Clinical trials: Open Angle Glaucoma -Ocular Hypertension
Open-angle Glaucoma, Ocular Hypertension
Travoprost 0.004%/Timolol 0.5% Versus Latanoprost 0.005%/Timolol in Chinese Patients With Open-Angle Glaucoma or Ocular Hypertension
Eligible patients will be randomized in a 1.1 ratio to receive Travoprost 0.004%/timolol 0.5% once daily or Latanoprost 0.005%/Timolol 0.5% once a day for 8 Weeks.
- Trial name
- NCT00872651
- Testing
- Travoprost 0.004%/Timolol 0.5%, Latanoprost 0.005% / Timolol 0.5%
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Alcon Research
Angiography, Glaucoma, Open-Angle
The Relationship Between Macular OCTA and GCIPL and Their Combinational Index Using AI
Macular GCIPLT and vessel density will be measured with Spectralis optical coherence tomography and Topcon swept-source OCT respectively.
- Trial name
- NCT03369886
- Testing
- Optical Coherence Tomography Angiography (OCTA)
- Where
- South Korea
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Eye Diseases, Glaucoma, Open-Angle
Evaluation of the iStent Versus Two Ocular Hypotensive Agents in Patients With Primary Open-angle Glaucoma (POAG)
Prospective, unmasked, randomized evaluation of the iStent in patients with primary open-angle glaucoma. Patients will be randomized to one of two groups: 1) iStent, or 2) medication.
- Conditions
- Eye Diseases, Glaucoma, Open-Angle, Glaucoma
- Trial name
- SL (NCT00913029)
- Testing
- iStent, latanoprost/timolol
- Where
- 16 sites in Armenia, Austria and 7 more
- Volunteers
- 192 people
- Sponsor
- Glaukos Corporation
Open-angle Glaucoma (OAG), Ocular Hypertension (OHT)
Direct vs Standard SLT for Glaucoma: A Noninferiority Trial
This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss.
- Trial name
- NCT07408154
- Testing
- Direct Selective laser Trabeculoplasty
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Medical University of South Carolina
Glaucoma, Cataract
Observational Study to Evaluate Long Term Outcomes for Ocular Hypertension and Glaucoma Patients Treated With the SpyGlass Bimatoprost Implant System / IOL Combination
The goal of this clinical trial is to further observe and learn if the SpyGlass Pharma Bimatoprost Implant System / IOL Combination works to treat cataracts and either ocular hypertension or glaucoma.
- Conditions
- Glaucoma, Cataract, Ocular Hypertension
- Trial name
- NCT07154810
- Where
- Honduras
- Volunteers
- 23 people
- Sponsor
- SpyGlass Pharma, Inc.
Primary Open-Angle Glaucoma (POAG)
MEXIDOL® Sequential Therapy of Patients With Primary Open-angle Glaucoma (POAG)
Hypothesis: The use of neurocytoprotectors helps restore the functional activity of mitochondria, improve the nervous activity of the retina and optic nerve, and stabilize the glaucomatous process.
- Trial name
- NCT06437639
- Testing
- Mexidol
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Pharmasoft
Primary Open-Angle Glaucoma, Ocular Hypertension
Dose-Ranging Study of the Bimatoprost Ocular Insert
The Bimatoprost Ocular Insert is intended to provide sustained delivery of bimatoprost to the ocular surface to lower the intraocular pressure (IOP) in patients with Open-Angle Glaucoma or Ocular Hypertension.
- Trial name
- NCT02358369
- Testing
- Bimatoprost, Timolol 0.5%
- Where
- 10 sites in United States
- Volunteers
- 156 people
- Sponsor
- ForSight Vision5, Inc.
Primary Open-Angle Glaucoma (POAG), Ocular Hypertension (OHT)
Study of Trabodenoson in Adults With Ocular Hypertension or Primary Open-angle Glaucoma
Phase III trial involving topical application, in both eyes, of trabodenoson ophthalmic formulation 3.0% or 6.0% once per day or 4.5% twice per day, placebo twice per day, or timolol 0.5% twice per day for 12 weeks in adult…
- Trial name
- MATrX-1 (NCT02565173)
- Testing
- trabodenoson 4.5% BID, trabodenoson 6.0% QD, trabodenoson 3.0% QD
- Where
- United States
- Volunteers
- 303 people
- Sponsor
- Inotek Pharmaceuticals Corporation
Glaucoma
A Clinical Study Comparing the Inflammatory Response of the Ex-Press Mini Shunt to Trabeculectomy
The less invasive nature of the Ex-Press Mini shunt with mitomycin C induces less post-operative inflammation than trabeculectomy with mitomycin c.
- Trial name
- Optonol (NCT00597181)
- Testing
- Trabeculectomy with mitomycin c, Ex-Press mini shunt with mitomycin c
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Obstructive Sleep Apnoea, Primary Open-angle Glaucoma
PAIR Study-PAP And IOP Relationship: Study 2
Some people with Primary Open-angle Glaucoma (POAG) also suffer from Obstructive Sleep Apnoea (OSA), a common sleep disorder which is known to affect heart and blood vessels, and may contribute to glaucoma progression.
- Trial name
- PAIR2 (NCT03145129)
- Testing
- Continuous Positive Airway Pressure
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Glaucoma, Primary Open Angle Glaucoma
Ahmed Glaucoma Valve Surgery With Mitomycin-C
This study will determine the effectiveness of Mitomycin-C use in the glaucoma surgery Ahmed valve implantation. Approximately 100 patients will be enrolled, with half receiving the Mitomycin-C treatment and the other half…
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Secondary Glaucoma, Neovascular Glaucoma
- Trial name
- AMCT (NCT02805257)
- Testing
- Mitomycin-C, Balanced Salt Solution, Ahmed Glaucoma Valve Implant
- Where
- 4 sites in United States, China and 2 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Open Angle Glaucoma, Ocular Hypertension
A Long Term Study of STN1012600 in Subjects With Open Angle Glaucoma or Ocular Hypertension
To evaluate safety and the ocular hypotensive effect of STN1012600 ophthalmic solution 0.002% alone or in combination with Timolol ophthalmic solution 0.5% for 52 weeks in subjects with open angle glaucoma or ocular hypertension.
- Trial name
- NCT05503901
- Testing
- STN1012600 ophthalmic solution 0.002%, STN1012600 ophthalmic solution 0.002% and Timolol ophthalmic solution 0.5%
- Where
- 18 sites in Japan
- Volunteers
- 131 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Glaucoma, Open-Angle
Early Evaluation of the Beacon Aqueous Microshunt in Patients Refractory to Drug Therapy in the European Union
This is prospective, non-randomized, single-arm study to assess the safety and effectiveness of lowering intraocular pressure with the Beacon Aqueous Microshunt. A total of 65 subjects will be enrolled at five centers.
- Trial name
- EARLY BIRD EU (NCT03634319)
- Testing
- Beacon Aqueous Microshunt
- Where
- 2 sites in Germany
- Volunteers
- 10 people
- Sponsor
- MicroOptx
Glaucoma, Cataract
Evaluation of Microinvasive Glaucoma Surgery: MINIject® Versus Hydrus® Microstent in Combination With Cataract Surgery
The study aims to investigate postoperative outcomes after two different MIGS implants (MINIject or Hydrus) in combination with cataract surgery for patients with glaucoma.
- Trial name
- MINHY (NCT06844292)
- Testing
- MINIject with Cataract Surgery, Hydrus Microstent with Cataract Surgery
- Where
- Austria
- Volunteers
- 152 people
- Sponsor
- Medical University of Graz
Glaucoma, Open-Angle
Travoprost Intraocular Implant + iStent Infinite
Adult subjects with elevated intraocular pressure will be randomized to receive iStent infinite trabecular bypass system plus a travoprost intraocular implant or receive a sham procedure plus a travoprost intraocular implant and…
- Trial name
- NCT06066645
- Testing
- Travoprost Intraocular Implant, iStent infinite
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Glaukos Corporation
Glaucoma, Ocular Hypertension
Safety and Efficacy of Brinzolamide Dosed TID With Dorzolamide Dosed TID in Reducing Intraocular Pressure in Patients With Open Angle Glaucoma or Ocular Hypertension
Safety and Efficacy of Brinzolamide Dosed TID With Dorzolamide Dosed TID in Reducing Intraocular Pressure in Patients With Open Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT00761995
- Testing
- Azopt, Cosopt
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Alcon Research
Glaucoma, Glaucoma, Open-Angle
Clinical Study of Glaukos® Trabecular Micro-Bypass System Model iS3 Infinite Vs. Competitor
A study of the iStent Infinite product in the treatment of open-angle glaucoma vs competitor
- Trial name
- NCT05127551
- Testing
- iStent Infinite, Competitor Device
- Where
- Canada
- Volunteers
- 179 people
- Sponsor
- Glaukos Corporation
Primary Open-angle Glaucoma
Impact of Glaucoma and Visual Field Loss on Life Space
Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on…
- Trial name
- NCT03673644
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Alabama at Birmingham
Primary Open Angle Glaucoma, Ocular Hypertension
A Phase 2, Dose Finding Study of PF-03187207 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension.
To investigate dose response, safety and efficacy of PF-03187207 in patients with primary open-angle glaucoma or ocular hypertension
- Trial name
- NCT00595101
- Testing
- PF-03187207, Latanoprost 0.005%, PF-03187207 Vehicle
- Where
- 13 sites in Japan
- Volunteers
- 117 people
- Sponsor
- Bausch & Lomb Incorporated
Glaucoma, Glaucoma, Open-Angle
Treatment Outcomes of a Novel Glaucoma Tube Shunt Implant for Intraocular Pressure Control in Eyes With Refractory Glaucoma
The aim of this study is to determine the effectiveness of lowering intraocular pressure and safety profile of the Paul Glaucoma Implant (Advanced Ophthalmic Innovations, Singapore).
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Surgery, Intraocular Pressure
- Trial name
- NCT04297930
- Testing
- Paul Glaucoma Implant Surgery
- Where
- Singapore
- Volunteers
- 82 people
- Sponsor
- National University Hospital, Singapore
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