Clinical trials: Operative Bleeding
Anticoagulant-induced Bleeding, Dental Diseases
Intra- and Post- Operative Bleeding After Simple Dental Extraction in Direct Oral Anticoagulant Therapy
Direct Oral Anticoagulants were recently approved for medical treatment of several condition such as, non valvular atrial fibrillation, deep venous thrombosis, and others, substituting sometimes the conventional oral…
- Trial name
- NOADB (NCT03124030)
- Testing
- simple dental extraction
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Trephined Syndrome, Sinking Skin Flap Syndrome
Prevalence of Trephined Syndrome After Decompressive Craniectomy
Decompressive craniectomy is frequently used to treat increased intracranial pressure or an intracranial mass effect. Trephined Syndrome describes a neurological deterioration, which is attributed to a large craniectomy.
- Conditions
- Trephined Syndrome, Sinking Skin Flap Syndrome, Traumatic Brain Injury, Stroke
- Trial name
- TS (NCT03186157)
- Testing
- Decompressive craniectomy, Cranioplasty
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- University Hospital, Geneva
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Sequestration of Platelets Prior to Bypass Reduces Bleeding After Cardiac Surgery
Excessive bleeding is common after cardiac surgery. This may result in patients receiving a blood transfusion or suffering the life-threatening complication of cardiac tamponade.
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Blood Platelet Disorders, Blood Coagulation Disorders
- Trial name
- NCT00359398
- Testing
- Platelet rich plasma sequestration
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
BPH With Urinary Obstruction, BPH
Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP
Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent treatment option for benign prostatic hypertrophy (BPH) as recommended by the American Urological Association (AUA) Guidelines.
- Conditions
- BPH With Urinary Obstruction, BPH, Hematuria, Same Day Discharge
- Trial name
- NCT05620784
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Rhinosinusitis Chronic, Sinus Cancer
TIVA vs TXA in Sinus Surgery to Evaluate Operative Blood Loss and Surgical Field Quality
The goal of this interventional study is to compare the efficacy (surgical field quality and intra-operative blood loss) or cost of TIVA alone to general inhalational anesthetics with intravenous TXA in patient participants who…
- Conditions
- Rhinosinusitis Chronic, Sinus Cancer, Sinus Polyp, Encephalocele
- Trial name
- NCT05639686
- Testing
- Tranexamic acid injection, Total Intravenous Anesthesia, Inhalational isoflurane
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Our Lady of the Lake Hospital
Seroma
The Effect of Arista on Post-Operative Bleeding and Wound Drainage Following Mastectomy
Study aim was to evaluate topical MPH on the risk of post-mastectomy seroma formation as measured by total drain output and total drain days.
- Trial name
- NCT03647930
- Testing
- Microporous Polysaccharide Hemospheres (MPH)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Memorial Health University Medical Center
Infertility, Abnormal Uterine Bleeding (AUB)
Evaluation of the Uterine Cavity After Operative Hysteroscopy
This study will focus on evaluation of the uterine cavity after operative hysteroscopy using three dimensional transvaginal ultrasonography and office hysteroscopy to detect and residual or recurrent abnormalities or intrauterine…
- Conditions
- Infertility, Abnormal Uterine Bleeding (AUB), Intrauterine Adhesion, Submucous Leiomyoma of Uterus
- Trial name
- NCT06924437
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Pancreatectomy, Complication of Surgical Procedure
Pancreaticoduodenectomies With Complete Arterial Coverage by Retromesenteric Omentoplasty
To assess the efficacy of complete covering using retromesenteric omentoplasty vs. partial covering or no covering of peripancreatic arteries in decreasing incidence of grade B+C post-pancreatectomy hemorrhage (PPH), i.e.
- Trial name
- PACOMARCO (NCT05992857)
- Testing
- Pancreaticoduodenectomy without retromesenteric omental flap, Pancreaticoduodenectomy with retromesenteric omental flap
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Surgical Blood Loss, Spinal Surgery
Efficacy of Suction Enabled Retraction Device
This is a prospective randomized controlled trial of the Suction-Integrated Surgical Tissue Elevator \& Retractor [SISTER] device to assess: Effects on operative time and efficiency of exposure in open lumbar spine cases.
- Trial name
- NCT03160170
- Testing
- SISTER device
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Miami
Heart Surgery
Moderate Bleeding in Cardiac Surgery Post Operative
Determine a bleeding threshold by measuring the blood volume in ml / kg / h collected in the drainage system to define moderate bleeding postoperative cardiac surgery and define the population.
- Trial name
- SPO (NCT02712879)
- Where
- France
- Volunteers
- 303 people
- Sponsor
- University Hospital, Montpellier
Anticoagulant-induced Bleeding, Periodontal Diseases
Evaluation of the Intra- and Post- Operative Bleeding After Periodontal Debridement in Direct Anticoagulant Patients
Direct Oral Anticoagulants were recently approved for medical treatment of several condition such as, non valvular atrial fibrillation, deep venous thrombosis, and others, substituting sometimes the conventional oral…
- Trial name
- NOADB_db (NCT03124004)
- Testing
- periodontal debridement
- Where
- Italy
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Diabetic Retinopathy, Vitreous Hemorrhage
Preoperative Bevacizumab for Vitreous Hemorrhage
The purpose of this study is to determine whether preoperative intravitreal bevacizumab is effective in reducing intra-operative and postoperative bleeding in diabetic patients submitted to pars plana vitrectomy for vitreous…
- Trial name
- IBEVI (NCT00596297)
- Testing
- bevacizumab, pars plana vitrectomy
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo
Post Operative Hemorrhage
Intravenous Tranexamic Acid Versus Pericervical Tourniquet To Decrease Blood Loss In Trans-Abdominal Myomectomy
Intravenous Tranexamic Acid Versus Pericervical Tourniquet To Decrease Blood Loss In Trans-Abdominal Myomectomy
- Trial name
- NCT02733952
- Testing
- Tranexamic Acid, Pericervical Tourniquet
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams Maternity Hospital
Blood Loss Massive, Post Operative Hemorrhage
Evaluation of the Quantra QStat System in Obstetric Patients
This pilot study will assess the performance of the Quantra System with the QStat Cartridge versus standard of care coagulation testing in bleeding pregnant women at delivery.
- Trial name
- NCT05875987
- Testing
- Quantra System
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- HemoSonics LLC
Edema, Ecchymosis; Eyelid
The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery
Tranexamic acid (TXA) is a synthetic inhibitor of plasminogen lysine receptor that has used to reduce intra-operative bleeding in a number of clinical scenarios.
- Trial name
- NCT04951128
- Testing
- Tranexamic acid injection, Local anesthetic control
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Consultants in Ophthalmic and Facial Plastics Surgery
Post Operative Blood Loss
Role of Topical Tranexamic Acid in Total Hip Arthroplasty
Total hip arthroplasty (THA) is a procedure associated with perioperative blood loss, requiring blood transfusions in some patients.
- Trial name
- TXA (NCT01866943)
- Testing
- Tranexamic Acid, Normal Saline Solution
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Intra Operative Bleeding, Blood Salvage
Exposure of Salvaged Blood to Inflammation and Oxidative Stress: the Effect of Different Anticoagulant Regimes (HECICS)
The primary aim of this randomized controlled study is to determine whether the use Anticoagulant Citrate Dextrose Solution--Formula A (ACD-A) in cell salvage reduces inflammation and oxidative stress in cell saver blood compared…
- Trial name
- HECICS (NCT02674906)
- Testing
- ACD-A, Heparin
- Where
- Belgium
- Volunteers
- 75 people
- Sponsor
- Ziekenhuis Oost-Limburg
Bleeding Disorder, Hypofibrinogenemia; Acquired
Adjusted Fibrinogen Replacement Strategy
The main purpose of this study was to demonstrate the efficacy and safety of intraoperative use of fibrinogen concentrate BT524, as a complementary therapy for the management of uncontrolled severe hemorrhage in acquired…
- Trial name
- AdFIrst (NCT03444324)
- Testing
- BT524, FFP/Cryo
- Where
- 19 sites in Belgium, Czechia and 5 more
- Volunteers
- 222 people
- Sponsor
- Biotest
Bone Tumor
The Epidural Anesthesia on the Intra-operative and Post-operative Amount of Bleeding Post Lower Limb Salvage Surgery
Epidural anesthesia is a very useful tool in lower limb salvage surgery, which helps pain control intra and more importantly post-operative pain.
- Trial name
- NCT01679691
- Testing
- epidural anesthesia
- Where
- Egypt
- Sponsor
- Children's Cancer Hospital Egypt 57357
Surgical Procedures, Operative
A Study Comparing ETHICON™ 4000 Stapler System With Standard of Care Stapling Devices in Adults Undergoing Gastric and Thoracic Procedures
The purpose of this study is to compare how well the ETHICON™ 4000 Stapler works as compared to the standard stapling devices by assessing how often air leaks and bleeding along the staple line occur during lung and stomach…
- Trial name
- NCT07744568
- Testing
- ETHICON™ 4000 Stapler System, Standard of Care Stapler and Reloads
- Volunteers
- 300 people
- Sponsor
- Ethicon Endo-Surgery