Clinical trials: Open Nephrectomy
Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H)
Implementation of a Pain Management Plan in Major Open Abdominal Surgeries.
Introduction: Major abdominal surgery encompasses a broad range of surgical procedures in heterogeneous patient populations.Management of postoperative pain has received keen attention in recent years with considerable concurrent…
- Conditions
- Abdomen Cancer, Pancreas Adenocarcinoma (MSI-H), Colectomy Left/Right/Total Under Laparotomy, Hepatectomy
- Trial name
- NCT07901582
- Testing
- Epidural administered opioid
- Where
- Greece
- Volunteers
- 58 people
- Sponsor
- National and Kapodistrian University of Athens
Renal Transplant Donor of Left Kidney
Enhanced Recovery Open Versus Laparoscopic Donor Nephrectomy
A phase III randomized trial conducted to compare recovery outcomes between laparoscopic and open donor nephrectomy within a specified enhanced recovery protocol
- Trial name
- MEnROL (NCT02699489)
- Testing
- Laparoscopic donor nephrectomy, Open donor nephrectomy
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Clear Cell RCC
Perioperative Trial With IO/TKI for Multi-stage Clear Cell Renal Cell Carcinoma
The IO/TKI regimens which combines Immune checkpoint inhibitors (IO) with Tyrosine Kinase Inhibitors (TKI) have become the standard first-line option for advanced ccRCC.
- Trial name
- TRIPLE-PATH (NCT07571551)
- Testing
- Toripalimab, Lenvatinib
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Jinling Hospital, China
Postoperative Pain
Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy
Open nephrectomy is one of the most common surgical procedures in urologic practice. Pain after surgery remains a significant clinical problem as it impairs recovery adversely and may lead to the transition to chronic pain.
- Trial name
- NCT02653651
- Testing
- Ketamine, Lidocaine
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University Tunis El Manar
Open Nephrectomy Surgery
Comparing the Efficacy of Epidural and Quadratus Lumborum Analgesia After Open Nephrectomy Surgery
This study aims to assess if Quadratus Lumborum (QL) blocks are non-inferior to epidural analgesia for pain control and opioid consumption through the third postoperative day in patients having open partial nephrectomy.
- Trial name
- QL Analgesia (NCT03110081)
- Testing
- Quadratus lumborum block, Epidural analgesia
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- The Cleveland Clinic
Rhomboid Intercostal Block
Rhomboid Intercostal and Subserratus Plane (RISS) Block on Postoperative Painafter Open Nephrectomy Surgery
Rhomboid intercostal block (RIB) is a new interfascial plane block describe by Elsharkawy et al. in 2016. The region described is understood because the triangle of auscultation that's bounded medially by inferior a part of the…
- Trial name
- NCT05301075
- Testing
- Rhomboid Intercostal and Sub-Serratus block
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain, Open Nephrectomy
Comparison of Serratus Intercostal Plane Blcok With Erector Spinae Plane Block for Open Nephrectomy
Effective postoperative pain management following open nephrectomy remains a significant clinical challenge. Inadequate pain control after this procedure may lead to impaired respiratory function, delayed mobilization, prolonged…
- Trial name
- NCT07556536
- Testing
- Serratus Intercostal Plane Block, Erector Spinae Plane Block
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Fayoum University Hospital
Postoperative Delirium (POD) After Nephrectomy
A Prospective Comparative Clinical Trial of Postoperative Delirium Incidence in Open Versus Laparoscopic Nephrectomy
A prospective comparative clinical trial of postoperative delirium incidence in open versus laparoscopic nephrectomy
- Trial name
- NCT07892898
- Testing
- Open Nephrectomy, Laparoscopic Nephrectomy
- Where
- Egypt
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Efficacy and Safety of Finerenone and Empagliflozin in Delaying Renal Function Progression After Radical Nephrectomy in High-Risk CKD Patients: A Multicenter RCT
The goal of this clinical trial is to evaluate whether Finerenone and Empagliflozin, either alone or in combination, can delay the progression of renal function decline in patients at high risk for chronic kidney disease (CKD)…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Nephrectomy, Chronic Kidney Disease(CKD)
- Trial name
- EmFin-Nx (NCT06818305)
- Testing
- Finerenone (BAY 94-8862), Empagliflozin 10 mg
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jinling Hospital, China
Transversus Abdominis Plane Block, External Oblique Intercostal Plane Block
Transversus Abdominis Plane Block Versus External Oblique Intercostal Plane Block for Postoperative Analgesia in Pediatrics Undergoing Open Nephrectomy
The aim of this study is to compare the ultrasound guided TAP Block and EOIP block for postoperative analgesia in pediatrics undergoing open nephrectomy.
- Conditions
- Transversus Abdominis Plane Block, External Oblique Intercostal Plane Block, Postoperative Analgesia, Pediatrics
- Trial name
- NCT06452225
- Testing
- External Oblique Intercostal Plane Block, Transversus Abdominis Plane Block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Pre- and Postoperative Analgesia, Spinal Anesthesia
Randomized Study of Spinal Anesthesia Compared With Traditional Epidural Anesthesia Concerning Peroperative and Postoperative Pain After Open Nephrectomy in Patients With Renal Cell Carcinoma
The study aim to study whether spinal anesthesia (using: bupivacain, morfin och klonidin) can be better than epidural anesthesia during and after open surgery for renal cell carcinoma.
- Conditions
- Pre- and Postoperative Analgesia, Spinal Anesthesia, Renal Cell Carcinoma
- Trial name
- ASA (NCT02030717)
- Testing
- klonidin, epidural anesthesia
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Umeå University
Trifecta Achievement, Pentafecta Achievement
Trifecta Achievement in Open and Laparoscopic Partial Nephrectomy
Background: Partial nephrectomy (PN) is a reference standard for the management of the cT1 renal mass, primarily due to better preservation of renal function.
- Trial name
- Trifecta (NCT06960135)
- Testing
- open partial nephrectomy, laparoscopic partial nephrectomy
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- South Valley University
Erector Spinae Plane Block, Thoracic Epidural Analgesia
Ultrasound-guided Continuous Erector Spinae Plane Block Versus Thoracic Epidural Analgesia in Open Nephrectomy
There are different case studies about the use of erector spinae block (ESPB ) in nephrectomy, but there are no enough randomized controlled studies about it until now so it will be one of the earliest studies that investigate…
- Conditions
- Erector Spinae Plane Block, Thoracic Epidural Analgesia, Nephrectomy
- Trial name
- NCT04947644
- Testing
- Thoracic epidural analgesia, Ultrasound guided continuous erector spinae plane block
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- National Cancer Institute, Egypt
Renal Cell Carcinoma, Metastatic
Intratumoral Vaccination With Intuvax Pre-nephrectomy Followed by Sunitinib Post-nephrectomy vs Sunitinib Post-nephrectomy in Newly Diagnosed Metastatic Renal Cell Carcinoma (mRCC)
The purpose of this study is to compare tumor response, progression free survival (PFS) and overall survival (OS) in newly diagnosed mRCC patients treated with Intuvax (INN: ilixadencel) pre-nephrectomy followed by Sunitinib…
- Trial name
- MERECA (NCT02432846)
- Testing
- Intuvax (INN: ilixadencel), Sunitinib
- Where
- 28 sites in United States, Czechia and 7 more
- Volunteers
- 88 people
- Sponsor
- Mendus
Kidney Transplantation
Donor Recipient Kidney Function Following Open Surgical vs. Laparoscopic Kidney Donation
This study will evaluate the differences between open surgical kidney donation and laparoscopic kidney donation on kidney donors and recipients.
- Trial name
- NCT00100516
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Postoperative Pain
QL Block Versus EO Plane Block for Analgesia After Open Nephrectomy
This prospective randomized clinical trial aims to compare two ultrasound-guided regional anesthesia techniques, the transmuscular quadratus lumborum (QL) block and the external oblique (EO) plane block, for pain relief after…
- Trial name
- NCT07787221
- Testing
- Quadratus Lumborum Block (QLB), External Oblique Plane Block
- Where
- 2 sites in Egypt
- Volunteers
- 54 people
- Sponsor
- Cairo University
Opioid Free Anesthesia
A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery
Patients undergoing nephrectomy have a high incidence of postoperative pain. In the perioperative period, these patients are often treated with patient-controlled opioids, epidural analgesia, or both.
- Trial name
- NCT05312541
- Testing
- pre emptive local anaesthetic wound infiltration
- Where
- Egypt
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Regional Blocks, Renal Surgery
Preoperative Versus Postoperative Quadratous Lunborum Block in Nephrectomy
A multimodal analgesia regimen is suggested after nephrectomy, although some patients still report agonising pain. Regional anesthesia approaches may improve postoperative pain management and reduce the requirement for opioids…
- Trial name
- NCT05860309
- Testing
- quadratous lumborum block
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Renal Cell Carcinoma
Comparison of Postoperative Analgesic Efficacy of the Erector Spina Plane Block and Quadratus Lumborum Block in Open Nephrectomy: a Prospective Randomized Clinical Study
patients who will undergo elective open nephrectomy will be divided into three groups; the control (PCA), the erector spina plane block, and the quadratus lumborum block.
- Trial name
- NCT05810571
- Testing
- preoperative remifentanil consumption, postopeartive controlled anlagesia with morphine
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kocaeli University
cT2a N0NxM0 Renal Tumor
Study of Axitinib for Downstaging Large Renal Tumors Not Primarily Suitable for Partial Nephrectomy (AXIPAN)
Axitinib (AXITINIB) is an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors 1, 2, and 3 which has achieved objective response rate of 44.2% in phase II study in cytokine-refractory metastatic…
- Trial name
- AXIPAN (NCT02597322)
- Testing
- AXITINIB
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris