Clinical trials: Open Fractures
Open tíbia Fracture
Minimally Invasive Locking Plate Fixation vs Reamed Intramedullary Nail Fixation on Patients With Open Tibia Fracture
The best treatment for the open tibia fractures remains controversial. It is unknown whether minimally invasive locking plate or reamed intramedullary nail fixation will result in lower complication rates and better function.
- Trial name
- NCT04072094
- Testing
- Minimally Invasive Locking Plate Fixation, Intramedullary Nail Fixation
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hip Fractures
Regional Anesthesia by PENG-Block in Emergency Department
The study is a single-centre, open-label randomized comparative trial. Adult patients admitted to the emergency department for a hip fracture will be enrolled.
- Trial name
- ED-PENGBLOCK (NCT05673486)
- Testing
- PENG Block, Multimodal analgesia
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Mandibular Fractures, Symphysis Fractures
Evaluation of Pin Buckle Bone Plates for Management of Anterior Mandibular Fractures
This randomized clinical study aims to evaluate the clinical and radiographic outcomes of a novel Pin Buckle bone plate compared with conventional two-miniplate fixation for the management of anterior mandibular (symphysis and…
- Conditions
- Mandibular Fractures, Symphysis Fractures, Parasymphysis Fractures
- Trial name
- NCT07736430
- Testing
- Pin Buckle Bone Plate, Conventional Titanium Miniplates
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Proximal Humeral Fracture
Orthopaedic Treatment Proximal Humeral Fractures
Prospective non-randomized, open, unicentric observational study to compare two different treatments for Three-four parts fractures of proximal humerus (Neer's Classification) in elderly patients (over 75 years old).
- Trial name
- NCT03339570
- Testing
- Orthopedic treatment for a proximal humeral fracture
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Mikel Aburto
Ankle Fractures
Arthroscopic Assisted Open Reduction Internal Fixation Versus Open Reduction Internal Fixation in Ankle Fractures
The objective of this study is to compare the functional outcomes of patients with ankle fractures treated by Arthroscopic assisted Open Reduction Internal Fixation (AORIF) versus Open Reduction Internal Fixation (ORIF).
- Trial name
- NCT03084263
- Testing
- Arthroscopic Assisted Open Reduction Internal Fixation, Open Reduction Internal Fixation
- Where
- United States
- Sponsor
- Corewell Health West
PreTerm Birth, Stress Reaction
The Contribution of Parent-infant Interaction While Singing During Kangaroo Care, on Preterm-infants' Autonomic Stability and Parental Anxiety Reduction
The current study will investigate the combination of the two modalities in a mixed-methods design, in order to provide comprehensive knowledge regarding the effects of family-centered MT during KC, on premature-infants'…
- Trial name
- NCT03023267
- Testing
- Music therapy and Kangaroo care, Kangaroo Care alone
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Severe Open Fractures of the Tibia (Shin) Bone
Assessment of Fixation Strategies for Severe Open Tibia Fractures
The purpose of this study is to compare the use of modern ring external fixation versus internal fixation for fracture stabilization of severe open tibia fractures.
- Trial name
- FIXIT (NCT01494519)
- Testing
- Surgery with an external ring fixator, Definitive fixation with a locked IM nail or plate
- Where
- 33 sites in United States
- Volunteers
- 442 people
- Sponsor
- Major Extremity Trauma Research Consortium
Lower Extremity Fractures.
A Study of Postsurgical Pain Control for Lower Extremity Fractures
Postsurgical pain may effectively be treated with a multimodal approach that incorporates the use of local anesthetics. Bupivacaine is a local anesthetic that has been proven to be effective at reducing postsurgical pain.
- Trial name
- NCT02214810
- Testing
- Bupivacaine/Exparel
- Where
- United States
- Sponsor
- Broward Health
Subcondylar Process of Mandible Open Fracture, Facial Nerve Injuries
Evaluation of Preauricular Retromandibular Anteroparotid Versus Retromandibular Through Parotid Approach
Of all the bones in the maxillofacial area, the condylar process is the most susceptible to fracture. The incidence of condylar fracture accounts for 25% to 50% of all mandibular fractures.
- Trial name
- NCT03803150
- Testing
- PRA approach, RT approach
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Breast Cancer
Anastrozole Biphosphonate Study in Postmenopausal Women With Hormone-Receptor-Positive Early Breast Cancer
The purpose of this study is to evaluate safety parameters of anastrozole with regard to its potential effects on postmenopausal bone loss and on lipid profiles.
- Trial name
- SABRE (NCT00082277)
- Testing
- Anastrozole, Risedronate Sodium
- Where
- 35 sites in United States, Canada and 6 more
- Volunteers
- 237 people
- Sponsor
- AstraZeneca
Open Fracture of Hip
Rivaroxaban Safety Profile in the Prophylaxis of Venous Thromboembolism After Hip Fracture Surgery
Arterial and venous thromboembolism represents one of the most common preventable health problems. Patients undergoing surgery, especially hip fracture surgery are at high risk for deep vein thromboembolism (VTE) without…
- Trial name
- NCT01509118
- Where
- 7 sites in Thailand
- Volunteers
- 500 people
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Pain, Postoperative, Fractures, Closed
Cognitive Behavioural Therapy to Reduce Persistent Post-Surgical Pain After Fracture
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Fractures, Closed, Fractures, Open
- Trial name
- SPOC_CBT (NCT03196258)
- Testing
- Cognitive behavioural therapy
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McMaster University
Prevent Osteoporosis and Osteoporotic Fractures, Improve Quality of Life
BREAST CANCER AND EXERCISE
A Finnish Breast Cancer Group Study (BREX 01-2004). A multicenter phase III open randomised trial of the efficacy of exercise in the prevention of long-term adverse effects of adjuvant treatments and breast cancer recurrences in…
- Conditions
- Prevent Osteoporosis and Osteoporotic Fractures, Improve Quality of Life, Improve Weight Control, and Muscular and Cardiovascular Fitness, Help the Patients to Return to Working Life
- Trial name
- BREX (NCT00639210)
- Testing
- supervised training
- Where
- Finland
- Volunteers
- 573 people
- Sponsor
- Finnish Breast Cancer Group
Condylar Process of Mandible Open Fracture
Assessment of Condylar Position With Management of Unilateral Mandibular Angle Fracture
The objective of this study is to assess condylar position and occlusion after open reduction and internal fixation using two miniplates versus patient specific plate
- Trial name
- NCT07858890
- Testing
- 2 mini plates, patient specific plates
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Unstable Sacral/Pelvic or Acetabular Fracture
A Comparison Study for Unstable Sacrum/Pelvis and Acetabular Fracture Treated With Open Reduction and Internal Fixation With Minimally Invasive Internal Fixation
Unstable sacral/pelvic or acetabular fracture are severe high energy fractures Surgical intervention are necessary after patient's conditions are stable.
- Trial name
- NCT05683314
- Testing
- Tranditional open reduction and internal fixation
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- China Medical University Hospital
Wounds, Wounds and Injuries
Pilot Trial for WounDx™ Clinical Decision Support Tool
The purpose of this research is to evaluate the overall use of the WounDx medical device in a clinical setting, such as a hospital.
- Conditions
- Wounds, Wounds and Injuries, Extremity Injury, Traumatic Wounds and Injuries
- Trial name
- NCT06921707
- Testing
- Clinical Decision Support Tool, Standard of Care (SOC)
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Scaphoid Fixation
Early Active Controlled Motion (EACM) Rehabilitation Protocol Post Open Reduction and Internal Fixation (ORIF) of Scaphoid Fractures: A Pilot Study
There is poor research supporting the benefits of Early Active Controlled Motion (EACM) protocols post operative scaphoid fixation.
- Trial name
- NCT03996512
- Testing
- Early Active Controlled Motion (EACM)
- Sponsor
- University of Florida
Osteopetrosis
Outcomes of Patients With Osteopetrosis Weight-bearing Bone Fractures
Osteopetrosis is a rare genetic disorder characterized by the abnormal hardening and density of bones, leading to increased brittleness and susceptibility to fractures.
- Trial name
- NCT06521580
- Testing
- Open reduction and internal fixation
- Where
- Egypt
- Volunteers
- 6 people
- Sponsor
- Kasr El Aini Hospital
Primary Osteoarthritis, Secondary Osteoarthritis
Prospective Study for the Evaluation of the Cementless Anatomic Femoral Stem Minimax -Launay
This is a post-marketing surveillance on MiniMAX Stem
- Conditions
- Primary Osteoarthritis, Secondary Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT06012656
- Testing
- MiniMAX
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Medacta International SA
Humerus Fracture Displaced Proximal
Cell Therapy by Autologous BMC for Large Bone Defect Repair
In the present phase-II clinical trial the researchers investigate efficacy and proof of concept of the augmentation with preoperatively isolated autologous BMC cells seeded onto ß-TCP in combination with an angle stable fixation…
- Trial name
- BMC2012 (NCT02803177)
- Testing
- BMC2012, beta-TCP Chronos® Synthes
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Goethe University