Clinical trials: Oocyte
Oocyte Cryopreservation
Paired Non-inferiority Study Comparing Overture Semi-automated Vitrification System ("DaVitri") to Standard Manual Process for Clinical Pregnancy Outcomes
This study will recruit 260 female recipients (and up to a maximum of 130 donors). This study is a sequel to the protocol CP-DV-000-GEN-003, entitled, "NON-INFERIORITY STUDY COMPARING OVERTURE SEMI-AUTOMATED VITRIFICATION SYSTEM…
- Trial name
- NCT06853418
- Testing
- Oocyte Cryopreservation
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Overture Life
Pesticide Poisoning
Impact of Oocytes With CLCG on ICSI Outcomes and Their Potential Relation to Pesticide Exposure
Oocyte quality is a key limiting factor in female fertility which is primarily reflected in morphological features. Centrally located cytoplasm granulation (CLCG) is one type of cytoplasmic dimorphism exhibited by oocytes that…
- Trial name
- CLCG-ICSI (NCT03647020)
- Where
- France
- Volunteers
- 633 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Oocyte Cryopreservation
Optimization of Oocyte Warming Protocols
This is a retrospective study with a sibling design comparing new oocyte thawing protocols (rapid and ultra-rapid) with the traditional method
- Trial name
- OVOfast (NCT07105891)
- Testing
- Thawing protocol
- Where
- Italy
- Volunteers
- 399 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Diminished Ovarian Reserve (DOR)
Clinical Study on ShouTai Pills for Improving Reduced Ovarian Reserve
Grounded in the 'disease-syndrome combination' paradigm, this study endeavors to address the pivotal scientific issues pertaining to the clinical precision of Traditional Chinese Medicine (TCM) in managing Diminished Ovarian…
- Trial name
- NCT07737847
- Testing
- Shoutai Pill
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Peking Union Medical College Hospital
Infertility
In Vitro Maturation (IVM) of Human Oocytes
The objectives of this study are to evaluate the clinical efficacy of Natural in vitro Fertilization and in vitro maturation.
- Trial name
- IVM (NCT01550861)
- Testing
- in vitro maturation, Polar Body Biopsy with preimplantation genetic screening
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
In-vitro Fertilization
Time-lapse Evaluation of Human Embryo Development in Single Versus Sequential Culture Media - a Sibling Oocyte Study
Current human IVF technology employs two strategies with respective culture media for embryo development; 'let the embryo choose' (utilizes single step media) and 'back-to-nature' (utilizes sequential media).
- Trial name
- NCT01507883
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bahceci Health Group
Female Patients Aged 5-35 Prior to Systemic Chemotherapy, With Significant Risk of Ovarian Toxicity
Fertility Preservation by Ovarian and Oocyte Cryopreservation
Success rates of cancer treatment have increased significantly resulting in many girls and young women who are treated now and will be cancer survivors. Nevertheless, cancer treatment may result in long term side effects.
- Trial name
- HFPP (NCT00578500)
- Testing
- ovarian transplantation
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Infertility
Oocyte Survival After Vitrification With Slush Nitrogen Compared With Liquid Nitrogen
The purpose of this study is to determine if the use of slush nitrogen results in higher post-thaw survival rates for oocytes compared to conventionally used liquid nitrogen.
- Trial name
- NCT04342364
- Testing
- Vitrification via slush nitrogen, Vitrification via liquid nitrogen
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Follicle Size, Embryologic Parameters
Effect of Duration and Follicle Diameter During Oocyte Pick up on Embryological Parameters
Investigators aim to investigate if the time spent for smaller follicles worth to deal with. The difference between follicle groups are recorded for embryological parameters.
- Conditions
- Follicle Size, Embryologic Parameters, Duration
- Trial name
- NCT05666401
- Testing
- follicle diameter and duration of procedure
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 291 people
- Sponsor
- Eurofertil IVF Health Center
Infertility
Comparison of Embryo Transfer in Egg Donation Recipients With Transvaginal and Transabdominal Ultrasound
Transabdominal ultrasound guidance is the golden standard for embryo transfers. Transvaginal ultrasound guidance was proposed recently to provide better visualization and reduce patient discomfort as embryo transfer can be…
- Trial name
- NCT01805505
- Testing
- Transvaginal ultrasound-guided embryo transfer, Transabdominal ultrasound-guided embryo transfer
- Where
- Spain
- Volunteers
- 346 people
- Sponsor
- IVI Madrid
Infertility, Female
Biological Effects of Treatment With Resveratrol in ART Patients
To evaluate the effects of a new nutraceutical formulation containing resveratrol (trademark GENANTE) on gamete quality in order to improve the reproductive process during ART.
- Trial name
- NCT04386499
- Testing
- Resveratrol, Folic acid
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Breast Cancer, Infertility
RCT of Fixed vs Titrated Letrozole in Breast Cancer Patient Undergoing IVF
The purpose of this study is to compare two different ways to administer Letrozole to determine their effectiveness in blocking estrogen production during ovarian stimulation in patients with breast cancer prior to…
- Trial name
- NCT01035099
- Testing
- Letrozole
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Pain Threshold, Conscious Sedation
Correlation Between Pain Threshold and Analgesic Consumption in Transvaginal Oocyte Aspiration Patients
Nowadays, in vitro fertilization (IVF) is an important component of modern infertility treatment. One of the critical stages of the IVF process is oocyte (egg) retrieval, which requires both anesthesia and analgesia; this…
- Conditions
- Pain Threshold, Conscious Sedation, Oocyte Retrieval
- Trial name
- NCT07262216
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Burcu ayvazoğlu
Reproductive Issues
Maternal KIR and Fetal HLA Influence Reproductive Success in ART-oocyte Donor.
The present project is an ambispective study designed to answer how HLA-F SNPs, as well as KIR-HLA-C compatibility, influence reproductive outcomes in oocyte donation cycles.
- Trial name
- NCT05606679
- Testing
- Analysis combinations of maternal KIR and HLA-C genotypes
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- IVI Madrid
Ovarian Hyperstimulation Syndrome
Tolerability of Quinagolide in a Dose-titration Regimen in Oocyte Donors at Risk of Developing Ovarian Hyperstimulation Syndrome
Assess the tolerability of quinagolide 200 μg/day in a dose-titration regimen in oocyte donors undergoing controlled ovarian hyperstimulation and at risk of developing OHSS Secondary Objectives Estimate the effects of a…
- Trial name
- NCT00665041
- Testing
- Quinagolide
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
HCG Day Follicle Diameter, Reproduction Results
Comparison of Follicle Diameter on hCG Day and Follicle Diameters on OPU (Oocyte Pick up) Day and the Effect of Follicle Diameters on Embryo Development and Pregnancy Outcomes
Evaluation of follicle diameters on human chorionic gonadotrophin(hCG) day and oocyte pick up (OPU) day of follicles developing after gonadotropin treatment, the relationship between follicle diameter and maturation in oocytes…
- Trial name
- NCT04679688
- Testing
- descriptive
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Infertility
Freeze All on Oocyte Maturatin by Gonadotropin Agonist Versus Human Chorionic Gonadotroipin
Estradiol valerate in the form of cycloprogenova™ (white tablet only) was started on day 2 or 3 of cycle with oral dose 4 mg divided on 2 doses in addition to Aspocid 75 mg once daily with folic acid 500 mcg once daily.
- Trial name
- NCT04749979
- Testing
- Agonist (decapeptyl ), HCG ( eg. Choriomon )
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin
GnRH Antagonist for Treatment of Early Ovarian Hyperstimulation Syndrome
The aim of this study is to analyze the effectiveness of GnRh antagonist in the treatment of early ovarian hyperstimulation syndrome.
- Conditions
- Ovarian Hyperstimulation Syndrome, Effects of Gonadotropin, Oocyte Maturation
- Trial name
- NCT01268761
- Testing
- GnRH antagonist (Cetrorelix)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Fertility Preservation
Oocyte Vitrification for In Vitro Fertilization (IVF) Patients and Women With Fertility Threatening Conditions
Vitrification is a method of cryopreserving tissue for future use. It is widely used to preserve extra, good quality embryos generated from infertility treatments.
- Trial name
- NCT01448460
- Volunteers
- 8 people
- Sponsor
- University of Louisville
In Vitro Maturation of Oocytes
Is in Vitro Maturation of Oocytes Influenced by the Origin of Gonadotropins Used in Maturation Medium: is There a Difference in Efficiency When Using Urinary Versus Recombinant Produced Follicle Stimulating Hormone and Human Chorionic Gonadotropin
Standard IVM currently contains urinary purified hormones which might contain contaminants possibly affecting maturation of embryo development.
- Trial name
- IVM-FSHhCG (NCT05370794)
- Testing
- rhCG= Ovitrelle®, 250g/0.5ml = 26000IU/ml, Merck-Serono, rFSH = Gonal F®, 300IU/0.5ml, Merck-Serono
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- Universitair Ziekenhuis Brussel