Clinical trials: Open Bite, open to volunteers
Acute Mild Basilar Artery Occlusion, Basilar Artery Occlusion
The Efficacy and Safety of Endovascular Treatment for Acute Mild Basilar Artery Occlusion
This study assesses the efficacy and safety of endovascular treatment for acute mild basilar artery occlusion within a multicenter, prospective, open-label, endpoint-blinded, randomized controlled clinical trial.
- Conditions
- Acute Mild Basilar Artery Occlusion, Basilar Artery Occlusion, Endovascular Treatment
- Trial name
- NCT07390032
- Testing
- Endovascular Recanalization Strategy, Best Medical Management
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Feng Gao
Atrial Fibrillation, Percutaneous Coronary Intervention
LAAO Versus NOAC in Patients with AF and PCI
Atrial fibrillation (AF) coincides with coronary artery disease (CAD) shared common risk factors and pathophysiologic pathways. CAD affects approximately 25% of AF patient according to the trial Atrial Fibrillation Follow-up…
- Trial name
- NCT05353140
- Testing
- The WATCHMAN/WATCHMAN FLX device, Rivaroxaban + Clopidogre, Aspirin + Clopidogrel
- Where
- China
- Volunteers
- 1,386 people
- Sponsor
- Xijing Hospital
Fertility, Fertility, Male
Plan A Occlusion and Reversal System Feasibility Study
Prospective, multicenter, single-arm, open label, interventional clinical trial investigating the safety and effectiveness of the Plan A Male Contraceptive System to occlude the vas deferens to block the passage of sperm and then…
- Conditions
- Fertility, Fertility, Male, Healthy Male Adults
- Trial name
- NCT07361120
- Testing
- Occlusion System
- Where
- 3 sites in Australia, Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Next Life Sciences
Multiple Myeloma, Newly Diagnosed
MRD-Adaptive Guided Immunotherapy With CAR-T for Transplant-Ineligible Patients With Multiple Myeloma
This is a prospective, single-center, clinical study to evaluate the efficacy and safety of a fully immunotherapy-based strategy guided by MRD-driven dynamic risk stratification in transplant-ineligible patients with newly…
- Trial name
- MAGIC-TIEMM (NCT07106736)
- Testing
- BCMA CAR-T, GPRC5D/CD3 BiTEs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Graft Patency
Study of Feasibility for Surgical Patients Undergoing Heart Surgery With the Mammary Arteries: Reviewing Infection, Occlusion Rates and Pain Assessments.
The Pilot study for the COMFORT Trial is a single centre trial to determine the feasibility of the full COMFORT Trial. The main COMFORT Trial will be a multi-centre trial to investigate the coronary artery bypass grafting…
- Trial name
- COMFORT pilot (NCT07599553)
- Testing
- Skeletonized vs non-skeletonized harvesting of the left internal mammary artery
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ischemic Stroke
Combined Thrombectomy for Distal MediUm Vessel Occlusion StroKe
A phase III, randomized, multi-center, investigational, open label clinical trial that will examine whether treatment with endovascular thrombectomy is superior to standard medical therapy alone in patients who suffer a Distal…
- Trial name
- DUSK (NCT05983757)
- Testing
- Experimental: endovascular thrombectomy in patients who suffer a distal medium vessel occlusion, Standard medical management
- Where
- 4 sites in United States
- Volunteers
- 584 people
- Sponsor
- Raul Nogueira
Aortic Aneurysm, Abdominal, Abdominal Aortic Occlusion
Liposomal Bupivacaine/Bupivacaine in Rectus Sheath Blocks Versus Ropivacaine in Rectus Sheath Blocks And Catheters
The goal of this pilot study is to compare single shot rectus sheath blocks of liposomal bupivacaine/bupivacaine mixture to bilateral rectus sheath catheters infused with ropivacaine (standard of care at our facility) in patients…
- Conditions
- Aortic Aneurysm, Abdominal, Abdominal Aortic Occlusion, Aortoiliac Occlusive Disease, Aortic Diseases
- Trial name
- EXODUS (NCT05972018)
- Testing
- Liposomal bupivacaine, Ropivacaine, Bupivacain
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hartford Hospital
Acute Ischemic Stroke
Intravenous Tirofiban After Bridging Therapy for Acute Stroke With Atherosclerotic Large Artery Occlusion
The investigators propose to assess the efficacy and safety of intravenous tirofiban after bridging therapy (endovascular therapy [EVT] following intravenous Tenecteplase) for acute ischemic stroke due to intracranial…
- Trial name
- RESCUE-AS (NCT07335107)
- Testing
- Intravenous Tirofiban, Standard Medical Therapy
- Where
- China
- Volunteers
- 564 people
- Sponsor
- Beijing Tiantan Hospital
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE3 (NCT07046299)
- Testing
- Endovascular Therapy Plus Best Medical Treatment, Best Medical Treatment Alone
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Capital Medical University
Multiple Myeloma (MM)
A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects
The main purpose of the study is to understand the safety and tolerability of cemsidomide when given along with elranatamab in subjects with relapsed or refractory multiple myeloma.
- Trial name
- NCT07280013
- Testing
- Cemsidomide, Elranatamab
- Where
- 20 sites in United States
- Volunteers
- 60 people
- Sponsor
- C4 Therapeutics, Inc.
Open Bite
Myofunctional Therapy in Open Bite - RCT
The goal of this clinical trial is to learn if myofunctional therapy in 6-10-year-old children with infant type of swallowing and open bite is effective.
- Trial name
- Myofunctional (NCT06574490)
- Testing
- Myofunctional therapy (+), Myofunctional therapy (-)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Piotr Fudalej
Stroke
Precision Reperfusion Therapy for Disabling Minor Stroke With Large Vessel Occlusion Beyond Time Window
To verify the efficacy and safety of intravenous tenecteplase (TNK) in patients with disabling minor stroke and large vessel occlusion (LVO) within a 4.5-24 hour time window.
- Trial name
- TIME-MINOR (NCT07476898)
- Testing
- Tenecteplase (0.25mg/kg), Standard Medical Management
- Where
- 30 sites in China
- Volunteers
- 864 people
- Sponsor
- First Hospital of China Medical University
Ischemic Stroke
Head dOwn Position Before Endovascular Treatment for Large veSsel Occlusion (HOPES5)
Recent studies suggest that head-down positioning (HDP) intervention may improve outcomes in ischemic stroke. In the era of reperfusion therapy, a key protective strategy is to administer neuroprotective interventions before…
- Trial name
- NCT07172789
- Testing
- head down position
- Where
- China
- Volunteers
- 210 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke
Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-BEYOND
The benefit-risk profile of thrombolysis for acute ischemic strokes beyond 24 hours has never been investigated. We initiated a multicenter, prospective, randomized, open label, blinded-endpoint (PROBE) controlled trial to assess…
- Trial name
- TRACE-BEYOND (NCT06954155)
- Testing
- Tenecteplase (0.25mg/kg), Standard medical treatment
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Beijing Tiantan Hospital
Ischemic Stroke
Direct Ischemic Conditioning for Endovascular Recanalization for Anterior Large Vessel Occlusion (DICER-aLVO)
Acute ischemic stroke (AIS) is the most common type of stroke, with high incidence rate and mortality. Endovascular therapy is currently the most effective treatment for AIS with large vessel occlusion, but only about 50% of…
- Trial name
- DICER-aLVO (NCT06940128)
- Testing
- Direct Ischemic Conditioning A, Direct Ischemic Conditioning B, Direct Ischemic Conditioning C
- Where
- China
- Volunteers
- 120 people
- Sponsor
- General Hospital of Shenyang Military Region
Stroke Acute, Thrombectomy
Thrombectomy Versus Best Medical Management in Large Vessel Occlusion Stroke Patients Presenting Beyond 24 Hours and With Presence of Collateral Flow on CT Angiography
The goal of this clinical trial is to investigate if endovascular treatment (EVT) can effectively treat patients with large vessel occlusion (LVO) who present beyond the typical 24-hour window after symptom onset.
- Conditions
- Stroke Acute, Thrombectomy, Medical Treatment, Large Vessel Occlusion
- Trial name
- NCT06654375
- Testing
- Endovascular Thrombectomy
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Tianjin Huanhu Hospital
Sleep Related Breathing Disorder, Snoring
IOA Preventing Occlusal Changes With MAD Use
This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive…
- Conditions
- Sleep Related Breathing Disorder, Snoring, Obstructive Sleep Apnea (OSA), Open Bite
- Trial name
- NCT07103941
- Testing
- AM Aligner, Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Isabel Moreno Hay
Acute Ischemic Stroke, Intracranial Atherosclerosis ICAS
Effect of Balloon Angioplasty vs Stenting Following Residual Stenosis After Endovascular Treatment of Intracranial Atherosclerotic Acute Ischemic Stroke
The ANGEL-ICAS trial is a multicenter, prospective, randomized, open-label, blinded-endpoint study designed to determine whether rescue balloon angioplasty is noninferior to rescue stenting in patients with intracranial…
- Trial name
- ANGEL-ICAS (NCT07026331)
- Testing
- balloon angioplasty, Stent
- Where
- China
- Volunteers
- 486 people
- Sponsor
- Beijing Anzhen Hospital
Anterior Open Bite in Mixed Dentition
Treatment Effects of Vertical Holding Appliance in Comparison to Zachrisson Transpalatal Arch on Anterior Open Bite Correction
The aim of the study is to assess the treatment effects of ZTPA versus VHA in the correction of anterior open bite in mixed dentition.
- Trial name
- NCT07379632
- Testing
- Zachrisson transpalatal arch, Vertical holding appliance
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Open Bite, Malocclusion Class I
Clinical Comparison of Clear Aligners and Fixed Appliances in Dental Anterior Open Bite
Dental anterior open bite is a challenging orthodontic condition with a high risk of relapse in adults. This randomized controlled clinical trial aims to compare the effectiveness and post-treatment stability of in-house clear…
- Trial name
- NCT07778108
- Testing
- In-House Clear Aligners, Fixed Orthodontic Appliances
- Volunteers
- 46 people
- Sponsor
- Sana'a University