Clinical trials: Oocyte Donation
Ovulation, Ovarian Function
Exogenous Progesterone as Ovulation Trigger
The goal of this clinical trial is to learn whether the sudden administration of vaginal micronized progesterone during the late follicular phase can trigger an LH surge and reactivation of oocyte meiosis in healthy oocyte donors…
- Conditions
- Ovulation, Ovarian Function, Assisted Reproductive Treatments, Oocyte Maturation
- Trial name
- PRO-TRIGGER (NCT07466199)
- Testing
- Vaginal micronized progesterone
- Where
- Portugal
- Volunteers
- 10 people
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Female Infertility
Effect of Growth Hormone on Uterine Receptivity in Women With RIF in an Oocyte Donation Program
105 infertile women are enrolled in the randomized controlled trial: 70 women with a history of RIF with donated oocytes and 35 infertile women undergoing the first oocyte donation attempt.
- Trial name
- NCT03237117
- Testing
- Growth Hormone (GH)
- Where
- Spain
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Competence Centre on Health Technologies
Aneuploidy Rate
Aneuploidy Rate and Stimulation Protocol: Recombinant Follicle Stimulating Hormone (FSH) Versus Human FSH
Several stimulation protocols have been used in in vitro fertilization (IVF) in a cycle of egg donation; recombinant FSH and human FSH are included. The effect of each kind of hormone on aneuploidy rate it is unknown.
- Trial name
- NCT01164943
- Testing
- Stimulation with human FSH, Stimulation with recombinant FSH
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Vitrification, Egg Donor
Validation of Donor Oocytes Semi-automated Vitrification
Oocyte vitrification is an effective method of freezing which has been authorized in France since 2011. The arrival of this technique has led to real improvements in the survival rate of oocytes after warming compared to that…
- Conditions
- Vitrification, Egg Donor, Fertility, Assisted Reproductive Technology
- Trial name
- GAVIDO (NCT06238570)
- Testing
- Gavi, Merck® (automated vitrification instrument), Vitrolife system
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Infertility, Premature Ovarian Failure
Modified Natural Cycle Offers a Chance of Pregnancy in Patients With Poor Response and High Basal FSH
The purpose of this study is to evaluate the effectiveness of a modified natural cycle in patients with previous poor response to infertility drugs and high basal FSH, prior to proceeding to oocyte donation or abandoning…
- Trial name
- NCT00417157
- Testing
- recombinant FSH (Puregon, Organon, The Netherlands), GnRH antag: Ganirelix (Orgalutran, Organon, The Netherlands), hCG (Pregnyl, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Eugonia
Pregnancy, Embryo Implantation
Administration of GnRH Antagonist to Oocyte Donation Recipients
This prospective and randomized study was performed to evaluate whether the replacement of GnRH agonist by a GnRH antagonist in oocyte donation recipients during endometrial preparation has any impact on pregnancy and…
- Trial name
- GnRH-Ovodon (NCT00635258)
- Testing
- triptorelin (Decapeptyl®, Ipsen Pharma, Barcelona, Spain), GnRH antagonist (Orgalutran®)
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Ginecologia y Obstetricia.
Infertility
Use of a Synthetic Macromolecule (Hydroxypropyl Cellulose ) and Trehalose as Additives for Oocyte Vitrification
This study is aimed to evaluate the use of Hydroxypropyl Cellulose (HPC) as substitute for the traditional protein supplement (Synthetic Serum Substitute; SSS) and Trehalose as substitute for the most widely used sugar (Sucrose)…
- Trial name
- NCT01745523
- Testing
- Synthetic macromolecule HPC and trehalose, SSS containing HSA and sucrose
- Where
- Spain
- Volunteers
- 440 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Ovarian Stimulation
Impact of Three Different Gonadotrophin Regimes on Egg Donation Program
Exploratory study assessing the effect of three gonadotrophin protocols on Controlled Ovarian Stimulation (COS) parameters and IVF outcome in oocyte donors undergoing GnRH analogue (long protocol).
- Trial name
- NCT00829075
- Testing
- r-FSH, HP-hMG, r-FSH plus HP-hMG
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Closed Vitrification of Oocytes
This study is aimed to evaluate the use of a closed device for storage of vitrified oocytes.
- Trial name
- NCT01745536
- Testing
- Oocytes are vitrified/stored using a closed device, Oocytes are vitrified/stored using an open device
- Where
- 2 sites in Spain
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
GERM CELLS
Motivations and Psychological Aspects of Gamete Donation
The objective of this project is to describe the motivations, the representation of donation and sterility, to evaluate the psychological aspects of the new male and female candidates to gamete donation and then to compare the…
- Trial name
- DONDON2 (NCT06014151)
- Testing
- questionnaires
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Poor Response to Ovulation Induction
Ovarian Response in Oocyte Donors Triggered With GnRH Agonists
The use of agonist of GnRH (aGnRH) trigger to avoid ovarian hyperstimulation syndrome is nowadays widely used. The action of the aGnRH in the hypophysis triggers an LH and FSH surge, which mimicks the natural surge that occurs in…
- Trial name
- NCT05109403
- Where
- Spain
- Volunteers
- 224 people
- Sponsor
- Clínica EUGIN
Ectopic Pregnancies
Activin A and Inhibin A in Predicting Outcome of Pregnancies of Unknown Location After Assisted Reproductive Technology
The purpose of this study is to determine the predictive value of a single serum determination of activin A and inhibin A for the prognosis of ectopic pregnancy after in Vitro Fertilization (IVF) cycles, in both native and…
- Trial name
- NCT01589016
- Where
- Spain
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA