Clinical trials: Ophthalmic Solutions
Chronic Angle-closure Glaucoma
A Study to Assess the Effect of Rho-Kinase Inhibitor AR-12286 Ophthalmic Solution 0.5% and 0.7% in Patients With Chronic Angle-closure Glaucoma
To evaluate the ocular hypotensive efficacy of Rho kinase Inhibitor (AR-12286 0.5% and 0.7%) ophthalmic solutions in patients diagnosed with chronic angle-closure glaucoma treated for 6 months.
- Trial name
- ROCK - CACG (NCT02152774)
- Testing
- Rho-Kinase Inhibitor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New York Glaucoma Research Institute
Cataract, Inflamation
A Study Comparing Sub-Tenon Steroid Injection Versus Eye Drops for Reducing Postoperative Inflammation After Cataract Surgery
After cataract surgery, postoperative inflammation is commonly treated with corticosteroid eye drops such as prednisolone acetate 1%. However, frequent dosing may reduce patient compliance.
- Conditions
- Cataract, Inflamation, Phacoemulsification
- Trial name
- NCT07567118
- Testing
- Triamcinolone acetonide injection, prednisolone acetate 1%
- Where
- Syria
- Volunteers
- 72 people
- Sponsor
- Damascus University
Hyperopia, Myopia
A Phase 1/2 Crossover Study to Assess EXP039 for Myopia or Hyperopia
Assess the Safety, Pharmacodynamics, and Efficacy of EXP039 Ophthalmic Solution in Participants with Myopia or Hyperopia
- Trial name
- NCT04883996
- Testing
- 1% EXP039, Saline control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Canyon City Eyecare
Dry Eye Syndromes
Investigation of Preservative-Free Ophthalmic Solution in Ocular Dryness
This is a multicenter, prospective, observational, open-label, non-interventional study evaluating the clinical performance and the safety of 4 daily instillations of the ophthalmic solution in the treatment of eye discomfort, in…
- Trial name
- NCT05778942
- Testing
- Eyestil SYNFO
- Where
- 4 sites in Spain
- Volunteers
- 35 people
- Sponsor
- SIFI SpA
Keratoconus
Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus
The objectives of this study are to evaluate the safety and efficacy of corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System as compared to placebo in impeding the progression…
- Trial name
- NCT01972854
- Testing
- riboflavin solution, KXL System
- Where
- 11 sites in United States
- Volunteers
- 92 people
- Sponsor
- Glaukos Corporation
Graves Disease
Effect of Lugol's Solution in the Patients With Graves' Disease
Context: Although some of endocrine surgeons administer Lugol's solution to decrease thyroid gland vascularity, there is still no agreement on its effectiveness.
- Trial name
- NCT00432146
- Testing
- lugol's solution
- Volunteers
- 36 people
- Sponsor
- Istanbul University
Dry Eye
Long-term Effects of Acoltremon vs. Control in Dry Eye Disease
This is a prospective, longitudinal, single-center study designed to evaluate the long-term changes in symptoms and tear production in subjects with dry eye disease.
- Trial name
- NCT07659626
- Testing
- Acoltremon 0.003%, Refresh classic preservative free
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Eye Care Institute
Neurotrophic Keratitis
A Phase II Study of STSP-0902 Ophthalmic Solution in Patients With Neurotrophic Keratitis
This is a Phase II, double-blind, placebo-controlled study to evaluate the safety and efficacy of STSP-0902 ophthalmic solution in patients with neurotrophic keratitis (NK).
- Trial name
- NCT06975748
- Testing
- STSP-0902 ophthalmic solution
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Staidson (Beijing) Biopharmaceuticals Co., Ltd
Dry Eye Disease
Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease
The purpose of this trial is to compare the effectiveness and safety of INS365 Ophthalmic Solution with Placebo when applied topically in subjects with dry eye disease.
- Trial name
- NCT00403715
- Testing
- diquafosol tetrasodium (INS365) Ophthalmic Solution
- Volunteers
- 500 people
- Sponsor
- Merck Sharp & Dohme LLC
Keratoconjunctivitis Sicca
A Dose-Escalation Study to Assess the Safety and Tolerability of LX214 Ophthalmic Solution in Healthy Volunteers, Followed by an Open-Label Evaluation of LX214 in Patients With Keratoconjunctivitis Sicca (KCS)
This is a first-in-man study for the purpose of determining the safety and tolerability of LX214 ophthalmic solution in healthy volunteers and in patients with dry eye syndrome.
- Trial name
- NCT00851734
- Testing
- voclosporin ophthalmic solution
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Lux Biosciences, Inc.
Decrease in Night Vision, Disturbance; Vision, Loss
Single Dose Study of Phentolamine Mesylate Eye Drops in Patients With Severe Night Vision Disturbances
The objectives of this study are: To assess the effect of ophthalmic phentolamine mesylate in mesopic conditions on the four endpoints: 1. Contrast sensitivity 2. Low contrast visual acuity 3. Wavefront aberrometry 4.
- Trial name
- SNV (NCT04004507)
- Testing
- Phentolamine Mesylate Ophthalmic Solution 1%
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Opus Genetics, Inc
Dry Eye
Civamide Nasal Solution for the Treatment of Dry Eye
Keratoconjunctivitis sicca (KCS) or Dry Eye Syndrome is a disease of the surface of the eye, tear film, and related ocular tissues.
- Trial name
- NCT02116244
- Testing
- Civamide Nasal Spray
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Winston Laboratories
Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB)
Pilot Study of ELK-003 Eye Drops for Treating Ocular Manifestations of Epidermolysis Bullosa
This study consists of two phases: an Observational Phase to evaluate the natural history of ocular manifestations in subjects with Dystrophic and Junctional Epidermolysis Bullosa, followed by a Treatment Phase to assess the…
- Conditions
- Junctional Epidermolysis Bullosa, Epidermolysis Bullosa (EB), Dystrophic Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
- Trial name
- GOTAS-ELK-EB (NCT06713434)
- Testing
- ELK-003 (Standarized Amniotic Fluid Secretome Eye Drops)
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Fundación DEBRA Chile, Niños Piel de Cristal
Ocular Redness, Eye Irritation
An Investigation of FID 123320 for the Reduction of Ocular Redness in Pediatric and Adult Populations
The purpose of this study is to assess the safety and efficacy of FID 123320 Ophthalmic Solution compared to Vehicle for relieving redness of the eye due to minor eye irritations in pediatric and adult populations.
- Trial name
- NCT06538662
- Testing
- FID 123320 Ophthalmic Solution, Vehicle
- Where
- 10 sites in United States
- Volunteers
- 283 people
- Sponsor
- Alcon Research
Ocular Hypertension, Open-angle Glaucoma
Evaluation of Netarsudil (AR-13324) Ophthalmic Solution in Patients With Glaucoma and Ocular Hypertension
Evaluation of the ocular hypotensive efficacy and safety of Netarsudil (AR-13324) Ophthalmic Solution compared to Timolol Maleate Ophthalmic Solution
- Trial name
- NCT02207621
- Testing
- AR-13324 Ophthalmic Solution 0.02%, Timolol maleate Ophthalmic Solution 0.5% BID, AR-13324 Ophthalmic Solution 0.02% BID
- Where
- United States
- Volunteers
- 756 people
- Sponsor
- Aerie Pharmaceuticals
Mydriasis, Dilation
Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasis
The objectives of this study are: To evaluate the efficacy of Nyxol (phentolamine mesylate ophthalmic solution 1%) to expedite the reversal of pharmacologic mydriasis To evaluate the safety of Nyxol To evaluate the effect of…
- Trial name
- NCT04024891
- Testing
- Phentolamine Mesylate Ophthalmic Solution 1%
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Opus Genetics, Inc
Keratoconus
Corneal Collagen Cross-linking With Hypotonic Riboflavin in Corneas Thinner Than 400 Microns
Corneal ectasia is a relative weakness in the structure of the cornea, which produces a progressive change in its shape which results in visual distortion.
- Trial name
- HypotonicRibo (NCT00890266)
- Testing
- Collagen cross-linking with hypotonic riboflavin
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Corneal Epithelial Defect
ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects in a Phase Ⅱ Clinical Trial
A multicenter, randomized, double-blind, placebo-controlled clinical trial was designed. The study included two experimental groups (low-dose ZKY001 eye drops group and medium-dose ZKY001 eye drops group) and a placebo control…
- Trial name
- NCT06213727
- Testing
- lowe-dose ZKY001 eye drops, Medium-dose ZKY001 eye drops, ZKY001 simulated eye drops
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Dry Eye Syndromes
To Evaluate the Efficacy and Safety of HUC3-053 in Patients With Dry Eye Syndrome
This is a multi-center, randomized, double-blinded, non-inferiority study to evaluate the efficacy and safety of HUC3-053 in patients with dry eye syndrome.
- Trial name
- NCT06388070
- Testing
- HA 0.3%, Hyalein Mini Eye Drops
- Where
- South Korea
- Volunteers
- 297 people
- Sponsor
- Huons Co., Ltd.
Keratoconus, Corneal Ectasia
Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refractive Surgery
The objectives of this study are to evaluate and compare the safety and efficacy of three treatment regimens for corneal collagen cross-linking performed with VibeX (riboflavin ophthalmic solution) and the KXL System in impeding…
- Trial name
- NCT01459679
- Testing
- KXL System (15 mW/cm2), KXL System (30 mW/cm2), KXL System (45 mW/cm2)
- Where
- 83 sites in United States, Puerto Rico
- Volunteers
- 1,721 people
- Sponsor
- American-European Congress of Ophthalmic Surgery
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