Clinical trials: Ondansetron
Ondansetron, Laparoscopic
Intravenous Versus Perineural Ondansetron for Laparoscopic Sleeve Gastrectomy
This prospective randomized non-inferiority study will be conducted to compare the analgesic anti-emetic effects of intravenous ondansetron versus perineural ondansetron in patients undergoing laparoscopic sleeve gastrectomy.
- Conditions
- Ondansetron, Laparoscopic, Gastrectomy
- Trial name
- NCT06810882
- Testing
- Perineural ondansetron, Intravenous ondansetron
- Where
- Egypt
- Volunteers
- 482 people
- Sponsor
- Tanta University
Post-Operative Nausea and Vomiting, Breast Cancer
Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)
The goal of this clinical research study is to learn if light electrical stimulation to the wrist area during surgery is feasible in women having breast surgery.
- Trial name
- NCT02473042
- Testing
- Electrical Stimulation, Zofran, Dexamethasone
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy
Bioavailability Study of Ondansetron 24 mg Orally Disintegrating Tablets Under Fasting Conditions
Single-dose cross over comparative bioavailability of Ondansetron 24 mg oDT and Zofran 24 mg ODT
- Trial name
- NCT00659074
- Testing
- Ondansetron, Zofran
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Delayed Gastric Emptying
Evaluating Neostigmine Effect on Reducing Gastric Residual Volume as Compared With Metoclopramide and Ondansetron
One big problem in mechanically ventilated ICU patients is delayed gastric emptying. Delayed gastric emptying in these patients, causes intolerance and high gastric residual volume (GRV) that can lead to abdominal distention…
- Trial name
- NCT05342818
- Testing
- Neostigmine, Ondansetron 8mg, Metoclopramide Injection
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Tanta University
Esophagogastroduodensocopy (EGD) Procedure
Oral Ondansetron to Improve Patient Experience of Unsedated Esophagogastroduodenoscopy Pilot Study
The goal of this interventional pilot study is to explore the feasibility of administering ondansetron prior to esophagogastroduodenoscopy (EGD), and preliminarily test if it can alleviate the gagging reflex, nausea and vomiting…
- Trial name
- NCT07264738
- Testing
- ondansetron and dyclonine hydrochloride, dyclonine hydrochloride only
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking Union Medical College Hospital
Healthy
Open-label, Normal Healthy Volunteer Clinical Trial of a Novel Ondansetron Formulation
The goals of this open-label Phase Ia study are to evaluate the Pharmacokinetics (PK) profiles of new novel single-dose Ondansetron Pulsatile Release (Ond-PR) formulations in normal healthy volunteers.
- Trial name
- NCT01290276
- Testing
- Ond-PR1, Ond-PR1 + MPh-IR, Ond-PR2
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Tong Lee
Nausea, Vomiting
Efficacy & Safety of the Oral Neurokinin-1 Antagonist, Aprepitant, in Combo With Ondansetron & Dexamethasone in Patients Undergoing Auto Peripheral Blood Stem Cell Transplantation
The purpose of this study is to determine the efficacy of aprepitant in preventing acute and delayed chemotherapy induced nausea and vomiting when administered in combination with intravenous or oral ondansetron and intravenous…
- Trial name
- NCT00314743
- Testing
- Ondansetron, Dexamethasone, Aprepitant
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
Ondansetron
Ondansetron and the QT Interval In Adult Emergency Department Patients
The purpose of this study is to assess the use of the medication ondansetron (zofran) in the emergency department. There are studies of the ability of ondansetron to cause a prolongation in the QT interval (a certain measurement…
- Trial name
- NCT01759420
- Testing
- Ondansetron
- Where
- 2 sites in United States
- Volunteers
- 28 people
- Sponsor
- C.R.Darnall Army Medical Center
Ondansetron Lozenge, Postoperative Nausea and Vomiting
Preoperative Ondansetron Lozenge for Prevention of Postoperative Nausea and Vomiting in Pediatrics Undergoing Squint Surgeries
The aim of this study is to evaluate the role of ondansetron lozenge on prevention of postoperative nausea and vomiting (PONV) in pediatrics undergoing squint surgeries.
- Conditions
- Ondansetron Lozenge, Postoperative Nausea and Vomiting, Pediatrics, Squint
- Trial name
- NCT06423820
- Testing
- Ondansetron lozenge
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Bone Cement Syndrome
The Effect of iv Ondansetron on Reducing Hypotension Due to BCIS in Total Knee Prosthesis Surgery
Bone cement implantation syndrome (BCIS) is a complication associated with the implantation of polymethylmethacrylate bone cement.
- Trial name
- NCT05405608
- Testing
- Ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Ataturk University
Sleep Syncope
Study of Ondansetron in the Prevention of Sleep Syncope: The Nineth Prevention of Syncope Trial (POST9)
At least 5% of patients with vasovagal syncope also have Sleep Syncope. Patients awake from sleep with profound malaise and gastrointestinal vagal symptoms. About 75% have severe nausea and about 40% have lower abdominal cramps.
- Trial name
- POST9 (NCT05657925)
- Testing
- ondansetron 8 mg
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of Calgary
Allergy
The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron
Perioperative anaphylaxis is a potentially life-threatening drug allergic reaction that can occur during anesthetic procedures. The purpose of this research is to determine the maximal nonirritating skin testing concentrations of…
- Trial name
- NCT07103720
- Testing
- Skin Testing
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Methamphetamine Dependence, Cocaine Dependence
PHASE IIA: Trial of a Novel Ondansetron Formulation (OND-PR002) and Immediate-Release Methylphenidate (Ritalin®)(OND003IND)
The main purpose of this study is to determine the outcome of a drug combination treatment on detoxified and stabilized methamphetamine (METH) and/or cocaine (COC) dependent users.
- Trial name
- NCT01377662
- Testing
- OND-PR002 and MPh-IR
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Tong Lee
Postoperative Nausea and Vomiting, Nausea and Vomiting, Postoperative
Post-Operative Nausea And Vomiting Study In Female Patients
The primary purpose of this study is to determine an effective dose of this NK-1 anti-emetic medication to prevent nausea and vomiting in females after surgery.
- Trial name
- NCT00274690
- Testing
- GW679769
- Where
- 44 sites in United States, Denmark and 9 more
- Volunteers
- 435 people
- Sponsor
- GlaxoSmithKline
Nausea, Postoperative, Vomiting, Postoperative
Palonosetron vs. Ondansetron for Postoperative Nausea and Vomiting in Bariatric Surgery
Evaluate the safety and efficacy of palonosetron versus ondansetron to reduce and control post-operative nausea in bariatric surgery.
- Conditions
- Nausea, Postoperative, Vomiting, Postoperative, Patient Reported Outcomes, Pain, Postoperative
- Trial name
- NCT04533867
- Testing
- Laparoscopic sleeve gastrectomy, Palonosetron 1mcg/kg, Ondansetron 1 mg/kg, max dose 8 mg
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Bagcilar Training and Research Hospital
Healthy Participants
Three-way Crossover Study Comparing Ondansetron ODFS Administered With and Without Water to Zofran ODT Without Water
This study conducted in healthy male and female adult participants compared the bioavailability and relative safety and tolerance of a single dose of ondansetron 8 mg Orally Dissolving Filmstrip (ODFS) administered under fasting…
- Trial name
- NCT01220167
- Testing
- Ondansetron 8 mg ODFS without water, Ondansetron 8 mg ODFS with water, Zofran ODT (ondansetron 8 mg) without water
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Aquestive Therapeutics
Anesthesia; Adverse Effect, Spinal and Epidural
Prophylaxis Ephedrine or Ondansetron Prevents Hypotension After Spinal Anesthesia for Cesarean Section
Maternal hypotension after spinal anesthesia in parturients undergoing cesarean section is a very common problem leading to several complications to both patients and their babies.
- Trial name
- NCT02194192
- Testing
- Ondansetron, Ephedrine
- Where
- Thailand
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Vomiting of Pregnancy
Ondansetron VS Doxylamine and Pyridoxine in Treating Nausea of Pregnancy
Our purpose is to determine whether ondansetron, a commonly used antiemetic, is equivalent in efficacy to the combination of pyridoxine and doxylamine, the currently recommended first line therapy for nausea and vomiting in…
- Trial name
- NCT01668069
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- United States Naval Medical Center, San Diego
Acute Myelogenous Leukemia, Chemotherapy-induced Nausea and Vomiting
Palonosetron Versus Ondansetron for the Prevention of Nausea and Vomiting
The goal of this clinical research study is to compare the effectiveness of 3 drug schedules in preventing chemotherapy-related nausea and/or vomiting in patients with acute myelogenous leukemia (AML) or high-risk myelodysplastic…
- Trial name
- NCT01031498
- Testing
- Ondansetron, Palonosetron
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- M.D. Anderson Cancer Center
To Analyze and Compare the Efficacy and Safety of Ondansetron and Tablet for the Prevention of Moderate and Hypoemetic Chemotherapy
Comparative Study on the Efficacy and Safety of Ondansetron Oral Membrane for the Prevention of Vomiting During Moderate Hypoemetic Chemotherapy
Children aged 4-15 years scheduled to receive Moderate or low emetic chemotherapy were randomly assigned to arm-A (Ondansetron mouth soluble film) or arm-B (Ondansetron tablet).
- Trial name
- Ondansetron (NCT06371014)
- Testing
- Ondansetron oral membrane
- Volunteers
- 200 people
- Sponsor
- Shanghai Children's Medical Center