Clinical trials: One Lung Ventilation
One-lung Ventilation
Clamping the Double Lumen Tube
Nowadays, lung isolation techniques are an essential part of thoracic anesthesia. The two principal devices used in order to achieve one-lung ventilation (OLV) are the double lumen tube (DLT) and the bronchial blocker (BB).
- Trial name
- C-TDL (NCT03508050)
- Testing
- Clamping the Double Lumen Tube
- Where
- Canada
- Volunteers
- 37 people
- Sponsor
- Jean Bussières
Thoracoscopic Surgery, Double Lumen Tube Intubation
Video-guided Versus Conventional Right-sided Double-Lumen Tubes for One-Lung Ventilation in Thoracoscopic Surgery
This multicentre randomised controlled trial compares a video-guided right-sided double-lumen tube with a conventional right-sided double-lumen tube in adults undergoing elective thoracoscopic surgery requiring one-lung…
- Conditions
- Thoracoscopic Surgery, Double Lumen Tube Intubation, One-Lung Ventilation
- Trial name
- RIGHT-VDLT (NCT07362797)
- Testing
- Video-guided right-sided double-lumen tube, Conventional right-sided double-lumen tube
- Where
- 3 sites in China
- Volunteers
- 566 people
- Sponsor
- Diansan Su
Invasive Mechanical Ventilation, HSV Throat Reactivation
Preemptive Treatment With Acyclovir in Intubated and Mechanically Ventilated Patients With Herpes (PTH2)
This research aims to assess the interest of preemptive treatment with Acyclovir in mechanically ventilated patients with reactivation of Herpes simplex (HSV) in the throat and failure of one organ or less.
- Trial name
- PTH2 (NCT06217406)
- Testing
- Intravenous acyclovir (ACYCLOVIR ), Saline bags
- Volunteers
- 246 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation Complication
Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation
One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction.
- Trial name
- NCT02191371
- Testing
- propofol, desflurane
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Seoul National University Hospital
Extravascular Lung Water
Effect of PCV and VCV on Extravascular Lung Water
Volume controlled ventilation (VCV) and pressure controlled ventilation (PCV) are the common ventilatory modes during OLV undergoing thoracic surgery.
- Trial name
- NCT03514706
- Testing
- volume controlled ventilation, pressure controlled ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Mechanical Ventilation, Thoracic Surgery
Effects of Oxygen Supply After Lung Isolation in Thoracic Surgery
The goal of this randomized clinical trial is to compare a liberal versus restrictive oxygen supply (fraction of inspired oxygen, FiO2) strategy in patients scheduled for thoracic surgery requiring one-lung ventilation during…
- Conditions
- Mechanical Ventilation, Thoracic Surgery, One-Lung Ventilation
- Trial name
- NCT05946707
- Testing
- restrictive oxygen supply, liberal oxygen supply
- Where
- Austria
- Volunteers
- 55 people
- Sponsor
- Medical University Innsbruck
One Lung Ventilation in Thoracic Surgery
The Effects of Dexmedetomidine on Inflammatory Mediators After One Lung Ventilation During Video-assisted Thoracoscopic Surgery
During lung surgery, mechanical one-lung ventilation is usually mandatory to provide appropriate surgical condition. However, not only mechanical ventilation is associated with inflammatory response, but also one lung ventilation…
- Trial name
- NCT02439905
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Esophageal Cancer
Bispectral Index Throughout Esophageal Cancer Operation
The investigators try to conduct a study to assess the impact of changing patients' lateral decubitus position on BIS readings during esophageal cancer operation.
- Trial name
- NCT03397745
- Testing
- BIS
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Samsung Medical Center
Videoassisted Thoracoscopic Surgery,One-lung Ventilation
The Application of Lung Ultrasound Combine With Diaphragm Ultrasound During Thoracic Surgery
Perioperative lung-protective strategies had been advocated in one-lung ventilation but normal respiratory functions were yet impacted during videoassisted thoracoscopic(VATS) surgery.
- Trial name
- NCT03802968
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Elective Thoracic Surgery, One Lung Ventilation
Selective Lobar Blockade and Bronchial Blockers
Selective lobar blockade (SLB) is a specific technique that allows collapse of the operated lobe during thoracic surgery while the other lobes are ventilated.
- Trial name
- NCT02032342
- Testing
- Endobronchial double lumen tube, Arndt® blocker, Cohen blocker
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Imam Abdulrahman Bin Faisal University
Lung Cancer
Effects of Intraoperative Continuous Airway Pressure (CPAP) on the Inflammatory Response to One-lung Ventilation
This is a randomized placebo-controlled trial studying the effects of intraoperative continuous airway pressure (CPAP) on the inflammatory response of the lung with cancer undergoing lobectomy.
- Trial name
- NCT01368601
- Testing
- CPAP (Continuous airway pressure)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Parc de Salut Mar
Mechanical Ventilation, Postoperative Pulmonary Complications (PPCs)
Flow-Controlled Ventilation to Improve Postoperative Pulmonary Outcome After Thoracic Surgery
In an international multicenter randomized clinical pilot trial, intraoperative flow-controlled ventilation (FCV) will be compared with volume-controlled ventilation (VCV) in patients scheduled for (open, video- or…
- Trial name
- PROFLOW-THORAC (NCT07623395)
- Testing
- Flow-Controlled Ventilation, Volume-Controlled Ventilation
- Where
- 7 sites in Austria, France and 2 more
- Volunteers
- 140 people
- Sponsor
- Cantonal Hospital of St. Gallen
One Lung Ventillation (OLV), Erector Spina Plan Block
Effect of Erector Spinae Plane Block on Cerebral Oxygenation During One-Lung Ventilation
The aim of this study is to evaluate the effect of the erector spinae plane block, used to reduce postoperative pain, on cerebral oxygenation in thoracic surgery patients undergoing one-lung ventilation in the lateral decubitus…
- Conditions
- One Lung Ventillation (OLV), Erector Spina Plan Block, Near Infrared Spectroscopy, Cerebral Desaturation
- Trial name
- NCT07432230
- Testing
- Erector Spinae Plane Block, A preoperative erector spinae plane block will not be administered
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Kayseri City Hospital
Pulmonary Disease, Chronic Obstructive
Breathing Helium-Hyperoxia During Exercise in Patients With Chronic Obstructive Pulmonary Disease
Regular exercise can help patients with the lung disease, chronic obstructive pulmonary disease (COPD). But COPD patients have a hard time with training because of their breathing.
- Trial name
- NCT01283685
- Testing
- breathing helium-hyperoxia, breathing supplemental oxygen
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- West Park Healthcare Centre
Thoracic Anesthesia, One Lung Ventillation (OLV)
Association Between One Lung Ventilation and Myocardial Injury Markers (Troponin T and I) in Thoracic Surgical Procedures (OLVTIS)
This prospective single-group cohort study aims to investigate the association between the One-Lung Ventilation (OLV) technique and myocardial injury, as measured by postoperative Troponin T and Troponin I levels, in patients…
- Trial name
- OLVTIS (NCT07302243)
- Where
- Indonesia
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universitas Jenderal Soedirman
COVID-19
Study to Evaluate the inHaled Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) On the Protective-Efficacy in Adults (SeiHOPE)
This phase III clinical trial is an endpoint-driven randomized, double-blind, parallel-controlled, multicenter clinical trial, and around 13,000 subjects aged 18 years and above who have previously received 1 dose of…
- Trial name
- NCT05124561
- Testing
- Recombinant COVID-19 vaccine (adenovirus type 5 vector) for Inhalation (Ad5-nCoV-IH)
- Volunteers
- healthy volunteers welcome
- Sponsor
- CanSino Biologics Inc.
High Altitude, Healthy
Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy…
- Conditions
- High Altitude, Healthy, Healthy Adult, High Altitude Effects
- Trial name
- NCT07804589
- Testing
- Re-Ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Thoracic Surgical Procedures, One-lung Ventilation (OLV)
Study of Cardiac Power Index During Supine, Lateral, and Between Left and Right Positions During Two- and One-Lung Ventilation (OLV): Comparison of Hemodynamic Changes After Lung Recruitment Maneuver and Fluid Challenge Among Responders and Non-Responders (SVI, MAP, CPI Changes).
The aim of this trial is to study the changes of the Cardiac Power Index (CPI) during supine and lateral decubitus position in two and one lung ventilation respectively.
- Conditions
- Thoracic Surgical Procedures, One-lung Ventilation (OLV), Hemodynamic Changes
- Trial name
- NCT07037225
- Testing
- Fluid challenge during one-lung ventilation (OLV) in the lateral decubitus position, Hemodynamic monitoring
- Where
- Greece
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Maria Fountoulaki
Patients Undergoing Elective Thoracic Surgery Requiring Obligatory Single-lung Ventilation During Surgery
Prospective, Randomized Clinical Trial Evaluating the ETView Double-Lumen Tube
No prospective randomized clinical trial assessed the performance of this new device in a clinical setting. Consequently the aim of this study is to determine clinical performance of this new device compared with conventional…
- Trial name
- NCT01807676
- Testing
- ET View Double Lumen Tube, conventional Double Lumen Tube
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- University of Zurich
Ventilator Lung
Electrical Impedance Tomography in One-Lung Ventilation
Mechanical ventilation can cause damage to the lung parenchyma, this is known as ventilatory induce lung injury (VILI).To avoid this damage, ventilatory strategies have been created, focused on the reduction of tidal volume…
- Trial name
- NCT03728010
- Testing
- Electrical impedance tomography. Pulmonary mechanics measurement.Arterial gas measurement. Esophageal pressure measurement
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- University of Chile