Clinical trials: Operative Surgical Procedure
Pain, Postoperative
Analgesic Efficacy of Repeated Doses of Intravenous (IV) Acetaminophen in Post-operative Pediatric Spine Fusion Patients
This is a prospective, randomized, double-blinded, placebo controlled trial Potential subjects will be identified from the Pre-Surgical Anesthesia Clinic visit.
- Trial name
- IV APAP SF (NCT01394718)
- Testing
- Intravenous Acetaminophen
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Children's Hospital of Philadelphia
Pre-Operative Testing for Cataract Surgery
Using Behavioral Economics to Reduce Low-Value Care
There is strong consensus - based on robust randomized trial data - that routine pre-operative (pre-op) testing for cataract surgery is inappropriate.
- Trial name
- NCT04104256
- Testing
- Nudge #1: Alert highlighting the safety/potential harms to patients of undergoing pre-op tests, Nudge #2: Alert highlighting the financial harms to the patient experiencing pre-op tests, Nudge #3: Alert highlighting potential psychological harms to the patient of experiencing pre-op tests
- Where
- United States
- Volunteers
- 1,045 people
- Sponsor
- University of California, Los Angeles
Acute Pain, Post Operative Pain
Study of MR-107A-02 in the Treatment of Post Surgical Dental Pain.
MR-107A-02 is being studied to investigate its efficacy, safety and dose-response after dental surgery.
- Conditions
- Acute Pain, Post Operative Pain, Pain
- Trial name
- NCT05317312
- Testing
- MR-107A-02
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Mylan Specialty, LP
Post Operative Surgical Site Infection
Local Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures at High Risk of Infection: A Multicenter Randomized, Controlled Trial (VANCO)
The Vancomycin Study is a multi-center, prospective randomized controlled trial that will compare the proportion of deep surgical site infections within 6 months in patients treated with local Vancomycin powder compared to those…
- Trial name
- VANCO (NCT02227446)
- Testing
- Vancomycin antibiotic powder
- Where
- United States
- Volunteers
- 1,036 people
- Sponsor
- Major Extremity Trauma Research Consortium
Staphylococcal Infections, Surgical Site Infection
Effect of Exeporfinium Chloride (XF-73) Gel on Nasal S.Aureus in Patients at Risk of Post-op Staphylococcal Infection
This study looks at the difference between XF-73 and placebo in reducing the carriage of a bacteria S. aureus in the nose before, during and after heart surgery.
- Trial name
- NCT03915470
- Testing
- XF-73
- Where
- 21 sites in United States, Georgia and 1 more
- Volunteers
- 124 people
- Sponsor
- Destiny Pharma Plc
Intraoperative Bleeding
Adjunctive Application of BioFoam Surgical Matrix in Liver Surgery
This is a prospective, multicenter, randomized, controlled investigation. Subjects in which bleeding from the exposed parenchymal surface is observed intraoperatively following the ligature of vessels visible with the unaided eye…
- Trial name
- BARRIER (NCT01458561)
- Testing
- BioFoam Surgical Matrix, Gelfoam Plus
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- CryoLife, Inc.
Surgery
Continuous Non-Invasive SpHb and PVI Monitoring on Intra-Operative and Post-Surgical Clinical Outcomes
The study evaluates the use of noninvasive hemoglobin with In Vivo feature and PVi monitoring using pulse-oximetry based technologies and their effect on the management of transfusion and infusion decisions and clinical outcomes…
- Trial name
- NCT02986789
- Testing
- In vivo SpHb and PVi Monitoring
- Volunteers
- 43 people
- Sponsor
- Masimo Corporation
Postoperative Insomnia, Postoperative Delirium
Efficacy of Suvorexant on Post-operative Sleep Disturbance
The study is a parallel group, double blind, randomized trial. Subjects will be recruited from individuals undergoing elective surgery for orthopedic, abdominal, urologic, gynecologic or spine reasons.
- Trial name
- NCT05823844
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Columbia University
Adrenergic Beta-Receptor Blockader, Troponin Levels
Pilot - Peri-operative Beta Blockade
Perioperative cardiac adverse events [heart injuries caused by general anesthesia and surgical procedures] are a significant public health issue, with more than 60,000 deaths per annum in patients having surgery for non-heart…
- Conditions
- Adrenergic Beta-Receptor Blockader, Troponin Levels, Cardiomyopathy, Post-surgical
- Trial name
- NCT02746575
- Testing
- metoprolol
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Alcohol Drinking
Alcohol Screening and Pre-Operative Intervention Research Study
This study aims to learn more about how to improve patients' health before and after a scheduled surgery by examining acceptability and initial efficacy of pre-operative alcohol use reduction interventions.
- Trial name
- ASPIRE (NCT03929562)
- Testing
- Brief advice, Health coaching
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Michigan
Care, Postoperative, Pain, Postoperative
Psychological Influences on Postoperative Recovery
The primary hypothesis tested in this project is that the preoperative behavioral stress response predicts postoperative behavioral and clinical recovery of children undergoing surgery.
- Conditions
- Care, Postoperative, Pain, Postoperative, Surgical Procedures, Operative, Otorhinolaryngologic Surgical Procedures
- Trial name
- NIH (NCT00581139)
- Testing
- Preoperative Preparation Program (Child Life Specialist), Midazolam, Parental Presence during Induction of Anesthesia
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- University of California, Irvine
Post-operative Pain
Uniport and Multiport Epidural Catheters in Post-surgical Patients
The investigators hypothesize that multi-port thoracic epidural catheters will provide superior pain relief when compared to uniport catheters for post-surgical patients.
- Trial name
- NCT02159560
- Testing
- Epidural catheter
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Beth Israel Deaconess Medical Center
Post-Operative Delirium
A Study to Evaluate ICU Simulation Experience in the Cardiothoracic Surgical Population to Reduce Post-operative Delirium
The purpose of this study is to evaluate the effect of a pre-ICU admission virtual reality ICU simulation on post-operative delirium in the elective cardiothoracic surgical population while in the intensive care unit.
- Trial name
- NCT05159648
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Mayo Clinic
Scars
Safety and Efficacy of SLI-F06 in Wound Healing and Scar Appearance
Multicenter, double-blind study comparing SLI-F06 to vehicle formulation buffer for the improvement in scar appearance and wound strength in routine surgical excisions, as well as post-operative abdominoplasty scar appearance.
- Trial name
- NCT03880058
- Testing
- SLI-F06, Formulation buffer
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Scarless Laboratories, Inc.
Post-operative Situation
Study of a Prototype Software to Help Surgical Patients Manage Their Pain Medication
The experimental medical device is a prototype software. The device comes in the form of a smartphone with a touch interface. The smartphone used to support the software is a commercial smartphone marked CE.
- Trial name
- MORPHEE 2 (NCT05707247)
- Testing
- software
- Where
- France
- Volunteers
- 37 people
- Sponsor
- University Hospital, Strasbourg, France
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Surgical Site Infection, Unplanned Fracture-Related Reoperation
Pre-operative Alcohol Skin Solutions in Fractured Extremities
The prevention of infection is an important goal influencing peri-operative care of extremity fracture patients. Standard practice in the operative management of extremity fractures includes sterile technique and pre-operative…
- Conditions
- Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture, Closed Lower Extremity Fracture
- Trial name
- PREPARE (NCT03523962)
- Testing
- DuraPrep, ChloraPrep
- Where
- 27 sites in United States, Canada
- Volunteers
- 8,485 people
- Sponsor
- University of Maryland, Baltimore
Skin Cancer
ObservAtional Study to Investigate Surgical Site Infection in Ulcerated Skin Cancers
The investigators aim to recruit 311 participants to this study from three UK Dermatology departments. The investigators will invite people with suspected skin cancers whose lesions have a broken surface (also known as ulcerated)…
- Trial name
- OASIS (NCT03782727)
- Where
- 3 sites in United Kingdom
- Volunteers
- 148 people
- Sponsor
- Cardiff and Vale University Health Board
Rectal Cancer, Colon Cancer
Perfusion Assessment in Laparoscopic Left Anterior Resection
The purpose of this study is to demonstrate that NIR fluorescence angiography using the PINPOINT Endoscopic Fluorescence Imaging System ("PINPOINT System" or "PINPOINT") can assess viability of colon tissue during laparoscopic…
- Conditions
- Rectal Cancer, Colon Cancer, Crohn's Disease, Polyp
- Trial name
- PILLAR II (NCT01560377)
- Testing
- PINPOINT Endoscopic Fluorescence Imaging System
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- Novadaq Technologies ULC, now a part of Stryker
Operative Surgical Procedures
Glottic View Using Supraglottic Devices in Pediatric Patients
Endotracheal intubation is the gold standard for securing the airway. However, while managing patients with difficult airways, various supraglottic devices have been used as rescue airway devices.
- Trial name
- NCT02532465
- Testing
- Air-Q, i-gel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Senthil G. Krishna