Clinical trials: Open Angle Glaucoma -Ocular Hypertension
Primary Open Angle Glaucoma, Ocular Hypertension
Study of the Intraocular Pressure (IOP)-Lowering Efficacy of Azopt 1.0% Compared to Timolol 0.5% in Patients With Glaucoma or Ocular Hypertension
This is a multiple-dose study of the IOP-lowering efficacy of Azopt (brinzolamide) 1.0% compared to timolol 0.5% when added to a prostaglandin analogue (PGA) as adjunctive therapy over a 24 hour period in patients with glaucoma…
- Trial name
- NCT00300079
- Testing
- brinzolamide 1.0%
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alcon Research
Primary Open Angle Glaucoma, Primary Open-Angle Glaucoma, Unspecified Eye
Glaucoma Screening Using Dynamic Analysis of Computerized Pupillary Light Reflex Assessment Device
To explore an effective diagnostic tool of glaucoma through the dynamic analysis of computerized pupillary light reflex assessment device (CPLRAD) pupillography based on iris recognition techniques and investigate its feasibility…
- Conditions
- Primary Open Angle Glaucoma, Primary Open-Angle Glaucoma, Unspecified Eye, Primary Open Angle Glaucoma of Both Eyes, Suspect Glaucoma
- Trial name
- NCT04595227
- Testing
- Computerized pupillary light reflex assessment device
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University
Open Angle Glaucoma or Ocular Hypertension
A Phase III Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution Compared With Latanoprost Ophthalmic Solution in Subjects With OAG or OHT
The purpose of this study is to investigate the intraocular pressure-lowering effect and the safety of DE-117 ophthalmic solution compared with Latanoprost ophthalmic solution in subjects with open angle glaucoma or ocular…
- Trial name
- NCT02981446
- Testing
- DE-117, Latanoprost ophthalmic solution
- Where
- Singapore
- Volunteers
- 370 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Open Angle Glaucoma, Narrow Angles
Comparison of Gonioscopy With Cirrus and Visante
The aim of this study is to analyze similarities and evaluate interchangeability of Visante and Cirrus OCT (optical coherent tomography)and to compare agreement between gonioscopy and the two systems for evaluation of anterior…
- Conditions
- Open Angle Glaucoma, Narrow Angles, Angle Closure Glaucoma
- Trial name
- ASOCT (NCT01895686)
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Wills Eye
Primary Open Angle Glaucoma, Ocular Hypertension
Comparison of Brimonidine Purite, Dorzolamide, and Brinzolamide as Adjunctive Therapy to Prostaglandin Analogs
The purpose of this study is to compare the efficacy of brimonidine Purite, dorzolamide, and brinzolamide in reducing intraocular pressure when added to prostaglandin analog therapy (bimatoprost, latanoprost, or travoprost) in…
- Trial name
- NCT00675207
- Testing
- Brimonidine purite 0.15%, Dorzolamide 2%, Brinzolamide 1%
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern Ophthalmic Institute S.C.
Glaucoma, Glaucoma, Open-Angle
Longitudinal Study on Glaucoma Surgery Using XEN® Gel Stent
To evaluate the safety and efficacy of the XEN® Gel Stent in mild to moderate glaucoma patients undergoing glaucoma surgery.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Primary Open Angle
- Trial name
- NCT03151577
- Testing
- XEN® Gel Stent implantation
- Volunteers
- 150 people
- Sponsor
- Swiss Vision Network
Open Angle Glaucoma
Comparative Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma
The primary objectives of the study are: 1. To compare the proportion of patients who achieve a successful response to treatment (reduction in Intraocular Pressure (IOP) of >15%) between patients treated with laser surgery…
- Trial name
- RiGOR (NCT01645319)
- Where
- United States
- Volunteers
- 2,597 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Glaucoma, Open-Angle
Early Evaluation of the Beacon Aqueous Microshunt in Patients Refractory to Drug Therapy in the European Union
This is prospective, non-randomized, single-arm study to assess the safety and effectiveness of lowering intraocular pressure with the Beacon Aqueous Microshunt. A total of 65 subjects will be enrolled at five centers.
- Trial name
- EARLY BIRD EU (NCT03634319)
- Testing
- Beacon Aqueous Microshunt
- Where
- 2 sites in Germany
- Volunteers
- 10 people
- Sponsor
- MicroOptx
Glaucoma, Open-Angle
Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% to LUMIGAN® In The Treatment of Chronic Open-Angle Glaucoma
This is a randomized, double-masked, two-treatment, single-period, parallel design, multiple dose at multiple clinical trial sites designed to demonstrate bioequivalence with clinical endpoint in subjects with chronic open-angle…
- Trial name
- Glaucoma (NCT04890106)
- Testing
- Test - Bimatoprost 0.01% Ophthalmic Solution, Reference - LUMIGAN® (Bimatoprost 0.01% Ophthalmic Solution)
- Where
- 9 sites in United States
- Volunteers
- 310 people
- Sponsor
- Mankind Pharma Limited
Glaucoma
Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin Tartrate
This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently…
- Trial name
- NCT06730516
- Testing
- Latanoprost (Xalatan), Brimonidine 0.2 %
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
OAG - Open-Angle Glaucoma, OHT - Ocular Hypertension
Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension
Firecrest study is evaluating the intraocular pressure (IOP)-lowering effect, safety, and tolerability of Qlaris' preservative free [PF], fixed-dose combination [FDC] investigational product (IP) in subjects with open-angle…
- Trial name
- Firecrest (NCT07354516)
- Testing
- QLS-111-FDC, Latanoprost (0.005%)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Qlaris Bio, Inc.
Glaucoma, Open-Angle, Ocular Hypertension
Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
This study will evaluate the safety and efficacy of Triple Combination Therapy compared with Fixed Combination brimonidine tartrate/timolol ophthalmic solution in patients with primary open-angle glaucoma or ocular hypertension.
- Trial name
- NCT01241240
- Testing
- bimatoprost/brimonidine tartrate/timolol ophthalmic solution (Triple Combination Therapy), Fixed Combination 0.2% brimonidine tartrate/0.5% timolol ophthalmic solution
- Where
- 2 sites in Colombia, Mexico
- Volunteers
- 192 people
- Sponsor
- Allergan
Glaucoma, Open-Angle, Glaucoma, Primary Open Angle
Following Patients After Selective and Pascal Laser Trabeculoplasty for Treatment of Chronic Open-Angle Glaucoma
The purpose of this study is to follow and describe the outcomes of patients after selective and pascal laser trabeculoplasty treatment for chronic open-angle glaucoma.
- Conditions
- Glaucoma, Open-Angle, Glaucoma, Primary Open Angle, Exfoliation Glaucoma, Glaucoma, Pigmentary
- Trial name
- FPSPLTTCOAG (NCT02679482)
- Where
- Colombia
- Volunteers
- 36 people
- Sponsor
- Fundación Oftalmológica Nacional
Ocular Hypertension, Open Angle-glaucoma
A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)
The primary objectives of this study are to compare the safety, tolerability, and mean change from baseline in diurnal intraocular pressure (IOP) of ONO-9054 30 µg/mL (0.003%) to latanoprost 0.005% following ocular instillation…
- Trial name
- NCT02083289
- Testing
- ONO-9054, Latanoprost
- Where
- 12 sites in United States
- Volunteers
- 123 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Glaucoma, Primary Open Angle, Ocular Hypertension
Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
The purpose of this study is to compare the efficacy and tolerance of generic travoprost with its brand name formulation. In this open label, randomized, crossover study, the primary outcome will be intraocular pressure and the…
- Trial name
- NCT02796560
- Testing
- Brand name travoprost, Generic travoprost
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Université de Sherbrooke
Open Angle Glaucoma, Ocular Hypertension
DE-111 Against Tafluprost Ophthalmic Solution 0.0015% Alone and Concomitant Use of Tafluprost Ophthalmic Solution 0.0015% Plus Timolol Ophthalmic Solution 0.5%
DE-111 ophthalmic solution will be evaluated for superiority in comparison with Tafluprost 0.0015% ophthalmic solution, or for non-inferiority in comparison with Tafluprost 0.0015% and Timolol ophthalmic solution 0.5% used…
- Trial name
- NCT01342081
- Testing
- DE-111 ophthalmic solution, Tafluprost ophthalmic solution 0.0015%, Concomitant use of tafluprost ophthalmic solution 0.0015% plus timolol ophthalmic solution 0.5%
- Where
- Japan
- Volunteers
- 489 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Macular Degeneration, Dry, Primary Open-angle Glaucoma
Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study
It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems.
- Trial name
- NCT03921931
- Testing
- White light stimulation
- Where
- Austria
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Open-Angle Glaucoma, Ocular Hypertension
Cosopt Versus Xalatan
To compare the 24-hour efficacy and safety, measured every three hours, of the dorzolamide/timolol fixed combination given twice daily versus latanoprost and placebo each given once daily.
- Trial name
- NCT00273429
- Testing
- timolol maleate 0.5%, dorzolamide/timolol maleate fixed combination, latanoprost 0.005%
- Where
- 2 sites in United States
- Sponsor
- Pharmaceutical Research Network
Iris Diseases
Electron Microscopic Examination of Iris Tissue in Buphthalmos
To revise the etiology of the primary congenital glaucoma in some infants.
- Trial name
- NCT07034651
- Testing
- Combined trabeculotomy trabeculectomy with mitomycin C
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Assiut University
Vitamin D Deficiency, Primary Open-angle Glaucoma
Comparison of Vitamin D Status and Vitamin D Receptor Polymorphisms in Patients With High Myopia and Primary Open-angle Glaucoma
Vitamin D deficiency is known to be significantly associated with high myopia. This study investigated the vitamin D status in patients with high myopia and primary open-angle glaucoma, in order to understand the relationship…
- Conditions
- Vitamin D Deficiency, Primary Open-angle Glaucoma, High Myopia, Vitamin D Receptor Polymorphisms
- Trial name
- NCT03021629
- Testing
- Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Lv Yingjuan
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