Clinical trials: Operation Finding
Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma
A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma
The goal of this clinical trial is to learn whether the Ad5.F35-hGCC-PADRE vaccine is safe and can stimulate an immune response against gastrointestinal (GI) cancers in patients with pancreatic, colorectal, esophageal, gastric…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma, Gastric Adenocarcinoma, Clinical Stage II Gastric Cancer AJCC v8
- Trial name
- NCT04111172
- Testing
- Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma
Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors
This phase I trial is studying the side effects of fluorine F18 EF5 when given during positron emission tomography to find oxygen in tumor cells of patients who are undergoing surgery or biopsy for newly diagnosed brain tumors.
- Conditions
- Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, Adult Brain Stem Glioma
- Trial name
- NCT00110032
- Testing
- EF5, conventional surgery, positron emission tomography
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Cancer Institute (NCI)
Sentinel Lymph Node Biopsy, Breast Cancer
A Study to Find the Best Dose of ASP5354 to Show Lymph Nodes in People With Breast Cancer or Melanoma During Surgery
This study was for women with breast cancer and for adults with melanoma. Breast cancer was a type of cancer when cells in the breast turn into cancer cells, which might grow out of control.
- Conditions
- Sentinel Lymph Node Biopsy, Breast Cancer, Melanoma
- Trial name
- NCT05457842
- Testing
- pudexacianinium chloride
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Astellas Pharma Inc
Elective Surgery Requiring Laryngeal Mask Airway General Anesthesia
ED90 of Tegileridine Combined With Propofol for LMA Insertion
This is a prospective two-group dose-finding trial using biased-coin sequential up-and-down design. We plan to enroll 108 patients who need general anesthesia with laryngeal mask airway placement, divided into young group (18-64…
- Trial name
- NCT07665151
- Testing
- Tegileridine combined with Propofol for anesthesia induction
- Where
- China
- Volunteers
- 109 people
- Sponsor
- Shiyou Wei
Glioblastoma
Dose Finding for Intraoperative Photodynamic Therapy of Glioblastoma
The phase II study evaluate a light dose escalation in a classical intraoperative PDT regimen mediated by 5-ALA-PpIX, in glioblastoma patients with access to full surgical removal of the contrast enhancement.
- Trial name
- DOSINDYGO (NCT04391062)
- Testing
- Gliolan, Intraoperative PDT
- Where
- 2 sites in Belgium, France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Lille
Pancreatic Adenocarcinoma
Cetuximab-IRDye 800CW and Intraoperative Imaging in Finding Pancreatic Cancer in Patients Undergoing Surgery
This phase 1-2 trial studies the side effects and best dose of cetuximab-IRDye 800CW when used with intraoperative imaging, to determine the utility of cetuximab-IRDye 800CW to identify and assess pancreatic cancer in patients…
- Trial name
- NCT02736578
- Testing
- Cetuximab-IRDye800, Cetuximab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Eben Rosenthal
Recurrent Renal Cell Cancer, Stage I Renal Cell Cancer
Fluorescence Imaging in Finding Tumors in Patients With Kidney Tumors
RATIONALE: Using fluorescence imaging may determine the extent of kidney tumors and help in planning surgery. PURPOSE: This phase I trial is studying the best way to give indocyanine green (ICG) fluorescence imaging in finding…
- Conditions
- Recurrent Renal Cell Cancer, Stage I Renal Cell Cancer, Stage II Renal Cell Cancer
- Trial name
- NCT01281488
- Testing
- fluorescence imaging, laparoscopic surgery, indocyanine green
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- City of Hope Medical Center
Cardiac Surgical Procedures, Coronary Artery Bypass
Treatment With 5-AminoLEvuliNic Acid Before Cardiac Surgery
TALEN is a prospective randomised double-blind placebo-controlled phase 2 study of 5-Aminolevulinic Acid with Sodium Ferrous Citrate (5-ALA-SFC) in adult patients undergoing cardiac surgery on cardiopulmonary bypass (CPB).
- Conditions
- Cardiac Surgical Procedures, Coronary Artery Bypass, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- TALEN (NCT07027670)
- Testing
- 5-Aminolevulinic Acid hydrochloride (5-ALA), Sodium ferrous citrate (SFC)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Oxford
Spinal Ischemia, Stroke
The Darbepoetin Alfa for Ischemic Surgical Complications (DISC) Dose Finding Trial
Numerous neuroprotectants have been effective when given prior to ischemic stroke in animals, yet they have all have failed when given after ischemic stroke in humans. A novel approach to ischemic neuroprotection is needed.
- Conditions
- Spinal Ischemia, Stroke, Neuroprotection
- Trial name
- DISC (NCT00647998)
- Testing
- Darbepoetin alfa, Standard care
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Pennsylvania
Diabetic Foot, Diabetic Neuropathies
Dose-finding Study: Popliteal Sciatic Nerve Block in Patients Undergoing Diabetic Foot Surgery
The purpose of this study was to determine the minimum effective dose of a local anesthetic for proper anesthesia for popliteal sciatic nerve block under ultrasound guidance in patients undergoing surgery for diabetic foot…
- Trial name
- NCT04981067
- Testing
- Maintain the concentration of ropivacaine as same as those used in the previous participant, Decrease the ropivacaine concentration by 0.05% from the concentration used in the previous participant, Increase the ropivacaine concentration by 0.05% from the concentration used in the previous participant
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Hip Fractures, Pain, Acute
PENG: an Estimation of ED50 in Neck of Femur Fracture
The effective dose of local anaesthetic used in PENG blocks to achieve analgesia in patients with fractured neck of femur is unknown.
- Trial name
- NCT05095025
- Testing
- Bupivacaine Hydrochloride 20ml injectate
- Where
- Ireland
- Volunteers
- 50 people
- Sponsor
- University College Cork
Brachial Plexus Blockade, Shoulder Surgery
Dose-Finding Study: MEV90 for Local Anesthetic in Interscalene Block for Supraclavicular Nerves Block
This study aims to determine the minimum effective volume (MEV90) of local anesthetic required to achieve sensory block of the supraclavicular nerves when performing a single-shot ultrasound-guided interscalene brachial plexus…
- Conditions
- Brachial Plexus Blockade, Shoulder Surgery, Superficial Cervical Plexus Block
- Trial name
- NCT07338916
- Testing
- Ultrasound-Guided Interscalene Block with Bupivacaine
- Where
- Chile
- Volunteers
- 57 people
- Sponsor
- Hospital del Trabajador de Santiago
Postoperative Pain Management, Video-assisted Thoracoscopic Surgery (VATS)
Minimum Effective Volume of Bupivacaine for Serratus Posterior Superior Intercostal Plane Block in Video-Assisted Thoracoscopic Surgery
This study determined the median effective volume (EV50) of bupivacaine required for the serratus posterior superior intercostal plane (SPSIP) block in patients undergoing video-assisted thoracoscopic surgery (VATS).
- Trial name
- SPSIP-EV50 (NCT07446959)
- Testing
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Bursa City Hospital
Endometrial Clear Cell Adenocarcinoma, Endometrial Mixed Adenocarcinoma
PET/CT and Lymph Node Mapping in Finding Lymph Node Metastasis in Patients With High-Risk Endometrial Cancer
This clinical trial studies positron emission tomography (PET)/computed tomography (CT) and lymph node mapping in finding lymph node metastasis in patients with endometrial cancer that is at high risk of spreading.
- Conditions
- Endometrial Clear Cell Adenocarcinoma, Endometrial Mixed Adenocarcinoma, Endometrial Serous Adenocarcinoma, Grade 3 Endometrial Endometrioid Adenocarcinoma
- Trial name
- NCT01737619
- Testing
- Computed Tomography, Indocyanine Green Solution, Laboratory Biomarker Analysis
- Where
- 7 sites in United States
- Volunteers
- 101 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer Patients Diagnosed With Locally Advanced or Metastatic Pancreatic Cancer Not Amenable to Curative Surgical Resection
Combination Therapy of L19IL2 and Gemcitabine in Advanced Pancreatic Cancer Patients
Systemic treatment for advanced, non-resectable pancreatic cancer still having minimal impact on the survival of patients. Even with the application of more potent gemcitabine-based regimens, survival of more than 1 year is…
- Trial name
- NCT01198522
- Testing
- L19IL2 monoclonal antibody-cytokine fusion protein in combination with gemcitabine
- Where
- 5 sites in Germany, Italy
- Volunteers
- 28 people
- Sponsor
- Philogen S.p.A.
Breast Cancer, Sentinel Lymph Node Biopsy (SLNB)
Finding Sentinel Lymph Nodes During Mastectomy Using Indocyanine Green (INIGMA Study)
This pilot study evaluates the diagnostic value of indocyanine green (ICG) fluorescence for sentinel lymph node biopsy (SLNB) performed through the mastectomy incision in breast cancer patients.
- Conditions
- Breast Cancer, Sentinel Lymph Node Biopsy (SLNB), Sentinel Lymph Node Detection, Sentinel Lymph Node
- Trial name
- INIGMA (NCT07362485)
- Testing
- Indocyanine green (ICG)-fluorescence guided sentinel lymph node biopsy
- Where
- 2 sites in Netherlands
- Volunteers
- 90 people
- Sponsor
- Isabelle Henskens
Colorectal Cancer
Immunoscintigraphy Using Radiolabeled Monoclonal Antibody in Finding Tumor Cells in Patients With Colorectal Cancer
RATIONALE: Diagnostic procedures, such as immunoscintigraphy, using a radiolabeled monoclonal antibody may help find and diagnose colorectal cancer.
- Trial name
- NCT00647153
- Testing
- pharmacological study, single photon emission computed tomography, iodine I 123 anti-CEA recombinant diabody T84.66
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- City of Hope Medical Center
Blood Transfusion, Blood Transfusion, Autologous
A Study to Determine the Safety and Effectiveness of Epoetin Alfa in Facilitating Self-donation of Blood Before Surgery in Patients Who Are Not Anemic and Who Will be Undergoing Orthopedic or Heart and Blood Vessel Surgery
The purpose of this study is to determine whether epoetin alfa will enable self-donation of at least 4 units of blood during the 2-week period before surgery (which is a shorter period of time than the conventional 3-week blood…
- Conditions
- Blood Transfusion, Blood Transfusion, Autologous, Orthopedic Procedures, Orthopedic Surgery
- Trial name
- NCT00270075
- Testing
- epoetin alfa
- Volunteers
- 80 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Orthopedic Surgery
Dose Finding Study of Remimazolam for Laryngeal Mask Airway Insertion
Laryngeal mask airways (LMA) are widely used in patients receiving general anesthesia and are known to have the following advantages over the endotracheal tube: lower incidence of postoperative sore throat, lower incidence of…
- Trial name
- NCT05298228
- Testing
- Remimazolam bolus does administration
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Yonsei University
Phase 1: Pain Management, Phase 2: Pain Management
Dose-finding Study of Intrathecal Paracetamol Administered Immediately Before Spinal Anaesthesia
Two-part study of intrathecal paracetamol administered immediately before spinal anaesthesia in patients scheduled for hip replacement surgery
- Trial name
- NCT02654860
- Testing
- Paracetamol 3%, Hyperbaric Bupivacaine HCl 0.5%
- Where
- Switzerland
- Volunteers
- 69 people
- Sponsor
- Sintetica SA