Clinical trials: Only Child, open to volunteers
sFlt1 Mediated Preterm Preeclampsia, Preeclampsia
A Study to Investigate the Safety, Pharmacodynamic and Pharmacokinetic Characteristics of CBP-4888 in Hospitalized Participants With Preterm Preeclampsia and Their Children up to 24 Months
This study is a dose finding study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of subcutaneous CBP-4888 in hospitalized participants with Preterm Preeclampsia receiving Standard of Care, Expectant…
- Conditions
- sFlt1 Mediated Preterm Preeclampsia, Preeclampsia, Preterm Preeclampsia
- Trial name
- NCT07282171
- Testing
- CBP-4888
- Where
- 3 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Comanche Biopharma
SHANK3 Haploinsufficiency, Phelan-McDermid Syndrome
JAG201 Gene Therapy Study in Children & Adults With SHANK3 Haploinsufficiency
This is a Phase 1/2, first in human, open-label, dose-escalation study to evaluate the safety, tolerability, and clinical activity of a single dose of JAG201 administered via intracerebroventricular (ICV) injection in pediatric…
- Trial name
- NCT06662188
- Testing
- JAG201
- Where
- 3 sites in United States
- Volunteers
- 6 people
- Sponsor
- Jaguar Gene Therapy, LLC
Autism Spectrum Disorder
Dialectic Behaviour Therapy (DBT) for People With Autism: A Multiple Baseline Single Case Design
The goal of this experimental study is to test the effectiveness of Dialectic Behavioural Therapy in patients with Autism Spectrum Disorder. The aim questions are: 1.
- Trial name
- DGT-ASS (NCT07786883)
- Testing
- Dialectic Behavioural Therapy
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- GGZ Friesland
Asthma in Children, Genetic Disease
Association Between Genetic Polymorphisms and Type 2 Asthma in Children
To further understand the role of gene single nucleotide polymorphism (SNP) in the occurrence of type 2 inflammation-related asthma in children by analyzing the gene single nucleotide polymorphism (SNP), lung function and type 2…
- Conditions
- Asthma in Children, Genetic Disease, Inflammation
- Trial name
- SNP (NCT06840717)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Celiac Disease, Malabsorption Syndromes
Immune Responses to Gluten
This is a study of immune responses after eating gluten powder in people with celiac disease and healthy controls.
- Conditions
- Celiac Disease, Malabsorption Syndromes, Digestive System Disease, Intestinal Disease
- Trial name
- NCT05209568
- Testing
- Gluten Powder
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Children, Only, Vestibular Disorder
Vestibular and Postural Function in an Unselected Group of Children With Sensorineural Hearing Loss
The goal of this prospective cohort study is to investigate the vestibular function in children with unilateral or bilateral sensorineural hearing loss.
- Conditions
- Children, Only, Vestibular Disorder, Vestibular Function, Sensorineural Hearing Loss
- Trial name
- VASIC (NCT06229717)
- Testing
- video Head Impulse Test, Cervical Vestibular Evoked Myogenic Potential, Ocular Vestibular Evoked Myogenic Potential
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Gødstrup Hospital
Varicella (Chickenpox), Varicella Immunisation
Immunogenicity and Safety of Varicella Vaccine, Live in Healthy Vietnamese Children
This is a single armed, Phase 3 study to assess the immunogenicity and safety of the varicella vaccine manufactured by Sinovac. A total of 300 healthy participants aged 1-12 years will be enrolled.
- Trial name
- NCT07473427
- Testing
- Varicella Vaccine
- Where
- Vietnam
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Sinovac (Dalian) Vaccine Technology Co., Ltd.
Myopia
Wearability of and Myopia Progression With ZEISS MyoCare Spectacle Lenses
This is a clinical trial evaluating the wearability and effectiveness of three types of ZEISS spectacle lenses in controlling myopia progression.
- Trial name
- NCT07021560
- Testing
- ZEISS MyoCare spectacle lenses, ZEISS SV RX SPH 1.5, ZEISS Clearview
- Where
- Vietnam
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ZEISS Vision Care
Endocrinology
Retrospective Study of the Cohort of Transgender Patients Who Began Medical Support Before the Age of 18
Gender incongruence is characterized by a marked and persistent incongruity between the gender with which a person identifies and their assigned sex.
- Trial name
- TRANS (NCT07163832)
- Where
- France
- Volunteers
- 115 people
- Sponsor
- University Hospital, Strasbourg, France
Hemiparesis, Children, Only
Effect of Task Oriented Training With Functional Electrical Stimulation on Balance in Children With Hemiparesis
To investigate the efficacy of combination of task-oriented training and Functional electrical stimulation of ankle dorsiflexor muscles on: 1. Strength of ankle muscles in children with hemiparesis. 2.
- Trial name
- NCT07648511
- Testing
- Selected therapeutic program, Selected Task oriented training program, Selected Functional electrical stimulation
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Cairo University
Ureteropelvic Junction Obstruction, Chronic Kidney Diseases
The PRO-FUTURE Project
The goal of this observational study is to learn about specific biomarkers of unilateral ureteropelvic junction obstruction (UPJO) in children undergoing surgical intervention for unilateral UPJO compared with controls.
- Trial name
- PRO-FUTURE (NCT06382233)
- Testing
- Identification of Diagnostic Biomarkers
- Where
- 5 sites in Italy
- Volunteers
- 85 people
- Sponsor
- University of Campania Luigi Vanvitelli
Duchenne Muscular Dystrophy (DMD)
DMD and Gamified Physiotherapy
Duchenne Muscular Dystrophy (DMD) is a progressive neuromuscular disease that limits children's physical function, mobility, and participation in daily life.
- Trial name
- Gamified DMD (NCT07368400)
- Testing
- Gamified Mobile Physiotherapy Exercise Application, Standard Home Exercise Instructions
- Volunteers
- 46 people
- Sponsor
- Başak Çağla Arslan
Asthma in Children
SMART Implementation-Effectiveness Trial 2
While single maintenance and reliever therapy (SMART) has been the preferred management strategy for Step 3 and 4 (moderate/severe) asthma management since the 2020 NIH asthma guideline updates, adoption of SMART has not been…
- Trial name
- SMART SIMPLE (NCT07138027)
- Testing
- Clinical decision support + education (CDS+) and population health management (PHM), Control
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital of Philadelphia
Ulcerative Colitis
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
The aim of this study is to evaluate the efficacy, safety, tolerability, and pharmacokinetics (PK) of filgotinib as a treatment for UC in children and adolescents aged from 8 to less than 18 years.
- Trial name
- Galapeduca (NCT06865417)
- Testing
- Filgotinib
- Where
- 46 sites in Belgium, Croatia and 11 more
- Volunteers
- 80 people
- Sponsor
- Alfasigma S.p.A.
CHD - Congenital Heart Disease, Single Ventricle Heart Disease
PRecision Integrated Saturation Monitor
The purpose of this study is to find out if an abdominal pulse oximeter device is as accurate as a conventional fingertip pulse oximeter in pediatric patients.
- Trial name
- PRISM (NCT07686341)
- Testing
- vital sign monitoring
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Le Bonheur Children's Hospital
Pouchitis
A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis
When some people have their large bowel removed, a surgeon can make a "pouch" from part of the small bowel to connect it to the back passage (anus). Pouchitis is when the pouch becomes inflamed (swollen) or infected.
- Trial name
- NCT06443502
- Testing
- Vedolizumab, Concomitant Antibiotic Therapy
- Where
- 14 sites in Belgium, Croatia and 6 more
- Volunteers
- 30 people
- Sponsor
- Takeda
Problem Behavior, Developmental Delay
Problem Behavior Assessment and Intervention in IDEA Part C Services
The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services.
- Conditions
- Problem Behavior, Developmental Delay, Developmental Disability
- Trial name
- NCT06771284
- Testing
- Function-based assessment and intervention
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Choledochal Cyst
Timing of Operation in Children With a Prenatal Diagnosis of Choledochal Cyst
In this prospective study, we tried to select the operation time according to the cyst size and evaluate the treatment effect.
- Trial name
- CDCPS (NCT05620485)
- Testing
- laparoscopic-assisted CDC excision and hepaticojejunostomy
- Volunteers
- 30 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Down Syndrome
How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome
The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS).
- Trial name
- NCT06951516
- Testing
- Linguistic simplification
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University
Wheezing
PREcision Medicine Directed Corticosteroids In Children With preSchool Wheeze
Young children frequently attend the emergency department (ED) with wheeze which is usually triggered by a virus infection, such as the common cold.
- Trial name
- PRECISE (NCT06580600)
- Testing
- Point of care respiratory virus testing
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast