Clinical trials: Oocyte
Infertility (IVF Patients), Oocyte Competence
The EPIC Study: Exploring Paternal Age and the Influence on Blastocyst Culture
This study aims to assess the effect of age of the male partner and the reproductive ability of sperm prepared via sperm selection devices (Zymot) compared to routine embryologist selected sperm after density gradient…
- Conditions
- Infertility (IVF Patients), Oocyte Competence, Sperm DNA Fragmentation, Paternal Age
- Trial name
- EPIC (NCT06629766)
- Testing
- Microfluidic sperm separation device, Density grade centrifugation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Endometriosis
Endometriosis Impact on Oocyte Quality
The aim of this study is to evaluate the impact of endometriosis on folliculogenesis and oocyte quality. To do so, a metabolomic approach will be conducted in order to analyze the follicular fluid.
- Trial name
- EndOvo (NCT03241329)
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Poor Response to Ovulation Induction
Ovarian Response in Oocyte Donors Triggered With GnRH Agonists
The use of agonist of GnRH (aGnRH) trigger to avoid ovarian hyperstimulation syndrome is nowadays widely used. The action of the aGnRH in the hypophysis triggers an LH and FSH surge, which mimicks the natural surge that occurs in…
- Trial name
- NCT05109403
- Where
- Spain
- Volunteers
- 224 people
- Sponsor
- Clínica EUGIN
Fertility Disorders
Effect of Oocyte Denudation Time and Intracytoplasmic Sperm Injection Time on Embryo Quality
An observational analytic retrospective study was conduct using cross-sectional study. The subject were oocytes from in-vitro fertilization procedures using the ICSI method at the assisted reproductive technology clinic in a…
- Trial name
- NCT05448859
- Testing
- intracytoplasmic sperm injection
- Volunteers
- 200 people
- Sponsor
- Universitas Padjadjaran
Fertility Issues, Reproductive Issues
The Stanford Egg Freezing Study
The purpose of this study is to see if the investigators can obtain non-inferior clinical outcomes (similar numbers of oocytes) using the Cardinal protocol, a cost-conscious, low-intensity egg freezing protocol, compared to other…
- Trial name
- NCT05842070
- Testing
- Low-Intensity Egg Freezing Protocol, High-Intensity Egg Freezing Protocol
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Stanford University
Women Infertility
Lipoic Acid Supplementation in IVF
Alpha-Lipoic Acid (ALA) is a natural molecule that can make a significant contribution to the success of embryo implantation phase, because it exerts, directly or indirectly, an immunomodulatory activity.
- Trial name
- NCT03023514
- Testing
- Oral Lipoic acid, Vaginal Progesterone
- Where
- Greece
- Volunteers
- 172 people
- Sponsor
- Lo.Li.Pharma s.r.l
Poor Ovarian Reserve
Dual Trigger in the Final Oocyte Maturation in Poor Ovarian Responders
This is a randomized controlled clinical trial to investigate the effect of dual trigger (hCG and GnRH agonist) on the final oocyte maturation compared to the standard hCG trigger in patients with poor ovarian reserve seeking…
- Trial name
- NCT04224818
- Testing
- Dual trigger, hCG (standard)
- Where
- Lebanon
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Ovarian Reserve, SARS-CoV-2 Infection
Effect of Sars-cov-2 on Donor Oocyte Quality and Quantity, a Multicenter Retrospective Study.
Purpose: To determine the impact of SARS-CoV-2 infection and immunization on ovarian response to controlled ovarian stimulation (COS) and embryo development after in vitro fertilization (IVF) Methods: A retrospective multicentric…
- Conditions
- Ovarian Reserve, SARS-CoV-2 Infection, Blastocyst
- Trial name
- NCT05562479
- Testing
- Sars Cov 2 infection, Sars Cov 2 vaccination
- Where
- Colombia
- Volunteers
- 428 people, healthy volunteers welcome
- Sponsor
- Novafem
Stimulation in the Ovary, Embryo
Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A.
The PPOS protocol (Progestin-primed Ovarian Stimulation) involves avoiding ovulation during ovarian stimulation with progesterone.
- Conditions
- Stimulation in the Ovary, Embryo, Oocyte, Oocyte Retrieval
- Trial name
- PPDUO (NCT06637189)
- Testing
- Ganirelix, Medroxyprogesterone Acetate 10 MG
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ginefiv
Infertility, Polycystic Ovaries
Invitro Maturation of Oocytes for Patients With Polycystic Ovaries
In vitro maturation of oocytes after minimal gonadotropin stimulation in patients with polycystic ovaries, to prevent cases of ovarian hyperstimulation.
- Trial name
- NCT00631982
- Testing
- in vitro matuartion of oocytes
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Assaf-Harofeh Medical Center
Polycystic Ovary Syndrome
Molecular Basis of PCOS in Oocytes and Surrounding Cells
Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age that is characterized by elevated androgen levels, ovulatory dysfunction and polycystic ovarian morphology (PCOM).
- Trial name
- NCT04493788
- Testing
- Blood test, ultrasound and egg retrieval
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Male
Sperm Selection Using Microfluidic Technology
This clinical study has been organised to investigate whether microfluidic technology may be considered as a new procedure for routine sperm preparation during assisted reproduction.
- Trial name
- MSS (NCT04997070)
- Where
- Belgium
- Volunteers
- 1,038 people, healthy volunteers welcome
- Sponsor
- CRG UZ Brussel
Automatic Vitrification, Manual Vitrification
Interest of Automated Oocyte Freezing
In the space of a few decades, oocyte cryopreservation has become established in the world of reproductive biology with the authorization of oocyte vitrification.
- Trial name
- Instruvit (NCT03570073)
- Testing
- Manual vitrification, Vitrification with GaviTM system
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Infertility Primary
The Aim of This Study is to Determine if Oocyte Sorting for Group Culture Using an Artificial Intelligence Image Analysis Tool (MagentaTM) Increases the Usable Blastocyst Yield and Subsequent Pregnancy in Patients Undergoing IVF
The aim of this study is to determine if oocyte sorting for group culture using an artificial intelligence image analysis tool (MagentaTM) increases the usable blastocyst yield and subsequent pregnancy in patients undergoing IVF.
- Trial name
- NiOS (NCT06521372)
- Testing
- Magenta AI image analysis tool
- Where
- 3 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Ovation Fertility
Infertility
Ultra-rapid Blastocyst Vitrification: Pilot Randomized Study
Blastocyst vitrification is standard in assisted reproduction, but clinical data on ultra-rapid vitrification are limited. This pilot study evaluates the safety, feasibility, and preliminary clinical performance of an ultra-rapid…
- Trial name
- NCT07556601
- Testing
- Standard Vitrification, Ultra-Rapid Vitrification
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Fundacion Dexeus
Embryo Development
Culture Media and Blastocyst Development
The aim of this non-interventional study is to compare the blastulation rate per fertilized oocyte in two different single step culture media commercially available (GEMS and Irvine culture media).
- Trial name
- NCT03497052
- Testing
- In vitro culture in medium 1, In vitro culture in medium 2
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Clinica Valle Giulia
Infertility
Progevera 10 mg® Versus Orgalutran® in Ovarian Stimulation Cycles of Oocyte Donors
Evaluation of efficacy and safety of medroxiprogesterone acetate (Progevera 10 mg®) versus GnRh antagonist (Orgalutran®) in ovarian stimulation cycles of oocyte donors
- Trial name
- NCT02796105
- Testing
- Progevera, Orgalutran
- Where
- Spain
- Volunteers
- 232 people
- Sponsor
- Fundació Privada Eugin
PCOS, IVF
IVM Versus IVF in High Antral Follicle Count Patients
In vitro maturation (IVM) is postulated to be an alternative to conventional in vitro fertilization (IVF) to avoid ovarian hyperstimulation syndrome.
- Conditions
- PCOS, IVF, IVM
- Trial name
- NCT03405701
- Testing
- IVM, IVF
- Where
- Vietnam
- Volunteers
- 546 people
- Sponsor
- Mỹ Đức Hospital
Infertility
Role of Myo-inositol and D-chiro-inositol on Oocyte Quality
Controlled ovarian hyperstimulation with gonadotropins is an integral part of the various stimulation protocols for patients undergoing in-vitro fertilization (IVF) and other Assisted Reproductive Technologies (ART) such as…
- Trial name
- NCT01338844
- Testing
- Myo-inositol, D-chito-Inositol
- Where
- 3 sites in Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Infertility, Infertility, Female
Aftificial Inteligence in Assisted Reproductive Techniques to Assess Oocyte Quality and Embryo Ploidy
The assisted reproduction success rate is affected by several factors including the age of the women, oocyte quality and maturation state, as well as sperm quality.
- Conditions
- Infertility, Infertility, Female, Infertility, Male, Infertility Unexplained
- Trial name
- SMARTAI (NCT06539104)
- Testing
- arteficial inteligence evaluation of oocyte and embryo development
- Where
- 4 sites in Czechia
- Volunteers
- 1,000 people
- Sponsor
- Charles University, Czech Republic