Clinical trials: Oncologic
Breast Cancer Metastatic
Evaluation of Somatostatin Receptor Expression in PET 68Ga-DOTATOC in Patients Followed for Metastatic Breast Cancer
DOTABREAST: Evaluation of Somatostatin Receptor Expression in PET 68Ga-DOTATOC in Patients Followed for Metastatic Breast Cancer This is a prospective, monocentric, non-controlled, non-randomized, open-label, interventional study.
- Trial name
- DOTABREAST (NCT06611891)
- Testing
- 68Ga-DOTATOC
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Grenoble
Chemotherapy-Induced Nausea and Vomiting
Fosaprepitant + 5HT3 Receptor Antagonists + Dexamethasone in Germ Cell Tumors
The hypothesis is that the substitution of multi-day oral aprepitant with (intravenous) IV fosaprepitant, in combination with a 5-HT3 receptor antagonists (5HT3RA) + dexamethasone will provide comparable protection from 5 day…
- Trial name
- NCT01736917
- Testing
- Fosaprepitant, Dexamethasone, 5HT3
- Where
- 4 sites in United States
- Volunteers
- 65 people
- Sponsor
- Lawrence Einhorn
Solid Tumours
To Determine the Effect of Food on the Pharmacokinetics of Olaparib and the Effect of Olaparib on QT Interval Following Oral Dosing of a Tablet Formulation in Patients With Advanced Solid Tumours
This is a 3 part study for patients with solid tumours. The purpose of Part A is to measure the amount of olaparib or its breakdown products in the bloodstream for up to 72 hours after eating and the effect of olaparib on QT…
- Trial name
- NCT01921140
- Testing
- Olaparib tablets, Pharmacokinetic sampling, Dietary Fasted
- Where
- 12 sites in Belgium, Denmark and 2 more
- Volunteers
- 60 people
- Sponsor
- AstraZeneca
Pediatric Cancers, Oncology
Long Term Follow-Up of Patients on Children's Cancer Group Protocols- (CCG-LTF1) FOLLOW-UP DATA
This protocol is not an independent research study, but rather a means to aggregate Children's Cancer Group protocols that are closed to patient entry for the purpose of collecting current status information on those patients…
- Trial name
- NCT00588289
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Non-Small Cell Lung Cancer (NSCLC)
U3-1402 in Metastatic or Unresectable Non-Small Cell Lung Cancer
This study was designed to evaluate safety and antitumor activity of HER3-DXd in two parts: Dose Escalation and Dose Expansion. In Dose Escalation, HER3-DXd was evaluated in participants with metastatic or unresectable NSCLC with…
- Trial name
- NCT03260491
- Testing
- HER3-DXd (FL-DP), HER3-DXd (CTM-1 Lyo-DP), HER3-DXd (CTM-3 Lyo-DP)
- Where
- 37 sites in United States, Japan and 4 more
- Volunteers
- 312 people
- Sponsor
- Daiichi Sankyo
Selected Advanced Solid Tumors
A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors
The purpose of this study is to evaluate MEDI5752 and carboplatin and pemetrexed or paclitaxel or nab-paclitaxel in adult subjects with advanced solid tumors, when administered as a single agent or combined with chemotherapy.
- Trial name
- NCT03530397
- Testing
- MEDI5752, Pemetrexed, Carboplatin
- Where
- 40 sites in United States, Australia and 7 more
- Volunteers
- 400 people
- Sponsor
- MedImmune LLC
Chronic Illness, Hematologic Malignancy
Distracting Through Procedural Pain and Distress
Children with acute and chronic illness undergo frequent, painful, and distressing procedures. This randomized control trial was used to evaluate the effectiveness of guided imagery (GI) vs virtual reality (VR) on the procedural…
- Conditions
- Chronic Illness, Hematologic Malignancy, Bone Marrow Transplant Infection, Oncology
- Trial name
- NCT04892160
- Testing
- Guided Imagery, Virtual Reality
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- Medical College of Wisconsin
Neuroblastoma
Impact of Image-defined Risk Factors on the Outcome of Patients With Neuroblastoma: A Retrospective Study
The aim of this study is to evaluate Image-defined Risk Factors (IDRF) in patients with neuroblastoma, at the time of their initial presentation, as a prognostic factor for prediction of subsequent outcome \& complications…
- Trial name
- NCT02558244
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Anemia
Transfusion Requirements in Critically Ill Oncologic Patient
Blood transfusion in critical ill patients has been associated to several complications and worse outcome. Particularly in oncologic patients, red blood cell transfusion has been investigated as a factor of worse outcome and…
- Trial name
- TRICCOP (NCT01648946)
- Testing
- Red blood cell transfusion
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Cancer
EXCEL-Punjabi: A Culturally Tailored Exercise Oncology Pilot Feasibility Intervention
The goal of this pilot feasibility study is to explore the feasibility and exploratory effects of a culturally-tailored exercise oncology intervention in Punjabi-speaking individuals of South Asian heritage and their support…
- Trial name
- EXCEL-Punjabi (NCT07643389)
- Testing
- EXCEL-Punjabi
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Oncology
STEP2 vs. Routine Early Palliative Care: Randomized Noninferiority Trial
Palliative care aims to improve quality of life for people with advanced illness, and early palliative care (EPC) has been shown to benefit patients with late-stage cancer.
- Trial name
- STEP2 RNT (NCT07446660)
- Testing
- Virtual and in-person Symptom screening with Targeted Early Palliative care (STEP2), Early Palliative Care (EPC)
- Where
- Canada
- Volunteers
- 652 people
- Sponsor
- University Health Network, Toronto
Cancer
Stereotactic Body Radiotherapy (SBRT) Plus Immunotherapy for Cancer
Study to determine the best dose of stereotactic body radiation therapy (SBRT) to be administered in combination with immunotherapy drugs including urelumab, cabiralizumab and nivolumab .
- Trial name
- C4-MOSART (NCT03431948)
- Testing
- Nivolumab, Cabiralizumab, Urelumab
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Chicago
Multiple Myeloma, Solid Tumors
A Study of DKN-01 in Multiple Myeloma or Advanced Solid Tumors
The purpose of this trial is to characterize the safety and toxicity of DKN-01 by determining a maximum-tolerated dose and associated dose limiting toxicity. To evaluate the pharmacodynamic response in patients with cancer.
- Conditions
- Multiple Myeloma, Solid Tumors, Non-Small Cell Lung Cancer
- Trial name
- NCT01457417
- Testing
- DKN-01
- Where
- 8 sites in United States
- Volunteers
- 32 people
- Sponsor
- Leap Therapeutics, Inc.
Hepatocellular Carcinoma, Advanced Cancer
CVM-1118 in Combination With Nivolumab for Unresectable Advanced Hepatocellular Carcinoma
CVM-1118 is a new small molecule chemical entity being developed as a potential anti-cancer therapeutic by TaiRx, Inc. CVM-1118 is a potent anti-cancer agent in numerous human cancer cell lines.
- Trial name
- NCT05257590
- Testing
- Nivolumab Injection [Opdivo], CVM-1118
- Where
- 5 sites in Taiwan
- Volunteers
- 95 people
- Sponsor
- TaiRx, Inc.
Small Cell Lung Cancer
A Study of Subjects With Previously Untreated Extensive-Stage Small-Cell Lung Cancer (SCLC) Treated With Platinum Plus Etoposide Chemotherapy With or Without Darbepoetin Alfa
The purpose of this study is to evaluate whether increasing or maintaining hemoglobin concentrations with darbepoetin alfa, when administered with platinum-containing chemotherapy in subjects with previously untreated…
- Trial name
- NCT00119613
- Testing
- darbepoetin alfa
- Volunteers
- 600 people
- Sponsor
- Amgen
Cutaneous Squamous Cell Carcinoma, Basal Cell Carcinoma
IFx-Hu2.0 for the Treatment of Patients With Skin Cancer
One hundred patients will receive IFx-Hu2.0 on an outpatient basis at a single time point in a single lesion. These patients will be assessed for any immediate adverse reactions and at Week 4 (Day 28+/-5 days) for any delayed…
- Trial name
- NCT04925713
- Testing
- IFx-Hu2.0
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- TuHURA Biosciences, Inc.
Digestive Cancer, Metastatic Colorectal Cancer
TARGETed Therapy Drug MONITOring in DIGestive Oncology
Targeted therapy drug monitoring in digestive oncology: Dosage of plasma levels of various multikinase inhibitors (MKI) in patients treated for advanced digestive cancer (gastrointestinal stromal tumor (GIST), metastatic…
- Conditions
- Digestive Cancer, Metastatic Colorectal Cancer, Hepatocellular Carcinoma, GIST
- Trial name
- TARGETMONITO (NCT05443087)
- Testing
- Blood sampling to build population pharmacokinetics model
- Where
- 29 sites in France
- Volunteers
- 330 people
- Sponsor
- UNICANCER
Prostate Cancer (Adenocarcinoma)
Predictive Factors for 10-year Biochemical Recurrence and Urinary Continence Following Robot-assisted Radical Prostatectomy for Prostate Cancer
The aim of the present project is to evaluate long-term oncological and functional treatment outcomes, as well as patient satisfaction, ten years after radical prostatectomy in patients initially enrolled in CPRRP study.
- Trial name
- NCT07439913
- Testing
- Radical prostatectomy
- Where
- Slovakia
- Volunteers
- 120 people
- Sponsor
- F.D. Roosevelt Teaching Hospital with Policlinic Banska Bystrica
Cancer
Heparin Versus Normal Saline in Peripherally Inserted Central Catheter Lines
The study team will be performing a study comparing the use of Heparin Flushes vs. Normal Saline Flushes in making sure central lines stay open.
- Trial name
- NCT05029596
- Testing
- Normal Saline Group, Heparin Group
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Rectal Cancer
The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer
This trial (molecular characterization trial) focuses on rectal cancer, a common cancer that is treated with radiotherapy (RT) as standard of care and represents a setting in which to study the effects of RT on the immune system.
- Trial name
- ROBIN (NCT05943210)
- Testing
- Short Course Radiation Therapy (scRT), Total Mesenteric Excision (TME)
- Where
- 5 sites in United States
- Volunteers
- 25 people
- Sponsor
- Weill Medical College of Cornell University
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