Clinical trials: Operative Surgical Procedures
Surgical Procedures, Operative
Arterial Pulse Waveform Contour Analysis for Intraoperative Goal Directed Therapy in Major Abdominal Surgery
This study evaluates whether using information from a special arterial blood pressure monitor to guide how much fluid is given during surgery changes how long a patient stays in the hospital after the surgery.
- Trial name
- NCT01082614
- Testing
- Vigileo
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Loma Linda University
Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy
Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery
This prospective, observational, non-randomized clinical study aims to evaluate the intraoperative and postoperative effects of opioid-free multimodal anesthesia compared with opioid-containing anesthesia methods in adult…
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation With Radiculopathy, Lumbar Degenerative Spondylolisthesis, Lumbar Disc Degeneration
- Trial name
- NCT07489001
- Testing
- Opioid-free Anesthesia, Erector Spinae Plane Block, Opioid based Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Marmara University
Knee Injuries and Disorders, Hip Injuries and Disorders
Impact of Different Educational Approaches on Post-operative Opiate Utilization After Elective Lower Extremity Surgery
The purpose of this study is to evaluate the use of post-operative opioid use after two different educational interventions. The investigators will compare changes in pain, disability and sleep between groups 6 months after…
- Conditions
- Knee Injuries and Disorders, Hip Injuries and Disorders, Opiate Addiction
- Trial name
- OpiateLEO (NCT02997644)
- Testing
- Video Education, Usual Care Group
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Non Small Cell Lung Cancer, Lung Cancer
Phase II Lung Metcore - Preoperative Metformin for Lung Cancer
This is a phase II single centre open label single arm pre-operative window of metformin treatment in stage I-IIIa Non small cell lung cancer.
- Trial name
- Metcore (NCT03086733)
- Testing
- Metformin
- Where
- 2 sites in Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Surgery, Anxiety
Pediatric Preoperative Virtual Reality Program
Does the introduction of a preparatory virtual reality (VR) program that is used in the home environment, have an effect on the anxiety level of children immediately before surgery, prior to administration of preoperative…
- Trial name
- PPVRP (NCT03957525)
- Testing
- Pre-Operative Preparatory Virtual Reality Program
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Thoralf Liebs
Femoroacetabular, Impingement
Dynamic Imaging of the Hip for Pre-operative Planning
One of the leading causes of hip arthritis is femoro-acetabular impingement which means the hip joint is deformed such that the hip joint jams in the front when the hip is bent all the way forward.
- Trial name
- NCT00605969
- Testing
- Motion analysis, Computed Tomography
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Bloodloss, Surgical Procedures, Operative
Outcomes and Safety Trial Investigating Ecallantide's Effect on Reducing Surgical Blood Loss Volume in Subjects at High Risk of Bleeding Exposed to Cardio-pulmonary Bypass During Cardiac Surgery
A Phase 2 Randomized Double-Blind Active-Controlled Study in Subjects Exposed to Cardio-pulmonary Bypass During Cardiac Surgery at High Risk of Bleeding
- Trial name
- CONSERV-2 (NCT00888940)
- Testing
- Ecallantide, Cyklokapron(R)
- Where
- 34 sites in United States, Germany and 1 more
- Volunteers
- 243 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Polypharmacy, Surgical Procedure, Operative
Polypharmacy and Outcomes After Elective Noncardiac Surgery
This study investigates the association of preoperative polypharmacy with outcomes and healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program
- Conditions
- Polypharmacy, Surgical Procedure, Operative, Morality, Epidemiology
- Trial name
- NCT03133182
- Testing
- Polypharmacy
- Volunteers
- 266,499 people
- Sponsor
- Ottawa Hospital Research Institute
Stoma Ileostomy, Surgical Wound
The Use of Post-operative NPWT Dressing in the Prevention of Infectious Complications After Ostomy Reversal Surgery
Introduction: Although negative-pressure wound therapy (NPWT) is likely advantageous for wound healing, the efficacy and safety of its prophylactic use remain unclear.
- Conditions
- Stoma Ileostomy, Surgical Wound, Negative Pressure Wound Therapy, Postoperative Wound Infection
- Trial name
- NCT04088162
- Testing
- Postoperative Negative Pressure Wound Therapy KCI NANOVA
- Where
- 2 sites in Poland
- Volunteers
- 70 people
- Sponsor
- Michał Pędziwiatr
Vascular Diseases
Predictors of Post Operative Outcome in Peripheral Vascular Surgical Patients
Over 3000 people each year undergo bypass operations to their lower limbs, and these operations carry significant risks with approximately 1 in 20 of these people dying in hospital, and another 1 in 20 having a heart attack.
- Trial name
- NCT01417910
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- York Teaching Hospitals NHS Foundation Trust
Pain, Post Operative, Anxiety
Music Therapy in the Treatment of Perioperative Anxiety and Pain
A large number of adults who undergo surgery experience perioperative anxiety and pain. The current recommended approach to perioperative pain management is a multimodal approach including opioids.
- Conditions
- Pain, Post Operative, Anxiety, Opioid Use
- Trial name
- NCT05263635
- Testing
- Music therapy, Standard of Care Enhanced Recovery After Surgery (ERAS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Shoulder Instability
Operative Treatment of Traumatic Anteroinferior Shoulder Instability in Young Male Patients
Glenohumeral joint is prone to instability, i.e. the humeral head may dislocate off the scapular glenoid plate especially in the anteroinferior direction.
- Trial name
- NCT01998048
- Testing
- Latarjet, Bankart
- Where
- 8 sites in Finland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Arthroplasties, Hip Replacement, Arthroplasties, Knee Replacement
The Effect of A New Perioperative Practice Model on Patient, Nursing And Organisational Outcomes
The aim of the study is to improve the surgical patients' care process. The objective is to explore the effect of a new perioperative practice model on 1) patient outcomes (satisfaction, surgery-related anxiety and quality of…
- Trial name
- NCT02906033
- Testing
- New perioperative practice model
- Where
- Finland
- Volunteers
- 517 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Orthopaedics Wound Dressings
Comparative Efficacy of Advanced and Traditional Wound Dressings in Post-Operative Orthopedic Care
Title: Comparative Efficacy of Advanced and Traditional Wound Dressings in Post-Operative Orthopedic Care: A Randomized Controlled Trial Objective: The primary objective of this study is to evaluate and compare the efficacy of…
- Trial name
- NCT06540040
- Testing
- Aquacel Ag, OPSITE, MEPILEX POST OP BORDER
- Where
- India
- Volunteers
- 320 people
- Sponsor
- Nidhi Srivastava
Pain, Acute, Pain, Chronic
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic…
- Conditions
- Pain, Acute, Pain, Chronic, Chronic Post Operative Pain
- Trial name
- NCT07144033
- Testing
- Butyrate and Taurine
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Intraoperative Workflow, Anesthesia and Procedure Related Time Intervals
Influence of Resident Training on Intra-operative Workflow
Anaesthesia and surgery related time intervals of three standard operations are compared depending on whether residents or consultants are performing anaesthesia and surgery.
- Trial name
- NCT00591435
- Testing
- Comparison of performance of consultants versus residents
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University Hospital Schleswig-Holstein
Surgical Site Infection
Evaluation of Peri-operative Risk Factors for Surgery Site Infection in Cardiac Surgery
There is a recent increase in incidence of surgical site infection after cardiac surgery in our hospital, in spite of specific measures taken concerning some aspects of the surgical procedures, targeting a better control of the…
- Trial name
- PRISCCA (NCT02392936)
- Testing
- Sternotomy for coronary artery bypass graft, valvuloplasty, aortic surgery or combined procedures, under extracorporeal circulation or not, in emergency or scheduled.
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Gallbladder Disease, Biliary Colic
Fluorescence Imaging on the da Vinci Surgical System for Intra-operative Near Infrared Imaging of the Biliary Tree (up to 2-weeks Post-operatively)
The investigators hypothesize that the da Vinci Fluorescence Imaging Vision System provides real-time endoscopic near infrared fluorescence imaging of the biliary anatomy as defined as identifying biliary vessels; either cystic…
- Conditions
- Gallbladder Disease, Biliary Colic, Gallstones
- Trial name
- NCT01410734
- Testing
- Indocyanine green (ICG)
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 72 people
- Sponsor
- Intuitive Surgical
Pain, Postoperative, Hernia, Ventral
An Open-label Safety and Pharmacokinetic Study of INL-001 in Adults Following Various Open Soft-Tissue Surgeries
This is a multicenter, Phase 3, open-label, safety, tolerability, and characterization of pharmacokinetics study of the INL 001 (bupivacaine HCl) implant, at 300 mg, in patients following various soft-tissue surgeries: open…
- Conditions
- Pain, Postoperative, Hernia, Ventral, Abdominoplasty, Hysterectomy
- Trial name
- NCT04785638
- Testing
- INL-001 (bupivacaine hydrochloride) implant
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Innocoll
Pelvis; Fracture
Surgical Treatment of Pelvis in Fragility Fracture in Germany: a Prospective, National, Multicenter, Observational, Comparative Cohort Study Comparing Isolated Posterior Versus Combined Anterior-posterior Surgical Fracture Stabilization
Over a period of approximately two years, patients above the age of 65 who have suffered from an FFP equal to or higher than type IIc FFP, according to Rommens and Hofmann, will be eligible for inclusion.
- Trial name
- AO TOP (NCT06550934)
- Testing
- Fracture stabilization
- Volunteers
- 420 people
- Sponsor
- AO Innovation Translation Center