Clinical trials: Open Fractures
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Deep Venous Thrombosis
Low-Molecular-Weight Heparin (LMWH) for Deep Venous Thrombosis (DVT) Prophylaxis
1. The use of LMWH following open reduction and internal fixation of ankle fractures will reduce the number of thrombi formed. 2. The rates of clinically significant DVT will be equivalent between two groups.
- Trial name
- NCT01029821
- Testing
- Low-Molecular-Weight Heparin
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Wound; Head, Multiple, Wound; Head, Scalp
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
This study will evaluate the use of free autologous dermal fat grafting (also called free dermal fat autografting) to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts…
- Conditions
- Wound; Head, Multiple, Wound; Head, Scalp, Wound; Head, Wound Infection
- Trial name
- FTFDT3 (NCT03872544)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Dufresne, Craig, MD, PC
Opioid Use, Fractures, Bone
Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures
An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control.
- Conditions
- Opioid Use, Fractures, Bone, Trauma
- Trial name
- NCT06113211
- Testing
- Narcotic pain medication, Nonnarcotic pain medications
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Henry Ford Health System
Atrophic Nonunion of Fracture
Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones
The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in non-union fractures (pseudoarthrosis) of long bones in comparison to the standard treatment of autologous iliac crest.
- Trial name
- NCT02230514
- Testing
- XCEL-MT-OSTEO-ALPHA, autologous iliac crest, Surgery
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Banc de Sang i Teixits
Open tíbia Fracture
Open Tibia Fractures a Comparative Study Between Biplane External Fixator and Locked Intramedullary Nail
The objective of this research is to prospectively evaluate a group of patients with shaft compound fracture of the tibia, treated with a biplanar external fixator or locked intramedullary reamed nail.
- Trial name
- NCT02064595
- Testing
- External fixator, Intramedullary nail
- Volunteers
- 68 people
- Sponsor
- Fabio lucas rodrigues
Mandible Fracture
Radiographic and Clinical Evaluation of Three-Dimensional Delta Plate in Internal Fixation of Mandibular Sub-condylar Fractures.
In this study, we intend to examine the efficacy of 3D delta plates through radiographic evaluation of anatomic reduction and vertical ramus height as the main outcome and clinical assessment of pain and range of mandibular…
- Trial name
- NCT07311239
- Testing
- Three Dimensional Delta Plate
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Ain Shams University
Scaphoid Fixation
Early Active Controlled Motion (EACM) Rehabilitation Protocol Post Open Reduction and Internal Fixation (ORIF) of Scaphoid Fractures: A Pilot Study
There is poor research supporting the benefits of Early Active Controlled Motion (EACM) protocols post operative scaphoid fixation.
- Trial name
- NCT03996512
- Testing
- Early Active Controlled Motion (EACM)
- Sponsor
- University of Florida
Wounds, Wounds and Injuries
Pilot Trial for WounDx™ Clinical Decision Support Tool
The purpose of this research is to evaluate the overall use of the WounDx medical device in a clinical setting, such as a hospital.
- Conditions
- Wounds, Wounds and Injuries, Extremity Injury, Traumatic Wounds and Injuries
- Trial name
- NCT06921707
- Testing
- Clinical Decision Support Tool, Standard of Care (SOC)
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Pain, Postoperative, Pain, Acute
Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial
Psychological factors such as stress, distress, anxiety, depression, and poor coping strategies may be associated with ongoing pain following injuries such as fractures.
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed
- Trial name
- COPE (NCT04274530)
- Testing
- Cognitive Behavioural Therapy
- Where
- 10 sites in United States, Canada
- Volunteers
- 1,024 people
- Sponsor
- McMaster University
Fractures, Open, Wounds and Injuries--Infections
Acute Application of Antibiotic Powder in Open Fracture Wounds
The purpose of this study is to help determine the best treatment for severe injures like open fracture wounds. Some broken bone injuries can be more likely to get an infection. It is mostly due to the way they were injured.
- Conditions
- Fractures, Open, Wounds and Injuries--Infections, Anti-Bacterial Agents, Fractures, Bone
- Trial name
- APOW (NCT04872400)
- Testing
- Vancomycin, Tobramycin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Spinal Cord Injury, Bone Loss
Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide
The purpose of this study is to determine if a year of alendronate treatment will maintain or increase bone mass density (BMD) compared to baseline BMD values in people with chronic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02195895
- Testing
- Alendronate, Calcium, Vitamin D
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Open Tibia Fracture, Open Dislocation of Ankle
Accelerated Flap Coverage in Severe Lower Extremity Trauma
The goal of this randomized controlled trial is to determine if accelerated flap coverage compared to standard flap coverage timing leads to improved infection-related complications in patients with open fractures and/or…
- Conditions
- Open Tibia Fracture, Open Dislocation of Ankle, Extremity Fracture Lower, Extremity Injuries Lower
- Trial name
- FLAP ATTACK (NCT06293469)
- Testing
- Accelerated Flap Coverage Surgery, Standard of Care Flap Timing
- Where
- 11 sites in United States, Australia and 2 more
- Volunteers
- 356 people
- Sponsor
- Johns Hopkins University
Tibia Fracture
OIF/β-TCP in Patients With Open Tibial Fractures in Need of Bone Grafting
A prospective, randomized, evaluator-blinded, controlled study for subjects with open tibial fractures classified as Gustilo type II, IIIA or IIIB (see Appendix 1) who will receive bone graft implantation for the potential of…
- Trial name
- NCT04960722
- Testing
- OIF/β-TCP
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- BioGend Therapeutics Co.Ltd
Acetabular Fracture
RCT Determining Best Treatment for Geriatric Acetabular Fractures
There is debate over the best management for acetabular (hip) fractures that occur within the geriatric population. Geriatric patients, 60 years or older, are at greater risk for operative complications because they tend to have…
- Trial name
- GeriTab (NCT03419182)
- Testing
- Open Reduction internal Fixation, Open Reduction Internal Fixation with Total Hip Arthroscopy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Maryland, Baltimore
Scaphoid Fracture, Scaphoid Nonunion
Arthroscopic vs. Open Bone Grafting for Scaphoid Delayed/Nonunion
Single site, prospective, observer-blinded randomized controlled trial. Eighty-eight patients aged 18-68 years with scaphoid delayed/non-union, will be randomized, 1:1, to either open iliac crest cancellous graft reconstruction…
- Trial name
- NCT05574582
- Testing
- Graft reconstruction and internal fixation with compression screw
- Where
- Denmark
- Volunteers
- 88 people
- Sponsor
- Herlev and Gentofte Hospital
Distal Radius Fractures
Outcome Study of Complex Distal Radius Fractures
The purpose of this study is to collect information about how people do after different treatments of a broken wrist to see if one treatment has better results.
- Trial name
- NCT00160810
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Florida
Open Fracture Wounds
Fluid Lavage of Open Wounds
Open fracture wounds are a constant challenge to orthopaedic surgeons, with infections a common complication. There is currently little evidence as to which is the most effective way to wash out these wounds.
- Trial name
- FLOW (NCT00788398)
- Testing
- Saline Solution, Soap solution, Gravity Flow Irrigation
- Where
- 31 sites in United States, Australia and 3 more
- Volunteers
- 2,540 people
- Sponsor
- Prisma Health-Upstate
Wound Infection, Fractures, Open
Tobramycin Injection to Prevent Infection in Open Fractures
The goal of open extremity fracture (OEF) treatment is to promote fracture healing and restore function while preventing the development of infection.
- Conditions
- Wound Infection, Fractures, Open, Surgical Site Infection
- Trial name
- NCT04964947
- Testing
- Tobramycin Injection
- Where
- 3 sites in United States
- Volunteers
- 600 people
- Sponsor
- Massachusetts General Hospital
Stroke, Hip Fractures
Outcome of Rehabilitation of Older People in Primary Health Care
The Outcome of Multi-Disciplinary, Structured Rehabilitation of Older People in a District Inpatient Rehabilitation Centre is better than in a Standard Primary Health Care Rehabilitation Programme in Short Term Beds in Nursing…
- Conditions
- Stroke, Hip Fractures, Osteoarthritis, Chronic Disease
- Trial name
- NCT01457300
- Testing
- Rehabilitation
- Where
- 2 sites in Norway
- Volunteers
- 302 people
- Sponsor
- University of Oslo