Clinical trials: Ophthalmic Solutions
Congenita Nasolacrimal Duct Obstruction, Preterm Neonates
Euphrasia Eye Drops in Preterm Infants With First Signs of Congestion of Nasolacrimal Duct
Congenital nasolacrimal duct obstruction (CNLDO) occurs in approximately 10 to 20% of all term newborns, and is the most common cause of persistent tearing and ocular discharge in children.
- Conditions
- Congenita Nasolacrimal Duct Obstruction, Preterm Neonates, Ocular Discharge
- Trial name
- Euphrasia (NCT04122300)
- Testing
- Euphrasia Officinalis Preparation
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- University of Bern
Myopia
Atropine (0.02%, 0.04%) Combined With Defocus DIMS for Moderate and High Myopia Control
To evaluate the effectiveness and safety of DIMS, low concentration atropine eye drops,and atropine combined with DIMS in controlling axial length and refraction in children with moderate to high myopia.
- Trial name
- atropine (NCT06523504)
- Testing
- DIMS, The 0.02% ATP Group, The 0.04% ATP Group
- Where
- China
- Volunteers
- 410 people
- Sponsor
- Ruihua Wei
Dry Eye Syndromes
Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers
The "dry eye syndrome" DES is a highly prevalent ocular disease, in particular in the elderly population. One mainstay of therapy for patients suffering from DES is the use of topically administered lubricants.
- Trial name
- NCT01015209
- Testing
- Chitosan- N- Acetylcysteine eye drops
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cataract
Taurine Eye Drops May Prevent the Progression of Cataract
The aim of the current intervention study is to determine the effectiveness of taurine containing eye drops (available under brand name VIZILOTON) to prevent the progression of grade I and II senile cataract.
- Trial name
- NCT06639711
- Testing
- Taurine
- Where
- Iraq
- Volunteers
- 50 people
- Sponsor
- University Of Anbar
Pharmacokinetics
Tear Concentrations and Pharmacokinetics of Azithromycin Eye Drops in Healthy Volunteers
To evaluate azithromycin tear concentrations after one drop of azithromycin eyedrops (2.5ml/25mg) in healthy volunteers.
- Trial name
- NCT03252067
- Testing
- azithromycin eyedrop
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Macular Degeneration, Diabetic Retinopathy
Ocular Discomfort Assessment After Intravitreal Injections
In this study, ocular discomfort following intravitreal injection in naïve patients will be studied, as well as the efficacy of wetting agent (Optive eyewash) to prevent ocular discomfort.
- Conditions
- Macular Degeneration, Diabetic Retinopathy, Retinal Artery Occlusion, Myopia, Degenerative
- Trial name
- EVAGO (NCT02806830)
- Testing
- Optive
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Dry Eye Syndromes
Clinical Study to Investigate the Efficacy and Safety of SJP002 Ophthalmic Solution in Patients With Dry Eye Syndrome.
This study is to evaluate the efficacy and safety of SJP002 ophthalmic solution compared to placebo in patients with Dry Eye Syndrome.
- Trial name
- NCT03723811
- Testing
- SJP002 BID, SJP002 QID
- Where
- South Korea
- Volunteers
- 152 people
- Sponsor
- Samjin Pharmaceutical Co., Ltd.
Dry Eye Syndromes
Efficacy and Acceptability of Two Lubricant Eye Drops
Efficacy and acceptability of two new artificial tears following two weeks of treatment in patients with dry eye. Patients will be randomized to 1 of 2 treatments for 7 days then crossover to the alternate treatment for 7 days.
- Trial name
- NCT00756678
- Testing
- Lubricant Eye Drops (Optive™), Lubricating Eye Drops (blink® Tears)
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Allergan
Dry Eye Syndromes
Lifitegrast Eye Drops in Healthy Subjects：Phase I Study
This is a single-center, randomized, double-blind, single-dose, two-period crossover Phase I clinical trial designed to: Compare the pharmacokinetic (PK) profiles of Lifitegrast Ophthalmic Solution and Xiidra® in plasma and tears…
- Trial name
- NCT07040826
- Testing
- Xiidra, Lifitegrast
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Dry Eye
Clinical Evaluation of Lifitegrast Ophthalmic Solution 5.0% in Dry Eye Disease Using In Vivo Confocal Microscopy
This is a single center, open label trial to evaluate Lifitegrast Ophthalmic Solution 5.0% in Dry Eye Disease using In Vivo Confocal Microscopy (IVCM
- Trial name
- (IVCM) (NCT07560735)
- Testing
- Lifitegrast Ophthalmic Solution 5.0% (Xiidra)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Toyos Clinic
Dry Eye
Study of DE-089 Ophthalmic Solution in Patients With Dry Eye
Safety and efficacy of DE-089 ophthalmic solution in patients with dry eye will be evaluated in comparison with sodium hyaluronate ophthalmic solution.
- Trial name
- NCT01101984
- Testing
- diquafosol ophthalmic solution, 0.1% sodium hyaluronate ophthalmic solution.
- Where
- 2 sites in China, Singapore
- Volunteers
- 400 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Dry Eye, Dry Eye Syndromes
The TRANQUILITY Trial: Clinical Trial to Assess the Efficacy and Safety in Subjects With Dry Eye Disease
The TRANQUILITY Trial: Multi-Center Randomized, Double-Masked, Parallel Design, Vehicle-Controlled Phase 2/3 Clinical Trial to Assess the Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects…
- Trial name
- NCT04674358
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Vehicle Opthalmic Solution
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Dry Eye Syndromes
Lubricating Effectiveness of Carragelose Eye Drops in Patients Affected by Mild to Moderate Dry Eye
Patients suffering from dry eye syndrom will treat their eyes with Carragelose® eye drops three times a day for 28 days. Before, in the middle and at the end of the treament period patients will be exposed to adverse conditions…
- Trial name
- NCT06262100
- Testing
- Carragelose
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Marinomed Biotech AG
Age-Related Macular Degeneration
First-in-Human Study of LHA510 in Elderly Subjects and Patients With Age-Related Macular Degeneration
The purpose of this first-in-human study is to assess the local ocular and systemic safety and tolerability of LHA510 eye drops when administered at various concentrations and dosing frequencies.
- Trial name
- NCT02076919
- Testing
- LHA510 Ophthalmic Suspension, LHA510 Vehicle
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Glaucoma, Open-angle, Ocular Hypertension
A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
This is a Phase I, multi-center, randomized, adaptive, investigator/patient-masked, placebo-controlled, parallel multiple-ascending dose study (Part A) with an extension including up to two selected doses from Part A and…
- Trial name
- NCT03293992
- Testing
- 0.01% RO7058584, 0.1% RO7058584, 1% RO7058584
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Hoffmann-La Roche
Dry Eye Disease
A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Dry Eye Disease
The objective of this study is to compare the safety and efficacy of azithromycin ophthalmic solution, 1% in dry eye subjects over a four week treatment period, using placebo as a comparison.
- Trial name
- NCT01014078
- Testing
- Azithromycin Ophthalmic Solution, 1%
- Where
- 9 sites in United States
- Volunteers
- 112 people
- Sponsor
- Merck Sharp & Dohme LLC
Myopia
A Phase III Clinical Study of the Efficacy and Safety of Two Low-concentration Atropine Sulfate Eye Drops
This study was a randomized, double-blind, placebo-controlled, multicenter, superiority design, phase III clinical trial to compare the efficacy and safety of two low-concentration atropine sulfate eye drops versus placebo in…
- Trial name
- Mini-CHAMP (NCT06209281)
- Testing
- Lower dose atropine sulfate eye drops, Low dose atropine sulfate eye drops
- Where
- China
- Volunteers
- 526 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Dry Eye
Ocular Tolerability of Voclosporin Ophthalmic Solution Versus Restasis® in Subjects With Dry Eye Disease
Evaluate the tolerability, efficacy and safety of VOS versus Restasis® in subjects with mild to moderate Dry Eye Disease (DED).
- Trial name
- NCT03597139
- Testing
- Voclosporin Ophthalmic Solution, Restasis®
- Where
- 7 sites in United States
- Volunteers
- 100 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Glaucoma, Adherence
Effect of SMS Reminder and Free Eye Drops on Follow-up Adherence After Trabeculectomy Surgery in Rural China
The purpose of the study is to use a randomized controlled design to determine the impact of a SMS messaging associated with free eye drops intervention on the following outcomes among patients after trabeculectomy surgery in…
- Trial name
- NCT02328456
- Testing
- SMS and free eye drops
- Where
- China
- Volunteers
- 209 people
- Sponsor
- Congdon Nathan
Myopia
Bromday Versus Nevanac Eye Drops to Control Pain Following Photorefractive Keratectomy
This study will compare the effect of two topical non-steroidal antiinflammatory agents to control pain after photorefractive keratectomy (PRK) eye surgery.
- Trial name
- NCT01475877
- Testing
- Bromfenac
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virdi Eye Clinic
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