Clinical trials: Ophthalmic Solutions
Dry Eye
Evaluation of an Investigational Lubricant Eye Drop on Lipid Layer Thickness
The purpose of this study is to evaluate the effects of an investigational lubricant eye drop on tear film lipid layer thickness of dry eye patients.
- Trial name
- NCT01066988
- Testing
- ORB Ocular Emulsion, SootheXP Emollient (Lubricant) Eye Drops
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Dry Eye Syndrome
Allogeneic Versus Autologous Serum Eye Drops
Serum eye drops (SEDs) are used to treat patients with extreme dry eyes and other corneal defects. Serum is used in severe ophthalmic cases where conventional eye drops (artificial tears) have insufficient effect.
- Trial name
- AVAnS (NCT03085290)
- Testing
- Autologous serum eye drops, Allogeneic serum eye drops
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sanquin Research & Blood Bank Divisions
Ocular Pain, Dry Eye
Effect of Acoltremon Ophthalmic Solution 0.003% on Tear Production and Symptoms in Patients With Tear Deficiency and Concurrent Neuropathic Corneal Pain
This study is designed to provide clinical data on how acoltremon ophthalmic solution 0.003% affects tear production and ocular symptoms in participants with tear deficiency and concurrent neuropathic corneal pain.
- Trial name
- AURORA (NCT07849803)
- Testing
- acoltremon ophthalmic solution 0.003%
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of South Florida
Healthy Subjects
A Dose-escalation Clinical Trial After Multiple Dosing of HL217 Eye Drop in Healthy Male Subjects
The study is a single center, double-blind, randomized, parallel group, multiple ascending dose study in 16 healthy male volunteers.
- Trial name
- NCT03648346
- Testing
- Cohort 1: HL217 Ophathalmic Solution BID, Cohort 2: HL217 Ophathalmic Solution QID
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.
Eye Diseases
Next Generation Ophthalmic Irrigating Solution Posterior Segment Study
The purpose of this study is to evaluate the safety of Next Generation Ophthalmic Irrigating Solution (NGOIS) compared to BSS PLUS for use during surgery for removal of epimacular membrane and vitrectomy.
- Trial name
- NCT00333203
- Testing
- Next Generation Ophthalmic Irrigating Solution (NGOIS), BSS Plus
- Where
- United States
- Volunteers
- 369 people
- Sponsor
- Alcon Research
Vernal Keratoconjunctivitis
Evaluation of the Efficacy and Safety of Tacrolimus Drops in Children With Vernal Keratoconjunctivitis
Non-interventional single-center cohort study (Rothschild Foundation Hospital) of patients aged 0 to 18 years followed up in ophthalmology for KCV, treated with tacrolimus 0.1% eye drops previously treated with ciclosporin 2%…
- Trial name
- KERAVER (NCT05076084)
- Testing
- QUICK questionnaire and 6 additional questions, Retrospective collection of clinical data from the patients' medical records
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Dry Eye Disease
Evaluation of the Safety, Tolerability and Efficacy of iNexin™ for the Treatment of the Signs and Symptoms Associated With Dry Eye Disease
The primary objective of this study is to evaluate the safety and tolerability of iNexin™ The secondary objective is to compare the efficacy of iNexin™ to Vehicle for the treatment of the signs and symptoms associated with dry…
- Trial name
- NCT05031806
- Testing
- iNexin™ (0.08% aCT1), iNexin™ (0.4% aCT1), iNexin™ (2.0% aCT1)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Xequel Bio, Inc.
Dry Eye Disease
Safety and Efficacy of ST-100 (Vezocolmitide) Ophthalmic Solution 60 μg/ml Ophthalmic Solution in Subjects Diagnosed With Dry Eye Disease (DED)
A Phase 3 Multi-Center, Randomized, Double Masked, Vehicle Controlled Study to Assess the Safety and Efficacy of ST-100 (vezocolmitide) Ophthalmic Solution 60 μg/ml Ophthalmic Solution in Subjects Diagnosed with Dry Eye Disease…
- Trial name
- NCT06178679
- Testing
- ST-100 (vezocolmitide), Vehicle
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- ORA, Inc.
Healthy
Study Evaluating Safety of BT01001 Ophthalmic Solution
This Phase I study is designed to evaluate the safety, tolerability, and pharmacokinetic profile of BT01001 Ophthalmic Solution in healthy adult volunteers.
- Trial name
- NCT07313722
- Testing
- BT01001 5 mg/ml（0.5%）, BT01001 10 mg/ml（1.0%）, BT01001 15 mg/ml（1.5%）
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Beyang Therapeutics Co., Ltd.
Retinopathy of Prematurity
Pharmacokinetics and Safety of Dexamethasone Eye Drops in Preterm Infants
Background and study aims When an infant is born premature, the blood vessels in the eyes have not developed fully on the retina, and can start to grow incorrectly and result in blindness.
- Trial name
- NCT05387941
- Testing
- Dexamethasone Ophthalmic
- Where
- 2 sites in Sweden
- Volunteers
- 11 people
- Sponsor
- Region Skane
Dry Eye Disease (DED)
Evaluation of Ophtholic Ultra for Ocular Surface Protection After Cataract Surgery
Study of the Effectiveness and Safety of Ophtholic Ultra in Preventing and Correcting Ocular Surface Disturbances After Uncomplicated Cataract Surgery This is a single-center, prospective, randomized, controlled, assessor-masked…
- Trial name
- NCT07868965
- Testing
- Ophtholic Ultra, Standard postoperative therapy without lubricating eye drops
- Where
- Kazakhstan
- Volunteers
- 60 people
- Sponsor
- Kazakh Eye Research Institute
Diabetic Eye Problems
Use of 3% Diquafosol Topical Ophthalmic Solution for Diabetic Dry Eye
Diquafosol ophthalmic solution (DQS) stimulates P2Y2 receptors on the ocular surface, which enhances mucin secretion from goblet cells.
- Trial name
- NCT05193331
- Testing
- 3% Diquafosol tetrasodium
- Where
- China
- Volunteers
- 70 people
- Sponsor
- He Eye Hospital
Primary Open Angle Glaucoma of Both Eyes
Comparative Study of Dorzol Eye Drops, 20 mg/ml Versus Trusopt® Eye Drops, 20 mg/ml
The goal of this study is to compare efficacy and safety of Dorzol 20 mg/mL Eye Drops manufactured by JADRAN-GALENSKI LABORATORIJ d.d.
- Trial name
- NCT05973305
- Testing
- Dorzol 20 mg/ml, Trusopt 20 mg/ml
- Where
- Russia
- Volunteers
- 118 people
- Sponsor
- Jadran Galenski laboratorij d.d.
Acute Infectious Keratoconjunctivitis
Study of INV-102 Ophthalmic Solution in Adults With Acute Infectious Keratoconjunctivitis
Phase 2, randomized study to assess topically administered eyedrops of INV-102 compared to vehicle during 1-week dosing in participants with Acute Infectious Keratoconjunctivitis (AIK).
- Trial name
- NCT05636228
- Testing
- INV-102, Vehicle
- Where
- 12 sites in United States, Thailand
- Volunteers
- 93 people
- Sponsor
- Invirsa, Inc.
Glaucoma
Will Restasis Eye Drops Increase Your Chance of Having a Successful Surgery?
The purpose of this study is to determine whether reducing inflammation of the surface of the eye with topical Restasis after glaucoma surgery will improve surgical outcomes and increase patient comfort.
- Trial name
- NCT00405431
- Testing
- Restasis, Endura (artificial tears)
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Wills Eye
Retinopathy of Prematurity
Effect of Benoxinate Hydrochloride Eye Drops on The Premature Infant Pain Profile Score During Retinopathy of Prematurity Screening
Aims: To evaluate the effects of topical Benoxinate HCL eye drops on the Premature Infant Pain Profile (PIPP) scores in infants undergoing Retinopathy of Prematurity (ROP) screening.
- Trial name
- NCT06461975
- Testing
- Benoxinate Hydrochloride, artificial tear (Sodium Hyaluronate 2 mg/ml) eye drops.
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Alexandria University
Corneal Edema
Efficacy and Tolerance of Hypertonic Sodium Chloride (NaCl 5%) Eye Drops Without Preservatives in Corneal Edema
Corneal edema is frequently found in clinical practice as a common sign of acute corneal disease due to different etiologies that cause an accumulation of extracellular fluid in the cornea.
- Trial name
- NCT04125394
- Testing
- hypertonic Sodium chloride (NaCl 5%) eye drops solution in single-dose
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Tiedra Farmacéutica SL
Neurotrophic Keratopathy
Assessment of the Safety and Efficacy Study of RGN-259 Ophthalmic Solutions for Neurotrophic Keratopathy : SEER-1
The objective of this study is to assess the safety and efficacy of RGN-259 Ophthalmic Solution compared to placebo for the treatment of NK.
- Trial name
- NCT02600429
- Testing
- RGN-259
- Where
- 11 sites in United States
- Volunteers
- 18 people
- Sponsor
- ReGenTree, LLC
Corneal Edema After Cataract Surgery
A Study to Investigate the Safety and Efficacy of Ripasudil (K-321) Eye Drops After Cataract Surgery
The purpose of this study is to assess the safety and efficacy of K-321 in subjects after cataract surgery
- Trial name
- NCT05528172
- Testing
- Ripasudil
- Where
- 45 sites in United States, Puerto Rico
- Volunteers
- 330 people
- Sponsor
- Kowa Research Institute, Inc.
Dry Eye Disease
Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease
The objective of this study is to assess safety and efficacy of DE-089 ophthalmic solution in patients with dry eye disease in Taiwan.
- Trial name
- NCT03216096
- Where
- 2 sites in Taiwan
- Volunteers
- 20 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
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