Clinical trials: Ophthalmic Solutions
Allergic Conjunctivitis
Evaluation of the Safety and Efficacy of Ketotifen 4.0% Patch as Compared to Placebo Patch, Olopatadine 0.2% Ophthalmic Solution, and Artificial Tears in the Conjunctival Allergen Challenge (CAC) Model of Acute Allergic Conjunctivitis
This is a phase 2 study that will consist of 4 visits over a 5 week period. Drug will be evaluated using the conjunctival allergen challenge model of allergic conjunctivitis.
- Trial name
- NCT00836485
- Testing
- Ketotifen 4.0% Patch, Olopatadine 0.2%, Artificial tears
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Senju USA, Inc.
Primary Open Angle Glaucoma, Ocular Hypertension
A Comparative Confirmatory Study of STN1012600 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension
To investigate whether the IOP lowering efficacy of STN1012600 ophthalmic solution 0.002% is non-inferior to that of latanoprost 0.005% in subjects with POAG or OHT after treatment for 4 weeks.
- Trial name
- NCT05495061
- Testing
- STN1012600 ophthalmic solution 0.002%, Latanoprost ophthalmic solution 0.005%
- Where
- 44 sites in Japan
- Volunteers
- 325 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Cataract, Inflammation
Indomethacin Eyedrops Compared With Ketorolac Eyedrops for Ocular Inflammation Following Cataract Surgery
This study is being conducted to show that indomethacin is at least as effective as ketorolac for the prevention of ocular inflammation following cataract surgery.
- Trial name
- NCT00904904
- Testing
- Indomethacin ophthalmic solution, Ketorolac Ophthalmic Solution
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Bausch & Lomb Incorporated
Ocular Hypertension, Primary Open Angle Glaucoma
Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AKB-9778 Ophthalmic Solution
The purpose of this Phase 1b study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of AKB-9778 ophthalmic solution (eye drops) administered for 7 days in adults.
- Trial name
- NCT04284514
- Testing
- AKB-9778 Ophthalmic Solution
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Aerpio Therapeutics
Dry Eye
Acute Comfort and Blurring Profile Evaluation of Marketed Lubricant Eye Drops
To evaluate drop comfort, acceptability and blur profile between four marketed artificial tears in dry eye patients
- Trial name
- NCT00756093
- Testing
- Systane Ultra Lubricant Eye Drops, Optive Lubricant Eye Drops, Blink Tears
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Alcon Research
Bacterial Conjunctivitis
Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Tobramycin for Bacterial Conjunctivitis (C-01-401-004)
The purpose of this study is to evaluate the clinical and microbial efficacy and safety of AzaSite compared to tobramycin for bacterial conjunctivitis.
- Trial name
- NCT00105469
- Testing
- AzaSite, Tobramycin
- Where
- 26 sites in United States
- Volunteers
- 743 people
- Sponsor
- Merck Sharp & Dohme LLC
Meibomian Gland Dysfunction
Safety and Efficacy Study of a Testosterone Eye Drop for the Treatment of Meibomian Gland Dysfunction
The objective of this study is to assess the safety and efficacy of testosterone 0.03% ophthalmic solution compared to vehicle for the treatment of meibomian gland dysfunction.
- Trial name
- NCT00755183
- Testing
- testosterone ophthalmic solution, vehicle of testosterone ophthalmic solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- ORA, Inc.
Open-Angle Glaucoma, Ocular Hypertension
Adjunctive Study of AL-37807 Ophthalmic Suspension
The purpose of the study is to compare the safety and intraocular pressure-lowering efficacy of AL-37807 ophthalmic suspension vs. Timolol gel forming solution vs.
- Trial name
- NCT00620256
- Testing
- AL-37807 ophthalmic suspension, 0.1%, Timolol gel forming solution, 0.5%, AL-37807 ophthalmic solution vehicle
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Alcon Research
Presbyopia
Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia
The objectives of this study are: To evaluate the safety and efficacy of Nyxol alone and with adjunctive low dose pilocarpine to improve distance-corrected near visual acuity (DCNVA) in subjects with presbyopia.
- Trial name
- VEGA-2 (NCT05646719)
- Testing
- Phentolamine Opthalmic Solution 0.75%, Low dose pilocarpine, Low dose pilocarpine vehicle
- Where
- 26 sites in United States
- Volunteers
- 333 people
- Sponsor
- Opus Genetics, Inc
Ocular Dryness
Clinical Investigation on the Use of Ophthalmic Solution Based on Sodium Hyaluronate in Treatment of Eye Discomfort
The purpose of this study is to assess the performance and safety resulting from the treatment of an ophthalmic solution for the ocular discomfort and in particular in presence of ocular dryness.
- Trial name
- NCT05777798
- Testing
- Hyalistil Bio PF
- Where
- 2 sites in Italy
- Volunteers
- 28 people
- Sponsor
- SIFI SpA
Opthalomology/Dry Eye
An Interventional, Confirmative, Post Marketing Clinical Followup (PMCF) Study to Evaluate Performance and Safety of Ophthalmic Solutions Used to Relieve Dry Eyes Like Symptoms in Glaucoma Patients.
Study Rationale: The glaucomas are a group of optic neuropathies characterized by progressive degeneration of retinal ganglion cells.
- Trial name
- M-GLAU-01-2020 (NCT05773976)
- Testing
- Afomill Refreshing Soothing, Afomill Anti-redness Eye Drops, Iridil
- Where
- 2 sites in Italy
- Volunteers
- 59 people
- Sponsor
- Montefarmaco OTC SpA
Keratitis, Ulcerative, Corneal Ulcer
Wharton's Jelly Eye Drops in the Treatment of Chronic Keratitis
The purpose of this open, non-comparative, multicenter trial is to assess the impact of eye drops made of Wharton's jelly extract in the treatment of chronic keratitis that failed available therapies.
- Trial name
- NCT05200000
- Testing
- SygeLIX-Coll-T
- Where
- 6 sites in France
- Volunteers
- 20 people
- Sponsor
- TBF Genie Tissulaire
Dry Eye Syndromes
Study of Tisporin Eye Drops Group and Restasis Eye Drops Group After Treatment, Each Treatment Group Comparisons for Evaluation of Efficacy and Safety in Moderate to Severe Dry Eye Disease
The purpose of this clinical Study is Tisporin Eye Drops 0.05%(Cyclosporine ophthalmic solution) group and Restasis Eye Drops 0.05%(Cyclosporine ophthalmic suspension) group 12 weeks after treatment, each treatment group…
- Trial name
- HL_TSPR_302 (NCT02229955)
- Testing
- Cyclosporine ophthalmic solution
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Allergic Conjunctivitis
Study of DE-114 Ophthalmic Solution in Patients With Allergic Conjunctivitis
The purpose of the study is to demonstrate safety and efficacy of DE-114 ophthalmic solution compared to its Placebo and Olopatadine hydrochloride 0.1% ophthalmic solution in patients with allergic conjunctivitis.
- Trial name
- NCT01363700
- Testing
- DE-114 ophthalmic solution, Olopatadine Hydrochloride 0.1% Ophthalmic Solution
- Where
- Japan
- Volunteers
- 87 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Healthy
Clinical Study to Investigate the Systemic Exposure, Safety, and Local Tolerability of SJP002 Ophthalmic Solution in Healthy Male Volunteers
This is a phase1, single center, double-blind, placebo control, randomized study and consisted of single dosing(period 1) and multiple dosing(period 2).
- Trial name
- NCT02924155
- Testing
- SJP002
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Samjin Pharmaceutical Co., Ltd.
Corneal Ectasia
Safety and Efficacy Study for Corneal Collagen Cross-Linking in Eyes With Corneal Ectasia After Refractive Surgery
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression…
- Trial name
- NCT01643252
- Testing
- riboflavin: 0.12% riboflavin ophthalmic solution with the KXL system
- Sponsor
- Glaukos Corporation
Keratoconus
Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression…
- Trial name
- NCT01643226
- Testing
- riboflavin solution, KXL System
- Where
- 8 sites in United States
- Volunteers
- 230 people
- Sponsor
- Glaukos Corporation
Neovascular Age Related Macular Degeneration
Efficacy and Safety of Squalamine Lactate Eye Drops in Subjects With Neovascular (Wet) Age-related Macular Degeneration (AMD)
The purpose of this study is to evaluate the safety and efficacy of topical ophthalmic squalamine lactate eye drops in treating patients with neovascular age-related macular degeneration (wet AMD), a degenerative retinal eye…
- Trial name
- NCT01678963
- Testing
- Squalamine lactate, Vehicle control
- Where
- 20 sites in United States
- Volunteers
- 142 people
- Sponsor
- Ohr Pharmaceutical Inc.
Corneal Diseases
Phase I Clinical Study of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defect
One dose group of 0.004% was used.
- Trial name
- NCT07132437
- Testing
- ZKY001 EYE DROPS
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Fungal Keratitis
Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis
A Phase II, Multi-center, Randomized, Masked, Parallel-Control Study to Evaluate the Clinical Efficacy and Safety of IVIEW-1201 (1.0% PVP-Iodine) Gel Forming Ophthalmic Solution in the Treatment of Fungal Keratitis.
- Trial name
- NCT06463678
- Testing
- IVIEW-1201, NATACYN®
- Volunteers
- 60 people
- Sponsor
- IVIEW Therapeutics Inc.