Clinical trials: Operable Breast Neoplasms
Breast Cancer
CETRA: Neoadjuvant Caelyx and Trastuzumab in Her-2 Positive Breast Cancer
The purpose of this study is to evaluate the rate of pathologic complete response when giving docetaxel and trastuzumab followed by caelyx (liposomal doxorubicin), cyclophosphamide and trastuzumab before surgery in treating women…
- Trial name
- CETRA (NCT00434031)
- Testing
- docetaxel, cyclophosphamide, trastuzumab
- Where
- Italy
- Sponsor
- National Cancer Institute, Naples
Breast Cancer
A Study of Giredestrant (GDC-9545) in Postmenopausal Women With Stage I-III Operable, Estrogen Receptor-Positive Breast Cancer
This study will evaluate the pharmacodynamics, pharmacokinetics, safety, and biologic activity of giredestrant in participants with Stage I-III operable estrogen receptor (ER)-positive, human epidermal growth factor receptor 2…
- Trial name
- NCT03916744
- Testing
- Giredestrant, Surgery
- Where
- 15 sites in United States, Australia and 3 more
- Volunteers
- 75 people
- Sponsor
- Genentech, Inc.
Locally Advanced Breast Cancer and Large Operable Breast Cancer
Randomized Controlled Trial of Neo-adjuvant Progesterone and Vitamin D3 in Women With Large Operable Breast Cancer and Locally Advanced Breast Cancer
Randomized Controlled Trial of Neoadjuvant Progesterone and Vitamin D3 in women with Large Operable Breast Cancer and Locally Advanced Breast Cancer - A Feasibility Study Primary Progesterone Timing of surgery during the…
- Trial name
- NCT01608451
- Testing
- Cholecalciferol, Inj. Progesterone
- Where
- India
- Volunteers
- 800 people
- Sponsor
- Tata Memorial Hospital
Breast Cancer
Efficacy and Safety of TAC and Exemestane as Neoadjuvant Chemotherapy in the Postmenopausal Women With Breast Cancer
Select the postmenopausal patients with breast cancer who is confirmed by core needle biopsy and at the clinical stage T2-4N0-2M0.Treat them with 4 cycles of TAC as neoadjuvant chemotherapy (Docetaxel was 75mg/m2, the EPI 60mg/m2…
- Trial name
- NCT01648608
- Testing
- Exemestane
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Tianjin Medical University
Breast Cancer, Breast Tumors
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer
The purpose of this study is to determine the effects of combining metformin and atorvastatin treatment in patients with newly diagnosed breast cancer during the interval between breast biopsy and surgery.
- Conditions
- Breast Cancer, Breast Tumors, Cancer of Breast
- Trial name
- NCT01980823
- Testing
- Metformin, Atorvastatin, Breast surgery
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Columbia University
Breast Cancer
Lifestyle Intervention for High Risk Cancer Survivors
The goal of this behavioral research study is to find out more about the health behaviors of cancer survivors. Researchers want to understand the cultural, social, and environmental factors related to physical activity and…
- Trial name
- NCT01508273
- Testing
- Exercise Program, Website, Exercise DVD
- Where
- 3 sites in United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
HER2-positive Breast Cancer
Markers to Evaluate the Efficacy of PH-based Regimen as a Neoadjuvant Therapy for Operable HER2 Positive Breast Cancer
This study is to explore the markers in early prediction of the efficacy of pre-operative pertuzumab plus trastuzumab (PH) combined with chemotherapy for early stage or locally advanced human epidermal growth factor receptor-2…
- Trial name
- PHC-BC (NCT04281641)
- Testing
- TCHP
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Fudan University
Breast Neoplasms
Docetaxel, Doxorubicin (A), Cyclophosphamide (C) (TAC) vs 5-Fluorouracil, A, C (5FAC) Breast Cancer Adjuvant Treatment
This is a prospective, non-blinded randomized phase III trial. Patients will be post-surgically stratified at inclusion first according to the participating institution, then according to menopausal status and will be randomly…
- Trial name
- NCT00121992
- Testing
- Docetaxel, 5-fluorouracil, Doxorubicin
- Where
- Spain
- Volunteers
- 1,060 people
- Sponsor
- Spanish Breast Cancer Research Group
Breast Cancer, Surgery
Optimizing the Care Pathways of Patients Treated for Operable Breast.
This prospective, multicenter, observational study aims to explore a comprehensive approach to the care of early breast cancer patients in a regional health territory (including 1.5 million women and characterized by a breast…
- Trial name
- OPTIsoins01 (NCT02813317)
- Where
- 9 sites in France
- Volunteers
- 617 people
- Sponsor
- Institut Curie
Primary Breast Cancer
Minus Anthracycline or Short-Term Versus Epirubicin and Cyclophosphamide Followed by Paclitaxel Regimen for Adjuvant Breast Cancer Therapy
We aimed to evaluate the noninferiority of short-term anthracycline-free chemotherapy (TC, six cycles of docetaxel and cyclophosphamide) or short-term anthracycline-based chemotherapy (CEF-T, three cycles of…
- Trial name
- NCT01314833
- Testing
- Docetaxel Cyclophosphamide, Cyclophosphamide Fluorouracil Epirubicin Docetaxel, Epirubicin Cyclophosphamide Paclitaxel
- Where
- China
- Volunteers
- 1,570 people
- Sponsor
- Fudan University
Operable Breast Neoplasms
Trial of Endocrine Against Locoregional Therapy First in Postmenopausal Women With Early Breast Cancer
The hypothesis to be addressed in this randomized phase III trial is that 4 months of letrozole may be superior to surgery as primary therapy for early stage hormone receptor positive breast cancer in postmenopausal women…
- Trial name
- REAL (NCT00908531)
- Testing
- letrozole (Femara)
- Where
- 9 sites in Denmark
- Volunteers
- 123 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Breast Cancer
TMEM-MRI: A Pilot Feasibility Study of MRI for Imaging of TMEM in Patients With Operable Breast Cancer
The aim of this study is to assess feasibility of a new imaging technology in the management of breast cancer - Tumor Microenvironment of Metastasis - Magnetic Resonance imaging (TMEM-MRI).
- Trial name
- TMEM-MRI (NCT03694756)
- Testing
- TMEM-MRI, FNA
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Montefiore Medical Center
Breast Cancer
Neoadjuvant Sequential Administration of Two Gemcitabine Combinations in Operable Breast Cancer
Gemcitabine and anthracycline combination has shown encouraging activity as neoadjuvant chemotherapy in locally advanced breast cancer.
- Trial name
- NCT00191789
- Testing
- gemcitabine, doxorubicin, cisplatin
- Where
- 3 sites in India
- Volunteers
- 65 people
- Sponsor
- Eli Lilly and Company
Breast Cancer
PROACT - Pre-Operative Arimidex Compared To Tamoxifen
The purpose of this study is to compare tamoxifen, versus a newer treatment, ARIMIDEX, which we already know to be well tolerated.
- Trial name
- NCT00232661
- Testing
- ARIMIDEX (anastrazole), NOLVADEX (tamoxifen)
- Where
- 79 sites in United States, Belgium and 8 more
- Volunteers
- 452 people
- Sponsor
- AstraZeneca
Breast Cancer
Everolimus in Treating Women With Breast Cancer That Can Be Removed by Surgery
RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00855114
- Testing
- everolimus, therapeutic conventional surgery
- Where
- United States
- Sponsor
- Masonic Cancer Center, University of Minnesota
Stage II Breast Cancer, Stage III Breast Cancer
Neoadjuvant Trial of Capecitabine for Axillary Lymph Node Positive Operable Breast Cancer
This randomized phase II trial compared pathologic response rates (pCR) of early breast cancer following neoadjuvant fluorouracil-epirubicin-cyclophosphamide(FEC) and capecitabine-epirubicin-cyclophosphamide (XEC).
- Trial name
- NCT02115152
- Testing
- fluorouracil, capecitabine, cyclophosphamide
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Guangxi Medical University
Breast Cancer
Post Operative Adjuvant Chemotherapy Followed by Adjuvant Tamoxifen vs Nil for Patients With Operable Breast Cancer
Post operative adjuvant chemotherapy followed by adjuvant Tamoxifen vs nil for patients with operable breast cancer
- Trial name
- NCT00538330
- Testing
- Tamoxifen
- Volunteers
- 2,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Breast Cancer
Self-Reported Exercise Behavior and Short-Term Patient Outcomes in Women Undergoing Radiation Treatment for Operable Breast Cancer
Using an observational prospective design, potential subjects will be identified and screened for eligibility via medical record review of breast cancer patients scheduled for radiation therapy at Duke Radiation Oncology Clinic.
- Trial name
- NCT02050620
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Highly Endocrine Responsive Operable Breast Cancer
Neoadjuvant Endocrine Therapy in Breast Cancer
The study aimed to compare the duration to complete or partial response (CR/PR) and the overall response rates (ORR) after six months of neoadjuvant endocrine therapy between pre-menopausal group and post-menopausal group with…
- Trial name
- NCT03397537
- Testing
- Letrozole 2.5Mg Tablet, GnRH analogue
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Guangdong Provincial People's Hospital
Breast Cancer
Tamoxifen Following Combination Chemotherapy in Treating Women With Operable Invasive Breast Cancer
RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Hormone therapy using tamoxifen may fight breast cancer by blocking the uptake of estrogen.
- Trial name
- NCT00002579
- Testing
- CMF regimen, cyclophosphamide, fluorouracil
- Where
- 10 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Scottish Cancer Therapy Network