Clinical trials: Only Child
Healthy
A Study of Comparing Safety and Reactogenicity, of Lyophilized BCG Vaccine IP of Green Signal Bio Pharma Private Limited, India With BCG Vaccine of Serum Institute of India Limited in 120 Healthy Children.
To compare Safety and Reactogenecity of BCG vaccine of Green Signal Biopharma Private Limited India with BCG vaccine of serum institute of India limited (SIIL), India in 120 healthy children.
- Trial name
- NCT01250249
- Testing
- BCG Vaccine IP - Serum Institute of India
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Green Signal Biopharma Private Limited
Asthma in Children
EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD
In this Study i'll compare the effectiveness of two drugs used in acute exacerbation of asthma by their sideffects, complaince and improvement in the PRAM score. The better one would be adapted in our clinical practice.
- Trial name
- NCT05850143
- Testing
- Dexamethasone, Prednisolone
- Where
- Pakistan
- Volunteers
- 192 people
- Sponsor
- DR. MOHAMMAD ALI ARIF
Children with Medical Complexity, Child, Only
Emergency Care Action Plans for Infants with Medical Complexity
An Emergency Care Action Plan (ECAP) is a tool intended to be helpful to providers when treating a child with complex medical needs during an emergency.
- Conditions
- Children with Medical Complexity, Child, Only, Infant Morbidity, Infant Conditions
- Trial name
- ECAP (NCT06444282)
- Testing
- Emergency Care Action Plan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Vermont
Ascaris Lumbricoides, Ascaris Suum
Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2
Objectives: The overall objective is to monitor efficacy of mebendazole (MBZ) against Soil-Transmitted Helminths (STH). The primary objective is: (1) to monitor the efficacy a single dose 500 mg of mebendazole (MBZ) against…
- Conditions
- Ascaris Lumbricoides, Ascaris Suum, Trichuris Trichiura, Trichuris Vulpis
- Trial name
- ConWorm (NCT01379326)
- Testing
- Mebendazole
- Where
- 9 sites in Argentina, Australia and 6 more
- Volunteers
- 250 people
- Sponsor
- University Ghent
Functional Constipation (FC)
Efficacy of Notrande Shuhuajun Probiotic Supplement on Lmproving Constipation in Preschool Children
The goal of this interventional study is to evaluate the effectiveness of Notrande Shuhuajun Probiotic Supplement intake on the improvement of functional constipation in preschool children (3-6 years old).
- Trial name
- NCT07002489
- Testing
- Nuotelande Shuhuajun Study Product
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Shandong Sibote Biotechnology Co., Ltd.
Sickle Cell Disease
Dense Red Blood Cells in Sickle Cell Children
Quantitative and prognostic evaluation of dense red blood cells in sickle cell children: preliminary single center study from the Creteil pediatric cohort.
- Trial name
- DREPADENSE (NCT02887118)
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Myopia, Progressive, Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression
This is a monocenter, randomized, controlled, parallel-group, double-masked clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation at baseline compared to a…
- Trial name
- NCT05331378
- Testing
- Test myopia control lenses, Single vision lenses
- Where
- Singapore
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Essilor International
Atopic Dermatitis
Use of Complementary and Alternative Medicine in Children and Adults With Atopic Dermatitis
Complementary and alternative medicine are increasingly used all around the world and more specifically in chronic diseases such as atopic dermatitis.
- Trial name
- NCT05833880
- Testing
- Self-administered questionnaire
- Where
- France
- Volunteers
- 89 people
- Sponsor
- Central Hospital, Nancy, France
Colitis, Ulcerative
A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
The purpose of this study is to determine the safety, efficacy, and pharmacokinetics (PK) of etrasimod for the treatment of moderately to severely active ulcerative colitis in pediatrics participants (≥ 2 years up to < 12 years…
- Trial name
- ELEVATE-UCkids (NCT07470879)
- Testing
- Etrasimod
- Where
- 46 sites in United States, Australia and 8 more
- Volunteers
- 24 people
- Sponsor
- Pfizer
Hereditary Angioedema (HAE)
A Pharmacokinetic, Tolerability and Safety Study of Icatibant in Children and Adolescents With Hereditary Angioedema
HGT-FIR-086 is a multicenter, open-label, non-randomized, single-arm study to evaluate the Pharmacokinetics, tolerability,safety, and efficacy on reproductive hormones, of a single subcutaneous (SC) administration of icatibant in…
- Trial name
- NCT01386658
- Testing
- icatibant
- Where
- 26 sites in United States, Australia and 8 more
- Volunteers
- 32 people
- Sponsor
- Shire
Small Cell Lung Carcinoma
A Phase 1 Study to Evaluate the Pharmacokinetics of JDQ443 in Participants With Hepatic Impairment Compared to Matched Healthy Control Participants.
The purpose of this study is to evaluate the effect of hepatic impairment on the systemic pharmacokinetics (PK), safety, and tolerability of JDQ443 in participants with varying degrees of hepatic impairment.
- Trial name
- NCT05329623
- Testing
- JDQ443
- Where
- 2 sites in United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Children Under 18 Years Old With Kidney Disease
Study of FFI-1010 in Pediatric Kidney Disease
The purpose of this study is revealing that the ratio of creatinine clearance (Ccr) to inulin clearance (Cin) measuring at the same time is more than 1.2.
- Trial name
- NCT03345316
- Testing
- FFI-1010
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Fuji Yakuhin Co., Ltd.
GHD
A Study to Investigate the Safety and Efficacy of Once-weekly PEG-somatropin (GenSci004) in Children With Growth Hormone Deficiency
The purpose of this Phase 3 study is to evaluate the safety and efficacy of once-weekly GenSci004 over 108 weeks in children with GHD aged from 6 months to 17 years old, inclusive.
- Trial name
- ESCALATE (NCT06024967)
- Testing
- PEG-somatropin
- Volunteers
- 180 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Pulpectomy, Irreversible Pulpitis
Clinical and Radiographic Outcomes of Rotary Instrumentation in Primary Molars
This study will evaluate the clinical and radiographic outcomes of rotary versus manual pulpectomy in children with irreversible pulpitis.A single-visit pulpectomy will be performed for all patients.
- Trial name
- NCT07319741
- Testing
- Rotary Instrumentation, Manual Instrumentation
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Anfal mohamed elmotaz almogtaba
Critically Ill Children, Sepsis
Influencing Factors of Vancomycin Trough Level in Critically Ill Children With Sepsis
The aim of the work will be to measure the vancomycin trough concentration in critically ill children with sepsis in pediatric intensive care unit and its influencing factors.
- Trial name
- NCT06661772
- Testing
- Vancomycin trough concentration method
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Benha University
Tuberculosis, Rifampicin Resistant Tuberculosis
Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant Tuberculosis
The purpose of the study is to evaluate the pharmacokinetics (PK), safety, tolerability, and acceptability of a single dose of pretomanid, added to an optimized background tuberculosis treatment regimen (OBR), in children with…
- Trial name
- NCT05586230
- Testing
- Pretomanid, Optimized background regimen (OBR) for multidrug-resistant TB (MDR-TB)
- Where
- 5 sites in Brazil, South Africa and 1 more
- Volunteers
- 32 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 1 Diabetes
Closed-loop Control of Postprandial Glucose Levels in Children and Adults With Type 1 Diabetes
Current intensive insulin therapy in T1D involves prandial insulin boluses depending on the carbohydrate content of each ingested meal.
- Trial name
- NCT02490098
- Testing
- 6-day intervention with sensor-augmented pump therapy, 6-day intervention with single-hormone closed-loop strategy, 6-day intervention with dual-hormone closed-loop strategy
- Where
- Canada
- Sponsor
- Institut de Recherches Cliniques de Montreal
Signs and Symptoms, Respiratory
Compare Effects of EpiCor and Vitamin C to Vitamin C Alone on the Common Cold or Influenza in Healthy Children
The purpose of the clinical study is to evaluate efficacy of regular daily, 12 weeks, consumption of EpiCor syrup containing EpiCor and vitamin C in non-vaccinated children 1-6 years old on preventing episodes of the common cold…
- Trial name
- NCT04093206
- Testing
- EpiCor and Vitamin C, Vitamin C
- Where
- 21 sites in Slovenia
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Cargill
Osteoporosis
Denosumab for the Treatment of Osteoporosis in Children: A Pilot Study
The aim of this study is to acquire preliminary, pilot data over a 2-year period on the safety and efficacy of subcutaneous denosumab versus the current CHEO standard-of-care (intravenous zoledronic acid) for the treatment of…
- Trial name
- NCT02632916
- Testing
- Zoledronic Acid, Denosumab
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Eastern Ontario
Refractory Solid Tumors, Relapsed Solid Tumors
PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors
The phase 1 primary objective is to determine the pediatric recommended phase 2 dose (RP2D) of PEEL-224 as a single agent (phase 1A) and in combination with vincristine and temozolomide (phase 1B).
- Conditions
- Refractory Solid Tumors, Relapsed Solid Tumors, Relapsed Neuroblastoma, Refractory Neuroblastoma
- Trial name
- PEEL-224 (NCT06721689)
- Testing
- PEEL-224, Vincristine, Temozolomide (TMZ)
- Where
- 7 sites in United States
- Volunteers
- 59 people
- Sponsor
- Theodore Laetsch
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