Clinical trials: Open-heart Surgery
Coronary Artery Bypass Graft Surgery, Atherosclerosis
Effect of Evolocumab on Saphenous Vein Graft Patency Following Coronary Artery Bypass Surgery
The purpose of this study is to determine if evolocumab added to regular statin therapy improves vein graft patency after coronary artery bypass graft (CABG) surgery.
- Conditions
- Coronary Artery Bypass Graft Surgery, Atherosclerosis, Vein Occlusion
- Trial name
- NEWTON-CABG (NCT03900026)
- Testing
- Evolocumab
- Where
- 22 sites in United States, Australia and 2 more
- Volunteers
- 782 people
- Sponsor
- Unity Health Toronto
Coronary Disease, Shock, Cardiogenic
GLP-1 and Hyperoxia for Organ Protection in Heart Surgery
Patients undergoing open heart surgery are at risk of suffering damage to the heart, brain and kidneys. This study is designed as a 2-by-2 randomized clinical trial with the purpose of investigating the organ protective effects…
- Conditions
- Coronary Disease, Shock, Cardiogenic, Renal Failure, Stroke
- Trial name
- GLORIOUS (NCT02673931)
- Testing
- Byetta (Lilly, Exenatide), Conoxia (AGA, oxygen), 20% Human Albumin
- Where
- Denmark
- Volunteers
- 1,400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Open Heart Surgery
Benefit of Peri-operative Bilateral ESP Catheters for Enhanced Recovery for Cardiac Surgery (ERCS)
To demonstrate if the addition of peri-operative regional analgesia by Bilateral ESP catheters improves the enhanced recovery program after open heart surgeries for the duration of hospitalisation, quality of analgesia…
- Trial name
- ESP_ERCS (NCT04506762)
- Testing
- Regional analgesia
- Where
- Vietnam
- Volunteers
- 20 people
- Sponsor
- Vinmec Healthcare System
Postoperative Hemorrhage
Aprotinin US Special Access Protocol
This is a special access protocol that will allow physicians access to aprotinin during the temporary marketing suspension. The program will provide aprotinin for treatment of surgical patients undergoing coronary artery bypass…
- Trial name
- NCT00611845
- Testing
- Aprotinin (Trasylol, BAYA0128)
- Where
- 17 sites in United States
- Sponsor
- Bayer
Complications Due to Coronary Artery Bypass Graft, Coronary Artery Disease
Neurological Complications Comparing Endoscopically vs. Open Harvest of the Radial Artery
Coronary artery bypass grafting (CABG) using the radial artery (RA) has since the nineties gone through a revival. The initially reported worse outcome in RA graft patients compared to patients grafted with the saphenous vein…
- Conditions
- Complications Due to Coronary Artery Bypass Graft, Coronary Artery Disease, Myocardial Ischemia, Coronary Disease
- Trial name
- NEO (NCT01848886)
- Testing
- Endoscopic radial artery harvest, Open radial artery harvest, Mammarioradial graft (Y-graft)
- Where
- Denmark
- Volunteers
- 301 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Abdominal Cancer, Blood Pressure
The Effect of Patient Position Changes on Advanced Cardiac Indices in Cancer Surgery
Esophageal Doppler Monitoring (Deltex CardioQ Esophageal Doppler Monitor, ODM) is used to manage patients' fluid therapy by non-invasively measuring continuous cardiac output with an esophageal probe.
- Conditions
- Abdominal Cancer, Blood Pressure, Cardiac Indices
- Trial name
- NCT06293391
- Testing
- cardiac indices in supine and trendelenburg position
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital