Clinical trials: Oncologic
Marginal Zone Lymphoma
Obinutuzumab in Marginal Zone Lymphoma
For marginal zone lymphoma (MZL) Rituximab in combination with conventional chemotherapy are widely used for those patients who fail local therapy or do not qualify for such.
- Trial name
- NCT03322865
- Testing
- Obinutuzumab
- Where
- 12 sites in Germany
- Volunteers
- 56 people
- Sponsor
- Christian Buske
Iron Overload
Iron Overload in Pediatric Oncology Patients
The purpose of this study is to evaluate for iron overload in pediatric oncology and transplant patients who have completed their treatment between one to ten years ago.
- Trial name
- NCT01034072
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pain, Pain Management
Evaluating The Efficacy Of Pecs II Blockade Compared To Local Anesthetic Infiltration In Controlling Postoperative Pain In Patients Undergoing Oncologic Breast Surgery Under Opioid Free/Sparing Anesthesia.
Breast cancer is the malignant neoplasm with the highest incidence in women in Brazil, with the exception of non-melanoma skin tumors.
- Conditions
- Pain, Pain Management, Anesthesia
- Trial name
- pain (NCT06889870)
- Testing
- Pectoral Nerve Block, Local Anesthesia
- Where
- Brazil
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Cancer, Malnutrition
Prevalence of Malnutrition in Oncologic Patients
Malnutrition is a common phenomenon in cancer patients. Deteriorated nutritional status is associated with poor clinical outcome.
- Trial name
- NCT01120483
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Charite University, Berlin, Germany
Lung Cancer
Joint Thoracic Oncology Research Unit of LYon: Lung cancerS DatabaSE (ULYSSE)
Prospective longitudinal cohort associated to blood collection, pathological samples collection, and radiological and pathological imaging collection.
- Trial name
- ULYSSE (NCT05267041)
- Testing
- Blood sample, Questionnaire
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- Hospices Civils de Lyon
Gynecologic Oncology Patient
Psychological Services Integration in Gynecological Oncology Clinics
The purpose of this study is to understand the feasibility and impact of integrated psychological care in outpatient gynecologic oncology clinics with the goal of creating a new standard of care.
- Trial name
- NCT03481127
- Testing
- Integrated psychological care, Surveys, Blood draw
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Washington University School of Medicine
Cardiotoxicity, Cardiac Biomarkers
Cardiac Biomarkers in Patients Receiving Immune Checkpoint Inhibitors (PRIME-ICI)
Immune checkpoint inhibitors (ICIs) are widely used cancer treatments. Blood tests such as cardiac troponin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) can help clinicians investigate possible heart injury, but…
- Conditions
- Cardiotoxicity, Cardiac Biomarkers, Cancer
- Trial name
- PRIME-ICI (NCT07864727)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- South Tees Hospitals NHS Foundation Trust
Astrocytoma, Brain Cancer
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S
This is a multi-center, open-label, dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of QBS10072S in patients with advanced or metastatic cancers…
- Conditions
- Astrocytoma, Brain Cancer, Brain Metastases, Bladder Cancer
- Trial name
- NCT04430842
- Testing
- QBS10072S
- Where
- 2 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Quadriga Biosciences, Inc.
Urinary Bladder Neoplasm
The Importance of Muscle Function in Patients With Disseminated Bladder Cancer
This study investigates if reduced muscle mass and muscle function predispose to poor completion of oncological treatment in patients with bladder cancer (including cancer of the renal pelvis, ureter and urethra) and if muscle…
- Trial name
- NCT04144270
- Testing
- Evaluation of muscle mass and muscle function
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Brain Tumor, Pediatric
Measuring Brain Changes Following Cognitive Intervention in Pediatric Patients With Brain Tumors
The goal of this study is to learn if an online computerized training program improves processing speed, attention, and working memory in children with a primary brain tumor during and after active cancer treatment.
- Trial name
- NCT07558473
- Testing
- Online computerized cognitive training intervention focused on processing speed.
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Mucositis Oral
A Clinical Trial of the Administration of Light Therapy to Prevent Mouth Sores in Children With Cancer
The goal of this clinical trial is to learn if light therapy can prevent mouth sores in children with cancer. The main questions it aims to answer are: Is it reasonable and acceptable to provide light therapy for children with…
- Trial name
- PBM (NCT06623305)
- Testing
- Photobiomodulation for prevention arm, Photobiomodulation for exploratory arm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Prehabilitation, Oncology
Implementation of a Prehabilitation Program for Surgical Patients
Frailty is a state of increased vulnerability to stressors with increased rates of poor outcomes. Surgery is one of these stressors, and previous research has therefore shown increased rates of morbidity and mortality in frail…
- Conditions
- Prehabilitation, Oncology, Surgical Oncology
- Trial name
- NCT05377970
- Testing
- Thinkific Prehabilitation Exercise Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MaineHealth
Surgical Site Infection, Surgical Complication
Oral Antibiotic Bowel Preparation in Gynecologic Oncology Surgery
The purpose of this study is to investigate whether the use of a preoperative antibiotic bowel regimen is associated with a reduced risk of deep organ/space surgical site infection in gynecologic oncology surgery.
- Conditions
- Surgical Site Infection, Surgical Complication, Gynecologic Cancer
- Trial name
- NCT05210556
- Testing
- Diagnosed with Surgical Site Infection
- Where
- United States
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- WellSpan Health
Hematologic Neoplasms, Neoplasms
Animal-Assisted Intervention for Children With Cancer and Their Siblings
This study examined an animal-assisted program for children with hematologic or oncologic disease and their siblings. The program included ten weekly sessions involving dogs and donkeys.
- Trial name
- Ti Sento (NCT07861620)
- Testing
- Dog- and Donkey-Assisted Intervention
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Azienda Ulss 2 Marca Trevigiana
Breast Neoplasm, Prostate Neoplasm
Evaluating the Impact of Financial Navigation on Financial Catastrophe and Distress for Cancer Care
The goal of this study is to investigate the effectiveness of a structured financial navigation program in reducing financial catastrophe and financial distress for cancer patients in Nigeria.
- Conditions
- Breast Neoplasm, Prostate Neoplasm, Colon Neoplasm, Rectal Neoplasm
- Trial name
- COST-FIN (NCT06630962)
- Testing
- Financial Navigation Program
- Where
- 2 sites in Nigeria
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Advanced Renal Cell Carcinoma (aRCC)
Cabozantinib Post First-line Immuno-oncology Checkpoint Inhibitor Containing Combination
This study will collect real-world data for the new treatment pathways for all patients with Advanced Renal Cell Carcinoma (ARCC) who were treated with a 1L IO (first-line, Immuno-Oncology checkpoint inhibitor) combination…
- Trial name
- CARINA (NCT04957160)
- Where
- 9 sites in United Kingdom
- Volunteers
- 281 people
- Sponsor
- Ipsen
Cardiotoxicity, Gastrointestinal Neoplasms
Defining Robust Predictors of Chemotherapy Related Cardiotoxicity
Observational prospective cohort study designed for patients with gastrointestinal cancers receiving a fluoropyrimidine based chemotherapy regimen.
- Trial name
- NCT05159479
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- University College, London
Degradation of Top2b and Top2a in Human by Dexrazoxane, Time Course and Degradation of Top2b in Human by Dexrazoxane
Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane
The purpose of this research study is to determine whether early administration of Dexrazoxane prevents Doxorubicin induced cardiotoxicity.
- Conditions
- Degradation of Top2b and Top2a in Human by Dexrazoxane, Time Course and Degradation of Top2b in Human by Dexrazoxane, Effects of Dexrazoxane on Healthy Human
- Trial name
- PHOENIX1 (NCT03930680)
- Testing
- Dexrazoxane
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Metastatic Cancer to the Hip
Fully Constrained Acetabular Liner vs. Dual Mobility Hip Joint in the Surgical Treatment of Metastatic Bone Disease of the Hip
The purpose of the current study is to investigate whether dual mobility liners are non-inferior til constrained liners regarding the post-operative hip joint dislocation risk following total hip replacement in patients with…
- Trial name
- NCT05461313
- Testing
- Constrained Liner, Dual Mobility
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Lymphoblastic Leukemia, Pediatric, Obesity, Pediatric
Low GI Diet in Children and Adolescents With ALL
The study aims to determine the feasibility of a 6-month low glycemic dietary intervention in children and adolescents undergoing treatment for acute lymphoblastic leukemia.
- Trial name
- NCT03157323
- Testing
- Low Glycemic Index Diet
- Where
- 5 sites in United States
- Volunteers
- 88 people
- Sponsor
- Columbia University
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