Clinical trials: Open-angle Glaucoma (OAG)
Glaucoma
A Prospective, Multicenter, Open-label, Safety and Preliminary Efficacy Study of the Surgical Implantation of OPKO's Glaucoma Drainage Device (AquashuntTM) in Patients With Refractory Chronic Forms of Open Angle Glaucoma (OAG)
A prospective, multicenter, open-label, safety and preliminary efficacy study of the surgical implantation of OPKO's glaucoma drainage device (AquashuntTM) in patients with refractory chronic forms of open angle glaucoma (OAG).
- Trial name
- NCT00834223
- Testing
- Aquashunt
- Where
- Dominican Republic
- Volunteers
- 15 people
- Sponsor
- OPKO Health, Inc.
Open-Angle Glaucoma, Ocular Hypertension
Efficacy of Changing to TRAVATAN® From Prior Therapy
The purpose of this study was to assess the efficacy and tolerability of TRAVATAN® Solution without benzalkonium chloride (BAK) in patients previously on latanoprost 0.005% or bimatoprost 0.01% ophthalmic solution monotherapy.
- Trial name
- NCT01493427
- Testing
- Travoprost 0.004%
- Volunteers
- 202 people
- Sponsor
- Alcon Research
Glaucoma, Open-Angle, Ocular Hypertension
Dorzolamide+Timolol Multidose Preservative-free vs Dorzolamida+Timolol BAK Preserved Efficacy and Safety
The goal of this study is to evaluate the tolerability of the new formulation of Dorzolamide+Timolol preservative free developed in OSD Aptar Pharma multidose system in comparison with Dorzolamide +Timolol BAK preserved…
- Trial name
- NCT05857267
- Testing
- Dorzolamide / Timolol Ophthalmic Solution, dorzolamide/timolol
- Where
- 6 sites in Argentina
- Volunteers
- 84 people
- Sponsor
- Laboratorios Poen
Glaucoma, Open Angle Glaucoma (OAG)
Long-term Safety and Efficacy of a Modified Suprachoroidal Silicone Tube (SST) Shunt
The goal of this observational study is to evaluate the long-term safety and efficacy of a modified suprachoroidal silicone tube (SST) shunt in treating patients with primary open-angle glaucoma (POAG) and pseudo-exfoliative…
- Conditions
- Glaucoma, Open Angle Glaucoma (OAG), POAG, Ocular Hypertension
- Trial name
- NCT06691555
- Testing
- Suprachoroidal silicone tube (SST) shunt
- Where
- Georgia
- Volunteers
- 66 people
- Sponsor
- Davinci LTD
Open-angle Glaucoma, OAG
A Study to Evaluate Adverse Events and Change in Disease Activity With the XEN45 Glaucoma Treatment System Implantation In Adult Participants With Open-Angle Glaucoma in China
Glaucoma is the second most common cause of blindness in the world, second only to cataracts. The purpose of this study is to assess adverse events (AEs) and changes in disease activity in participants with open-angle glaucoma…
- Trial name
- NCT05821855
- Testing
- XEN45 Glaucoma Treatment System, Trabeculectomy
- Where
- 13 sites in China
- Volunteers
- 120 people
- Sponsor
- AbbVie
Glaucoma, Open-angle, Ocular Hypertension
A Long-term Safety Study of Once-daily Travatan
Long term safety study of TRAVATAN in patients with Open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00051168
- Testing
- Travatan
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- Alcon Research
Open Angle Glaucoma (OAG), Primary Open Angle Glaucoma (POAG)
Comparison of Goniotomy Device Outcomes in Combined Phacoemulsification-goniotomy Surgeries
The goal of this study is to determine of one of three different devices to perform goniotomy to treat glaucoma at the time of cataract surgery is more or less effective than the others.
- Conditions
- Open Angle Glaucoma (OAG), Primary Open Angle Glaucoma (POAG), Secondary Open Angle Glaucoma
- Trial name
- NCT07418853
- Testing
- Goniotomy
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Henry Ford Health System
Glaucoma, Ocular Hypertension (OH)
A Dose Evaluation Study for the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma
The purpose of this study is to evaluate the efficacy, safety and duration of the L-PPDS (latanoprost punctal plug delivery system) at different dose levels.
- Trial name
- NCT01481051
- Testing
- Latanoprost-PPDS
- Where
- 6 sites in United States
- Volunteers
- 57 people
- Sponsor
- Mati Therapeutics Inc.
Glaucoma, Open-Angle
Study of OMNI Surgical System and iStent for Eyes With OAG (Trident)
First, to compare safety and effectiveness outcomes for canaloplasty and trabeculotomy using the OMNI Surgical System to implantation of the iStent inject in lowering intraocular pressure (IOP) in pseudophakic eyes with open…
- Trial name
- NCT04658095
- Testing
- Canaloplasty and trabeculotomy with the OMNI system., iStent inject, Canaloplasty
- Where
- 5 sites in Germany, Spain and 1 more
- Volunteers
- 10 people
- Sponsor
- Sight Sciences, Inc.
Glaucoma, Ocular Hypertension
Long-Term Safety of Latanoprostene Bunod Ophthalmic Solution 0.024% in Japanese Subjects With OAG or OHT
The objective of this study is to demonstrate the clinical safety of latanoprostene bunod 0.024% once daily (QD) over a 1-year treatment period.
- Trial name
- JUPITER (NCT01895972)
- Testing
- Latanoprostene bunod
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Bausch & Lomb Incorporated
Open-angle Glaucoma (OAG), Ocular Hypertension (OHT)
Qlaris Study of QLS-111 in Combination With a PGA for OAG and/or OHT Patients
Qlaris Phase 2 clinical study investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in combination with latanoprost in open-angle glaucoma (OAG) and/or ocular hypertension (OHT) patients.
- Conditions
- Open-angle Glaucoma (OAG), Ocular Hypertension (OHT), Glaucoma
- Trial name
- NCT06249152
- Testing
- QLS-111, 0.015%, QLS-111, 0.030%, QLS-111, 0.075%
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Qlaris Bio, Inc.
Normal Tension Glaucoma (NTG), Glaucoma
DSLT in Normal Tension Glaucoma (NTG) Asian Eyes
The goal of this clinical trial is to evaluate the efficacy of direct selective laser trabeculoplasty (DSLT) or laser treatment in Asian patients with normal tension glaucoma.
- Conditions
- Normal Tension Glaucoma (NTG), Glaucoma, Open Angle Glaucoma (OAG), Glaucoma, Open Angle
- Trial name
- NCT07300852
- Testing
- Direct Selective Laser Trabeculoplasty (DSLT)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ngoc Nguyen Inc.
Open-Angle Glaucoma, Ocular Hypertension
Fixed Combination Brinzolamide 1%/Timolol 0.5% Versus Brinzolamide 1% + Timolol 0.5% in Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study was to compare the intraocular pressure (IOP)-lowering efficacy and safety of AZARGA™ (Brinzolamide 1%/Timolol 0.5% Ophthalmic Suspension), dosed twice daily versus AZOPT® (Brinzolamide 1% Ophthalmic…
- Trial name
- NCT01357616
- Testing
- Brinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension, Brinzolamide 1% ophthalmic suspension, Timolol 0.5% ophthalmic solution
- Volunteers
- 328 people
- Sponsor
- Alcon Research
Glaucoma, Open-Angle, Ocular Hypertension
A Safety and Efficacy Study of Travoprost 0.004% Compared to Latanoprost 0.005% in Patients With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)
The purpose of this study is to evaluate the safety and IOP-lowering efficacy of Travoprost (0.004%) compared to Latanoprost (0.005%) in patients with chronic open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00051142
- Testing
- Travoprost, Latanoprost
- Where
- United States
- Sponsor
- Alcon Research
Open-angle Glaucoma (OAG), Ocular Hypertension
Travoprost Five Day Posology Study
The purpose of this study is to determine the safety and efficacy of three concentrations of travoprost ophthalmic solution (Groups A, B and C) administered eight times daily.
- Trial name
- NCT01114893
- Testing
- Travoprost 0.004%, Travoprost Vehicle, Travoprost (Groups A, B and C)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Alcon Research
Open-Angle Glaucoma, Ocular Hypertension
A Phase 2 Study of Punctal Placement of the Latanoprost Punctal Plug Delivery System (L-PPDS)
The study objective is to compare IOP and safety outcomes based on plug placement (upper or lower puncta).
- Trial name
- NCT00821002
- Testing
- Latanoprost
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Mati Therapeutics Inc.
Glaucoma, Open-Angle, Ocular Hypertension
A 6-Week Safety and Efficacy Study of Travatan Compared to Xalcom in Subjects With Open-Angle Glaucoma(OAG) or Ocular Hypertension(OHT)
To compare the safety and IOP-lowering efficacy of TRAVATAN and XALCOM in subjects with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00051155
- Testing
- Travoprost (0.004%), Latanoprost (0.005%)/Timolol (0.5%)
- Where
- United States
- Sponsor
- Alcon Research
Glaucoma, Open-angle, Ocular Hypertension
A 12-Month Study to Evaluate the Efficacy and Safety of Once-Daily Instillation of Combination Glaucoma Therapy in Patients With Open-Angle Glaucoma or Ocular Hypertension
The purpose of this study is to evaluate the intraocular pressure(IOP)-lowering efficacy of a combination IOP-lowering therapy in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00311389
- Testing
- Travoprost 0.004%/Timolol maleate 0.5% ophthalmic solution, Latanoprost 0.005%/Timolol 0.005% ophthalmic solution
- Where
- Belgium
- Volunteers
- 408 people
- Sponsor
- Alcon Research
Open Angle Glaucoma or Ocular Hypertension
A Long-term Study of DE-117 Ophthalmic Solution Monotherapy and Concomitant Use of DE-117 Ophthalmic Solution With Timolol Ophthalmic Solution in Patients With OAG or OH: RENGE Study
The purposes of this study are to evaluate the long-term safety and intraocular pressure-lowering efficacy of DE-117 ophthalmic solution monotherapy and concomitant use of DE-117 ophthalmic solution with timolol ophthalmic…
- Trial name
- NCT02822729
- Testing
- DE-117 ophthalmic solution, Timolol ophthalmic solution
- Where
- Japan
- Volunteers
- 125 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Open Angle Glaucoma (OAG)
iStent Inject Versus Goniotomy With Kahook Dual Blade in Glauocma Treatment
The purpose of the study is to investigate the efficacy of cataract surgery in combination with Kahook Dual Blade Glide goniotomy (KDB) or iStent Inject W Trabecular Microbypass Stent (Istent) in eyes with Open-angle glaucoma.
- Trial name
- iSKDB (NCT07325552)
- Testing
- Goniotomy with KDB blade goniotomy, Two iStent inject implanation
- Where
- 2 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Bialystok