Inc.
Urinary Retention
Optimal Management of Urinary Catheter in Gyn Onc
This is a combined retrospective observational study that will collect data on urinary catheter removal of patients who underwent pelvic surgery by a gynecologic oncologist to assess timing safety and its implications in…
- Trial name
- NCT05538273
- Testing
- Early removal of urinary catheter postoperatively, Late removal of urinary catheter postoperatively
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- WellSpan Health
Inflammatory Myofibroblastic Tumor
Study of Crizotinib in Children and Adolescents With Myofibroblastic Tumors
Targeted therapy based on target identification by genetic examinations is a promising direction in the treatment of patients with a complicated course of inflammatory myofibroblastic tumor.
- Trial name
- NCT03874273
- Testing
- Crizotinib
- Where
- Russia
- Volunteers
- 25 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Infantile Neoplasms
Cancer in Infants: South Egypt Cancer Institute Experience
The aim of this study is to investigate the spectrum of various types of malignant neoplasms of infancy, according to the experience of South Egypt Cancer Institute, which represents the largest referral site in Upper Egypt.
- Trial name
- NCT02668354
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Assiut University
Neoplasia Prostate
PALLiON - PALLiative Care In ONcology
A major concern in today's oncology is the complexity of treatment that increases costs. A main contributor is the increasing use of chemo- and radiotherapy during end of life (EoL: the last 12 months of life).
- Trial name
- PALLiON (NCT03088202)
- Testing
- Educational program, Standardized care pathways, Early palliative care
- Where
- 12 sites in Norway
- Volunteers
- 659 people
- Sponsor
- Oslo University Hospital
Oncology
COVID-19 Detection Test in Oncology
EVIDENCE is a non interventional, French, multicenter study. Patients will be screened by local severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoassay in their oncology department (rapid diagnostic test (RDT) or…
- Trial name
- EVIDENCE (NCT04367870)
- Where
- 7 sites in France
- Volunteers
- 441 people
- Sponsor
- UNICANCER
Oncology, Insomnia
Efficacy of Hypno-ear-acupuncture on Insomnia in Advanced Cancer Patients
This randomized controlled trial aims to test if a combination of medical hypnosis and ear acupuncture improves sleep quality in patients with advanced cancer during a hospital stay in a palliative care unit.
- Conditions
- Oncology, Insomnia, Symptoms and Signs
- Trial name
- NCT06532188
- Testing
- Hypno-ear-acupuncture
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Hematologic Malignancy, Pediatric Cancer
Response to Influenza Vaccination in Pediatric Oncology Patients
Influenza infection occurring during oncologic treatment or following hematopoietic cell transplantation (HCT) is associated with increased risk of morbidity in the form of lower respiratory tract infection (LRTI) and mortality…
- Conditions
- Hematologic Malignancy, Pediatric Cancer, Transplant-Related Cancer
- Trial name
- NCT05384288
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- St. Jude Children's Research Hospital
Hematopoietic Cell Transplantation, Oncology
Pharmacogenomic-Guided Supportive Care in Hematopoietic Cell Transplantation
Hematopoietic cell transplantation (HCT) is the only curative treatment modality for many hematologic malignancies. Morbidity and mortality rates have declined drastically over the years, secondary to improvements in both…
- Trial name
- IMPPACT (NCT04727827)
- Testing
- Pharmacogenomic-guided supportive care
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pediatric Tumor, Familial Cancer
Analyse of Tumour and Constitutional DNA for the Study of the Determinism in Child Neoplasia
Background. Cancer is the leading cause of death by disease in children. Most pediatric tumors differ from adult tumors in terms of biological and clinical characteristics.
- Conditions
- Pediatric Tumor, Familial Cancer, Solid Tumor, Childhood, Hematological Tumor
- Trial name
- ALADIN (NCT04471961)
- Testing
- Exome sequencing in pediatrics cancers
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Advanced Solid Tumor
A Study of YL242 in Subjects With Advanced Solid Tumors
This is a multicenter, open-label study to evaluate the safety and tolerability of YL242 monotherapy and combination in participants with advanced solid malignant tumors.
- Trial name
- NCT07197827
- Testing
- YL242, YL242; Pembrolizumab, YL242; 5-FU; LV
- Where
- 15 sites in United States, Australia and 1 more
- Volunteers
- 424 people
- Sponsor
- MediLink Therapeutics (Suzhou) Co., Ltd.
Spinal Column Tumor
Primary Tumor Research and Outcomes Network
This project aims to establish a network of spine oncology centers dedicated to prospective multicenter research of patients diagnosed with a primary tumor of the spine and will include a comprehensive prospective clinical…
- Trial name
- PTRON (NCT02790983)
- Where
- 19 sites in United States, Australia and 7 more
- Volunteers
- 1,350 people
- Sponsor
- AO Innovation Translation Center
Covid19, Oncologic Disorders
COVID-19 Vaccination in Oncologic Patients
Evaluating the vaccination willingness in oncologic patients over six months as well as estimating the effects of radiotherapy/systemic anticancer treatment on the efficacy and toxicity of currently approved SARS-CoV-2 vaccines
- Trial name
- VINCI (NCT04918888)
- Where
- 2 sites in Austria
- Volunteers
- 1,150 people
- Sponsor
- Krankenhaus Barmherzige Schwestern Linz
Advanced Solid Malignancy
EMITT-1 (ERAP Mediated Immunopeptidome Targeting Trial - 1)
This is a Phase I/II, open-label, first-in human study of GRWD5769 alone, and in combination with another anti-cancer agent in advanced solid cancers.
- Trial name
- EMITT-1 (NCT06923761)
- Testing
- Module 1 (GRWD5769 on its own as monotherapy), Module 2 (GRWD5769 in combination with cemiplimab, administered IV)
- Where
- 28 sites in Australia, France and 2 more
- Volunteers
- 300 people
- Sponsor
- Grey Wolf Therapeutics
All Cancer
Comprehensive Digital Archive of Cancer Imaging-Radiation Oncology( CHAVI-RO )
In this pilot project Investigators propose to create annotated image data bank of patients suffering from cancer. The system will provide India's first comprehensive platform to upload annotated images with associated medical…
- Trial name
- NCT04249895
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Tata Medical Center
Patients With Lung, Breast, Head and Neck, or Pelvic Malignancies
Assessing the Impact of Electronic Capture of Patient Reported Outcomes in Radiation Oncology
The goals of this study are to assess the feasibility of weekly administration of site specific patient reported assessments using an electronic platform and to explore the correlation between patient reported outcomes as well as…
- Trial name
- NCT02756767
- Testing
- Survey
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Cytokine Release Syndrome, Neoplasms
Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event
Background: Drugs or cell therapies to treat cancer can sometimes cause cytokine release syndrome (CRS). That is, the body makes too many cytokines after treatment. Cytokines are proteins that play a role in the immune system.
- Conditions
- Cytokine Release Syndrome, Neoplasms, Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Trial name
- NCT07499128
- Testing
- TempTraq, VitalTraq
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Cancer Institute (NCI)
Cancer
Oncology Acute Care Follow-up Intervention Study
This pragmatic randomized controlled study evaluates an education intervention designed to increase patient engagement with Oncology Acute Care (OAC) services among patients being treated for cancer at Parkland Health.
- Trial name
- NCT07550192
- Testing
- Follow-up messaging
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Pulmonary Atelectasis
Lung Ultrasonography After Laparoscopic Gynecologic Surgery
This study evaluates the influence of surgical and anesthesia-related variable on atelectasis formation during laparoscopic gynecologic oncologic surgery by lung ultrasound.
- Trial name
- LUS-LPS (NCT04116567)
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- SONNINO CHIARA
Lung Cancer, Non-small Cell Lung Cancer
An Evaluation of the Clinical Treatment and Patient Values and Preferences of Patients Suffering From Advanced Non-small Cell Lung Cancer (NSCLC) Undergoing Chemotherapy
The main purpose of this study is the identification, description, and segmentation of non-small cell lung cancer (NSCLC) patients based on their value appraisal of treatment outcomes and all intermediate states of health, to…
- Trial name
- NCT00721981
- Where
- 8 sites in Germany
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
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