Clinical trials: Operative Surgical Procedures, active
Arthroscopic Knee Repair, Arthroscopic Hip Repair
PO Methadone Ortho Outpatient
The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage.
- Trial name
- NCT06351215
- Testing
- Methadone group
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Keck School of Medicine of USC
Neoplasms, Frailty
Ready for Safe Cancer Treatment (RESET): A Comprehensive Perioperative Program for Surgical Oncology
The goal of this randomized controlled clinical trial is to evaluate whether the Ready for Safe Cancer Treatment (RESET) program improves perioperative care and supports safe hospital discharge in two surgical populations: adult…
- Conditions
- Neoplasms, Frailty, Surgical Procedures, Operative
- Trial name
- RESET (NCT07727876)
- Testing
- RESET multimodal perioperative care pathway, Standard perioperative care
- Where
- 2 sites in Poland
- Volunteers
- 12,800 people
- Sponsor
- Regional Specialist Hospital in Wroclaw
Hemorrhage, Surgical, Tonsillar Bleeding
TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot Study
After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the…
- Trial name
- TEAPOT (NCT06580509)
- Testing
- Tranexamic Acid Injectable Product, Normal Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Postoperative Pain, Anxiety Postoperative
Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery
Patients who undergo cardiothoracic surgery often experience pain and anxiety around the time of surgery. Currently, treatments for pain and anxiety around the time of surgery include opioids and benzodiazepines, which can have…
- Conditions
- Postoperative Pain, Anxiety Postoperative, Opioid Use
- Trial name
- NCT04912531
- Testing
- Virtual Realty using a Microsoft Hololens, Empatica HR wristband, and EEG, Essence Olfactory Necklace, Bedside Olfaction Device
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Medication Related Osteonecrosis of the Jaw
MRONJ and Polynucleotides-Hyaluronic Acid Hydrogel (Regenfast®)
Several circumstances or conditions, such as wound extension or disease, can affect the hard and soft tissue healing after surgical treatment of MRONJ. Supportive therapies are therefore needed to help tissues wound healing.
- Trial name
- REG-MRONJ-1 (NCT06984107)
- Testing
- MRONJ resection plus PN+HA
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Vascular Surgical Procedure
Measurement Of NT-proBNP to Predict Outcomes in Surgery
The team is investigating whether N-terminal pro B-type natriuretic peptide (NT-proBNP) and other cardiac markers are useful for predicting outcomes for patients undergoing vascular surgery.
- Trial name
- MOBOS (NCT04014647)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Prehabilitation, Preoperative Care
Prehabilitation Before Major Surgery
The goal of this clinical trial is to learn if a virtually monitored, home-based prehabilitation program is feasible and acceptable for adults undergoing major elective surgery. The main questions it aims to answer are: 1.
- Conditions
- Prehabilitation, Preoperative Care, Elective Surgical Procedures, Postoperative Complications
- Trial name
- PRIME (NCT07590141)
- Testing
- Virtually Monitored Home-Based Prehabilitation Program
- Where
- 3 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Queen's University
Ankle Fractures
RCT Comparing Non-operative vs Operative Treatment of Suprasyndesmotic Ankle Fractures.
Weight-bearing radiographs will be used to evaluate the stability of suprasyndesmotic ankle fractures. Patients with stable fractures will be randomised to operative or non-operative treatment.
- Trial name
- NCT04615650
- Testing
- Surgical treatment, Ankle orthosis
- Where
- 4 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Sykehuset Innlandet HF
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Rotator Cuff Tear Surgical Repair
H-Wave® Device Stimulation for Post-operative Rotator Cuff Repair Surgery
The goal of this intent-to-treat study is to evaluate the efficacy of H-Wave Device Stimulation following rotator cuff repair surgery.
- Trial name
- NCT07501949
- Testing
- Routine post-surgical care plus H-Wave® Device Stimulation (HWDS), Routine post-surgical care
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Electronic Waveform Lab
Direct Oral Anticoagulants (DOACs), Oral Surgical Procedures
Oral Biopsy Bleeding in Patients on Direct Oral Anticoagulants (DOACs)
Direct oral anticoagulants (DOACs) are increasingly used, but evidence on bleeding risk during oral soft tissue biopsy is limited.
- Trial name
- DOACS_BX (NCT07520890)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Mandible Fracture, Post-operative Antibiotics
The MANTRA Trial (MANdibular TRauma and Antibiotic Use)
1. FULL TITLE OF THE PROJECT Should we use post-operative antibiotics following surgery for patients with mandible fractures? The MANTRA trial (MANdibular TRauma and Antibiotic use) 2.
- Trial name
- MANTRA (NCT05964140)
- Testing
- Different post-operative antibiotic regimens following surgical treatment of mandible fractures
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,841 people
- Sponsor
- East Lancashire Hospitals NHS Trust
Carcinoma, Squamous Cell, Oral Cancer
Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma
Participants in this study have a type of cancer called squamous cell carcinoma of the head and neck (SCCHN). Their SCCHN has spread around the area where the cancer first started. This is called locally-advanced SCCHN.
- Conditions
- Carcinoma, Squamous Cell, Oral Cancer, Oropharynx Cancer, Larynx Cancer
- Trial name
- NCT03174275
- Testing
- Durvalumab, Carboplatin, Nab-paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Surgical Wound, Post Operative Wound Infection
Early Versus Delayed Bathing of Orthopaedic Surgical Wounds
This is a single center randomized control trial assessing the effect of early versus delayed bathing on orthopaedic surgical wounds in patients undergoing surgical treatment of fractures.
- Trial name
- EVDB (NCT06014411)
- Testing
- Time to bathing (delayed), Time to bathing (early)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Hospital for Special Surgery, New York
Pilonidal Sinus, Wound Healing
ENVELOP: Wound Care Following Pilonidal Sinus Surgery
This is a single-blinded, multicentre, prospective randomised controlled trial (RCT) comparing post-operative and patient-reported outcomes for patients undergoing application of negative-pressure wound therapy (NPWT) after sinus…
- Trial name
- ENVELOP (NCT06647290)
- Testing
- Negative Pressure Wound Therapy, Standard wound care
- Where
- 10 sites in Ireland
- Volunteers
- 200 people
- Sponsor
- Royal College of Surgeons, Ireland
Cesarean Delivery
Post-Operative Cesarean Section Cosmesis
Given the high numbers of cesarean deliveries being performed today, there has been interest in optimizing surgical techniques. Several recent reviews have summarized the evidence for various steps of cesarean delivery, but…
- Trial name
- NCT06412978
- Testing
- absorbable subcuticular polyglycolic acid staples (INSORB), subcuticular, polyglecaprone suture (Monocryl)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hemorrhage, Surgical, Tonsillar Bleeding
TEAPOT Study Multisite
After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the…
- Trial name
- TEAPOT (NCT07565753)
- Testing
- Tranexamic Acid Injectable Product, Normal Saline
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Chronic Subdural Hematoma, Surgical Procedures, Operative
A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage.
- Conditions
- Chronic Subdural Hematoma, Surgical Procedures, Operative, Recurrence, Mortality
- Trial name
- SUPERDURA (NCT06621407)
- Testing
- 24 hours active subperiostal drainage, 24 hours passive subdural drainage
- Where
- 4 sites in Denmark
- Volunteers
- 354 people
- Sponsor
- Aalborg University Hospital
Proximal Humerus Fracture, 2 Part Fracture
Two- Part Proximal Humerus - Conservative vs Operative
The proximal humerus fracture (PHFs) is the third most common fracture type in the elderly, and represents 5% of the overall fractures. The incidence is increasing.
- Trial name
- NCT04106674
- Testing
- Open reduction internal stabilisation (ORIF)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Opioid Use, Opioid Prescribing, Dispensing, and Patient Use
Opioid Package Prototype (OPP)
The overall objective of this clinical trial is to identify the impact of selected package features, known as the Opioid Package Prototype (OPP), on the safe and effective use of opioids.
- Trial name
- NCT04598074
- Testing
- Opioid Package Prototype (OPP), Usual Care (standard amber vial)
- Where
- United States
- Volunteers
- 352 people
- Sponsor
- UConn Health