Clinical trials: Ondansetron
Indigestion, Diabetes Mellitus
Effects of Ondansetron on Gastrointestinal Sensorimotor Dysfunctions in Diabetes Mellitus and Dyspepsia
Researchers are trying to understand why people with indigestion and diabetes mellitus have gastrointestinal symptoms and in particular to understand whether symptoms are related to increased sensitivity to nutrients in the small…
- Trial name
- NCT03865290
- Testing
- Ondansetron 8mg
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy
Bioavailability Study of Ondansetron 16 mg Orally Disintegrating Tablets Under Fasting Conditions
Single-dose cross over comparative bioavailability of Ondansetron 16 mg ODT and Zofran 16 mg ODT
- Trial name
- NCT00659685
- Testing
- Ondansetron, Zofran ODT
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Acute Myelogenous Leukemia, Chemotherapy-induced Nausea and Vomiting
Palonosetron Versus Ondansetron for the Prevention of Nausea and Vomiting
The goal of this clinical research study is to compare the effectiveness of 3 drug schedules in preventing chemotherapy-related nausea and/or vomiting in patients with acute myelogenous leukemia (AML) or high-risk myelodysplastic…
- Trial name
- NCT01031498
- Testing
- Ondansetron, Palonosetron
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- M.D. Anderson Cancer Center
Post-operative Nausea and Vomiting
Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting
The aim is to evaluate the effectiveness of three different regimens of prophylactic ondansetron on the incidence and severity of post-operative nausea and vomiting.
- Trial name
- NCT03297021
- Testing
- Ondansetron 4 MG, Ondansetron 8mg
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Abdominal Pain, Inflammatory Bowel Diseases
Examining the Effect of Ondansetron on Bowel Prep Success
This is a pilot randomized-controlled trial assessing the utility of ondansetron for improving pediatric pre-colonoscopy bowel prep outcomes using the boston bowel preparation score, as well as assessing the impact on patient…
- Conditions
- Abdominal Pain, Inflammatory Bowel Diseases, Eosinophilic Gastroenteritis, Diarrhea
- Trial name
- NCT05439772
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- State University of New York - Downstate Medical Center
Alcohol Dependence
Ondansetron With Olanzapine for the Treatment of Alcohol Dependence: A Preliminary Clinical Trial
This study would like to test whether the combination of ondansetron and olanzapine will be superior to placebo at decreasing self-reported heavy drinking among early onset alcoholics.
- Trial name
- NCT00678457
- Testing
- Ondansetron, Olanzapine
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Vomiting in Infants and/or Children
Efficacy and Safety of the Administration of Ondansetron Versus Habitual Clinical Practice for the Treatment of Vomiting in Children With Mild and Moderate Dehydration: Randomized Clinical Trial
This clinical trial is intended to evaluate the efficacy and safety of the administration of ondansetron in children with mild-moderate dehydration.
- Trial name
- NCT04318847
- Testing
- Ondansetron 4 MG
- Volunteers
- 220 people
- Sponsor
- Lizar Aguirre Pascasio
Nausea and Vomiting, Postoperative, Nausea With Vomiting Chemotherapy-Induced
Crossover Study Comparing Ondansetron Orally Dissolving Film Strip (ODFS) With Zofran Orally Disintegrating Tablets
This was an open-label, balanced, two-treatment, two-period, randomized sequence crossover bioequivalence study with a 7-day washout between periods. Each treatment was administered after an overnight (10 hours) fast.
- Trial name
- 01905/08-09 (NCT01217190)
- Testing
- Ondansetron (ODFS), Zofran (ODT)
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- MonoSol Rx
Postoperative Nausea
Pharmacogenomics and Post-Operative Nausea and Vomiting
The Researchers overall goal is to evaluate the benefit and utility of preemptive genotypic data to guide post-operative nausea and vomiting treatment in the bariatric surgical population.
- Trial name
- NCT03503292
- Testing
- Granisetron, Ondansetron
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Myeloproliferative Disorders, Leukemia
Aprepitant or Ondansetron in Treating Nausea and Vomiting Caused By Opioids in Patients With Cancer
RATIONALE: Antiemetic drugs, such as aprepitant and ondansetron, may help lessen nausea and vomiting caused by opioids. It is not yet known whether aprepitant is more effective than ondansetron in treating nausea and vomiting…
- Conditions
- Myeloproliferative Disorders, Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00499668
- Testing
- aprepitant, ondansetron hydrochloride
- Sponsor
- Vanderbilt-Ingram Cancer Center
Postoperative Nausea and Vomiting (PONV), Subarachnoid Block
Comparison of Haloperidol and Ondansetron in Reducing Postoperative Nausea and Vomiting in RA-SAB Patients
This study aims to evaluate and compare the effectiveness of intravenous haloperidol and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing surgery with subarachnoid block (spinal…
- Conditions
- Postoperative Nausea and Vomiting (PONV), Subarachnoid Block, Spinal Anesthesia
- Trial name
- HALO-PONV (NCT07087925)
- Testing
- Haloperidol, Ondansetron 4mg
- Where
- Indonesia
- Volunteers
- 40 people
- Sponsor
- Rully Riyandika
Postoperative Nausea and Vomiting
Effect of Ramosetron in Prevention of Intrathecal Morphine Induced Nausea and Vomiting
We would like to know the prophylactic anti-emetic effect of ramosetron compare to ondansetron in patient undergone total knee arthroplasty with spinal anesthesia and intrathecal morphine .
- Trial name
- NCT02830906
- Testing
- ramosetron, Ondansetron
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Thammasat University
Alcoholism
Ondansetron Treatment for Alcoholism
The purpose of this study is to: a) evaluate the effectiveness of ondansetron (Zofran) in the treatment of alcohol dependent patients; b) investigate whether early versus late onset alcoholism predicts treatment outcome; and c)…
- Trial name
- NCT00000443
- Testing
- ondansetron (Zofran)
- Where
- United States
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Cancer (Solid Tumors), Vomiting
Steroid Sparing Regimen With Olanzapine and Palonosetron for Emetic Prevention for High Dose Cisplatin
A phase II study evaluating dexamethasone sparing regimen with olanzapine and palonosetron for patients receiving high dose cisplatin to prevent chemotherapy induced nausea and vomiting
- Conditions
- Cancer (Solid Tumors), Vomiting, Cisplatin, Olanzapine
- Trial name
- NCT07699276
- Testing
- dexamethasone sparing
- Where
- Thailand
- Volunteers
- 95 people
- Sponsor
- Mahidol University
Fasting State
Bioequivalence Study of Ondansetron Tablets USP 8 mg Under Fasting Condition
This is a randomized, open Label, balanced, two-treatment, two-period, two-sequence, single dose, cross over pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding…
- Trial name
- NCT01578252
- Testing
- Ondansetron Tablets USP 8 mg, Ondansetron Hydrochloride
- Where
- India
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- IPCA Laboratories Ltd.
Postoperative Vomiting
Postoperative Vomiting in Children: Comparison Tri - Versus bi -Prophylaxis
The purpose of this study is to evaluate the benefit of addition of droperidol to prophylaxis with ondansetron and dexamethasone in children with high risk of postoperative vomiting (POV).
- Trial name
- VPOP2 (NCT01739985)
- Testing
- Dexamethasone + ondansetron + Droperidol
- Where
- France
- Volunteers
- 322 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Nausea and Vomiting Chemotherapy-Induced, Nausea Post Chemotherapy
Study With IV NEPA (Fosnetupitant/Palonosetron) for the Prevention of Chemotherapy-induced Nausea and Vomiting in Paediatric Cancer Patients Undergoing Highly Emetogenic Chemotherapy (HEC)
Chemotherapy often causes nausea and vomiting (CINV), and this is a major problem for the children being treated for cancer. To prevent this, a combination of two substances in fixed proportion (IV NEPA) was developed.
- Trial name
- NCT06904235
- Testing
- IV NEPA (fosnetupitant/palonosetron), Reference Treatment: IV ondansetron infusion, Reference Treatment: IV fosaprepitant infusion
- Where
- 20 sites in Greece, Poland and 2 more
- Volunteers
- 95 people
- Sponsor
- Helsinn Healthcare SA
Nausea
EMS Use of Isopropyl Alcohol Aromatherapy Versus Ondansetron
Nausea is a common symptom encountered in the Emergency Medical Services (EMS) environment that is often treated with oral or intravenous anti-emetic medications.
- Trial name
- NCT02618343
- Testing
- IPA, Ondansetron
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Vomiting, Gastroenteritis
Efficacy of Ondansetron on Vomiting Due to Acute Gastroenteritis in Pediatric During Winter
Acute gastroenteritis is a common disease especially in children. With bronchiolitis and influenza, she participated widely in weight of winter epidemics that causes problems every year our health care system, particularly in the…
- Trial name
- Ondangapi (NCT02028910)
- Testing
- Ondansetron
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-Dural Puncture Headache
Comparing the Effects of Ondansetron Versus Dexamethasone on the Incidence of Post-dural Puncture Headache (PDPH) , Nausea and Vomiting After Spinal Anaesthesia of Parturients Undergoing Caesarean Section
Comparing dexamethasone and ondanestrone injection in ncidence of postdural puncture headache and post-partum nausea and vomiting
- Trial name
- NCT05202574
- Testing
- Intravenous drug
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University