Clinical trials: Oncologic Patients
Adenocarcinoma of the Pancreas, Advanced Solid Tumors
QUILT-2.014: Gemcitabine and AMG 479 in Metastatic Adenocarcinoma of the Pancreas
AMG 479 is an investigational fully human monoclonal antibody that targets type 1 insulin-like growth factor receptor (IGF-1R). Signaling through IGF-1R plays an important role in the regulation of cell growth and survival.
- Conditions
- Adenocarcinoma of the Pancreas, Advanced Solid Tumors, Cancer, Cancer of Pancreas
- Trial name
- GAMMA (NCT01231347)
- Testing
- AMG 479, gemcitabine
- Where
- 152 sites in United States, Australia and 30 more
- Volunteers
- 800 people
- Sponsor
- NantCell, Inc.
Oral Chemotherapy
Oncology - Bolstering Oral Agent Reporting Related to Distress
Individuals on oral chemotherapy (OC) often face many challenges requiring adequate informational support, monitoring, and management.
- Trial name
- ON-BOARD (NCT04984850)
- Testing
- Oral chemotherapy information and support
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- McGill University
Cancer
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Durvalumab
The rationale of the ROSY-D study is to continue to provide study treatment for patients who have participated in a parent study with Durvalumab and who are continuing to derive clinical benefit from treatment at the end of such…
- Trial name
- ROSY-D (NCT05303532)
- Testing
- Durvalumab
- Where
- 123 sites in United States, Argentina and 29 more
- Volunteers
- 214 people
- Sponsor
- AstraZeneca
Gynecologic Cancer, Anemia
Ferric Derisomaltose and Outcomes in the Recovery of Gynecologic Oncology: ERAS (Enhanced Recovery After Surgery)
Iron deficiency has been reported in approximately 35% of patients with a gynecologic malignancy. Blood transfusions are known to be immunosuppressive and carry immediate and long-term risks.
- Conditions
- Gynecologic Cancer, Anemia, Iron-deficiency
- Trial name
- FORGE II (NCT05407987)
- Testing
- Ferric derisomaltose
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- AHS Cancer Control Alberta
Cancer Patients
Effectiveness of Video Assisted Self Management Program on Chemotherapy Related Side Effects .
A study to assess the effectiveness of video assisted Self Management Program on chemotherapy side effects in terms of Knowledge, Self Efficacy and Severity of side effects among the Cancer patient receiving chemotherapy at…
- Trial name
- NCT05368116
- Testing
- Video Assisted Self Management Program, Standard of care
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Neoplasms, Ovarian Neoplasms
Biobehavioral Intervention in Gynecologic Oncology Patients
Baseline self-report outcome measures will be completed and additional assessments will occur mid-treatment , post-treatment , 3 months following completion of all sessions, and 6 months following completion of all sessions.
- Conditions
- Neoplasms, Ovarian Neoplasms, Uterine Neoplasms, Vulva
- Trial name
- NCT02454036
- Testing
- BBI intervention
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Rachel Miller
Cancer
CRQ Survey Study: Clinical Research Questionnaire of Oncology Patients - A Nationwide Survey
This is a translational, multicentre questionnaire study. The study design follows that of a cross sectional, quantitative research approach. Data collection will involve self-administered, paper-based questionnaires.
- Trial name
- NCT02836392
- Testing
- Questionnaire
- Where
- 14 sites in Ireland
- Volunteers
- 1,000 people
- Sponsor
- Cancer Trials Ireland
Advanced Melanoma
Assessment of Safety and Efficacy of OPM-101 Combined With Anti-PD-1 in Patients With Advanced Melanoma Showing Resistance to Anti-PD-1
This is a phase 1b/2a study including a dose escalation part (Phase 1b) and an extension part (Phase 2a). Both parts will be open-label, multicenter study of OPM-101 combined with the anti-PD-1 pembrolizumab as per standard of…
- Trial name
- REVERT (NCT07040436)
- Testing
- OPM-101
- Volunteers
- 41 people
- Sponsor
- Oncodesign Precision Medicine
Prostatectomy, Prehabilitation
The Effectiveness of Telemedicine Monitoring Prehabilitation in Prostate Cancer Patients Undergoing Radical Prostatectomy
The study titled " The effectiveness of telemedicine monitoring prehabilitation in prostate cancer patients undergoing radical prostatectomy " investigates the impact of a structured telemedicine-supported prehabilitation and…
- Conditions
- Prostatectomy, Prehabilitation, Telemedicine
- Trial name
- NCT06981026
- Testing
- Telemedicine-based prehabilitation and postoperative rehabilitation protocol, including physical activity monitoring, respiratory and postural training, and guidance via telehealth tools.
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- University Hospital Olomouc
Postoperative Nausea, Postoperative Nausea and Vomiting
Pre-operative Olanzapine as Prophylactic Antiemetic in Oncologic Patients
Olanzapine has been used as prophylactic antiemetic for chemotherapy induced nausea and vomiting. The project aims to evaluate the efficacy of olanzapine in combination with ondansetron and dexamethasone in patients at high risk…
- Trial name
- NCT03631004
- Testing
- Olanzapine
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Melanoma, Prostate Cancer
A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors
This is a first-in-human, open-label, dose escalation study to evaluate the safety and tolerability of pegilodecakin in participants with advanced solid tumors, dosed daily subcutaneously as a monotherapy or in combination with…
- Conditions
- Melanoma, Prostate Cancer, Ovarian Cancer, Renal Cell Carcinoma
- Trial name
- IVY (NCT02009449)
- Testing
- Pegilodecakin, Paclitaxel or Docetaxel and Carboplatin or Cisplatin, FOLFOX (Oxaliplatin/Leucovorin/5-Fluorouracil)
- Where
- 10 sites in United States
- Volunteers
- 353 people
- Sponsor
- Eli Lilly and Company
Breast Cancer
Real-world Data in Patients With Breast Cancer Treated With Abemaciclib
The present study will assess real-world clinical outcomes and adverse events from treatment with endocrine therapy combined with abemaciclib in patients with HR-positive, HER2-negative advanced breast cancer.
- Trial name
- ENDURANCE (NCT04985058)
- Where
- Greece
- Volunteers
- 108 people
- Sponsor
- Hellenic Cooperative Oncology Group
Solid Tumor or Lymphoma
Supportive Care Needs of Former Child, AYA Cancer Patients, and of Their Parents: Evaluation During Long-term Follow-up
Each year, there are 2100 new cases of cancer in children and adolescents/young adults (AYA) in France. Due to a significant improvement in the effectiveness of therapies, the survival rate of all types of cancer combined after 5…
- Trial name
- ExPEDAJAC (NCT04711733)
- Testing
- Interview, Self-report questionnaire, Medical consultation
- Where
- France
- Volunteers
- 99 people
- Sponsor
- Centre Leon Berard
Oncologic Disorders
Collaborative Network to Take Responsibility for Oral Anticancer Therapy 2
In 2015, the research team of KU Leuven and UGent started a pilot project supported by Kom op Tegen Kanker, called CONTACT-1. This multicentre before-after study aims at developing, implementing and evaluating a care pathway for…
- Trial name
- CONTACT-2 (NCT04142463)
- Testing
- Care pathway
- Where
- 10 sites in Belgium
- Volunteers
- 500 people
- Sponsor
- Ilyse Kenis
Advanced Solid Tumors, Colorectal Cancer
Safety Study of the Drug MM-151 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment
This study is a Phase 1 and pharmacologic open-labeled dose-escalation trial using a "3+3" design, evaluating MM-151 at varying dose levels and frequencies, and subsequently in combination with irinotecan.
- Conditions
- Advanced Solid Tumors, Colorectal Cancer, Squamous Cell Head and Neck Cancer, Non Small Cell Lung Cancer
- Trial name
- NCT01520389
- Testing
- MM-151, MM-151 + irinotecan
- Where
- 4 sites in United States
- Volunteers
- 112 people
- Sponsor
- Merrimack Pharmaceuticals
Pain, Nausea With Vomiting Chemotherapy-Induced
The Effect of Acupressure on Pain, Nausea-Vomiting, and Mental Well-Being in Oncology Patients
The goal of this clinical trial is to compare the effect of self acupressure and acupressure applied by therapists on pain, nausea-vomiting, and mental well-being in oncology patients.
- Conditions
- Pain, Nausea With Vomiting Chemotherapy-Induced, Mental Health Wellness 1
- Trial name
- NCT05898880
- Testing
- Self-acupressure, Acupressure by therapists, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Mersin University
Oncology, Bone Loss
Evaluating Radiomorphometric Indices and Fractal Dimension of the Pediatric Oncology Patients on Panoramic Images
This study evaluated pediatric oncology patients in terms of quality of bone and determine any relation between bone quality and radiotherapy/chemotherapy.
- Trial name
- NCT04213482
- Testing
- Panoramic Radiography
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nuh Naci Yazgan University
Childhood Cancer, Aplastic Anemia
Trial of Two Central Venous Catheter (CVC) Flushing Schemes in Pediatric Hematology and Oncology Patients
The purpose of this study is to determine whether flushing Central Venous Catheters (CVCs) with Normal saline once per week is not inferior to flushing with 10U/ml heparin 3 times per week, in preventing CVC occlusions.
- Conditions
- Childhood Cancer, Aplastic Anemia, Metabolic Disorders
- Trial name
- NCT01343680
- Testing
- Heparin, Normal saline
- Where
- 2 sites in Canada
- Volunteers
- 2 people
- Sponsor
- Alberta Children's Hospital
Multiple Myeloma, Solitary Plasmacytoma
MargheRITA (Remote Intelligence for Therapeutic Adherence)
It is essential to improve clinical efficiency and management of hematological and oncological patients treated on an outpatient basis.
- Conditions
- Multiple Myeloma, Solitary Plasmacytoma, Amyloidosis, Chronic Myeloid Leukemia
- Trial name
- MargheRITA (NCT05260203)
- Testing
- RITA (App)
- Where
- Italy
- Volunteers
- 124 people
- Sponsor
- Advice Pharma Group srl
Pediatric Hematology, Pediatric Oncology
Effect of Hand Puppet and Squeeze Toys on IV Placement in Pediatric Oncology Patients
This randomized controlled trial investigates hand puppet and squeeze toy techniques to reduce fear, emotional distress, and procedure time, and improve IV catheter placement success in 90 pediatric hematology-oncology patients…
- Trial name
- NCT07493018
- Testing
- Performing a Hand Puppet to Music, Hand Squeezing Soft Toy (Squishy)
- Volunteers
- 90 people
- Sponsor
- Akdeniz University
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