Clinical trials: Ondansetron
Radiotherapy-induced Nausea and Vomiting (RINV), Pediatric Cancer
Ondansetron Orodispersible Film for Vomiting Prevention in Pediatric Radiotherapy
The goal of this study is to evaluate the antiemetic efficacy and drug safety of ondansetron orodispersible film in pediatric patients with malignant tumors who received moderate emetic risk radiation induced vomiting, and to…
- Trial name
- NCT07217600
- Testing
- Ondansetron orodispersible film once, Ondansetron orodispersible film twice
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chongqing University Cancer Hospital
Pruritus Caused by Drug
Ondansetron Use for Preventing Pruritus in Patients Undergoing Cesarean Section
Opioids are often added with a local anesthetic to enhance the duration and quality of spinal anesthesia for cesarean delivery patients.
- Trial name
- NCT06297499
- Testing
- Ondansetron 8mg
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Obsessive Compulsive Disorder
Ondansetron Augmentation in Treatment-resistant OCD
The aim of this study is to evaluate whether ondansetron augmentation to SSRI will improve and ondansetron discontinuation will result in worsening of obsessive compulsive symptoms among obsessive compulsive disorder resistant…
- Trial name
- NCT01303536
- Testing
- Ondansetron
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Institute of Neuroscience, Florence, Italy
Postoperative Nausea and Vomiting, Chewing Gum
Treatment of Postoperative Nausea-Vomiting in Laparoscopic Cholecystectomy: Peppermint-Flavored Gum Versus Gum-Free
Postoperative nausea and vomiting (PONV) is an unwanted and distressing complication for patients. PONV affects one-third of untreated patients after general anesthesia.
- Trial name
- NCT04538300
- Testing
- Abramowitz Emesis Score, Degree of nausea, Observer's Assessment of Alertness/Sedation Scale
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Vomiting
The Efficacy of B6 and Metoclopramide Combination in Comparison With the Other Antiemetics
This study investigates the effectiveness of combining vitamin B6 (pyridoxine) and metoclopramide compared to standard antiemetic treatments for managing nausea and vomiting.
- Trial name
- NCT06390787
- Testing
- Metoclopramide and Vitamin B6, Vitamin B6, Ondansetron
- Where
- Iraq
- Volunteers
- 250 people
- Sponsor
- University of Baghdad
Palonosetron
Comparison of the Efficacy of Acupressure P6 Point, Dexamethasone and Ondansetron Versus Palonosetron Monotherapy for Preventing Postoperative Nausea and Vomiting in Laparoscopic Surgery
Postoperative nausea and vomiting (PONV) is defined as nausea and/or vomiting occurring within 24 hours after surgery, it commonly affects 20-30% patients but as high as 70-80% patients who are deemed high risk for PONV may be…
- Trial name
- NCT04461093
- Testing
- Acupressure wristband and Palanosetron
- Where
- 2 sites in Malaysia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mohd Zulfakar Mazlan, MBBS
Vomiting, Nausea
Intravenous And Oral Casopitant (GW679769) For The Prevention Of Chemotherapy Induced Nausea And Vomiting
This is a Phase III trial designed to demonstrate that casopitant (GW679769) plus dexamethasone and ondansetron is more effective in the prevention of vomiting than dexamethasone and ondansetron alone following the administration…
- Conditions
- Vomiting, Nausea, Nausea and Vomiting, Chemotherapy-Induced
- Trial name
- NCT00366834
- Testing
- Casopitant (GW679769) oral tablets, Casopitant (GW679769) intravenous, Dexamethasone intravenous
- Where
- 223 sites in United States, Argentina and 30 more
- Volunteers
- 1,840 people
- Sponsor
- GlaxoSmithKline
Nausea and Vomiting, Chemotherapy-Induced
A Study to Assess the Safety & Interaction Between GW679769, Dexamethasone, & Ondansetron When Taken by Healthy Adults
GW679769 may affect liver enzymes that metabolize dexamethasone and ondansetron. This study is designed to test the safety and the extent of the GW679769 affect on dexamethasone and ondansetron levels in humans.
- Trial name
- NCT00437229
- Testing
- Casopitant (GW679769) Oral Tablets, dexamethasone, ondansetron
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Schizoaffective and Schizophreniform Disorders, Schizophrenia
Double Blind, Placebo-Controlled, Randomised Investigation of Ondansetron in Schizophrenia
The aim of this study is to evaluate the overall effectiveness of Ondansetron as an adjunctive or "add-on" medication in the treatment of Schizophrenia. This study is a double blind, placebo-controlled, randomised, 12 week trial.
- Trial name
- NCT01121042
- Testing
- Ondansetron
- Where
- Australia
- Volunteers
- 85 people
- Sponsor
- Bayside Health
Cholecystitis, Pain
The Effect of Hyoscine-n-butylbromide on Nausea and Pain in Laparoscopic Cholecystectomy
The goal of this randomized double blind study is to compare the effects of hyoscine-n-butylbromide, and ondansetron on postoperative nausea-vomiting, and pain in patients who underwent laparoscopic cholecystectomy.The main…
- Conditions
- Cholecystitis, Pain, Nausea
- Trial name
- NCT06927817
- Testing
- hyoscine-n-butylbromide, ondansetron, • hyoscine-n-butylbromide • ondansetron
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Pediatric Solid Tumor, Unspecified, Protocol Specific
Ondansetron (ODF) Versus Ondansetron Intravenously for the Prevention of Chemotherapy-induced Nausea and Vomiting Compare in Children
The purpose is to evaluate the efficacy of ondansetron oral soluble film plus dexamethasone in preventing chemotherapy-induced nausea and vomiting (CINV) with MEC/HEC chemotherapy in children with solid tumor.
- Trial name
- NCT06208917
- Testing
- Ondansetron (Oral soluble film OR injections) ,Dexamethasone
- Where
- China
- Volunteers
- 376 people
- Sponsor
- Yizhuo Zhang
Neuropathic Pain
Tariquidar-ondansetron Combination in Neuropathic Pain
Prospective, randomized, double-blind, placebo controlled, cross-over proof of concept study. To determine the pharmacokinetics and tolerability of co-administration of 5-HT3R antagonist ondansetron with a P-glycoprotein…
- Trial name
- NCT04603066
- Testing
- Ondansetron 16 mg with Tariquidar
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Washington University School of Medicine
Radiotherapy Induced Nausea and Vomiting
Ramosetron Versus Ondansetron for Radiotherapy Induced Nausea and Vomiting
The purpose of this study is: 1. To compare prophylactic effect of ondansetron versus ramosetron on radiotherapy induced nausea and vomiting in the treatment of gastrointestinal cancer. 2.
- Trial name
- NCT00971399
- Testing
- ramosetron, ondansetron
- Where
- South Korea
- Volunteers
- 172 people
- Sponsor
- Seoul National University Hospital
Postoperative Nausea and Vomiting
Neurokinin Receptor Antagonist Associated to Ondansetron in PONV
The purpose of this study is to determine whether patients at high risk for postoperative nausea and vomiting can benefit from aprepitant, ondansetron and dexamethasone in the perioperative period.
- Trial name
- PONV (NCT02357693)
- Testing
- Aprepitant
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
IBS - Irritable Bowel Syndrome
TReatment of Irritable Bowel Syndrome With Diarrhoea Using Titrated ONdansetron Trial
A placebo controlled study to determine the efficacy and mode of action of ondansetron in the treatment of irritable bowel syndrome with diarrhoea.
- Trial name
- TRITON (NCT03555188)
- Testing
- Ondansetron
- Where
- 14 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Leeds
Postoperative Shivering, Postspinal Shivering
Comparison of Intravenous Ondansetron and Low Dose Ketamine in Preventing Post Spinal Shivering
This randomized controlled trial assessed whether intravenous ondansetron is more effective than low dose ketamine in preventing shivering after spinal anesthesia in adults undergoing elective surgery.
- Trial name
- NCT07334223
- Testing
- ondansetron, Ketamine (0.25 mg/kg)
- Where
- Pakistan
- Volunteers
- 180 people
- Sponsor
- Mayo Hospital Lahore
Laparoscopic Surgery, Pediatrics
Effect of Palonosetron, Ondansetron and Dexamethasone in the Prevention of Postoperative Nausea and Vomiting
Postoperative nausea and vomiting (PONV) is an important outcome for the patient; patients generally rate PONV as worse than postoperative pain.
- Conditions
- Laparoscopic Surgery, Pediatrics, Nausea and Vomiting, Postoperative, Antiemetics
- Trial name
- NCT05439798
- Testing
- Ondansetron+Dexamethasone, Palonosetron+Dexamethasone, Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Selcuk University
Motility Disorder of Intestine, Ondansetron
Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea
This is a double-blind, two period, two treatment crossover trial of ondansetron verses placebo studying the effects of ondansetron in the small and large bowel, specifically its effects on the amount of water in the gut…
- Conditions
- Motility Disorder of Intestine, Ondansetron, Small Bowel Water
- Trial name
- MOLID (NCT03833999)
- Testing
- Ondansetron 8mg, abdominal MRI, Lactulose
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Alcoholism
Ondansetron Treatment for Alcoholism
The purpose of this study is to: a) evaluate the effectiveness of ondansetron (Zofran) in the treatment of alcohol dependent patients; b) investigate whether early versus late onset alcoholism predicts treatment outcome; and c)…
- Trial name
- NCT00000443
- Testing
- ondansetron (Zofran)
- Where
- United States
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Nausea and Vomiting Chemotherapy-Induced, Nausea Post Chemotherapy
Study With IV NEPA (Fosnetupitant/Palonosetron) for the Prevention of Chemotherapy-induced Nausea and Vomiting in Paediatric Cancer Patients Undergoing Highly Emetogenic Chemotherapy (HEC)
Chemotherapy often causes nausea and vomiting (CINV), and this is a major problem for the children being treated for cancer. To prevent this, a combination of two substances in fixed proportion (IV NEPA) was developed.
- Trial name
- NCT06904235
- Testing
- IV NEPA (fosnetupitant/palonosetron), Reference Treatment: IV ondansetron infusion, Reference Treatment: IV fosaprepitant infusion
- Where
- 20 sites in Greece, Poland and 2 more
- Volunteers
- 95 people
- Sponsor
- Helsinn Healthcare SA