Clinical trials: Operative Surgical Procedures, open to volunteers
Post Operative Delirium, Cognitive Impairment
Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression
This study will examine whether noninvasive, transcutaneous vagal nerve stimulation (tcVNS) can help restore consciousness in patients in the operating room and the Post Anesthesia Care Unit (PACU).
- Conditions
- Post Operative Delirium, Cognitive Impairment, Vagus Nerve Stimulation, Depression
- Trial name
- tVNS (NCT07610655)
- Testing
- Transcutaneous vagal nerve stimulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Post Operative Pain
Efficacy of a Novel Nanoparticle -Augmented Disinfection Protocol
The ultimate biological aim of endodontic therapy is to either prevent or heal apical periodontitis. Root canal treatment can fail for various reasons, such as persistent infection, missing canals, ledges, canal transportation…
- Trial name
- NCT07800403
- Testing
- Novel Nanoparticle
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Minia University
Arthroplasty Complications, Pain, Postoperative
The Effectiveness of High-intensity Laser Therapy on Post-surgical Rehabilitation After Total Knee Arthroplasty
This randomized controlled trial aims to evaluate the effectiveness of high-intensity laser therapy (HILT) as an adjunct to conventional rehabilitation in patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT07568262
- Testing
- High level laser therapy
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Istituto Ortopedico Rizzoli
Asses Radiological Efficacy of Posterior Approach Regarding Correction of Cobb Angle Post Operative . • Asses, Scoliosis Idiopathic Adolescent Treatment
Surgical Outcomes and Complications of Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common form of scoliosis representing about 80-90% of all idiopathic scoliosis cases , characterized by lateral curvature of the spine of 10 degrees or more in children 10-18…
- Trial name
- Scoliosis (NCT07092917)
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University
Pain, Chronic, Pain, Chronic Post-Surgical
iCanCope With Post-Operative Pain (iCanCope PostOp)
There are few applications available in the community to help teenagers manage pain after surgery. The focus of this study is to better understand the pain experience of children after having surgery and to design a Smartphone…
- Trial name
- NCT05382962
- Testing
- iCanCope Post Op Application
- Where
- 2 sites in United States, Canada
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Diverticulitis, Colon Disease
Comparison of NOM for ACLD Between Medical and Surgical Ward
In Europe, patients with acute left colon diverticulitis (ALCD) are usually admitted to surgical wards even when only medical treatment is required.
- Conditions
- Diverticulitis, Colon Disease, Acute Diverticulitis
- Trial name
- NCT06265649
- Testing
- NOM
- Where
- Italy
- Volunteers
- 175 people
- Sponsor
- Ospedali Riuniti Trieste
Endometriosis, Deep Endometriosis
Ureteric Identification Using Indocyanine Green Dye Versus Conventional Ureteric Stenting to Reduce Post-operative Pain and Surgical Morbidity During Endometriosis Surgery
Endometriosis is a common (around 1 in 10 women), non-cancerous condition where tissue similar to the womb lining is found growing elsewhere, most commonly inside the pelvis.
- Trial name
- ICE (NCT06852248)
- Testing
- Ureteric stenting, Indocyanine green (ICG) dye
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University Hospitals of North Midlands NHS Trust
Critical Illness, Post Operative Complication
Safety and Feasibility of a Self-Balancing Exoskeleton for Rehabilitation in the Thoracic Surgical Intensive Care Unit: a Pilot Trial
Patients admitted to the Intensive Care Unit (ICU) after thoracic surgery often experience complications related to immobility, such as muscle weakness, pulmonary issues, and longer recovery times.
- Conditions
- Critical Illness, Post Operative Complication, Thoracic Surgery
- Trial name
- HEART (NCT07220733)
- Testing
- Self-balancing robotic exoskeleton (Atalante X)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wandercraft
Acute Uncomplicated Appendicitis
Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children
The majority of children with uncomplicated acute appendicitis may be considered for either a non-operative or an operative management.
- Trial name
- NACAC (NCT07587450)
- Testing
- Amoxi Clavulanate, appendicectomy
- Where
- 10 sites in France
- Volunteers
- 724 people
- Sponsor
- University Hospital, Toulouse
Arthroscopic Knee Repair, Arthroscopic Hip Repair
PO Methadone Ortho Outpatient
The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage.
- Trial name
- NCT06351215
- Testing
- Methadone group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Keck School of Medicine of USC
Cefoperazone/Sulbactam Induced Coagulopayjy
Impact of Hypoalbuminemia on Cefoperazone/Sulbactam Induced Coagulopathy in Post-Operative Surgical Patients
The goal of this observational study is to learn whether hypoalbuminemia in post surgical patients receiving cefoperazone/sulbactam therapy poses them to the risk of developing coagulopathy.
- Trial name
- NCT07773584
- Volunteers
- 108 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Adenocarcinoma of the Pancreas
Resection/Synchronous Pulmonary or Hepatic Oligometastatic Pancreatic Ductal Adenocarcinoma
This is a clinical trial that tests a surgical treatment. Everyone in the study will get the same treatment, and there is no comparison or placebo group.
- Trial name
- PHOLIPANC (NCT07340151)
- Testing
- Surgical resection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cardiac Rhythm Disorders, Urological Disorders
Product Surveillance Registry
The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products.
- Conditions
- Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders
- Trial name
- PSR (NCT01524276)
- Where
- 402 sites in United States, Argentina and 39 more
- Volunteers
- 100,000 people
- Sponsor
- Medtronic
Bowel Cleansing Prior to Clinical Procedures, Colorectal Anastomosis
Oral Antibiotics vs. No Antibiotics in Pediatric Colorectal Surgery
This study aims to evaluate whether giving oral antibiotics before elective colorectal surgery can improve recovery and reduce complications in children.
- Trial name
- PEACO (NCT07713433)
- Testing
- oral antibiotics, No Oral Antibiotics
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Muhammad Zubair Shoukat
Postoperative Complications
The South African Collaborative Surgical Outcomes Study (SACSOS)
Improving quality of perioperative care depends on reliable measurement of clinically important and patient-centred data, that will allow collaborative decision-making between patient and clinician.
- Trial name
- SACSOS (NCT05052021)
- Testing
- Public or Private Sector Patients
- Volunteers
- 1,000 people
- Sponsor
- Sefako Makgatho Health Sciences University
Dental, Dental Extraction
Insomnia and Post-Dental Surgery Pain: A Prospective Study
The purpose of this prospective observational study is to evaluate the relationship between preoperative sleep disturbances-specifically insomnia-and postoperative pain intensity following oral surgical procedures.
- Conditions
- Dental, Dental Extraction, Insomnia
- Trial name
- INDOLC (NCT07712432)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Pancreatic Ductal Adenocarcinoma (mPDAC), Pancreatic Ductal Adenocarcinoma (PDAC)
How Does Pre-operative Biliary Drainage in Pancreatic Adenocarcinoma Affect Surgical Outcomes in Pancreatic Cancer Surgery
Pre-operative biliary drainage (PBD) is a procedure used to relieve bile duct obstruction, a common issue in patients with pancreatic cancer.
- Trial name
- PBDSOO (NCT07444840)
- Testing
- Pre operative biliary drainage
- Volunteers
- 90 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Surgical Procedures, Operative
Detection of Health Risk Situations in the Anesthesia Consultation.
This study aims to estimate the proportion of patients seen in the anesthesiology consultation for planned surgery in whom a previously unknown health risk situation is detected (e.g., obesity, anemia, etc.).
- Trial name
- NCT06724380
- Testing
- unknown health risk situation
- Where
- Spain
- Volunteers
- 218 people
- Sponsor
- Consorci Sanitari de l'Alt Penedès i Garraf
Post-operative Complications
Reducing Deaths After Surgery in Low- and Middle-income Countries: A Pilot Cluster Randomised Trial
SurgPASS is a pilot randomised cluster trial utilising a pre-operative checklist with the aim of reducing deaths after surgery. If SurgPASS is successful, the intervention will be implemented in a separate full-scale cluster…
- Trial name
- SurgPASS (NCT06932653)
- Testing
- SurgPASS - intervention
- Where
- 5 sites in Benin, Ghana and 3 more
- Volunteers
- 300 people
- Sponsor
- University of Birmingham
Heart Valve Diseases, Cardiac Surgical Procedures
Assessment of Transnational Performance of the Universal Cardiac Surgical Risk Score Across International Sites
ATLAS is a prospective, observational, multicenter cohort study of how accurately the Universal Cardiac Surgical Risk Score (UCSRS) predicts 30-day outcomes after adult cardiac surgery, compared head-to-head with two established…
- Conditions
- Heart Valve Diseases, Cardiac Surgical Procedures, Coronary Artery Disease
- Trial name
- ATLAS (NCT07920575)
- Testing
- Risk score calculation
- Volunteers
- 5,000 people
- Sponsor
- Union Health System