Clinical trials: Oocyte
Infertility
Aurora Test for Patients Treated With Recombinant Gonadotropins
This is an observational study. The main aim is to determine the expression of potential biomarker genes in the cumulus cells isolated from individual oocytes in two patient cohorts: recombinant human Follicle Stimulating…
- Trial name
- AURORA-REC (NCT04710264)
- Testing
- AURORA-Rec
- Where
- Belgium
- Volunteers
- 137 people
- Sponsor
- Fertiga, Belgium
In Vitro Fertilization, Male Factor Infertility
Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility?
The purpose of this study is to determine the impact of the use of calcium ionophore on the ICSI outcomes in couples with severe male factor infertility.
- Trial name
- NCT02992665
- Testing
- Ca Ionophore A23187
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Infertility, Hypothalamic Amenorrhea
The Luveris In Vitro Fertilization Trial
The purpose of this study is to develop a new protocol using two different types of fertility drugs that is more similar to the way the hormones act in a normal menstrual cycle (period).
- Conditions
- Infertility, Hypothalamic Amenorrhea, Hyperprolactinemia
- Trial name
- NCT00889512
- Testing
- Luveris fixed dose, Luveris increasing dose
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University Reproductive Associates
IVM
IVM Survey Among Reproductive Medicine Specialists
Although IVM as a laboratory technology in reproductive medicine has existed for many decades, there is a lack of well-designed studies comparing the efficiency and the patient satisfaction related to IVM as compared to standard…
- Trial name
- NCT04488211
- Testing
- Survey
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Oocyte Retrieval for IVF
Virtual Reality Hypnosis as Sedation During Oocyte Retrieval: Effect on Propofol Consumption
An egg retrieval is performed during an IVF course. This painful procedure is performed using sedation to ensure patient comfort.
- Trial name
- VRH-IVF (NCT07104409)
- Testing
- virtual reality hypnosis device
- Volunteers
- 72 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Oocyte Quality Assessment Using Spectrophotometer
The Aim of the Study is to Check Whether Follicular Fluid Evaluation Using a Spectrophotometer Can Differentiate High Quality Oocytes From Low Quality Oocytes. Oocyte Quality Will be Defined Using GDF9, BMP15 and Oocyte Morphology.
The aim of the study is to check whether follicular fluid evaluation using a spectrophotometer can differentiate high quality oocytes from low quality oocytes.
- Trial name
- NCT07329998
- Testing
- Oocyte quality assessment using spectrophotometer
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hillel Yaffe Medical Center
Infertility and at High Risk of OHSS
Dual Trigger to Reduce Ovarian Hyperstimulation Syndrome
Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk…
- Trial name
- NCT02022228
- Testing
- triptorelin, hCG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chenshiling
Vitrification, Egg Donor
Validation of Donor Oocytes Semi-automated Vitrification
Oocyte vitrification is an effective method of freezing which has been authorized in France since 2011. The arrival of this technique has led to real improvements in the survival rate of oocytes after warming compared to that…
- Conditions
- Vitrification, Egg Donor, Fertility, Assisted Reproductive Technology
- Trial name
- GAVIDO (NCT06238570)
- Testing
- Gavi, Merck® (automated vitrification instrument), Vitrolife system
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ovarian Hyperstimulation Syndrome, Infertility, Female
Dual Trigger" in IVF Patients at High Risk of Ovarian Hyper Stimulation Syndrome
The present study aims to evaluate whether the use of a "dual trigger" can improve IVF outcomes, compared to GnRH agonist (GnRH-a) alone, in patients at high risk of OHSS undergoing a freeze-all cycle.
- Trial name
- NCT05638529
- Testing
- Pregnyl (1,500) IU, 1.5 mL of normal saline
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Mount Sinai Hospital, Canada
Infertility
The Influence of Different Concentrations of Glucose in Culture Media on In Vitro Fertilization (IVF) Outcome of Sibling Oocytes
The importance of glucose in culture media on fertilization and embryo development is still controversial. Although it has been reported that glucose is essential for fertilization process and biosynthesis of membrane lipid and…
- Trial name
- NCT02066584
- Testing
- Sibling oocyte incubation
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Hillel Yaffe Medical Center
Infertility
Comparison of DR-2011 to a Progesterone Vaginal Gel for Luteal Phase Replacement
This is a single-center, open-label, randomized, active-controlled study to compare DR-2011 to progesterone vaginal gel for luteal phase replacement.
- Trial name
- NCT00117468
- Testing
- DR-2011, Progesterone 8% Vaginal Gel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duramed Research
Infertility, Oocyte
Improvement of Live Babies Rates After ICSI, Using cpFT
Demonstrate the improvement of the live births rate after ICSI by supplementing the pre-ICSI incubation medium of oocytes and that of preimplantation embryos with cpFT at the 1st embryo transfer for women under 37 years old.
- Conditions
- Infertility, Oocyte, Pregnancy
- Trial name
- FERTICSI (NCT04954274)
- Testing
- Cyclic peptide Fertiline
- Where
- France
- Volunteers
- 366 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anxiety, Infertility, Female
Stress and Fertility: How to Lower Stress When Trying to Conceive
Psychological stress and its sources differ among the population and can be reduced in various ways. The practice of yoga has been shown to be an effective stress reducing agent.
- Trial name
- NCT03031990
- Testing
- In-person yoga for fertility group, Online yoga for fertility group, In person discussion only group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Fertility Centers of Illinois
Preeclampsia (PE) Risk, Oocyte Donation
Preeclampsia and Defective Placentation in Oocyte Donation: Importance of HLA-C and KIR
The IMMUN-OR study aims to study HLA-C/KIR combinations when looking at the risk of development of preeclampsia (PE) in pregnancies after oocyte donation.
- Trial name
- IMMUN-OR (NCT07178652)
- Volunteers
- 2,325 people
- Sponsor
- Universitair Ziekenhuis Brussel
Women Undergoing Oocyte Retrieval Procedures
Opioid Based Analgesia vs Non-opioid Analgesia for Oocyte Retrieval Procedure
It is unclear whether routine addition of opioids for analgesia during minor gynecological procedures is beneficial. In this single-center randomized single-blinded trial, the investigators aim to test the primary hypothesis that…
- Trial name
- NCT04933058
- Testing
- IV acetaminophen, IV fentanyl
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Infertility Assisted Reproductive Technology, Oocyte Retrieval
ART Cycle Outcomes When Only 1 to 3 Oocytes Are Retrieved
This is a monocentric retrospective observational study. The study focuses on the women who underwent Assisted Reproductive Technology (ART) cycles with poor ovarian response (POR), defined as <4 oocytes retrieved.
- Trial name
- POR (NCT06950476)
- Testing
- Oocyte Retrieval
- Volunteers
- 3,761 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Establish the Amount of CENPV Protein in Human Oocytes as a Diagnostic Tool Against Damage Caused by Ageing or by the Procedure of Vitrification of Oocytes, Advance Maternal Age
CENP-V as a Potential Diagnostic Marker of Damage in Human Oocytes
Proper chromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner.
- Conditions
- Establish the Amount of CENPV Protein in Human Oocytes as a Diagnostic Tool Against Damage Caused by Ageing or by the Procedure of Vitrification of Oocytes, Advance Maternal Age, Vitrification and Thawing
- Trial name
- CENP-PILOT (NCT06788379)
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Vida Recoletas Sevilla
Infertility, Reproductive Sterility
Does in Vivo Culture of Pre-cleavage Stage Embryo Reduce the Incidence of Aneuploidy?
This Clinical Study has been designed to assess and compare the impact of in vitro or in vivo culture conditions on the euploidy of sibling blastocysts.
- Trial name
- NCT02652143
- Testing
- AneVivo (Medical device for in vivo culture of embryos), comparator for embryo culture in vitro
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Anecova SA
Premature Luteinization
Effect of Premature Luteinization on the Oocyte Quality in Oocyte Donation Program.
Analyze the possible effect of the progesterone levels of the hCG administration on the oocyte embryo quality. The primary endpoint of this study is the pregnancy rate.
- Trial name
- NCT00455949
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing
The chances to achieve pregnancy after retrieving >15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining).
- Trial name
- NCT02026193
- Testing
- oocyte vitrification, embryo freezing
- Where
- Israel
- Volunteers
- 11 people
- Sponsor
- Rambam Health Care Campus