Clinical trials: Operative Surgical Procedures
Respiratory Failure, Acute Respiratory Failure Requiring Intubation
Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications
Respiratory complications represent the second most frequent type of postoperative complications with an incidence estimated to range from 2.0% to 7.9% It has been shown that intra-operative protective ventilation is associated…
- Conditions
- Respiratory Failure, Acute Respiratory Failure Requiring Intubation, Pulmonary Edema, Pneumonia
- Trial name
- NCT02399878
- Testing
- Inspiratory oxygen
- Volunteers
- 70,000 people
- Sponsor
- Massachusetts General Hospital
Chronic Postoperative Pain
Low Dose Peri-operative IV Ketamine for Chronic Post-surgery Pain Prevention
This study will test the null hypothesis that low-dose ketamine given peri-operatively will have no effect on the development of chronic post-surgical pain, in patients undergoing thoracotomy or video assisted thoracic surgery…
- Trial name
- NCT01296347
- Testing
- Ketamine
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- Imperial College Healthcare NHS Trust
Stress Urinary Incontinence
TVT-Secur Versus TVT-Obturator: A Randomized Trial of Suburethral Sling Operative Procedures
The purpose of this study is to determine whether TVT-Secur (TVT-S) (Hammock method) and TVT-Obturator (TVT-O) suburethral sling procedures have equivalent patient satisfaction and clinical efficacy in the treatment of stress…
- Trial name
- NCT00676273
- Testing
- TVT-Obturator (TVT-O), TVT-Secur (TVT-S) (Hammock method)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Boston Urogynecology Associates
Pancreatic Cancer
Porto-Venous Radiomics in Pancreatic Cancer
Multi-centre Retrospective Observational Cohort study of patients who underwent pancreaticoduodenectomy from 01/01/2005 to 01/02/2022 with histologically confirmed pancreatic head malignancy
- Trial name
- NCT05700110
- Testing
- Non-Interventional
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Post-operative Pain
Uniport and Multiport Epidural Catheters in Post-surgical Patients
The investigators hypothesize that multi-port thoracic epidural catheters will provide superior pain relief when compared to uniport catheters for post-surgical patients.
- Trial name
- NCT02159560
- Testing
- Epidural catheter
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiac Surgical Procedures, Wound Healing
Use of the Bra as Prevention of Sternal Wound Dehiscence in Cardiac Surgery
The aim of the study was to assess the efficacy of bra application as a prevention of dehiscence in women with median sternotomy.
- Trial name
- DEHISCENCIA (NCT04290260)
- Testing
- Use of breast bra, Usual care (not use of bra)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Germans Trias i Pujol Hospital
Malnutrition, Gastroenterological Cancer
The Impact of Perioperational Malnutrition on the Cost on Gastroenterological Cancer Patients
Undernutrition is a state marked by energy and/or protein intake deficiency or mal-absorption, and is often described as protein energy malnutrition (PEM). Malnutrition is common in hospitalized patients worldwide.
- Conditions
- Malnutrition, Gastroenterological Cancer, Surgical Procedures, Operative
- Trial name
- NCT00987883
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
Delirium, Thoracic Surgery
Cerebral Oxygen Desaturation and Post-Operative Delirium in Thoracic Surgical Patients
This study will assess the incidence and risk factors for post-operative delirium in patients undergoing thoracotomy. Specifically, the study will assess if there is any relationship between an intra-operative decrease in brain…
- Trial name
- NCT03165539
- Testing
- Cerebral oxygen saturation monitoring
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Wound Closure, Dehisced Surgical Wounds
Post Operative Skin Approximation With Cyanoacrylate Based Wound Closure Adhesives
surgical adhesive systems are used to close surgical cuts and simple skin wounds. This system is a non-invasive option, meaning it can be used instead of stitches or staples.
- Trial name
- NCT07613892
- Testing
- Evaluating wound closure products to close larger surgical site incisions, Evaluating wound closure products to close smaller surgical site incisions
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medline Industries
Surgical Wound Infection, Cystitis
The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study
All surgical procedures carry with them the risk of infection. Even a minor infection can extend the hospitalization after cardiac surgery. The average minimum increase in length of stay for a single infection is three days.
- Conditions
- Surgical Wound Infection, Cystitis, Bacteremia, Pneumonia
- Trial name
- NCT00164099
- Testing
- Synbiotic 2000
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Beth Israel Medical Center
Urogynecologic Surgery
Post-Operative Pain Management With NSAIDS
Specific Aim 1: To identify differences in pain perception and satisfaction with pain control in women undergoing urogynecologic surgery receiving nonsteroidal anti-inflammatory (NSAIDS) postoperatively by oral ibuprofen…
- Trial name
- NCT01971372
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Oklahoma
Surgical Procedures, Operative
ETT Cuff Leak: TV Ratios
In the past 5 years cuffed endotracheal tubes (ETT) have become the standard of care in pediatrics. However, hyperinflation of the cuff can compromise the tracheal mucosal perfusion while an inadequate seal may impact ventilation…
- Trial name
- NCT02768831
- Testing
- CPAP, Tidal volume
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Nationwide Children's Hospital
Post-operative Pulmonary Complications
Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients
The Investigators goal was to study the effect of high flow nasal cannula oxygen (HFNC) on the rate of post-operative pulmonary complications in thoracic surgical patients.
- Trial name
- NCT03024112
- Testing
- Heated humified high-flow nasal cannula Oxygen, Standard oxygen therapy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Colorado, Denver
Acromegaly
Peri-operative Dynamics of the Growth Hormone Axis in Subjects With Acromegaly
Acromegaly is a rare disorder characterized by excessive production of growth hormone most often by a pituitary adenoma. A pituitary adenoma is a tumor, almost always benign or non-cancerous, that grows on the pituitary, a small…
- Trial name
- NCT00921609
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Surgical Wound Infection
Vacuum Assisted Closure for Cesarean Section
To study if incisional vacuum-assisted closure can decrease the risk of infection in cesarean section incisions in the obese compared with standard sterile dressing.
- Trial name
- VACCS (NCT02390401)
- Testing
- Vacuum-assisted closure, Standard sterile dressing
- Where
- 4 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Surgical Procedures, Minimally Invasive
Comparison of Ivor Lewis and Tri-incision Approaches for Patients With Esophageal Cancer
Esophagectomy for esophageal cancer is a technically complex procedure which is associated with high perioperative mortality, even in high volume centers[1].
- Conditions
- Surgical Procedures, Minimally Invasive, Operative, Esophageal Neoplasms
- Trial name
- NCT02017002
- Testing
- Ivor Lewis, Tri-incision
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Surgical Field, Acute Postoperative Pain
Bupivacaine 0.125% Versus Bupivacaine 0.25% in Superficial Cervical Plexus Block for Tympanomastoid Surgeries in Adults
Bleeding is one of the most common complications in tympanomastoid surgery that could prolong the time of operation and also might lead to morbidity.
- Trial name
- NCT06381401
- Testing
- bupivacaine 0.25%, bupivacaine 0.125%
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Obese
Mechanical Ventilation in Obese Surgical Patients
The purpose of this study is to evaluate whether an intraoperative positive end-expiratory pressures (PEEP) setting strategy aimed at minimizing the mechanical power delivered to the lungs via transpulmonary pressure improves…
- Trial name
- NCT07774065
- Testing
- Standard PEEP (8 cmH₂O)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cicatrix, Scars
Study of the Effects of the Pulsed-dye Laser at 585nm and 595nm to Treat Post-operative Scars on Suture-removal Day
The purpose of this study is to compare the effects of the pulsed-dye laser (PDL) at two different wavelengths, 585nm and 595nm, in the treatment of post-surgical scars starting on suture-removal day.
- Trial name
- NCT00482144
- Testing
- PDL 450 microseconds, PDL 1.5 milliseconds
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Miami
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center