Clinical trials: Opacity
Lymph Node Excision
Systematic Sampling of Lymph Nodes vs. Lymphadenectomy According to Intraoperative Frozen Pathology for Pulmonary Invasive Adenocarcinoma With Ground-glass Opacity
The purpose of this study is to evaluate the impact of systematic sampling of lymph nodes vs. lymphadenectomy on outcome according to intraoperative frozen pathology for pulmonary invasive adenocarcinoma with ground-glass opacity…
- Trial name
- NCT03322826
- Testing
- systematic sampling of the lymph-node, lymphadenectomy
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Myopia, Small-incision Lenticule Extraction (SMILE) Surgery
Potential Risk Factors and Predictive Model Construction of OBL During SMILE
To explore the prediction of OBL by deep learning model in SMILE surgery
- Trial name
- NCT06577012
- Testing
- Small incision lenticule extraction
- Where
- China
- Volunteers
- 4,678 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pulmonary Lesions
Study of Ablation for the Pulmonary Focal Pure Ground Glass Opacity (pGGO)
With the advent of CT screening for lung cancer, there is an increase in the detection of pulmonary lesions with focal pure ground-glass opacity (pGGO).
- Trial name
- pGGO (NCT01429649)
- Testing
- cryotherapy or radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dongfang Hospital Beijing University of Chinese Medicine
Age-Related Macular Degeneration, Cataract
The Effect of Ranibizumab on Eye Lens Opacity in Cases With Age-Related Macular Degeneration
Purpose To evaluate the cataractogenic effect of intravitreal ranibizumab with the use of Lens Opacity Classification System III (LOCS III).
- Trial name
- NCT01330797
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Uludag University
STROMAL OPACITIES
LALAK for Opacities
The purpose of this protocol is to compare and develop new surgical technique of partial-thickness corneal transplantation for treating corneal opacity.
- Trial name
- NCT01901601
- Testing
- LALAK, IEK, Retrobulbar Block or General Anesthesia
- Sponsor
- Oregon Health and Science University
Posterior Capsule Opacification
An Innovative Method Fluid-jet to to Remove Residual Lens Fibers
Residual lens fibers (RLFs) on the posterior lens capsule during cataract surgery can cause after cataract, affecting visual quality and increasing the medical cost for further laser posterior capsulotomy.
- Trial name
- NCT03605160
- Testing
- traditional polish, fluid-jet
- Where
- China
- Volunteers
- 740 people
- Sponsor
- Sun Yat-sen University
Lung Diseases
Diagnostic Value of Chest Ultrasound in Pediatrics Lung Diseases
To evaluate the accuracy of chest ultrasound for diagnosis of different lung lesions in comparison to the gold standard among children.
- Trial name
- NCT04326972
- Testing
- ultrasound
- Volunteers
- 50 people
- Sponsor
- Assiut University
Other Vitreous Opacities, Bilateral
New Horizons in the Treatment of Vitreous Floaters
The Ultra Q Reflex® (Ellex) constitutes the only Nd:YAG laser approved for the treatment of vitreous floaters. No randomized controlled clinical trial has been carried out to this day in order to investigate its superiority over…
- Trial name
- Ellex (NCT02812004)
- Testing
- Ultra Q Reflex YAG laser (Ellex)
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Augenabteilung Allgemeines Krankenhaus Linz
Acute Lymphoblastic Leukemia, Bone Density Increased
Effects of Exercises on Total Body Health in Children With Acute Lymphoblastic Leukemia
In recent years, the survival of patients has increased with the success of leukemia treatment in children. However, according to the treatment modalities applied, complications such as changes in body composition such as…
- Trial name
- NCT04015882
- Testing
- Exercise therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Lung Cancer
Neoadjuvant Aumolertinib in Patients With AI-diagnosed EGFR-mutant High-risk Pulmonary Ground-glass Opacity.
This is a prospective, single-center, single-arm, phase II study evaluating the efficacy and safety of neoadjuvant aumolertinib in previously untreated patients with AI-diagnosed EGFR-mutant and resectable pulmonary ground-glass…
- Trial name
- NCT05946460
- Testing
- Aumolertinib
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Childhood Cataract
Infrared Choroidal Reflectance Camera for the Detection of Childhood Cataract
Sensitivity and specificity of current screening methods for childhood cataracts is poor. This results in delayed diagnosis and management which can decrease the visual prognosis following cataract surgery.
- Trial name
- NCT03035292
- Testing
- Red-reflex assessment, Infrared-reflex assessment
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Oesophageal Cancer, Rectal Cancer
Placing Trust in Endoscopic Ultrasonography: Impact on Planning Conformal Radiotherapy of Cancer of the Esophagus and Rectum
The purpose of this study is to estimate the rate of patients in whom a significant change in the area to be irradiated will be observed between the assessment before and after laying the evaluation of Trustees.
- Trial name
- FIDUCOR (NCT02526134)
- Testing
- radio opaque markers (Echo Tip Ultra Fiducial Needle - ETUF)
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Institut Paoli-Calmettes
Cataract, Lens Opacity
Comparison of Visual Outcomes After Implantation of the POD AY GF F (PhysIOL) and the POD AY 26P F (PhysIOL)
The study is a prospective randomised controlled study. The patients get monolateral IOL implantation of POD F GF and POD F in the contralateral eye. Both IOLs are trifocal IOLs consisting of the same optical design.
- Trial name
- NCT02981186
- Testing
- IOL implantation experimental, IOL implantation comparator
- Where
- Hungary
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Beaver-Visitec International, Inc.
Molar Incisor Hypomineralization
Three Approaches of Resin Infiltration for MIH Incisor Opacities
Molar incisor hypomineralization (MIH) is a condition which involves enamel hypomineralization of one to four first permanent molars with or without permanent incisors.
- Trial name
- NCT07715370
- Testing
- Resin infiltration, microabrasion, Etch-bleach
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Salt Hypertension From Excess Dietary Salt, Lens Opacities
Salt Sensitivity Hypertension and Lens Opacities
Salt-sensitive hypertension (SSH) accounts for about the half of all Hypertension (HT) cases .In SSH, Na+/K+-ATPase activity is impaired.
- Trial name
- NCT03385070
- Testing
- Lens examination
- Where
- Turkey (Türkiye)
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- Kecioren Education and Training Hospital
Congenital Cataract, Aphakic Glaucoma
Prophylactic Peripheral Iridectomy Prevents Aphakic Angle-closure Glaucoma
This is a retrospective, nonrandomized comparative trial with historical control to investigate the safety and efficacy of a novel progressive grasping peripheral iridectomy (PGPI) surgical method in preventing aphakic…
- Trial name
- NCT03610295
- Testing
- PPI group, cataract extraction
- Where
- 2 sites in China
- Volunteers
- 87 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Lung Nodules, Ultrasound
Ultrahigh-frequency Ultrasonography (UHFUS) in Detection of Small Pulmonary Ground Glass Opacity (GGO)
The purpose of this study is to assess the feasibility of UHFUS on detection of GGOs in excised lung tissue and investigate UHFUS features of GGO in vitro. Each GGO was detected by palpation, UHFUS and open biopsy in sequence.
- Conditions
- Lung Nodules, Ultrasound, Detection Rate
- Trial name
- UHFUSGGO (NCT05994898)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
Validation of AI-Based Detection of Idiopathic Pulmonary Fibrosis in Serial Chest Radiographs: A Retrospective Longitudinal Study
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease of unknown cause with a median survival of only 3-5 years after diagnosis.
- Trial name
- NCT07712952
- Testing
- VUNO Med-Chest X-ray
- Where
- South Korea
- Volunteers
- 175 people
- Sponsor
- Chung-Ang University Hospital
Pulmonary Lesion With Ground-glass-opacity
Lipiodol Localization for Ground-glass-opacity Minimal Surgery
The study object is to demonstrate the usefulness and safety of lipiodol localization technique for individuals undergoing ground-glass opacity (GGO) Video-assisted thoracic surgery (VATS) resection compared to hook wire…
- Trial name
- LOGIS (NCT02180568)
- Testing
- Lipiodol, Hookwire
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Severance Hospital