Clinical trials: Oocyte
Infertility, Premature Ovarian Failure
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH
The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs and high basal FSH, prior to proceeding to oocyte donation or abandoning…
- Trial name
- NCT00417157
- Testing
- recombinant FSH (Puregon, Organon, The Netherlands), GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands), hCG (Pregnyl, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Eugonia
Female Infertility, Oocyte Competence
Adipose Stem Cell Mitochondria Supplementation to Oocytes (ASCENT)
The purpose of this study is to investigate the potential of autologous adipose stem cell (ASC) mitochondrial transfer (ASCENT) to oocytes along with intracytoplasmic sperm injection (ICSI)as a means of enhancing embryo…
- Conditions
- Female Infertility, Oocyte Competence, Mitochondria, Recurent Implantation Failures
- Trial name
- NCT07066267
- Testing
- Experimental
- Where
- Sri Lanka
- Volunteers
- 20 people
- Sponsor
- Sunkaky Medical Cooperation
Infertility and at High Risk of OHSS
Repeated Injection of GnRH Agonist to Reduce Ovarian Hyperstimulation Syndrome
Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk…
- Trial name
- NCT02022241
- Testing
- triptorelin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chenshiling
Endometriosis, Cell Free DNA
Cell Free DNA Quantification in Patients With Endometriosis Followed Witd Medical Assistance to Procreation
Endometriosis is a common benign disease in premenopausal women and causes chronic pelvic pain and infertility. This infertility may be due to pelvic adhesions and surgery but also because of poor oocyte quality.
- Trial name
- ENDO-FIV (NCT05815134)
- Testing
- blood sample
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Fertility Preservation
Intranasal Nafarelin For Triggering Oocyte Maturation
This is a non-inferiority randomised, controlled clinical trial comparing subcutaneous triptorelin to intranasal nafarelin for the final maturation of oocytes in women undergoing fertility preservation cycles with oocyte…
- Trial name
- INFORM (NCT06763926)
- Testing
- Subcutaneous Triptorelin, Intranasal nafarelin
- Where
- 5 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Fundacion Dexeus
Dehydroepiandrosterone, DHEAS
Effects of Dehydroepiandrosterone Supplementation on Cumulus Cells Gene Expression Under Controlled Ovarian Hyper-stimulation in Patients With Diminished Ovarian Reserve
Diminished ovarian reserve (DOR) is one the challenge in the field of artificial reproductive technology (ART) while there is still no effective resolution of this disorder.
- Conditions
- Dehydroepiandrosterone, DHEAS, Gene Expression of Cumulus Cells., Ovarian Hyper-stimulation Protocol.
- Trial name
- NCT02150330
- Testing
- Dehydroepiandrosterone (DHEAS)
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
PCOS
IVM Versus Standard IVF in Infertile Patients Diagnosed With PCOS
A single center, prospective, open-label, non-inferiority randomized controlled clinical trials (1:1 treatment ratio) regarding pregnancy outcomes between IVM and standard IVF among infertility couples with PCOS in China.
- Trial name
- NCT03463772
- Testing
- standard IVF, In vitro maturation
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Jie Qiao
Acupuncture, in Vitro Fertilization
The Differences of Oocyte Maturation, Granulosa Cell Apoptosis Index Between Electroacupuncture And Sham Groups IVF
Interventional studies compared electroacupuncture group versus sham electroacupuncture group to granulosa cell apoptosis index, oocyte maturation, GDF9 and BMP15 levels, and fertilization rate in in vitro fertilization program
- Conditions
- Acupuncture, in Vitro Fertilization, BCL2 Gene mRNA Overexpression, Oocyte Maturation
- Trial name
- NCT03627533
- Testing
- Electroacupuncture
- Where
- Indonesia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
In Vitro Fertilization
Effect of Super-GDF9 on CAPA-IVM of COCs From Small Antral Follicles
CAPA-IVM (In Vitro Maturation) technology is an assisted reproductive method offering significant benefits in terms of safety and treatment costs, particularly for high-risk patients.
- Trial name
- sGDF-9 (NCT06766604)
- Testing
- Super-GDF9 supplementation during CAPA-IVM, Conventional CAPA-IVM
- Where
- Vietnam
- Volunteers
- 9 people
- Sponsor
- Mỹ Đức Hospital
Survival, Embryo Quality
Oocyte Survival After Vitrification in an Open or Closed Device With Closed Storage.
The survival rate (and embryo quality) of donor oocytes with two commercially available devices.
- Trial name
- NCT01952184
- Testing
- CBSvit HS device, Cryotop SC device
- Where
- Belgium
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility
Mitochondrial Activity of Cumulus Cells From the Cumulus-oocyte Complex and Oocyte Competence
The need for non-invasive biomarkers of oocyte competency has become urgent as women increasingly delay attempts at childbearing.
- Trial name
- NCT02793752
- Testing
- Age
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Infertility, Infertility, Male
Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection
Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF).
- Trial name
- NCT00114725
- Testing
- Laser-assisted intracytoplasmic sperm injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Subfertility
Endometrial Scratching in In Vitro Fertilization Cycles With Oocyte Donation
This study is designed to evaluate the potential benefit in pregnancy rates produced by an endometrial scratching made in an IVF cycle prior to embryo transfer in patients with donated oocytes.
- Trial name
- NCT01842178
- Testing
- scratching
- Where
- Spain
- Sponsor
- Centro de Infertilidad y Reproducción Humana
Assisted Reproductive Technology, Infertility
Sperm Micro-swim up Technique; Process and Select in the Same Dish: a Sibling-oocyte-split Design
A sibling-Oocyte-split design will be conducted on oocytes before denudation and divided into two groups : control group (MII oocytes will be injected using sperm processed by Density gradient method) and sample group ( MII…
- Trial name
- NCT05113225
- Testing
- Micro-swim up technique
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Royal Fertility Center, Egypt
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantage
This study evaluates a more affordable medication protocol for ovarian stimulation during in vitro fertilization (IVF). Standard IVF protocols use medications called gonadotropins to stimulate the ovaries to produce multiple…
- Conditions
- Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Infertile Patients, Infertility Drugs
- Trial name
- NCT07771283
- Testing
- Human Chorionic Gonadotropin (hCG), GnRH antagonist, Dual trigger (human chorionic gonadotropin plus GnRH-agonist)
- Where
- 3 sites in Uganda, Ukraine
- Volunteers
- 360 people
- Sponsor
- LTD "EKODNIPRO", Medical centre Medical Plaza Dnipro
Infertility
Oocyte Cryopreservation: Slow Cooling Versus Vitrification Techniques on Oocyte Survival
Oocyte cryopreservation has been studied for many years without much success in refining a method that has consistent, reliable results in producing viable embryos and clinical pregnancies.
- Trial name
- NCT00602966
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- UConn Health
Endometriosis
Fertility Preservation in Case of Endometriosis
Fertility Preservation is now considered as crucial for the well-being of women battling cancer. However, others indications have more recently emerged.
- Trial name
- PREFENDO (NCT03744754)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility, Female
Efficacy of Oocyte Activation With Two Types of Ca2+ Ionophore.
This study is a prospective ranzomized analysis including 372 human oocytes from 44 women. Half of the oocytes from the same patient will be randomly allocated to induce oocyte activation using two protocols: in protocol nº 1 we…
- Trial name
- Calcifer (NCT06106412)
- Testing
- Ionomycin SIGMA, A23187
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility, Female, ART
Comparing Two Types of Needle for Oocytes Retrieval
In the early stages of assisted reproductive technologies (ART), oocyte retrieval was performed via laparoscopy, a cumbersome and expensive process requiring general anesthesia.
- Trial name
- NEEDLE (NCT03611907)
- Testing
- Oocyte retrieval with only aspiration system "SL1(Cook® Single Lumen)", Oocyte retrieval with aspiration and flushing system "DL1 (Cook® EchoTip® Double Lumen)"
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
In Vitro Maturation of Immature Oocytes
The aim of this study is to aspirate immature oocytes from antral follicles and mature the oocytes in vitro. These mature oocytes will serve for fertilization and the creation of embryos which will be replace in the uterus as…
- Trial name
- NCT00480337
- Testing
- In Vitro Maturation of immature oocytes
- Where
- Israel
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sheba Medical Center