Clinical trials: Oncologic
Bladder Cancer
Early Intervention for Impairments Identified During Comprehensive Geriatric Assessment in Patients With Bladder Cancer
A Comprehensive Geriatric Assessment (CGA) is a set of tests used to evaluate a patient's medical, social, and functional status, and can identify impairments in these domains that may not be noticed otherwise.
- Trial name
- NCT04273724
- Testing
- Targeted Interventions for Impairments Identified During Geriatric Assessment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Waldenström's Macroglobulinemia
Efficacy of First Line DRC +/- Bortezomib for Patients With Waldenström's Macroglobulinemia
In Waldenström macroglobulinemia (WM) conventional chemotherapy induces only low CR rates and responses of short duration compared to other indolent lymphomas.
- Trial name
- NCT01788020
- Testing
- Dexamethasone, Rituximab, Cyclophosphamide, Dexamethasone, Rituximab, Cyclophosphamide, Bortezomib
- Where
- Germany
- Volunteers
- 202 people
- Sponsor
- University of Ulm
Neoplasm
Continuous Dosing of BAY73-4506 in Patients With Advanced Malignancies
Continuous dosing of BAY73-4506 in patients with advanced cancer
- Trial name
- NCT01117623
- Testing
- Escalation cohort: Regorafenib (Stivarga, BAY73-4506) 20 mg, Escalation cohort: Regorafenib (Stivarga, BAY73-4506) 40 mg, Escalation cohort: Regorafenib (Stivarga, BAY73-4506) 100 mg
- Where
- 5 sites in United States
- Volunteers
- 86 people
- Sponsor
- Bayer
Advanced Solid Tumor, Anal Cancer
Phase 1 Study of Oral TP-1454
This study will evaluate the safety and tolerability of oral TP-1454 in patients with advanced metastatic or progressive solid tumors and anal cancer.
- Trial name
- NCT04328740
- Testing
- TP-1454 monotherapy
- Where
- 11 sites in United States
- Volunteers
- 31 people
- Sponsor
- Sumitomo Pharma America, Inc.
Intraocular Pressure, Oncology
Effect of Position and Anesthetic Choice in Intraocular Pressure in Robotic GYN (Gynecologic) Oncology Patients
Steep Trendelenburg positioning and insufflation of the abdominal cavity have shown to increase intra ocular pressure. Different anesthetic techniques can alter intra ocular pressure and a small pilot study showed decrease in…
- Trial name
- NCT04281017
- Testing
- TIVA, Balanced anesthesia
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Florida
Glioma, Malignant
Efficacy of a Mixed Distancial Neuropsychological Rehabilitation Program in Patients With Grade 2 or 3 Diffuse Glioma
Diffuse low-grade glioma are rare brain tumors affecting young subjects (median age at diagnosis 38 years for grade 2 and 49 years for grade 3).
- Trial name
- FREEDOME (NCT06468176)
- Testing
- Cognitive Behavioral Therapy (CBT) neuropsychologist
- Where
- 8 sites in France
- Volunteers
- 187 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cancer
Evaluating the CAREchart@Home™ Program for Enhancing After-hours Cancer Care
The objective of the current project is to pilot the evaluation of the health and economic benefits of having online access to health information in the context of providing telemedicine support for oncology patients receiving…
- Trial name
- NCT04232709
- Testing
- Shared electronic patient record
- Where
- Canada
- Volunteers
- 105 people
- Sponsor
- Women's College Hospital
Cancer
The Use of Cannabidiol in Cancer Patients
Alternative and complementary medicines (MAC) are commonly used by cancer patients to help them to face with anticancer treatment, reduce oncology symptoms and/or anticancer treatment adverse effects, detoxifying the body.
- Trial name
- CANPADIOL (NCT05407298)
- Testing
- Non applicable
- Where
- France
- Volunteers
- 350 people
- Sponsor
- CHU de Reims
HER2-negative Breast Cancer
Functional Precision Oncology for Metastatic Breast Cancer
This is a pilot study to assess the feasibility of comprehensive genomic characterization and drug screening in metastatic breast cancer.
- Trial name
- FORESEE (NCT04450706)
- Testing
- Precision Medicine, Physican Decision Making
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Utah
Cancer, Frailty
G8 Screening Tool Validation in Older Adults With Cancer in Portugal
The G8 screening tool is widely recommended for the identification of frailty in older adults with cancer. However, prospective validation data in the Portuguese population are currently lacking.
- Conditions
- Cancer, Frailty, Aged
- Trial name
- G8-PT (NCT07487298)
- Testing
- G8 Screening Tool, Comprehensive Geriatric Assessment
- Where
- Portugal
- Volunteers
- 150 people
- Sponsor
- Hospital de Braga
Endometrial Cancer
Low-Residue Diet Versus Rectal Enema Before Laparoscopic Surgery for Endometrial Cancer
The goal of this clinical trial is to compare a standardized 3-day bowel preparation protocol with a rectal enema before laparoscopic surgery for endometrial cancer.
- Trial name
- NCT07702799
- Testing
- Low-Residue Diet, Sodium Phosphate Rectal Enema
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mahmut Yassa
Leukemia
Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00005585
- Testing
- cyclophosphamide, cytarabine, daunorubicin hydrochloride
- Where
- 123 sites in United States, Australia and 4 more
- Volunteers
- 838 people
- Sponsor
- Children's Oncology Group
Pediatric Oncology, Sleep Problems
The Impact of a Musical Starry Sky Projector on Fatigue, Sleep, and Quality of Life in Pediatric Oncology Patients
This study evaluated the effect of an Ocean Wave and LED Starry Sky Projector on fatigue, sleep, and quality of life in pediatric oncology patients.
- Conditions
- Pediatric Oncology, Sleep Problems, Fatigue Intensity, Quality of Life
- Trial name
- SLEEP (NCT06587815)
- Testing
- musical starry sky projector
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Trakya University
UTERINE CERVICAL NEOPLASMS, ENDOMETRIAL NEOPLASMS
Cost-Effectiveness and Patients Satisfaction of Conventional vs Robotic-Assisted Laparoscopy in Gynecologic Oncologic Indications
Laparoscopic surgery is gaining currency in the field of oncologic care, particularly for colorectal and gynecologic cancers. This innovation could be used either for staging purpose and therefore could steer global therapeutic…
- Trial name
- NCT02865889
- Testing
- Laparoscopy in Gynecologic Oncologic Indications, Conventional surgery (abdominal radical surgery)
- Where
- France
- Volunteers
- 343 people
- Sponsor
- Institut Paoli-Calmettes
Melanoma
A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma
The study design included an open-label, dose escalation phase followed by a blinded, randomized phase, which combined epacadostat (an oral IDO1 inhibitor) with an approved therapy and compared to approved therapy plus placebo in…
- Trial name
- NCT01604889
- Testing
- Epacadostat, ipilimumab
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Incyte Corporation
Metastatic Non Small Cell Lung Cancer
CARE Initiative: Real-world Emulation of the KEYNOTE-189 Trial [DS4]
The goal of this non-interventional study is to emulate the KEYNOTE-189 randomized controlled trial of pembrolizumab for the treatment of metastatic non-small cell lung cancer using real-world, electronic health record data.
- Trial name
- NCT06585189
- Testing
- Pembrolizumab, Pemetrexed, Cisplatin
- Volunteers
- 304 people
- Sponsor
- Aetion, Inc.
Non-small-cell Lung Carcinoma
PET Imaging in Potentially Surgically Resectable Non-small Cell Lung Cancers
Lung cancer remains the leading cause of cancer deaths in men and women. Although overall survival remains poor, early stage non-small cell lung cancer (NSCLC) is potentially curable.
- Trial name
- ELPET (NCT00136890)
- Testing
- PET Imaging
- Where
- 8 sites in Canada
- Volunteers
- 337 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Cervical Lesion
Clinical Trial Evaluating Secondary HPV Vaccination After Treatment of High-grade Cervical Lesions
This is a single-center, Phase II interventional study evaluating secondary HPV vaccination after treatment of high-grade cervical lesions.
- Trial name
- HPV2 (NCT06658405)
- Testing
- Human Papillomavirus 9-valent Vaccine, Recombinant
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Centre Oscar Lambret
Gastrointestinal Cancer, Gastrointestinal Disease
Advancing Nursing Practices in Hospital Oncology Care
The purpose of this study is to find out if a new training program for nurses called PACT (Partnership, Assessment, Care, and Transition) will be effective and relevant in helping nurses gain the skills needed to provide…
- Conditions
- Gastrointestinal Cancer, Gastrointestinal Disease, Nurse's Role
- Trial name
- NCT05053191
- Testing
- Partnership, Assessment, Care and Transition training intervention
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Oral Chemotherapy
Oncology - Bolstering Oral Agent Reporting Related to Distress
Individuals on oral chemotherapy (OC) often face many challenges requiring adequate informational support, monitoring, and management.
- Trial name
- ON-BOARD (NCT04984850)
- Testing
- Oral chemotherapy information and support
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- McGill University
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