Clinical trials: Ophthalmic Solutions
Healthy Adult Males Volunteers
Pharmacokinetic Study of STN1012600 Ophthalmic Solution in Healthy Adult Males Volunteers
To evaluate the safety and plasma pharmacokinetics of STN1012600 ophthalmic solution 0.002% (1 drop once daily for 7 days) in healthy adult male subjects.
- Trial name
- NCT05905653
- Testing
- STN1012600 ophthalmic solution 0.002%
- Where
- Japan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Elevated Intraocular Pressure
A Study of AR-12286 in Patient With Elevated Intraocular Pressure (IOP)
Double-masked, randomized, multi-center, placebo-controlled parallel-comparison of AR-12286.
- Trial name
- NCT00902200
- Testing
- AR-12286, AR-12286 vehicle
- Where
- 8 sites in United States
- Volunteers
- 89 people
- Sponsor
- Aerie Pharmaceuticals
Dry Eye Disease
Study of the Pharmacodynamic Activity of P-321 Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye Disease
The purpose of this Phase 2a study is to assess changes in tear volume by the non-invasive techniques Ultra High Resolution Optical Coherence Tomography (UHR-OCT) following the administration of P-321 Ophthalmic Solution or…
- Trial name
- NCT02824913
- Testing
- P-321 Ophthalmic Solution
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Parion Sciences
Pterygium, Bevacizumab
Topical Bevacizumab for Preventing Recurrent Pterygium
The purpose of this study is to determine whether bevacizumab eye drop is effective in the treatment of recurrent pterygium.
- Conditions
- Pterygium, Bevacizumab, VEGF, Anti-VEGF
- Trial name
- NCT01311960
- Testing
- bevacizumab eye drop 0.05%, normal saline 0.9%
- Where
- Thailand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Dry Eye Syndromes, Computer Vision Syndrome
Protecting the Eyes of Gamers With Lubricating Eyedrops
The excessive use of screens particularly amongst digital gamers can adversely impact the health of the surface of the eyes with symptoms and signs of surface damage.
- Trial name
- PROTEGE (NCT06163989)
- Testing
- TheaLoz Duo Eyedrop
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Aston University
Ocular Surface Disease, Dry Eye Syndrome (DES)
This is a Single Center, Open-label Prospective Study to Evaluate the Effect of Xiidra® (Lifitegrast Ophthalmic Solution 5.0%) on Tear Film Biomarkers in Dry Eye
This is a single-center prospective open-label, clinical trial to explore proteomic expression of tear fluid biomarkers in patients with dry eye treated with Lifitegrast.
- Trial name
- NCT07490535
- Testing
- (Xiidra®) Lifitegrast Ophthalmic Solution 5.0%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pittsburgh Research Institute
Age-related Wet Macular Degeneration
Study to Evaluate the Safety of CG-P5 Peptide Eye Drops in Patients Diagnosed With Age-related Wet Macular Degeneration
This will be a randomized, comparative, parallel, clinical study to assess initial safety and tolerability of CG-P5 peptide eye drops compared to placebo in patients diagnosed with age-related wet macular degeneration
- Trial name
- NCT06132035
- Testing
- CG-P5 peptide, Aflibercept Injection [Eylea]
- Where
- 7 sites in United States
- Volunteers
- 45 people
- Sponsor
- Caregen Co. Ltd.
Strabismus
The Effect of Povidone-iodine Ophthalmic Surgical Prep Solution on Respiration in Children Undergoing Strabismus Surgery With General Anesthesia.
Determine whether the application of povidone-iodine ophthalmic solution onto the ocular surface causes a change in respiration in children undergoing strabismus surgery with general anesthesia.
- Trial name
- NCT03349515
- Testing
- Provodine-Iodine Solution, Group B will receive three drops in each eye of ophthalmic balanced salt solution.
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Dry Eye Syndromes
The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye
Purpose To try to establish whether lid-parallel conjunctival folds (LIPCOF) can be influenced by increased lubrication with rewetting and lubricating eyedrops containing hydroxypropyl-guar, which has proven lubricating effect.
- Trial name
- LIPCOF (NCT01268735)
- Testing
- Lubricating eyedrops containing hydroxypropyl-guar
- Where
- Croatia
- Volunteers
- 229 people
- Sponsor
- University of Zagreb
Age-Related Macular Degeneration
A Study to Investigate the Effect on Central Macular Thickness of Treatment With MG-O-1002 Eye Drops in Participants Aged Over 45 With Neovascular Age-related Macular Degeneration (nAMD)
A 2 parts Phase II study to investigate the effect on central macular thickness of treatment with MG-O-1002 eye drops in participants aged over 45 with neovascular age-related macular degeneration (nAMD)
- Trial name
- NCT05390840
- Testing
- MG-O-1002
- Where
- 6 sites in Thailand
- Volunteers
- 36 people
- Sponsor
- Theratocular Biotek Co.
Cataract, Cystoid Macular Edema After Phacoemulsification
Effects of Bromfenac on Macular Thickness After Phacoemulsification Surgery
The goal of this clinical trial is to learn if bromfenac ophthalmic solution can prevent cystoid macular edema (CME) and reduce macular thickness in patients undergoing phacoemulsification surgery for cataract removal.
- Trial name
- NCT06785090
- Testing
- Bromfenac, Moxifloxacin 0.5% ophthalmic solution, Dexamethasone phosphate 0.1%
- Where
- Iraq
- Volunteers
- 87 people
- Sponsor
- Inas Abd
Myopia
Evaluation of Daily Disposable Lenses With Multi-Purpose Solution (MPS)
The purpose of this study is to evaluate daily disposable lenses inserted out of the blister package versus daily disposable lenses inserted after a pre-soak in Multi-purpose solution FID 107027.
- Trial name
- NCT00733291
- Testing
- Nelfilcon A contact lens, Etafilcon A contact lens, FID 107027 solution
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Alcon Research
Glaucoma, Ocular Hypertension
Tolerability, Safety and Efficacy of RKI983 Eye Drops in Subjects With Primary Open Angle Glaucoma and Ocular Hypertension
This study will evaluate the tolerability and safety of RKI983 ophthalmic solution and explore the effect of the compound on intraocular pressure in subjects with ocular hypertension.
- Trial name
- NCT00515424
- Testing
- RKI983
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- Novartis
Primary Open Angle Glaucoma of Both Eyes
Comparative Study of Dorzotimol Eye Drops, 20 mg/mL + 5 mg/mL Versus Cosopt® Eye Drops, 20 mg/mL + 5 mg/mL
The goal of this study is to compare efficacy and safety of Dorzotimol eye drops, 20 mg/mL + 5 mg/mL manufactured by JADRAN-GALENSKI LABORATORIJ d.d.
- Trial name
- NCT05973318
- Testing
- Dorzotimol eye drops, 20 mg/mL + 5 mg/mL, Cosopt eye drops, 20 mg/mL + 5 mg/mL
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Jadran Galenski laboratorij d.d.
Conjunctivitis, Allergic
AGN-229666 Ophthalmic Solution for the Treatment of Seasonal or Perennial Allergic Conjunctivitis
This study will evaluate the safety and efficacy of AGN-229666 for the treatment of seasonal or perennial allergic conjunctivitis.
- Trial name
- NCT02082262
- Testing
- AGN-229666
- Where
- Japan
- Volunteers
- 140 people
- Sponsor
- Allergan
Dry Eye
YM-101 Eye Drops in the Treatment of Dry Eye Syndrome
This study is a single-center, randomized, double-blind, placebo-controlled, cross-over clinical trial designed to evaluate the effectiveness and safety of YM-101 eye drops for the treatment of dry eye syndrome, using a placebo…
- Trial name
- NCT06792903
- Testing
- YM-101 high dose + artificial tear, YM-101 low dose + artificial tear
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Keratoconus
Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression…
- Trial name
- NCT01972854
- Testing
- riboflavin solution, KXL System
- Where
- 11 sites in United States
- Volunteers
- 92 people
- Sponsor
- Glaukos Corporation
Glaucoma
Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults With Primary Open Angle Glaucoma or Ocular Hypertension
Phase 2 Study of BL1107 Eye Drops vs. Timolol in Adults with Primary Open Angle Glaucoma or Ocular Hypertension
- Trial name
- NCT07168902
- Testing
- BL1107 Low dose, BL1107 High dose, Timolol maleate 0.5%
- Where
- 14 sites in United States
- Volunteers
- 252 people
- Sponsor
- Bausch & Lomb Incorporated
Dry Eye
IVIG-eye Drops Treatment for Dry Eye Disease
The main objective of this study is to establish whether patients with Dry Eye Disease are able to safely tolerate receiving Intravenous Immunoglobulin (IVIG) eye drops two times a day for eight weeks (primary 'safety and…
- Trial name
- NCT03992482
- Testing
- Intravenous Immune Globulin (IVIG)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Sandeep Jain, MD
Graves Disease
Effect of Lugol's Solution in the Patients With Graves' Disease
Context: Although some of endocrine surgeons administer Lugol's solution to decrease thyroid gland vascularity, there is still no agreement on its effectiveness.
- Trial name
- NCT00432146
- Testing
- lugol's solution
- Volunteers
- 36 people
- Sponsor
- Istanbul University
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