Clinical trials: Oocyte
Polycystic Ovary Syndrome, Infertility
New Application of Sequential in Vitro Muturation System for Infertility Patients With Polycystic Ovary Syndrome
Oocyte in vitro maturation (IVM) is an artificial reproductive technologies (ART) in which cumulus-oocyte complex (COC) are collected at the immature germinal vesicle (GV) stage from unstimulated or FSH-primed ovaries and matured…
- Trial name
- NCT03773263
- Testing
- sequential IVM system, intracytoplasmic sperm injection (ICSI), Thawed embryo transfer (TET)
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Infertility
EGG Sensor for Oocyte Characterization
While intracytoplasmic sperm injection (ICSI) has made significant progress in the treatment of male infertility, the cumulative delivery rate is less than 30%, and birth is sometimes only achieved after several transfers.
- Trial name
- EGG_SENSOR (NCT06497998)
- Testing
- Mechanical characterization
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
In Vitro Fertilization
Corifollitropin Alfa Application in PCOS Patients
Corifollitropin alfa, single dose administered sustains multiple follicular development for 7 days. However, It may induce ovarian hyperstimulation syndrome (OHSS), especially in high responder women such as patients of…
- Trial name
- NCT02215135
- Testing
- Corifollitropin alfa
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
IVF
Non-Invasive Preimplantation Genetic Screening for Aneuploidies and Clinical Outcomes in Egg Donation Patients
Preimplantation genetic testing for aneuploidies (PGT-A) is commonly used in IVF but requires embryo biopsy and shows limited benefit in egg donation cycles.
- Trial name
- niPGTAdon (NCT07364526)
- Where
- Spain
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Infertility
Safety and Efficacy of Freezing and Thawing of Human Eggs in Assisted Reproductive Technology
The purpose of this study is to determine the effectiveness of the ViaCell's product media for freezing and thawing human eggs for future use in assisted reproductive technology.
- Trial name
- NCT00451009
- Testing
- Viacell's product Media Kits
- Where
- 4 sites in United States
- Sponsor
- ViaCell
Oocyte Competence
Modulation Contrast Microscopy Imaging for Oocyte Quality Assessment
The present study aims to describe novel non-invasive parameters related to the competence of female reproductive cells (oocytes).
- Trial name
- NCT03683290
- Testing
- Image acquisition and analysis
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Center for Reproductive an Genetic Health
Infertility
Management of Abnormally Fertilized Zygotes? InVitro Correction of 3PN
In this newly developed protocol, and idea, is to manage those abnormally developed zygotes from different ART procedures. The investigators developed the plan and requirements needed to select the target extra nucleus or…
- Trial name
- NCT02358759
- Testing
- Correction of abnormally fertilized oocytes
- Where
- 2 sites in Bahrain, Egypt
- Volunteers
- 22 people
- Sponsor
- Ahmad Mustafa Mohamed Metwalley
Infertility
Final Oocyte Maturation Via Administration of GnRH Agonists Followed By Luteal Support With hCG
Study Objectives: 1. To prove that the use of GnHR agonist for final oocyte maturation results in a higher percentage of mature oocytes than the use of hCG. 2.
- Trial name
- NCT01638026
- Testing
- TRIPTORELIN ACETATE, hCG
- Where
- Israel
- Volunteers
- 93 people
- Sponsor
- HaEmek Medical Center, Israel
Infertility
Value of Follicular Flushing. Randomised Controlled Trial
The purpose of this study is to evaluate whether the addition of follicular flushing to the initial aspiration during oocyte retrieval increases the number of oocytes retrieved in women undergoing ovarian stimulation.
- Trial name
- NCT05473455
- Testing
- Experimental: Follicular aspiration with addition of follicular flushing.
- Where
- Greece
- Volunteers
- 105 people
- Sponsor
- Eugonia
Fertility Preservation
Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)
HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or…
- Trial name
- HOLIDAY (NCT07225660)
- Testing
- OCP pause
- Where
- 3 sites in United States
- Volunteers
- 394 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Poor Ovarian Response, Female Infertility of Other Origin
Exosome-Enriched Culture Media to Enhance In Vitro Maturation and Embryo Development in Poor Ovarian Responders Undergoing IVF
Evaluating the Efficacy of Exosome-Enriched Culture Media to Enhance In Vitro Maturation and Embryo Development in Poor Ovarian Responders Undergoing IVF Summary: This is a prospective, randomized controlled trial designed to…
- Conditions
- Poor Ovarian Response, Female Infertility of Other Origin, Oocyte Immaturity
- Trial name
- EXOMAT (NCT07085312)
- Testing
- Exosome-Enriched IVF Culture
- Where
- Venezuela
- Volunteers
- 10 people
- Sponsor
- Fertiaguerrevere
Infertility
Comparison of Transfers of Thawed Blastocysts Versus Blastocysts Derived From Thawed Bipronuclear Oocytes
The purpose of this study is to determine if cryopreservation at the blastocyst stage followed by embryo thaw and transfer is as effective as cryopreservation of bipronuclear oocytes followed by post-thaw extended culture (PTEC)…
- Trial name
- NCT01247987
- Testing
- Blastocyst cryopreservation, Bipronuclear oocyte cryopreservation
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bruce Shapiro M.D.
Pre-eclampsia, Oocyte Donation
PRIOR Study (Pre-eclampsia Risk In Oocyte Recipients)
The aim of this prospective observational cohort study is to investigate the pathophysiological mechanisms behind and risk of pre-eclampsia in women pregnant after fertility treatment with oocyte donation.
- Conditions
- Pre-eclampsia, Oocyte Donation, Pre-Eclampsia; Complicating Pregnancy, Pre-Eclampsia; Mild
- Trial name
- PRIOR (NCT07263490)
- Where
- 6 sites in Denmark
- Volunteers
- 462 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Infertility
Triggering Oocyte Maturation in POSEIDON Group 3 and 4 Poor Responders Using Double Trigger or HCG Trigger
The aim of this randomized controlled study is to compare the efficacy of double trigger protocol [ the co-administration of GnRH agonist with HCG ( 38 - 39 and 35 - 36 h prior to ovum pick-up, respectively ] with HCG in…
- Trial name
- NCT07569289
- Testing
- Double trigger, HCG trigger
- Where
- Egypt
- Volunteers
- 164 people
- Sponsor
- Bedaya Hospital
Infertility
Influence of a Prematuration Culture With a Phosphodiesterase-3 Inhibitor (PDE3-I) on Embryonic Aneuploidy Rate and Developmental Potential
A single centre randomised controlled trial investigating the influence of a novel prematuration system (PMS) using a phosphodiesterase-3 inhibitor for in-vitro maturation of oocytes - pilot study.
- Trial name
- NCT00822874
- Testing
- prematuration culture
- Where
- Belgium
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Implantation, Embryo
A Novel Approach to Endometrial Preparation in Recipients of Donor Eggs
This study compares two different methods to prepare the uterine lining of recipients for implantation in cycles using donor eggs. The study method requires less time than the standard method.
- Trial name
- NCT01424618
- Testing
- Leuprolide, Ganirelix
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kelly, Maureen, M.D.
ANXIETY
Music Therapy and Sedation for Pain and Anxiety During Oocyte Retrieval
This study is a prospective observational investigation aimed at examining the effect of music intervention on anxiety and pain levels in patients undergoing the ovum pick-up (OPU) procedure under sedation at an IVF center.
- Trial name
- NCT07898358
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Samsun University
Poor Ovarian Reserve
Autologous Intraovarian Platelet Rich Plasma Treatment in Women With Poor Ovarian Response
Reproductive age women diagnosed with poor ovarian response (POR) based on Bologna criteria with a history of at least two prior failed ICSI cycle will be recruited for the study.
- Trial name
- NCT04797377
- Testing
- Autologous ovarian PRP injection
- Where
- Bulgaria
- Volunteers
- 66 people
- Sponsor
- Nadezhda Women's Health Hospital
Preeclampsia, Oocyte-donation Pregnancies
Immunological and Cardiovascular Phenotyping of Oocyte-donation Pregnancies
The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
- Trial name
- NCT04731012
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Pain Management, Anxiety Management
The Effect of Andullation Therapy on Pain and Anxiety After Oocyte Retrieval
The goal of this clinical trial is to evaluate the effect of andullation therapy in the management of pain and anxiety that occur in the patient follow-up after oocyte retrieval.
- Conditions
- Pain Management, Anxiety Management, Oocyte Retrieval
- Trial name
- NCT06932575
- Testing
- Andullation Therapy Bed
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Eskisehir Osmangazi University