Clinical trials: Open Angle Glaucoma -Ocular Hypertension
Glaucoma, Glaucoma, Open Angle
Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments.
The purpose of this study is to evaluate the relationship between intraocular pressure and central corneal thickness using various instruments in ocular hypertension, normal-tension glaucoma, primary open angle glaucoma…
- Conditions
- Glaucoma, Glaucoma, Open Angle, Ocular Hypertension, Keratoconus
- Trial name
- NCT00347191
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Aston University
Glaucoma, Primary Open Angle, Distress, Emotional
Treating Psychosocial Distress in Glaucoma
In this study, using three phases, the investigators will use an iterative development approach to refine a behavioral intervention for managing concomitant psychosocial distress in glaucoma.
- Conditions
- Glaucoma, Primary Open Angle, Distress, Emotional, Anxiety, Depression
- Trial name
- NCT06053307
- Testing
- Acceptance commitment therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Glaucoma, Open-Angle, Glaucoma
iStent Inject New Enrollment Post-Approval Study
Study to evaluate the rate of clinically relevant complications associated with iStent inject placement in the post-market setting.
- Trial name
- NCT04624698
- Testing
- iStent Inject Implantation
- Where
- 3 sites in United States
- Volunteers
- 358 people
- Sponsor
- Glaukos Corporation
Open Angle Glaucoma, Ocular Hypertension
SYL040012, Treatment for Open Angle Glaucoma
The purpose of this double-masked, randomized, controlled study is to assess the safety and ocular hypotensive efficacy of four different doses of SYL040012 (bamosiran) eye drops compared to Timolol maleate 0.5% after 28…
- Trial name
- SYLTAG (NCT02250612)
- Testing
- 1 drop of 0.375% SYL040012 (bamosiran), 1 drop of 0.750% SYL040012 (bamosiran), 1 drop of 1.125% SYL040012 (bamosiran)
- Where
- 21 sites in United States, Estonia and 2 more
- Volunteers
- 184 people
- Sponsor
- Sylentis, S.A.
Glaucoma, Open-Angle
A Comparison of Cataract Surgery Alone and Cataract Surgery With iStent
This study aims to recruit patients of the Glaucoma Investigative and Research Unit (GIRU) of Royal Victorian Eye and Ear Hospital (RVEEH) with mild to moderate glaucoma who are due to undergo cataract surgery and randomise each…
- Trial name
- NCT03106181
- Testing
- iStent inject®, Phacoemulsification and intraocular lens implant
- Where
- Australia
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Royal Victoria Eye and Ear Hospital
Glaucoma, Primary Open Angle
Evaluation the Safety and Effectiveness of the GORE GDI in Adult Subjects With Primary Open-angle Glaucoma in Whom Previous Medical and Surgical Treatment Have Failed.
Evaluation the Safety and Effectiveness of the GORE GDI in Adult Subjects With Primary Open-angle Glaucoma in Whom Previous Medical and Surgical Treatment Have Failed.
- Trial name
- NCT07880132
- Testing
- GORE Glaucoma Drainage Implant
- Volunteers
- 70 people
- Sponsor
- Gore Ophthalmic
Ocular Hypertension, Open Angle Glaucoma
Effect of SIMBRINZA® Suspension as an Added Therapy to TRAVATAN Z®
The purpose of this study is to demonstrate the additive effect of brinzolamide 1%/brimonidine 0.2% (SIMBRINZA® suspension) in subjects with either open angle glaucoma or ocular hypertension who are currently on a prostaglandin…
- Trial name
- NCT01937299
- Testing
- Brinzolamide 1%/brimonidine 0.2% ophthalmic suspension, Vehicle, Travoprost 0.004% ophthalmic solution
- Volunteers
- 307 people
- Sponsor
- Alcon Research
Primary Open Angle Glaucoma
A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma
The purpose of this research study is to assess the ability of AMDX- 2011P to identify amyloid deposits in the retina of participants with Primary Open Angle Glaucoma (POAG).
- Trial name
- NCT06223048
- Testing
- AMDX-2011P
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Amydis Inc.
Glaucoma, Open-Angle, Ocular Hypertension
An Observational Study of Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) Who Switched IOP-lowering Treatments
This study is a prospective, observational study of changing from any IOP-lowering treatment to a prostaglandin analogue-containing IOP-lowering medication for patients with Primary Open Angle Glaucoma (POAG) or Ocular…
- Trial name
- NCT01735214
- Testing
- Prostaglandin Analogue -Containing IOP-Lowering Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 358 people
- Sponsor
- Allergan
Primary Open Angle Glaucoma, Exfoliation Syndrome
24-Hour Intraocular Pressure (IOP) Control With Travoprost/Timolol Fixed Combination
The purpose of this study is to compare the short-term (8 week) mean 24-hour intraocular pressure control and safety of TravTim fixed combination given once in the evening with placebo once in the morning versus TravTim given…
- Trial name
- NCT00331240
- Testing
- travoprost/timolol fixed combination
- Where
- Greece
- Volunteers
- 32 people
- Sponsor
- Aristotle University Of Thessaloniki
Primary Open-angle Glaucoma
SIGHT Study: Cost-effectiveness of InnFocus Microshunt Implantation vs. Trabeculectomy.
The standard surgical treatment for glaucoma is trabeculectomy. The PRESERFLO™ (formerly InnFocus) Microshunt (IMS) is a new, minimally invasive drainage device which has been suggested to result in similar IOP lowering, but with…
- Trial name
- SIGHT (NCT03931564)
- Testing
- PRESERFLO Microshunt implantation, Trabeculectomy
- Where
- Netherlands
- Volunteers
- 124 people
- Sponsor
- Maastricht University Medical Center
Ocular Hypertension, Open Angle Glaucoma
Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED)
To evaluate if preservative free cosopt is well tolerated in patients with Open angle glaucoma (OAG) or Ocular hypertension (OH) with dry eyes.
- Trial name
- DISCOVER (NCT00545064)
- Testing
- dorzolamide hydrochloride (+) timolol maleate
- Volunteers
- 176 people
- Sponsor
- Merck Sharp & Dohme LLC
Primary Open Angle Glaucoma
Visco-Circumferential-Suture-Trabeculotomy Versus Rigid Probe Viscotrabeculotomy in Primary Open Angle Glaucoma
Visco-Circumferential-Suture-Trabeculotomy versus Rigid probe Viscotrabeculotomy in Primary Open Angle Glaucoma.
- Trial name
- NCT05666440
- Testing
- Visco-Circumferential-Suture-Trabeculotomy in Primary Open Angle Glaucoma., Rigid probe Viscotrabeculotomy in Primary Open Angle Glaucoma.
- Volunteers
- 166 people
- Sponsor
- Mansoura University
Cataract, Ocular Hypertension
Evaluation of the Safety and Effectiveness of the Bimatoprost Implant System / IOL Combination in Patients With Ocular Hypertension or Mild to Moderate Open-angle Glaucoma
The goal of this clinical trial is to learn if the SpyGlass Pharma Bimatoprost Implant System / IOL Combination works to treat cataracts and either ocular hypertension or glaucoma.
- Conditions
- Cataract, Ocular Hypertension, Glaucoma
- Trial name
- NCT07154797
- Testing
- Bimatoprost Implant System / IOL Combination
- Where
- Honduras
- Volunteers
- 24 people
- Sponsor
- SpyGlass Pharma, Inc.
Open-angle Glaucoma
24-hour Study of Dorzolamide/Timolol and Latanoprost/Timolol Fixed Combinations
The primary objective of this crossover trial is to compare the 3-month mean 24-hour intraocular pressure (IOP) control and safety of dorzolamide/timolol fixed combination (DTFC) given twice daily, versus latanoprost/timolol…
- Trial name
- NCT00397241
- Testing
- Drug: dorzolamide/timolol, Drug: latanoprost/timolol, dorzolamide/timolol and latanoprost
- Where
- Greece
- Volunteers
- 33 people
- Sponsor
- Aristotle University Of Thessaloniki
Glaucoma, Open-Angle, Ocular Hypertension
A 5-Year Postmarketing Safety Study Of Xalcom In Patients With Open Angle Glaucoma Or Ocular Hypertension
To estimate the frequency of patients with ocular/periorbital adverse events. To identify any possible long-term adverse consequences of increased iris pigmentation and to follow serious adverse events throughout the study period.
- Trial name
- NCT00150267
- Testing
- Xalacom
- Where
- 74 sites in Australia, Belgium and 10 more
- Volunteers
- 976 people
- Sponsor
- Pfizer
Glaucoma, Open-Angle
Study of OMNI Surgical System and iStent for Eyes With OAG (Trident)
First, to compare safety and effectiveness outcomes for canaloplasty and trabeculotomy using the OMNI Surgical System to implantation of the iStent inject in lowering intraocular pressure (IOP) in pseudophakic eyes with open…
- Trial name
- NCT04658095
- Testing
- Canaloplasty and trabeculotomy with the OMNI system., iStent inject, Canaloplasty
- Where
- 5 sites in Germany, Spain and 1 more
- Volunteers
- 10 people
- Sponsor
- Sight Sciences, Inc.
Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma
Testing a Reading Module to Improve Reading Skills and Quality of Life in Glaucoma Patients
The goal of this interventional study is to test the effectiveness of reading rehabilitation module towards reading speed and error, and quality of life in glaucoma patients.The main questions it aims to answer are: 1.
- Conditions
- Primary Open Angle Glaucoma (POAG), Juvenile Open Angle Glaucoma, Normotensive Glaucoma, Primary Angle Closure Glaucoma
- Trial name
- NCT07741812
- Testing
- Reading Rehabilitation Module
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- Universiti Sains Malaysia
Glaucoma, Open-Angle, Suprachoroidal Space
Safety and Efficacy of Suprachoroidal Tube Shunt in Patients With Primary Open and Pseudoexfoliation Glaucomas
To assess safety and efficacy of a novel suprachoroidal silicone tube (SST) shunt for the treatment of primary open angle and exfoliative glaucomas.
- Conditions
- Glaucoma, Open-Angle, Suprachoroidal Space, Pseudo Exfoliation Syndrome
- Trial name
- NCT06154330
- Where
- Georgia
- Volunteers
- 91 people
- Sponsor
- Davinci LTD
Glaucoma, AMD
A Real-World Study of Interventional Clinical Outcomes in Patients With Open Angle Glaucoma and Other Chronic Eye Diseases
This is a real world investigation of patient who have undergone treatments for chronic eye conditions such as glaucoma and AMD.
- Conditions
- Glaucoma, AMD, Diabetic Retinopathy (DR)
- Trial name
- NCT07216677
- Testing
- Chronic Disease Intervention CDI
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Interstat LLC
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