Clinical trials: Oncologic Disorders, open to volunteers
Lung Cancer
Joint Thoracic Oncology Research Unit of LYon: Lung cancerS DatabaSE (ULYSSE)
Prospective longitudinal cohort associated to blood collection, pathological samples collection, and radiological and pathological imaging collection.
- Trial name
- ULYSSE (NCT05267041)
- Testing
- Blood sample, Questionnaire
- Where
- France
- Volunteers
- 4,000 people
- Sponsor
- Hospices Civils de Lyon
Lymphedema, Genital Neoplasm
Lymphedema After Gyneco-oncologic Treatment
Trial developed to inventory the incidence of early and advanced stage lower limb lymphedema in patients diagnosed with and treated for gynaecologic cancer.
- Trial name
- Gynolymph (NCT05469945)
- Testing
- Compressive garments class II
- Where
- 2 sites in Belgium
- Volunteers
- 218 people
- Sponsor
- University Hospital, Ghent
Survivorship
LiveWell mBc: Adapted Dialectical Behavioral Therapy Skills Training
In this pilot randomized controlled trial, women with metastatic breast cancer and at least mild distress (N=48) will be randomized to receive LiveWell mBC, a group-based adapted Dialectical Behavioral Therapy (DBT) Skills…
- Trial name
- NCT07539649
- Testing
- LiveWell mBC: A Group-Based Adapted Dialectical Behavioral Therapy Skills Training Program
- Volunteers
- 48 people
- Sponsor
- Medical University of South Carolina
Oral Mucositis, Head and Neck Cancer (H&N)
Oral Herpesviruses and Oral Mucositis in Patients Receiving Head and Neck Radiotherapy
Patients receiving radiotherapy for head and neck cancer often develop oral mucositis, a painful condition that causes redness and sores in the mouth.
- Conditions
- Oral Mucositis, Head and Neck Cancer (H&N), Radiotherapy Side Effects
- Trial name
- NCT07363031
- Testing
- Valacyclovir
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Instituto Oncoclinicas
Solid Tumor, Adult, Metastatic Breast Cancer
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
First in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-10203, a PI3Kα:RAS breaker, alone and in combination with other anti-cancer agents in patients with advanced solid tumors.
- Conditions
- Solid Tumor, Adult, Metastatic Breast Cancer, Advanced Breast Cancer, HER2 Mutation-Related Tumors
- Trial name
- NCT06625775
- Testing
- BBO-10203, Trastuzumab, Fulvestrant
- Where
- 44 sites in United States, Australia and 4 more
- Volunteers
- 392 people
- Sponsor
- TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)
Cancer Survivors, Anxiety
Internet-Delivered Psychological Treatment for Cancer Survivors
Negative psychological effects of cancer are common, but cancer survivors are rarely offered structured psychological treatment.
- Conditions
- Cancer Survivors, Anxiety, Depression
- Trial name
- IN-FACT-1 (NCT06046586)
- Testing
- Support and information, Behavioral activation, Systematic exposure with mindfulness training
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Metastatic Renal Cell Carcinoma
Urine Omics Predicting IO Therapy Responses in mRCC Patients
The study aims to identify urinary metabolite and protein markers that can predict anti-tumor efficacy and adverse events in subjects receiving IO-based therapies for metastatic renal cell carcinoma.
- Trial name
- NCT04712305
- Testing
- No intervention required
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Medical Education, Ovarian Cancer
Ultrasound Training Program for Gynecologic Cancer Staging in Residents
This is a prospective, interventional study aiming to develop and validate an ultrasound training program for gynecology and obstetrics residents, focused on the staging of gynecologic cancers, including ovarian, endometrial, and…
- Conditions
- Medical Education, Ovarian Cancer, Endometrial Cancer, Cervix Cancer
- Trial name
- Ultra-teaching (NCT07028229)
- Testing
- Training Group
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Cancer Metastatic, Advanced Colorectal Cancer
TL938 and Trastuzumab for Patients With HER2-positive Metastatic Colorectal Cancer
This is a Phase II trial designed to determine the optimal dose and evaluate the effectiveness of TL938 and trastuzumab in treating patients with HER2+ colorectal cancer that has metastasized or recurred and is inoperable.
- Trial name
- NCT06589830
- Testing
- TL938 Capsules, Trastuzumab
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Suzhou Teligene Ltd.
Digestive Oncology
An Artificial Intelligence Model for Aiding Claudin18.2 Expression Diagnosis in Gastric Adenocarcinoma
The investigators plan to develop a deep learning-based automatic interpretation model for Claudin18.2(CLDN18.2) using the institution's and multiple other centers' extensive pathological resources of digestive system…
- Trial name
- NCT07274579
- Where
- 2 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Nuclear Medicine, Oncology
Application of 18F-FDG PET/MRI for Initial Staging in Locally Advanced Nasopharyngeal Carcinoma
This single-center prospective observational study aims to evaluate the feasibility, cost-effectiveness, and clinical value of positron emission tomography/magnetic resonance imaging (PET/MRI) for initial staging in patients with…
- Trial name
- NCT06947759
- Testing
- PET/MRI
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taichung Veterans General Hospital
Multiple Myeloma
Follow-up of Patients With Multiple Myeloma in the West-Occitanie Region "Living With a Myeloma in West-Occitanie"
Actually very few real life data are available for patients with multiple myeloma (MM), whereas they're playing a more and more important role in health care decisions.
- Trial name
- VAMOS (NCT04888039)
- Testing
- quality of life questionnaires (EORTC QLQ-C30 ; EORTC QLQMY20 ; EQ-5D-5L ; Cohen's stress scale)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Toulouse
Oncology, Support Care
Breast Cancer and Chemobrain : Effects of Photobiomodulation on the Improvement of Perceived Cognitive Impairment
Breast cancer is one of the most common cancers in metropolitan France, with over 60,000 new cases in 2023. Mostly a female cancer, it can affect a young population, with around 20% of breast cancers occurring in women under 50.
- Conditions
- Oncology, Support Care, Cognitive Disorders
- Trial name
- REGAIN (NCT06995443)
- Testing
- Photobiomodulation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier de Valenciennes
Taste Alterations, Smell Disorder
Adaptation Strategies for Coping With the Impact of Sensory Alterations on Eating Behavior in Children With Cancer: A Qualitative Study From the Perspective of Children and Parents
Childhood cancer is a serious and life-changing disease that affects thousands of children every year worldwide. In addition to the disease itself, cancer treatments such as chemotherapy often cause difficult side effects.
- Conditions
- Taste Alterations, Smell Disorder, Eating Behavior Changes
- Trial name
- QUALISENS (NCT07490093)
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Leon Berard
Genome Instability, Genetic Predisposition to Disease
Mutational Oncology in Clinical Practice
The study of biological profiling is of fundamental importance in the diagnosis and treatment of many diseases, particularly oncological ones, and for this reason, the integration of molecular characterization into clinical…
- Conditions
- Genome Instability, Genetic Predisposition to Disease, Gene Rearrangement
- Trial name
- FPG-500 (NCT06020625)
- Testing
- Diagnostic Test
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Solid Tumor
The Intersection of Oncology Care and Worker Well-Being
The goals of this study will be a greater understanding of cancer patients' well-being experience through the care/treatment continuum.
- Trial name
- NCT05250284
- Testing
- WellBQ, PROMIS
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Colorado, Denver
Breast Cancer, Colon Cancer
A Manualized Post-Traumatic Growth Intervention for People With Cancer in Greece - IC-Growth
Cancer can be a very traumatic experience for the people affected and the majority of the psychological literature focuses on this.
- Conditions
- Breast Cancer, Colon Cancer, Head and Neck Cancers
- Trial name
- IC-Growth (NCT07108517)
- Testing
- IC-Growth ACT-Based Support Program
- Where
- Greece
- Volunteers
- 180 people
- Sponsor
- Centre for Research and Technology Hellas
Urologic Diseases, Male Infertility
Protocol N. 2014 - Observational Study on the Quality of Life of Outpatients
Prospective observational study on the quality of life of patients attending general urology, sexual medicine, reproductive medicine, functional urology, neuro-urology and uro-oncology clinics.The data relating to the clinical…
- Conditions
- Urologic Diseases, Male Infertility, Sexual Medicine
- Trial name
- NCT06193850
- Testing
- Observation during time
- Where
- Italy
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Heart Failure, Coronary Artery Disease
PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study
This is a single-center, double-arm, open-label, randomized feasibility study that will determine whether a novel clinical decision aid accessed via the electronic health record will be acceptable to both cancer survivors and…
- Conditions
- Heart Failure, Coronary Artery Disease, Peripheral Artery Disease, Ischemia
- Trial name
- NCT05377320
- Testing
- Clinical Decision Aid, Standard Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical College of Wisconsin