Clinical trials: Open Angle Glaucoma -Ocular Hypertension
Open-Angle Glaucoma, Ocular Hypertension
Efficacy and Safety Study of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% and Brimonidine 0.2%
The purpose of this study was to evaluate the efficacy and safety of a fixed combination of Brinzolamide/Brimonidine in lowering intraocular pressure (IOP) relative to each of its individual active components in patients with…
- Trial name
- NCT01297517
- Testing
- Brinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension, Brinzolamide ophthalmic suspension, 1%, Brimonidine tartrate ophthalmic solution, 0.2%
- Volunteers
- 1,001 people
- Sponsor
- Alcon Research
Congenital Glaucoma
Comparison Between Deep Sclerectomy and Traditional Trabeculotomy & Trabeculectomy in Congenital Glaucoma
The investigators hypothesize that deep sclerectomy in congenital glaucoma is a safer procedure and may yield better results than trabeculotomy trabeculectomy approach.
- Trial name
- NCT01460017
- Testing
- Deep Sclerectomy, Combined Trab
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- King Saud University
Glaucoma, Glaucoma, Open-Angle
The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients
Glaucoma represents a group of conditions that cause damage to the optic nerve and can lead to irreversible vision loss. Current treatments are aimed at lowering intraocular pressure while minimizing medication side effects.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma; Drugs, Droopy Eyelid
- Trial name
- NCT04007276
- Testing
- brimonidine tartrate ophthalmic solution 0.025%, sterile balanced saline solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tulane University
Glaucoma, Open-angle, Ocular Hypertension
A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to evaluate the intraocular pressure(IOP)-lowering efficacy of a combination IOP-lowering therapy in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00311389
- Testing
- Travoprost 0.004%/Timolol maleate 0.5% ophthalmic solution, Latanoprost 0.005%/Timolol 0.005% ophthalmic solution
- Where
- Belgium
- Volunteers
- 408 people
- Sponsor
- Alcon Research
Open Angle Glaucoma, Ocular Hypertension
Diurnal and Nocturnal Effect of Travatan With SofZia Preservative on Intraocular Pressure and Ocular Perfusion Pressure
The purpose of this research study is to determine the diurnal and nocturnal effects of Travoprost with SofZia (Travatan Z) on intraocular pressure and ocular perfusion pressure.
- Trial name
- NCT01779778
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)
Visual Outcomes of Vivity in Patients With Well Controlled Glaucoma
Glaucoma is a progressive optic neuropathy that results in a loss of contrast sensitivity and visual field if not detected and treated.
- Trial name
- NCT05075226
- Testing
- Vivity Extended Depth of Focus
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Cataract, Glaucoma, Open-Angle
Phaco-UCP Versus Phaco Alone for OAG and Cataract
This study was carried out to evaluate the safety and efficacy of combined phacoemulsification and Ultrasound ciliary plasty (Phaco-UCP) as a first-line surgical treatment of coexisting cataract and op /en angle glaucoma compared…
- Trial name
- NCT04430647
- Testing
- combined phacoemulsification and ultrasound ciliary plasty (Phaco-UCP), Phacoemulsification alone
- Where
- Egypt
- Volunteers
- 61 people
- Sponsor
- Ameera Gamal Abdelhameed
Open-angle Glaucoma, Ocular Hypertension
A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to determine whether a glaucoma therapy is safe and effective in treating patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00314158
- Testing
- Brinzolamide 10 mg/ml + Timolol 5 mg/ml eye drops, suspension, Brinzolamide 10 mg/ml (AZOPT) eye drops, suspension, Timolol 5 mg/ml eye drops, solution
- Where
- United States
- Volunteers
- 523 people
- Sponsor
- Alcon Research
Open-angle Glaucoma (OAG)
5-Year Postoperative Outcomes of Patients Who Completed the CREST Study
This study is designed to collect clinical data at 3, 4, and 5 years postoperatively for participants who completed the CREST Study without having secondary IOP-lowering surgery in the study eye(s).
- Trial name
- CREST-XT (NCT07480343)
- Testing
- CycloPen Micro-Interventional Cyclodialysis System, CycloPen Micro-Interventional Cyclodialysis System Post Cataract
- Where
- 10 sites in United States
- Volunteers
- 250 people
- Sponsor
- Iantrek, Inc.
Glaucoma, Open-Angle, Exercise Training
Exercise Training in Patients With Glaucoma
HIT GLAUCOMA is a multicenter exercise study for glaucoma patients between three institutes: the Department of Sport, Exercise and Health (DSBG) of the University of Basel, the Eye Clinic at the University Hospital Basel and the…
- Conditions
- Glaucoma, Open-Angle, Exercise Training, Microvascular Health
- Trial name
- HIT GLAUCOMA (NCT06058598)
- Testing
- Exercise Training, Lifestyle Counselling
- Where
- Switzerland
- Volunteers
- 168 people
- Sponsor
- Henner Hanssen
Open-angle Glaucoma
Two Trabecular Micro-bypass Stents & Postoperative Travoprost to Treat Glaucoma Subjects on Two Hypotensive Agents
The study objective was to evaluate the intraocular pressure (IOP) lowering effect of two iStent devices in eyes of subjects with primary open-angle glaucoma, washed out of two anti-glaucoma medications (one a Prostaglandin)…
- Trial name
- NCT02873806
- Testing
- Implantation of two iStent inject micro-bypass stents, Topical travoprost, Two iStent inject micro-bypass stents
- Where
- Armenia
- Volunteers
- 53 people
- Sponsor
- Glaukos Corporation
Pediatric Glaucoma
Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma
The purpose of this study is to compare the success rates and complications of two models of Ahmed glaucoma implants (FP7 and FP8) in patients with pediatric glaucoma.
- Trial name
- NCT01494974
- Testing
- FP7 Ahmed Glaucoma Drainage Implant, FP8 Glaucoma Drainage Implant
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Glaucoma, Open-Angle, Glaucoma, Narrow Angle
Clinical Study Evaluating the Efficacy and Safety of CID v2.2 in Glaucoma Surgery
The purpose of this study is to evaluate the safety and effectiveness of implanting a new version of an interposition supraciliary implant (SV22) as a stand-alone therapy for lowering intraocular pressure (IOP) in patients with…
- Trial name
- SAFARI4 (NCT05625958)
- Testing
- Cilioscleral Interposition Device
- Where
- 5 sites in Spain
- Volunteers
- 29 people
- Sponsor
- Ciliatech
Primary Open-angle Glaucoma, Glaucoma
Assessment of Endothelial Glycocalyx in Patients With Primary Open-angle Glaucoma
The glycocalyx is a fibrillary lining structure that covers the inner surface of blood vessels. Composed of glycoproteins and polysaccharides, it is an essential determinant of vascular endothelial physiology: it limits…
- Trial name
- GLAUCALYX (NCT05264818)
- Testing
- Glycocheck, Ophthalmological examinations
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Open-angle Glaucoma, Oular Hypertension
Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study was to evaluate the safety and intraocular-lowering efficacy of anecortave acetate depot when administered by anterior juxtascleral depot (AJD) for the treatment of elevated intraocular pressure (IOP) in…
- Trial name
- NCT00691717
- Testing
- Anecortave Acetate Sterile Suspension, 30 mg/mL, Anecortave Acetate Sterile Suspension, 60 mg/mL, Anecortave Acetate Sterile Suspension, 75 mg/mL
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Alcon Research
Glaucoma, Eye Diseases
A Prospective, Unmasked Evaluation of the iStent in Patients With Primary Open-Angle Glaucoma
Prospective, unmasked, evaluation of the iStent in patients that have primary open-angle glaucoma (OAG). Stent implantation in one eye will be used for analysis, with medication added at 6 months, as required.
- Conditions
- Glaucoma, Eye Diseases, Glaucoma, Open-Angle
- Trial name
- SY (NCT00911924)
- Testing
- iStent
- Where
- 13 sites in Armenia, Austria and 4 more
- Volunteers
- 112 people
- Sponsor
- Glaukos Corporation
Glaucoma, Open-Angle
Nailfold Capillary Blood Flow With Latanoprost Bunod
The purpose of this study is to look at the relationship of small blood vessels irregularities observed with an imaging system called video nailfold capillaroscopy in people with primary open-angle glaucoma.
- Trial name
- NCT03949244
- Testing
- Latanoprost 0.005%, Latanoprost bunod 0.024%, Normal saline 0.9%
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Glaucoma, Primary Open Angle, Ocular Hypertension
A Study of Patients With Primary Open Angle Glaucoma or Ocular Hypertension Switched to Lumigan® UD Monotherapy for Medical Reasons
The study will evaluate patients diagnosed with primary open angle glaucoma or ocular hypertension who are switched to Lumigan® UD monotherapy for medical reasons in accordance with physician standard clinical practice.
- Trial name
- NCT01853085
- Testing
- Bimatoprost Ophthalmic Solution
- Where
- Germany
- Volunteers
- 1,830 people
- Sponsor
- Allergan
Glaucoma, Open-Angle, Ocular Hypertension
Distribution of Risk Factors in Ocular Hypertension and Open-Angle Glaucoma Patients in Canada
This descriptive, non-interventional study will collect information on the presence of risk factors in newly diagnosed ocular hypertension and open-angle glaucoma patients in Canada.
- Trial name
- NCT00334750
- Testing
- There is no intervention in this study.
- Where
- 21 sites in Canada
- Volunteers
- 410 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Open-angle Glaucoma, Ocular Hypertension
AGN-193408 SR in the Treatment of Open-angle Glaucoma or Ocular Hypertension
This is a multicenter, open-label, dose escalation (Cohort 1) to masked, randomized, parallel-groups (Cohort 2) and (Cohort 3) study to evaluate the safety and efficacy of AGN-193408 SR in participants with open-angle glaucoma or…
- Trial name
- NCT04499248
- Testing
- AGN-193408 SR, Lumigan, Lumigan Vehicle
- Where
- 49 sites in United States, Japan
- Volunteers
- 100 people
- Sponsor
- AbbVie
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.