Clinical trials: Open Fractures
Stoke, Dementia
Evaluation of Usage and Efficacy of the 656 Online Platform for Reducing Caregiver Stress in Chinese Caregivers
This study aimed to assess the efficacy of a new online platform, 656 Online Platform, in Hong Kong in reducing caregiver stress and enhancing caregiver preparedness and competence of caring for older adults with stroke…
- Conditions
- Stoke, Dementia, Fall and Fractures Prevention
- Trial name
- NCT06771557
- Testing
- 656 Online Platform
- Where
- Hong Kong
- Volunteers
- 287 people
- Sponsor
- Hong Kong Metropolitan University
Open Fracture
Assessment of Severe Extremity Wound Bioburden at the Time of Definitive Wound Closure or Coverage
The purpose of this study is to characterize the bacteria in the wound "bioburden" at the time of definitive wound coverage/closure of severe tibia fractures in both the military and civilian populations.
- Trial name
- Bioburden (NCT01496014)
- Where
- 40 sites in United States
- Volunteers
- 646 people
- Sponsor
- Major Extremity Trauma Research Consortium
Infection, Wound Healing Problem
Fluid Lavage of Open Wounds (FLOW): Pilot Trial
The purpose of this trial is to investigate whether irrigation solution (soap vs. saline solution), or irrigation pressure (high vs. low) will decrease the rate of infection among patients with open fracture wounds.
- Conditions
- Infection, Wound Healing Problem, Nonunion
- Trial name
- FLOW (NCT01069315)
- Testing
- Type of fluid lavage solution, Type of fluid lavage pressure
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 111 people
- Sponsor
- McMaster University
Fracture, Pain
RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child
Randomized double blind Trial with the aim to estimate effectiveness of two therapeutic regimes per os on pain due to not compound bone fractures in child 4-17 years old: ketorolac 0,5 mg/kg (1 drop every 2 Kg) tramadol 2,5 mg/Kh…
- Trial name
- NCT00560443
- Testing
- ketorolac, tramadol
- Where
- Italy
- Volunteers
- 133 people
- Sponsor
- IRCCS Burlo Garofolo
Scoliosis, Scoliosis; Adolescence
Study Comparing the PathKeeper System for Pedicle Screw Positioning in Spine Surgery With Traditional Care
The goal of this is to evaluate performance of the Pathkeeper Surgical System. The main question[s]it aims to answer are: 1) evaluate pedicle screw position Participants will in compare Experimental arm: PathKeeper System (PKS)…
- Conditions
- Scoliosis, Scoliosis; Adolescence, Scoliosis Kyphosis, Scoliosis Lumbar Region
- Trial name
- PKSforPSP (NCT06554093)
- Testing
- Medical Device - PKS
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Deep Health Ltd.
Fractures
A New Treatment Protocol for Paediatric Mandibular Condylar Fractures
This study aim to evaluate the clinical and radiographic outcomes of mandibular condylar fractures in pediatrics treated simply with a mandibular manipulation technique accompanied by mouth opening training.
- Trial name
- NCT02237040
- Testing
- Mandibular manipulation technique
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Acetabular Fractures
Pericapsular Nerve Group (PENG) Block on Postoperative Pain Management After Acetabular Fracture Fixation
The goal of this clinical trial is to find out whether a Pericapsular Nerve Group (PENG) block, a type of nerve block used to control pain, can reduce pain after surgery in adults with an acetabular (hip socket) fracture who are…
- Trial name
- NCT07765095
- Testing
- Pericapsular nerve group (PENG) block
- Where
- Puerto Rico
- Volunteers
- 56 people
- Sponsor
- University of Puerto Rico
Fractures, Open
Ganga Hospital Scoring System In Type-IIIA/B Open Tibial Fractures
The aim of this study is to assess interobserver reliability, sensitivity for amputation, and specificity for salvage of GHS in type-III injuries with open tibial fractures and predict the potential number of inpatient days…
- Trial name
- NCT05435261
- Testing
- BKA, Debridement with Ex_Fix (salvage)
- Volunteers
- 87 people
- Sponsor
- Assiut University
Osteogenesis Imperfecta
Safety, Pharmacokinetics and Pharmacodynamics of BPS804 in Osteogenesis Imperfecta
This is a randomized, open label intra-patient dose escalation study to evaluate safety and tolerability, pharmacokinetics, and pharmacodynamics of BPS804 in adults with osteogenesis imperfecta (OI).
- Trial name
- NCT01417091
- Testing
- BPS804
- Where
- 6 sites in United States, Belgium and 2 more
- Volunteers
- 10 people
- Sponsor
- Ultragenyx Pharmaceutical Inc
Open Fracture of Tibia
Role of Vacuum in Open Fracture Tibia Grade III Type B
Evaluate the role of VAC in decreasing the time needed for soft tissue coverage and definitive fixation in open IIIB tibial fractures
- Trial name
- NCT04063111
- Testing
- vacuum assistant closure, CONVENTIONAL DRESSING
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mandibular Fractures
Open Versus Closed Reduction of Mandibular Sub-Condylar Fractures
Patients with mandibular sub-condylar fractures underwent either either open reduction with internal fixation (ORIF) or closed reduction with external fixation (CREF) and were followed up for 6 months to assess treatment adequacy…
- Trial name
- NCT03494309
- Testing
- Open Reduction & Internal Fixation, Closed Reduction & External Fixation
- Volunteers
- 70 people
- Sponsor
- King Edward Medical University
Closed Fracture Proximal Humerus, Four Part
Reverse Total Shoulder Arthroplasty Versus Open Reduction Internal Fixation of 3&4 Part Proximal Humerus Fractures
Will patients who suffer complex humerus fractures have better functional outcomes and less implant failure with shoulder replacement (reverse total shoulder arthroplasty, RTSA) compared to shoulder repair (open reduction and…
- Trial name
- NCT02597972
- Testing
- Fracture repair, Fracture repair with joint replacement
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Proximal Humeral Fracture
Orthopaedic Treatment Proximal Humeral Fractures
Prospective non-randomized, open, unicentric observational study to compare two different treatments for Three-four parts fractures of proximal humerus (Neer's Classification) in elderly patients (over 75 years old).
- Trial name
- NCT03339570
- Testing
- Orthopedic treatment for a proximal humeral fracture
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Mikel Aburto
Pilon Fracture
Treatment of Complex Pilon Fractures
This project intends to compare patient outcomes between patients undergoing ORIF compared to PA, or ankle fusion, following an acute pilon fracture.
- Trial name
- NCT06089525
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Wrist Fractures
Early Functional Outcomes After Closed Reduction With Pinning Versus Open Reduction Internal Fixation of Wrist Fractures
The purpose of this study is to compare early return to function in patients treated with closed reduction percutaneous pinning and open reduction internal fixation in displaced fractures of the distal radius.
- Trial name
- NCT00828685
- Testing
- CRPP, ORIF
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Open Fracture, Post-Op Wound Infection
Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens
To demonstrate noninferiority of three different empiric antimicrobial regimens compared to the traditional antimicrobial regimen for the management of grade III open fractures as well as evaluate outcomes among these groups.
- Trial name
- NCT03560232
- Testing
- Ceftriaxone, Ampicillin/sulbactam, Piperacillin/tazobactam
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mercy Health Ohio
Fracture of Calcaneus, Pilon or Tibial Plateau
Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries
This project is designed as a prospective, randomized, comparative study evaluating the use of a negative pressure vacuum device in treating soft tissue injuries and the surgical incision following open reduction and internal…
- Trial name
- VAC-ST (NCT00582998)
- Testing
- Standard Wound Dressing, Vacuum Assisted Closure Device
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- University of Alabama at Birmingham
Tibial Fractures
Multiregion BHA in Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT04056429
- Testing
- BHA
- Sponsor
- Carmell Therapeutics Corporation
Fractures, Bone, Nonunion of Fracture
Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care
Prospective registry and retrospective data collection study to assess the efficacy and safety of Vivigen Cellular Bone Matrix (Vivigen) in orthopaedic trauma patients who require bone grafting in the acute, delayed, non-union…
- Conditions
- Fractures, Bone, Nonunion of Fracture, Fractures, Open, Fractures, Ununited
- Trial name
- NCT04299022
- Testing
- Vivigen Cellular Bone Matrix
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- LifeNet Health
Open Tibia Fracture
Pilot RCT Local Gentamicin for Open Tibial Fractures in Tanzania
Local application of antibiotics directly to the traumatic wound is a promising strategy for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in…
- Trial name
- pGO-Tibia (NCT03559400)
- Testing
- local gentamicin injection
- Where
- Tanzania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco