Clinical trials: Oocyte
Infertility, Obesity
The Association Between Overweight and Oocyte Diameter in Women Undergoing Vitro Fertilization
We believe that there is an association between BMI and oocyte diameter in women undergoing IVF treatments. We plan to measure the oocyte diameter in 2 groups of women undergoing IVF.
- Trial name
- NCT01672931
- Testing
- Oocyte Measurement
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hillel Yaffe Medical Center
Hormone Disturbance
Oocyte Retrieval Progesterone Levels and IVF
Objective: To assess whether basal hormonal level can predict the elevation of P4 on the day of oocyte retrieval, as well as to examine the impact of P4 elevation on the day of oocyte retrieval on the outcome of assisted…
- Trial name
- NCT04447677
- Volunteers
- 164 people
- Sponsor
- University of Belgrade
Female Infertility Due to Diminished Ovarian Reserve
Alpha-Lipoic Acid Supplementation and IVF Outcomes in Women of Advanced Maternal Age
Female fertility declines with advancing age, largely because of deteriorating oocyte quality driven by mitochondrial dysfunction and oxidative stress within the ovarian microenvironment.
- Trial name
- NCT07685431
- Testing
- Alpha-Lipoic Acid (ALA)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Infertility
Performance Study of New Media for Vitrification of Human Oocytes
The purpose of this study is to evaluate safety and performance of Vitrolife´s new oocyte vitrification/warming media and the vitrification device Rapid-i™, when using vitrification as a cryopreservation method for human oocytes.
- Trial name
- NCT01481571
- Testing
- Vitrification medium oocyte, warming medium oocyte and Rapid-i
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Vitrolife
In Vitro Maturation of Oocytes
Fertilo In Vitro Research Study and Trial
The goal of this clinical trial is to evaluate the safety and efficacy of using Fertilo for In vitro maturation (IVM) in participants 18-35 years of age.
- Trial name
- FIRST (NCT06858111)
- Testing
- Fertilo, Medicult IVM
- Where
- 16 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Gameto, Inc.
Fertilization
Clinical Application of Artificial Oocyte Activation Technique (AOA) in ART
Oocyte activation is an imperative stage in the initiation of embryo development during the fertilization. Indeed, the entrance of sperm into the oocyte causes sequences of calcium oscillations in its cytoplasm, regulating a…
- Trial name
- NCT04519918
- Testing
- AOA
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Infertility, Fertility
A Trial to Compare the Efficacy and Safety of Ovarian Stimulation With GONAL-f® and Luveris® Starting on Day 1 Versus Day 6 in Women Undergoing Assisted Reproductive Technique
This is a phase IIIb, interventional, multicenter, multinational, randomised, open-label, comparative trial which primary objective is to generate data on the ovarian stimulation profile obtained when Luveris® is started either…
- Conditions
- Infertility, Fertility, Follicle Stimulating Hormone Deficiency
- Trial name
- NCT01497197
- Testing
- GONAL-f®, Luveris®, Recombinant human chorionic gonadotropin (r-hCG)
- Where
- United Arab Emirates
- Volunteers
- 174 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Subfertility
Is the IVF Outcome Dependent on the Time Interval Between hCG Administration and Oocyte Retrieval?
During controlled ovarian hyperstimulation (COH), human chorionic gonadotrophin (hCG) is administered to trigger the final follicular maturation before oocyte retrieval, in an attempt to mimic the physiologic effects of LH.
- Trial name
- NCT02044445
- Testing
- Oocyte retrieval will be performed 36 h or 38 h after hCG administration
- Where
- Greece
- Volunteers
- 154 people
- Sponsor
- Aristotle University Of Thessaloniki
Adenomyosis of Uterus, Implantation Failure
Linzagolix in Adenomyosis and Recurrent Implantation Failure
Adenomyosis is associated with impaired endometrial receptivity and reduced implantation rates in assisted reproduction, even when using high-quality embryos.
- Conditions
- Adenomyosis of Uterus, Implantation Failure, Infertility Female, Embryo Transfer
- Trial name
- LINZA-RIF (NCT07698561)
- Testing
- Linzagolix 200 mg (Yselty)
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Vida Fertility Institute
Low Ovarian Reserve, Poor Ovarian Response
Ovulation Trigger Strategies in Low Ovarian Reserve (TRIGGERBEST)
This study aims to compare different ovulation triggering strategies in women with low ovarian reserve undergoing fresh in vitro fertilization (IVF) cycles.
- Trial name
- TRIGGERBEST (NCT07816562)
- Testing
- Human chorionic gonadotropin (hCG), Follitropin delta, Triptorelin
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Infertility, In Vitro Fertilization
Virtual Reality for Acute Pain and Anxiety During Egg Retrieval for in Vitro Fertility Treatment
This study is a comparison between the current standard practice of performing a transvaginal oocyte retrieval (TVOR) with paracervical block (PCB) and a relatively recently developed technology of virtual reality that is added…
- Conditions
- Infertility, In Vitro Fertilization, IVF, ART
- Trial name
- NCT05438238
- Testing
- Oncomfort
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Intracytoplasmic Sperm Injection
Health of Children Born From ICSI With AOA (AOA-BABIES)
The investigators follow up on the development of children born from ICSI-AOA using the Developmental Red Flags and Ages \& Stages Third Edition (ASQ-3) Questionnaires to give strong evidence about the safety of AOA in assisted…
- Trial name
- NCT05578118
- Where
- Vietnam
- Volunteers
- 63 people
- Sponsor
- Mỹ Đức Hospital
Oocyte Retrieival and Post Operative Pain Control
Rectal Acetaminophen During Oocyte Retrievals
As the opioid epidemic shows no sign of abating, this national crisis deserves careful attention from all medical subspecialties.
- Trial name
- NCT05990868
- Testing
- Tylenol
- Volunteers
- 78 people
- Sponsor
- University of South Florida
IVF, Infertility
Evaluating Piezo-ICSI. - The EPI Study.
Intracytoplasmic sperm injection (ICSI) has successfully been used to treat both severe male infertility and fertilization failure since its introduction in the early 1990´s.
- Trial name
- NCT04669652
- Testing
- Piezo-ICSI
- Where
- 2 sites in United Kingdom
- Volunteers
- 265 people
- Sponsor
- Vitrolife
Pain Intensity Assessment
Pain Relief in Women Undergoing Oocyte Retrieval (OR) With Electro-acupuncture (EA) or Conscious Sedation (CS) in a Single Assisted Reproduction Centre.
This study aims to determine whether one can replace pain relief in women undergoing oocyte retrieval (OR) using electro-acupuncture (EA) instead of conscious sedation (CS).
- Trial name
- EA (NCT07041632)
- Testing
- electro-acupuncture, Conscious sedation
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Infertility
Oocyte Cryopreservation Comparing Fresh and Vitrified Sibling Oocytes
Vitrification is a method to cryopreserve biological specimens that are sensitive to chilling injury such as oocytes and embryos, and it has been employed with increased survival rate and live births (Hong et al., 1999; Kuleshova…
- Trial name
- NCT00986687
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- UConn Health
Controlled Ovarian Stimulation, Progesterone Variation on Trigger Day
Progesterone Variation on the Final Day of Oocyte Maturation.
The current study, aims through a robust design to provide a simple answer on whether progesterone levels of the same individual may significantly vary depending on the time of blood retrieval before the ovulation triggering, by…
- Conditions
- Controlled Ovarian Stimulation, Progesterone Variation on Trigger Day, Circadian Rhythm, Oocyte Donors
- Trial name
- NCT03366025
- Testing
- Serum progesterone measure
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Non-viable Oocytes, Extra Spermatozoa
Evaluation of Discarded Laboratory Pathological Specimens and Media
The researchers propose to investigate the causes, incidence, and time-related events of chromosomal and physiologic abnormalities as they relate to patient diagnosis, fertility drugs utilized, and in vitro laboratory culture…
- Conditions
- Non-viable Oocytes, Extra Spermatozoa, Seminal Fluid, Granulosa Cells
- Trial name
- NCT01219439
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Fertility
Evaluate Educational Interventions for Increasing Fertility Knowledge and Awareness
Fertility knowledge and awareness is considered insufficient in women of reproductive age from developed countries. The objective of this study is to evaluate if educational interventions in oocyte donors increase on their level…
- Trial name
- QUESE2 (NCT02364739)
- Testing
- Written information, Written and oral information
- Where
- Spain
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Fundació Privada Eugin
Invitro Fertilization, Diminished Ovarian Reserve
Effect of Follicular Flushing in Patients With Mono-follicular Growth Undergoing In Vitro Fertilization
Retrieval of an oocyte from a follicle relies on the release of the cumulus-oocyte-complex (COC) from the follicular wall into the lumen, thereby allowing aspiration by a needle.
- Conditions
- Invitro Fertilization, Diminished Ovarian Reserve, Oocyte
- Trial name
- NCT03831542
- Testing
- direct follicular aspiration, follicular flushing
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centrum Clinic IVF Center