Clinical trials: Ophthalmic Solutions
Bacterial Infections, Eye Infections
Study of AzaSite Versus Vigamox in the Tears of Healthy Volunteers
The purpose of this study is to evaluate the drug concentrations of AzaSite compared to Vigamox in tears of healthy volunteers
- Trial name
- NCT00575367
- Testing
- AzaSite (azithromycin ophthalmic solution), Vigamox (moxifloxacin hydrochloride ophthalmic solution)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Contact Lens Wear
An Evaluation of a Marketed Lubricated Eye Drop in Soft Contact Lens Wearers Who Experience Ocular Dryness
Study to evaluate subjective comfort associated with the use of a marketed lubricant eye drop, by subjects reporting ocular dryness and wearing soft contact lenses on a daily disposable replacement schedule.
- Trial name
- NCT01132287
- Testing
- FID 112903
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye Disease
Safety Study of Lifitegrast to Treat Dry Eye
The purpose of the study is to evaluate the safety of lifitegrast ophthalmic solution compared to placebo in the treatment of dry eye as assessed by ocular and non-ocular adverse events when administered BID for approximately 1…
- Trial name
- SONATA (NCT01636206)
- Testing
- Lifitegrast
- Where
- 23 sites in United States
- Volunteers
- 332 people
- Sponsor
- Shire
Conjunctivitis, Allergic
A Methodology Development Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis Using the Environmental Exposure Chamber
An Exploratory Clinical Trial Evaluating Reproxalap Ophthalmic Solutions (0.25% and 0.5%) in Subjects with Seasonal Allergic Conjunctivitis Using the Environmental Exposure Chamber (EEC)
- Trial name
- NCT03709121
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Reproxalap Ophthalmic Solution (0.5%), Vehicle Ophthalmic Solution
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Acute Infectious Keratoconjunctivitis
Study of INV-102 Ophthalmic Solution in Adults With Acute Infectious Keratoconjunctivitis
Phase 2, randomized study to assess topically administered eyedrops of INV-102 compared to vehicle during 1-week dosing in participants with Acute Infectious Keratoconjunctivitis (AIK).
- Trial name
- NCT05636228
- Testing
- INV-102, Vehicle
- Where
- 12 sites in United States, Thailand
- Volunteers
- 93 people
- Sponsor
- Invirsa, Inc.
Dry Eye Syndrome
Study of SkQ1 as Treatment for Dry-eye Syndrome
The purpose of this study is to evaluate whether SkQ1 ophthalmic solutions are safe and effective compared to placebo for the treatment of the signs and symptoms of dry eye syndrome.
- Trial name
- VISTA-1 (NCT03764735)
- Testing
- Low Dose - SkQ1, High dose - SkQ1, SkQ1 (Vehicle)
- Where
- 7 sites in United States
- Volunteers
- 452 people
- Sponsor
- Mitotech, SA
Dry Eye Syndrome
Efficacy and Safety of HU007 Eye Drops in Patients With Dry Eye Syndrome
A multicenter, Randomized, Double blind, Restasis®-controlled Non-inferiority, Moisview® Eye Drops-controlled Superiority, Phase III Study to Evaluate the Efficacy and Safety of HU007 Eye Drops in Patients with Dry Eye Syndrome
- Trial name
- NCT03461575
- Testing
- HU007, Restasis, Moisview
- Where
- South Korea
- Volunteers
- 209 people
- Sponsor
- Huons Co., Ltd.
Dry Eye
Late Phase II Confirmatory Study of DE-089 Ophthalmic Solution in Patients With Dry Eye
Dose response related to efficacy and safety of DE-089 ophthalmic solution are examined in patients with dry eye, using a multicenter, randomized, double-blind, parallel group comparison study, and the optimal concentration is…
- Trial name
- NCT01189032
- Testing
- DE-089 ophthalmic solution
- Where
- Japan
- Volunteers
- 320 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Presbyopia
A Study to Evaluate the Safety and Efficacy of EV06 Ophthalmic Solution in Improving Vision in Subjects With Presbyopia
The purpose of this study is to determine whether EV06 Ophthalmic Solution is safe and effective in improving distance corrected near vision in people who have presbyopia.
- Trial name
- NCT02516306
- Testing
- EV06 Ophthalmic Solution
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- Encore Vision, Inc.
Dry Eye
Acute Comfort and Blur Profile of a Lubricant Eye Drop Versus a Marketed Lubricant Eye Gel
The purpose of this study is to compare the comfort and blurriness of an investigational lubricant eye drop with a marketed lubricant eye gel.
- Trial name
- NCT01077011
- Testing
- Lubricant eye drop FID 115958D, GenTeal Gel
- Volunteers
- 25 people
- Sponsor
- Alcon Research
Dry Eye
The RENEW Trial: A Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
The RENEW Trial is a Multi-Center, Randomized, Double-Masked, Parallel-Group, Vehicle-Controlled, Adaptive Phase 3 Clinical Trial to Assess the Safety and Efficacy of Reproxalap 0.25% Ophthalmic Solution Compared to Vehicle in…
- Trial name
- NCT03879863
- Testing
- Reproxalap Ophthalmic Solution (0.25%) QID, Vehicle Ophthalmic Solution QID, Reproxalap Ophthalmic Solution (0.25%) QID to BID
- Where
- United States
- Volunteers
- 422 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Wet Age Related Macular Degeneration
Clinical Study for the Evaluation of Safety and Tolerability of SCAI-005 Eye Drops
To assess the single-dose and multiple-dose pharmacokinetics (PK), safety and tolerability of SCAI-005 eyedrops(axitinib) in healthy volunteers
- Trial name
- NCT06969001
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- SCAI Therapeutics
Dry Eye Syndromes
Safety Evaluation of a New Preservative in a Lubricating Eye Drop
This study is to evaluate the safety of a new preservative in a lubricant eye drop used four times a day in healthy adults and subjects diagnosed with dry eye.
- Trial name
- NCT01434277
- Testing
- Eye Drops with Experimental Preservative
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dry Eye Syndromes
Clinical Study to Investigate the Efficacy and Safety of SJP002 Ophthalmic Solution in Patients With Dry Eye Syndrome.
This study is to evaluate the efficacy and safety of SJP002 ophthalmic solution compared to placebo in patients with Dry Eye Syndrome.
- Trial name
- NCT03723811
- Testing
- SJP002 BID, SJP002 QID
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Samjin Pharmaceutical Co., Ltd.
Dry Eye Syndromes
Efficacy and Acceptability of Two Lubricant Eye Drops
Efficacy and acceptability of two new artificial tears following two weeks of treatment in patients with dry eye. Patients will be randomized to 1 of 2 treatments for 7 days then crossover to the alternate treatment for 7 days.
- Trial name
- NCT00756678
- Testing
- Lubricant Eye Drops (Optive™), Lubricating Eye Drops (blink® Tears)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Allergan
Dry Eye Syndromes
Lifitegrast Eye Drops in Healthy Subjects：Phase I Study
This is a single-center, randomized, double-blind, single-dose, two-period crossover Phase I clinical trial designed to: Compare the pharmacokinetic (PK) profiles of Lifitegrast Ophthalmic Solution and Xiidra® in plasma and tears…
- Trial name
- NCT07040826
- Testing
- Xiidra, Lifitegrast
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Dry Eye
Study of DE-089 Ophthalmic Solution in Patients With Dry Eye
Safety and efficacy of DE-089 ophthalmic solution in patients with dry eye will be evaluated in comparison with sodium hyaluronate ophthalmic solution.
- Trial name
- NCT01101984
- Testing
- diquafosol ophthalmic solution, 0.1% sodium hyaluronate ophthalmic solution.
- Where
- 2 sites in China, Singapore
- Volunteers
- 400 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Dry Eye, Dry Eye Syndromes
The TRANQUILITY Trial: Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease
The TRANQUILITY Trial: Multi-Center Randomized, Double-Masked, Parallel Design, Vehicle-Controlled Phase 2/3 Clinical Trial to Assess the Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects…
- Trial name
- NCT04674358
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Vehicle Opthalmic Solution
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Dry Eye Syndromes
Lubricating Effectiveness of Carragelose Eye Drops in Patients Affected by Mild to Moderate Dry Eye
Patients suffering from dry eye syndrom will treat their eyes with Carragelose® eye drops three times a day for 28 days. Before, in the middle and at the end of the treament period patients will be exposed to adverse conditions…
- Trial name
- NCT06262100
- Testing
- Carragelose
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Marinomed Biotech AG
Age-Related Macular Degeneration
First-in-Human Study of LHA510 in Elderly Subjects and Patients With Age-Related Macular Degeneration
The purpose of this first-in-human study is to assess the local ocular and systemic safety and tolerability of LHA510 eye drops when administered at various concentrations and dosing frequencies.
- Trial name
- NCT02076919
- Testing
- LHA510 Ophthalmic Suspension, LHA510 Vehicle
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research