Clinical trials: Ophthalmic Imaging
Optic Neuropathy, Optic Neuropathy, Ischemic
Building Research With Artificial Intelligence in Neuro-Ophthalmology
The research team, recognized as a world leader in Artificial Intelligence for neuro-ophthalmology, has shown that it is possible to diagnose certain neuro-ophthalmologic or neurologic disorders from a single retinal fundus image…
- Conditions
- Optic Neuropathy, Optic Neuropathy, Ischemic, Optic Neuritis, Optic Nerve Diseases
- Trial name
- BRAIN (NCT06390579)
- Testing
- Deep learning algorithm applied on retrospectively collected color fundus photographs
- Where
- France
- Volunteers
- 693 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Geographic Atrophy, Age-Related Macular Degeneration
Retinal Fundus Flavoprotein Fluorescence in Age Related Macular Degeneration
The goal of this clinical trial is to learn if the areas of stressed cells in the retina correlate to areas of disease identified in standard imaging and whether the images are helpful to identify potential areas of concern…
- Trial name
- FPF in AMD (NCT06381596)
- Testing
- OcuMet Beacon
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Wisconsin, Madison
Breast Sagging, Ptosis
Laser Fluorescent Imaging of Nipple and Areola During Breast Lift
Breast lift surgery performed in combination with breast implants is a common cosmetic operation. However, there have been concerns regarding the safety of this treatment combination.
- Conditions
- Breast Sagging, Ptosis, Loss of Breast Volume
- Trial name
- NCT02201979
- Testing
- Vertical breast lift with implants
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Swanson Center
Retinitis Pigmentosa, Usher Syndrome Type 2
Retinal Imaging in CNTF -Releasing Encapsulated Cell Implant Treated Patients for Early-stage Retinitis Pigmentosa
This clinical trial is a single-site, 30 patient study for participants who have early stage retinitis pigmentosa, or Usher syndrome (type 2 or 3). Funding Source - FDA OOPD and Foundation Fighting Blindness.
- Conditions
- Retinitis Pigmentosa, Usher Syndrome Type 2, Usher Syndrome Type 3
- Trial name
- NCT01530659
- Testing
- NT-501
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Neurotech Pharmaceuticals
Dry Eyes
Reproducibility of Anterior Segment Optical Coherence Tomography (AS-OCT) for Imaging Conjunctivochalasis
Conjunctivochalasis refers to loose redundant, non-edematous inferior conjunctiva that is situated between the globe and lower eyelid, and usually it occurs bilaterally.
- Trial name
- NCT01933178
- Testing
- Cirrus AS-OCT
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Diabetes Mellitus, Diabetic Retinopathy
Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling
This study intends to take the critical pathological mechanism of diabetic neurovascular coupling injury (NCI) as the starting point and utilize multi-modal imaging (MMI) technology of the eyes and brain as a means to conduct…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Cognitive Impairment, Neurovascular Coupling
- Trial name
- TCM-MMI (NCT06813274)
- Testing
- hypoglycemic treatment, Tangshen'an Granules, Ginkgo Leaf Tablets
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Hejiang Ye
Age-Related Macular Degeneration, NAMD
Targeted Fluorescence Imaging in AMD
Rationale: To track performance of intravitreal distribution of anti-VEGF-A (Bevazicumab-800CW) and provide information about neovascularization and inflammation in Age-Related Macular Degeneration (AMD), thereby predicting…
- Trial name
- LEAF (NCT05262244)
- Testing
- Bevacizumab-IRDye800CW
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Fovea Plana, Albinism
Genetic Analysis and Multimodal Retinal Imaging of Asymptomatic Fovea Plana Cases in the General Population
Albinism is a genetic condition, resulting from mutations in at least 19 known genes responsible for the production of melanin in the skin, hair and eyes. Ophthalmological manifestations are a constant feature of this disease.
- Trial name
- APOGEE (NCT04658381)
- Testing
- Genetic analysis, Ophthalmologic exam
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Parkinson Disease, REM Sleep Behavior Disorder
Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder
This is a prospective cohort study to evaluate degenerative changes in the brain by performing functional imaging analysis in patients with RBD and its correlations with clinical symptoms and dopaminergic degeneration.
- Trial name
- NCT02984137
- Testing
- testing, evaluation, sampling
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Progressive Supranuclear Palsy, Corticobasal Degeneration
Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers
This study will evaluate flortaucipir for brain imaging of tau in subjects with progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and healthy volunteers.
- Trial name
- NCT02167594
- Testing
- Flortaucipir F18, Brain PET scan
- Where
- 5 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Progressive Supranuclear Palsy
Pathophysiology of Gait and Posture in Progressive Supranuclear Palsy
The main hypothesis is that the gait and postural deficits in the Caribbean form of PSP may be associated with a dysfunction of the cerebral cortex, as they result from sub-cortical involvement in classical forms.
- Trial name
- Gait-PSP (NCT04096651)
- Testing
- gait recordings, brain magnetic resonance imaging, oculomotor movement recordings
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Ocular Tumor
A Study Comparing Two Optical Coherence Tomography Devices in People With Ocular Tumors
The purpose of this study is to compare two devices used for optical coherence tomography (OCT). OCT is a noninvasive imaging (scanning) method that uses reflected light to create pictures of the back of the eye, and doctors can…
- Trial name
- NCT07449195
- Testing
- Intalight Dream OCT, Heidelberg Spectralis OCT
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Peripheral Vascular Disease
Pilot Study to Determine Percent Tissue Perfusion and Cellular Viability Using SPY Imaging
Little is known about chronic wound microenvironments, especially in peripheral vascular disease (PVD) and diabetic patients. At the demarcation line, the percentage of viable cells and tissue is unclear.
- Trial name
- NCT01522495
- Testing
- SPY Imaging, ICG dye (0.2 - 0.5 mg/kg), SPY Imaging
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Georgetown University
Parkinson's Disease (PD)
PET-MRI of Reward System in Parkinson's Disease With RBD
Impulse control disorders (ICDs) are frequently observed in Parkinson's disease (PD) and can have a major functional impact on the quality of life of both the patient and their entourage.
- Trial name
- RBD Impulse (NCT07213219)
- Testing
- PET-MRI (Positron Emission Tomography - Magnetic Resonance Imaging).
- Where
- 3 sites in France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
Dry Eye Disease
A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory Treatment
This study aims to evaluate the performance of biomarkers and their responsiveness to standard-of-care treatments (Vevye® or Xiidra®), in participants with dry eye disease (DED) compared to healthy volunteers (control…
- Trial name
- NCT07025811
- Testing
- Vevye®, Xiidra®
- Where
- 8 sites in United States
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Glaucoma
Photographic Imaging of the Retina and Optic Nerve Head of Glaucoma Patients and Normal Controls
Retinal structures are difficult to visualize because the retina is optically transparent. In glaucoma, the microglia in the retina becomes activated in eyes with glaucomatous damage.
- Trial name
- NCT00430274
- Where
- Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Selim Orguel
Age-Related Macular Degeneration, Diabetic Retinopathy
Retinal Imaging Using NOTAL-OCT
Comparison between retinal measurements, done by the Notal-OCT imaging and a commercial OCT (Optical Coherence Tomography)
- Trial name
- NCT03374020
- Testing
- Notal OCT
- Volunteers
- 33 people
- Sponsor
- Notal Vision Ltd.
Retinitis Pigmentosa, Maculopathy, Age Related
Bimodal and Coaxial High Resolution Ophtalmic Imaging
The knowledge of the pathogenesis of retinal affections, a major cause of blindness, has greatly benefited from recent advances in retinal imaging.
- Conditions
- Retinitis Pigmentosa, Maculopathy, Age Related, Macular Dystrophy, Macular Edema
- Trial name
- AOSLO-OCT (NCT04620876)
- Testing
- Bimodal high resolution imaging of the retina
- Where
- France
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Diabetic Retinopathy
Intravitreal Aflibercept as Indicated by Real-Time Objective Imaging to Achieve Diabetic Retinopathy Improvement
The PRIME trial will assess the safety of 2 mg intravitreal aflibercept injections (IAI) to achieve and maintain DRSS improvements (2 or more steps) in patients with a baseline DRSS level of 47A to 71A inclusive through 104 weeks…
- Trial name
- NCT03531294
- Testing
- Aflibercept Injection
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Greater Houston Retina Research
Retinoblastoma, Pineoblastoma
Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging
MRI is useful for diagnosing pinealoblastoma in retinoblastoma patients
- Trial name
- NCT01884194
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany